BackgroundCollecting post-mortem brain tissue is essential, especially from healthy “control” individuals, to advance knowledge on increasingly common neurological and mental disorders. Yet, healthy individuals, on which this study is focused, are still understudied. The aim of the study was to explore, among healthy potential brain donors and/or donors’ relatives, attitude, concerns and opinion about post-mortem brain donation (PMBD).MethodsA convenience sampling of the general population (twins and their non-twin contacts) was adopted. From June 2018 to February 2019, 12 focus groups were (...) conducted in four Italian cities: Milan, Turin, Rome and Naples, stratified according to twin and non-twin status. A qualitative content analysis was performed with both deductive and inductive approaches. Emotional interactions analysis corroborated results.ResultsOne hundred and three individuals (49–91 yrs of age) participated. Female were 60%. Participants had scarse knowledge regarding PMBD. Factors affecting attitude towards donation were: concerns, emotions, and misconceptions about donation and research. Religion, spirituality and secular attitude were implied, as well as trust towards research and medical institutions and a high degree of uncertainty about brain death ascertainment. Family had a very multifaceted central role in decision making. A previous experience with neurodegenerative diseases seems among factors able to favour brain donation.ConclusionsThe study sheds light on healthy individuals’ attitudes about PMBD. Brain had a special significance for participants, and the ascertainment of brain death was a source of debate and doubt. Our findings emphasise the importance of targeted communication and thorough information to promote this kind of donation, within an ethical framework of conduct. Trust in research and health professionals emerged as an essential factor for a collaborative attitude towards donation and informed decision making in PMBD. (shrink)

Nineteenth-century Italy is a vast, unexplored territory in the history of modern political thought and liberal democratic theory. Apart from Mazzini, Pareto, and Mosca, the authors of this period are little read, even though their central concerns - the riddle of human liberation, progress, and liberty - are as important today as ever. This volume presents a selection of the writings of Carlo Cattaneo, one of the period's most important thinkers, as selected by an equally important personage of a subsequent (...) time, the anti-Fascist intellectual Gaetano Salvemini.Cattaneo had a profound sense of the historical contingencies underlying the quest both to understand human affairs and to realize a self-governing society. Cattaneo's ideas and framework of analysis - like those of John Stuart Mill and Alexis de Tocqueville - were not shaped by a narrow intra-academic agenda but by the great social, economic, and political transformations of his time. The issues he addressed included problems of revolution, reform, and change in the passage to modernity, which extended far beyond the confines of nineteenth-century Italy.The selection of original pieces presented in this translation is preceded by an introduction by the editors, Carlo G. Lacaita and Filippo Sabetti, which guides the reader through Cattaneo's thinking and puts it in a comparative context. Ultimately, however, it is the editors' goal to let this profound Italian thinker speak for himself. (shrink)