In lieu of an abstract, here is a brief excerpt of the content:The Arrows of Apollo BROOKE CLARK To Aachchi If thou beest he; But O how fallen, how changed From him who in the happy realms of light Clothed with transcendent brightness didst outshine Myriads though bright— —Milton, Paradise Lost i. Today, slumped at my desk, I glimpsed the sun. I wasn’t certain how long I had sat facing my own face’s dim reflection in my computer screen—chin ringed with (...) fat, the sharp-lined contours of my youth long gone, my cheekbones hidden, my bright gaze gone flat— and then—there—on the left side of my face a glow my slightest movement would erase. How that stippling brought me back to life: I felt like I was walking once again through woods where sunlight touched the trees in leaf. I felt warmth prickle up beneath my skin as though the flesh responded to the brief caress of light which brought hope rushing in, as though Apollo had reached down and laid his brilliant fingertips on what he’d made. A sharp, metallic rattle cut the air; Helen had stood up to close the blinds— Helen, too devoid of soul to care that some of us might greet the sun as friends. Her only comment was, “Jeez, what a glare!” arion 27.2 fall 2019 Sweet moments often come to such harsh ends: some people are too coarse for fragile joys, and spoil light with darkness, peace with noise. Helen was such a woman: lumpy, heavy, seemingly formed exclusively of fat, barely mobile yet constantly sweaty, like some malevolent Buddha, she sat and meditated acts of petty cruelty; each time she closed the blinds I heard, “Take that!” in their harsh snap, and felt as if she knew I longed for light, so wouldn’t let it through. Another bitter, desk-bound endomorph (although she would have seemed an Aphrodite to those who carved the Venus of Willendorf), and fated by her own obesity to be struck down and swiftly carried off by a sudden, massive coronary, in line at some all-you-can-eat buffet— she wasn’t worth my notice anyway, although she kept impinging on my sight, but then I caught the slight trace of a smirk when I turned back towards the vanished light (instead of going quietly back to work) and said, “The blinds were fine—it’s not too bright for me—without a window, it feels dark.” Helen snorted: “No thanks—too hot out there. I’m roastin’ like a turkey over here.” Who would not hate the court from which there lies no avenue or hope for an appeal? Her desk was on the coveted window side while mine sat boxed against an inside wall, and that gave Helen power over blinds and sunlight—that was office protocol. 64 the arrows of apollo I longed to feel Apollo’s fingertips but this slug-goddess ruled in grim eclipse. I felt like Milton’s Satan when he fell, plumbing so great a depth from such a height and measuring the lowest pits of Hell, prostrate, near dead—I sat, deprived of light, walled in by my grey-sided cubicle, and sank beneath my own despair’s dead weight. But why should Helen have the power to plunge me into darkness? I deserved revenge— revenge for all the time I’d wasted here, revenge for every hope that slowly died, revenge for every minute of every year, revenge for every bold attempt untried, revenge for every lonely, bitter tear I’d swallowed, choked back, or held in, uncried. Helen became, in that one poisoned moment, the symbol and the source of all my torment. Brooke Clark 65 ii. Boredom was my soul mate; the days slid by unused and empty; I sat and watched them go, hardly recalling that once even I had clung to aspirations—but it was so uncomfortably easy to let them die. I’d turned into a man I didn’t know: in youth, I’d never compromise or settle— so it seemed now—but memory gilds the nettle. Instead of working, I listened to the flies that mobbed the windows, struggling to get out; freedom stretched away... (shrink)

Planar cell polarity (PCP), the alignment of cells within 2D tissue planes, involves a set of core molecular regulators highly conserved between animals and cell types. These include the transmembrane proteins Frizzled (Fz) and VanGogh and the cytoplasmic regulators Dishevelled (Dsh) and Prickle. It is widely accepted that this core forms part of a ‘PCP pathway’ for signal transduction, which can affect cell morphology through activation of an evolutionary ancient regulatory module involving Rho family GTPases and Myosin II, and/or (...) the JNK kinase cascade. We have re‐examined the evidence for interactions between the proposed PCP pathway components, and question the placing of the cell morphology regulators in the same pathway as the PCP core. While Fz and Dsh are clearly involved in both PCP and Rho‐based cell morphology regulation, available evidence cannot currently discriminate whether these processes are linked mechanistically by a shared Fz/Dsh population, or pass by two distinct pathways. (shrink)

Planar cell polarity, the polarization of cells within the plane of the epithelium, orthogonal to the apical‐basal axis, is essential for a growing list of developmental events, and – over the last 15 years – has evolved from a little‐studied curiosity in Drosophila to the subject of a substantial research enterprise. In that time, it has been recognized that two molecular systems are responsible for polarization of most tissues: Both the “core” Frizzled system and the “global” Fat/Dachsous/Four‐jointed system produce molecular (...) asymmetry within cells, and contribute to morphological polarization. In this review, we discuss recent findings on the molecular mechanism that links “global” directional signals with local coordinated polarity. (shrink)