Studying knowledge utilization and related processes calls for a conceptual framework. We look at the actors that engage in these processes in a specific field of human activity, and the interfaces and linkages between them, as a Knowledge and Information System (KIS). Although this KIS perspective originates from agriculture it also can be applied to other knowledge domains. Evidence gathered shows that for a KIS to be effective the actors (e.g., researchers, extensionalists, and clients) must act synergically. This inspired us (...) to look for basic KIS principles that indicate opportunities for intervention. This article provides a brief state-of-the-art overview, presents some insights gained to date; and states the main issues for the use of information technology in knowledge management. (shrink)