The Nyāyamukha by Dignāga, considered the founder of the Buddhist epistemological school, is known to have been studied intensively by East Asian Buddhists and scholars through Xuanzang’s Chinese translation. However, Jinendrabuddhi’s commentary on Dignāga’s Pramāṇasamuccaya offers a clue that helps to better understand the religio-philosophical and historical position of the Nyāyamukha in South and East Asia. The eighth-century commentator describes the Nyāyamukha as a work for highly intelligent persons and contrasts it to Dignāga’s Pramāṇasamuccaya. He also preserves fragments of the (...) Nyāyamukha’s final verse, which served as the basis for a Sanskrit reconstruction of the verse, published in 2005. The present paper first examines the historical implications of Jinendrabuddhi’s interest in the Nyāyamukha and then discusses the hitherto accepted and yet problematic interpretation of its final verse. An analysis of relevant materials will include East Asian Buddhist sources in Chinese to seek evidence related to Jinendrabuddhi’s text. A detailed examination of hermeneutic aspects will lead us to reinterpreting the poison simile, “intellect-poison”, as well as a discussion of how this term was used by Vasubandhu. This will show that it is possible that the Sanskrit reconstruction should be modified slightly. (shrink)