Abstract
The purpose of this paper is to investigate how ISs may be conceptualized from an individual, neurobiological perspective. The point of departure is the fact that brains evolved to control the activities of bodies in the world. Based on a number of theoretical contributions bordering between the neural and social realms, a novel IS conceptualization emerges as a dialectical unity of functional organs in the brain and the IT artifact. As a consequence, the IS is conceptualized as intrinsically associated with the individual. I discuss implications of this position for epistemology, ontology, and representation, which are all fundamental aspects of IS research. In conclusion, I claim that a neurobiological perspective on IS has a great potential to advance the discussion of the nature of the IS.