Synthesis and antiviral activity of 2-3,5 dinitropheny1-5-substituted phenyl 1,3,4-oxadiazoles

International Journal of Advanced Academic Studies 2 (3):262-263 (2020)
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Abstract

3, 5 dinitro benzoic acid hydrazide was prepared by the hydrazinolysis of the corresponding ethyl ester. Condensation of this hydrazide with different aromatic acids in presence of POCl3 gave 2-3, 5 dinitropheny1-5-substituted pheny1 1, 3, 4-oxadiazoles. All the final compounds were tested against Ranikhet Disease Virus (RDV). However no compound showed antiviral activity against RDV.

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