The diffusion of Vygotsky’s work in Italy was analysed by first considering the issues related to the translation of his texts since the 1970s, particularly with regard to the project promoted by the publishing house of the Italian Communist Party and supervised by the author of this article. Second, the reception of cultural-historical theory was discussed in the context of Italian psychology and medicine in the 1970s and 1980s. After an early acceptance of Pavlovian theory by a few Italian psychologists (...) linked to the Communist Party, the need was felt to overcome physiological reductionism in relation to the new social and psychological problems connected with the development of Italian society. Finally, a brief reference was made to Italian neo-Vygotskyan trends in various areas of contemporary psychological research. (shrink)