The COVID-19 pandemic is a health issue leading older adults to an increased vulnerability to unfavorable outcomes. Indeed, the presence of physical frailty has recently led to higher mortality due to SARS-CoV-2 infection. However, no longitudinal studies have investigated the role of neuropsychogeriatric factors associated with lockdown fatigue in healthy cognitive aging. Eighty-one healthy older adults were evaluated for their neuropsychological characteristics, including physical frailty, before the pandemic. Subsequently, 50 of them agreed to be interviewed and neuropsychologically re-assessed during the (...) lockdown and immediately after it. Moreover, during another home confinement, they performed a psychological screening to evaluate possible mood changes and fatigue. According to Fried's frailty criteria, at T0, 63% of the sample was robust, 34.5% pre-frail, and only 2.5% frail. Significantly, these subjects presented a decrease in handgrip strength and walking speed. Results from Principal Component Analyses and multiple regression models highlighted the contribution of “cognitive” and “psychological” factors in explaining handgrip strength and gait speed. At T3, lockdown fatigue was explained by higher scores on the Beck Depression Inventory and lower scores on the Trail Making Test part A. Results from a moderated-mediation model showed that the effect of psychomotor speed on lockdown fatigue was mediated by depression, with a moderating effect of gait speed. Our findings highlight the complex interrelationship between cognitive, psychological, and physical factors in the emergence of pandemic fatigue in a carefully selected older population. (shrink)

Riassunto: Neuroeconomia e neuroetica sono settori delle neuroscienze cognitive che studiano i correlati neurali di aspetti distinti, sebbene strettamente interconnessi, del processo decisionale. Mentre la neuroeconomia studia i meccanismi cerebrali che guidano verso la massimizzazione dell’utilità economica personale, la neuroetica integra tali conoscenze con quelle fornite dalle neuroscienze sociali per affrontare domande tipiche dell'etica e della filosofia morale. Gli studi oggi disponibili in questo ambito vengono qui discussi al fine di mettere a confronto l’ipotesi secondo cui le scelte economiche individuali (...) e socio-morali sono supportate da un unico circuito cerebrale con differenti input specifici per dominio rispetto a quella che prevede basi cerebrali specifiche per la scelta in ambito socio-morale. In linea con il primo dei due modelli, i dati presenti in letteratura sembrano confermare l’esistenza di un singolo sistema cerebrale associato ai diversi tipi di scelta, indipendentemente dal contesto decisionale individuale vs. socio-morale. Parole chiave: Decision-making; Neuroeconomia; Neuroetica; Extended Common Currency Schema; Social Valutation Specific Schema From Neuroeconomy to Neuroethics: Towards a Neuroscience of Individual and Socio-Moral Decisions: Neuroeconomics and neuroethics are subfields of cognitive neuroscience that address the neural correlates of distinct, although strongly intertwined, facets of decision-making. While neuroeconomics investigates the neural mechanisms underlying the maximization of personal economic utility, neuroethics integrates such knowledge with that provided by social neurosciences, in order to address typical questions in ethics and moral philosophy. We review the available research to contrast the hypothesis that both individual economic and socio-moral choices rely on a common brain network receiving domain-specific inputs and the claim that a specific brain network underpins choices in a socio-moral context. In line with the former model, currently available evidence supports the existence of a single brain network associated with both choice types, regardless of the economic individual vs. socio-moral decisional context. Keywords : Decision-making; Neuroeconomics; Neuroethics; Extended Common Currency Schema; Social Valutation Specific Schema. (shrink)