Mitochondria hold diverse and pivotal roles in fundamental processes that govern cell survival, differentiation, and death, in addition to organismal growth, maintenance, and aging. The mitochondrial protein import system is a major contributor to mitochondrial biogenesis and lies at the crossroads between mitochondrial and cellular homeostasis. Recent findings highlight the mitochondrial protein import system as a signaling hub, receiving inputs from other cellular compartments and adjusting its function accordingly. Impairment of protein import, in a physiological, or disease context, elicits adaptive (...) responses inside and outside mitochondria. In this review, we discuss recent developments, relevant to the mechanisms of mitochondrial protein import regulation, with a particular focus on quality control, proteostatic and metabolic cellular responses, triggered upon impairment of mitochondrial protein import. (shrink)

The main purpose of this study was to examine the relationship between flow experience and goal orientation theory, as well as, the differences in flow experience based on the orthogonal model of goal orientation theory. Two hundred and seventy eight athletes completed the Task and Ego Orientation Sport Questionnaire based on how they usually feel. The Flow State Scale was completed thirty minutes after an important competition, along with the challenge-skill ratings, based on how athletes felt during the particular competition. (...) The results indicated that the athletes’ task orientation may be the critical factor for attaining flow in competitive sport, feeling more skillful and estimating the upcoming competition as challenging, while ego orientated athletes lack these elements, which are important for them to get into flow. Additionally, the balance between athletes’ goal orientation preferences seems important for the formation of flow experience. (shrink)

Τhis paper revisits the luxurious Palaiologan illuminated manuscript of the New Testament, Codex 31 of the Hagia Lavra monastery in Kalavryta. Iconographic and stylistic characteristics of the miniatures are compared with others and with seals of the early fifteenth century, as well as with the wall-paintings of the Pantanassa Monastery at Μystras (ca 1430). It is argued that the codex was commissioned by Georgios Kantakouzenos Palaiologos, a close collaborator of Konstantinos Palaiologos, Despot of the Morea and subsequent emperor, who lived (...) in Kalavryta and promoted his personal library, which was enjoyed even by Ciriaco of Ancona. (shrink)