Abstract
This Chapter aims to present a very preliminary exploration of the role and functioning of some ‘leading ideas’ that represent the most consistent attempts to balance freedom of scientific research with the need to protect participants and the community as a whole. To this end, we searched two databases, a scientific and a legal one, for some keywords (Freedom of research, Precautionary principle, Risk-based approach, Responsible research and innovation), to check the consistency of their presence and evolution over time. Without aiming to in-depth investigate the precise connotations of each term and the context in which they are used from time to time, the core idea is to provide a very first quantitative exploration, which lays the foundations for further future investigation.