Finding treasures in frozen cells: new centriole intermediates

Bioessays 29 (7):630-634 (2007)
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Abstract

Centriole duplication has been an area of interest since the late 1800s when Boveri suggested that these structures were central organizers for mitosis and cell division. Two groups1, 2 have delineated a linear pathway for centriole assembly. In C. elegans, Pelletier and coworkers1 have identified intermediates in the pathway using cryo‐electron tomography. Surprising, the first intermediate is a hollow tube of 60 nm that increases in diameter and then elongates before acquiring microtubules. Similar structures have not been observed to date in other centrioles. BioEssays 29:630–634, 2007. © 2007 Wiley Periodicals, Inc.

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