Abstract
The net scientific value of the basic principles of modern sciences (physics, chemistry, and biology) is analyzed in order to identify their debatable elements, and to conclude the non- validity of a strict positivism in which the building of purely rational knowledge and cosmovision is still possible on the basis of merely empirical facts. The different interpretation of the principles of quantum mechanics, the difficulties of an atomism strictly considered, and the postulates of the evolution of life, give enough arguments to legitimate the doubt in our scientific points of view as a coherent and acceptable philosophy of the nature