The chromosomes of eukaryotic cells possess many potential DNA replication origins, of which a subset is selected in response to the cellular environment, such as the developmental stage, to act as active replication start sites. The mechanism of origin selection is not yet fully understood. In this review, we summarize recent observations regarding replication origins and initiator proteins in various organisms. These studies suggest that the DNA‐binding specificities of the initiator proteins that bind to the replication origins and promote DNA (...) replication are primarily responsible for origin selection. We particularly focus on the importance of transcription factors in the origin selection process. We propose that transcription factors are general regulators of the formation of functional complexes on the chromosome, including the replication initiation complex. We discuss the possible mechanisms by which transcription factors influence the selection of particular origins. BioEssays 27:1107–1106, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Product recommendation system is realized by applying business rules acquired by data maining techniques. Business rules such as demographical patterns of purchase, are able to cover the groups of users that have a tendency to purchase products, but it is difficult to recommend products adaptive to various personal preferences only by utilizing them. In addition to that, it is very costly to gather the large volume of high quality survey data, which is necessary for good recommendation based on personal preference (...) model. A method collecting kansei information automatically without questionnaire survey is required. The constructing personal preference model from less favor data is also necessary, since it is costly for the user to input favor data. In this paper, we propose product recommendation system based on kansei information extracted by text mining and user's preference model constructed by Category-guided Adaptive Modeling, CAM for short. CAM is a feature construction method that can generate new features constructing the space where same labeled examples are close and different labeled examples are far away from some labeled examples. It is possible to construct personal preference model by CAM despite less information of likes and dislikes categories. In the system, retrieval agent gathers the products' specification and user agent manages preference model, user's likes and dislikes. Kansei information of the products is gained by applying text mining technique to the reputation documents about the products on the web site. We carry out some experimental studies to make sure that prefrence model obtained by our method performs effectively. (shrink)

Futabatei Shimei (1864-1909) was an early modern Japanese novelist, translator, and critic. He wrote what is now generally conceived of as the first Japanese ‘modern’ novel, Drifting Clouds (1887-89). He translated works by Turgenev, Leo Tolstoy, Garshin, Gorky, and others. He also published a number of critical essays, treatises on literary theory, political papers, and so forth. His early translation of Turgenev’s short stories: Aibiki (Rendevous, 1888) and Meguriai (Three Trysts, 1889) were extremely influential on the contemporary literati, who were (...) amazed at the fresh, poetic prose used in stark contrast to the traditional Japanese fiction in the pre-Reformation period. These translations, seen in the light of the present-day readers, were unique in what we might term today ‘foreignizing translation’. Lawrence Venuti in Invisibility of the Translator argues that the ideal of (English) translation has been to conceal itself as a translation, i.e. to present itself as an original text (chap I and passim). In that sense, Futabatei’s translations, scandalously presenting itself as a translation, that is to say, as an alien text, is extremely ‘foreignizing’. (shrink)

Spontaneous actions are preceded by brain signals that may sometimes be detected hundreds of milliseconds in advance of a subject's conscious intention to act. These signals have been claimed to reflect prior unconscious decisions, raising doubts about the causal role of conscious will. Murakami et al. (2014. Nat Neurosci 17: 1574–1582) have recently argued for a different interpretation. During a task in which rats spontaneously decided when to abort waiting, the authors recorded neurons in the secondary motor cortex. The (...) neural activity and relationship to action timing was parsimoniously explained using an integration-to-bound model, similar to those widely used to account for evidence-based decisions. In this model, the brain accumulates spontaneously occurring inputs voting for or against an action, but only commits to act once a certain threshold is crossed. The model explains how spontaneous decisions can be forecast (partially predicted) by neurons that reflect either the input or output of the integrator. It therefore presents an explicit hypothesis capable of rejecting the claim that such predictive signals imply unconscious decisions. We suggest that these results can inform the current debate on free will but must be considered with caution. (shrink)

Parties are back, and many are cheering. Party polarization has voters seeing stark differences between Democrats and Republicans and demonstrating more ideological constraint than previous generations. But these signs of a more “responsible” electorate are an illusion, because the public is no more knowledgeable than ever about the type of “information” it needs if it is to exercise effective control over the public‐policy outcomes it cares the most about. Indeed, polarization has produced a political environment where both voters and policy (...) makers may be less likely to learn about the potential consequences of their governing choices. The result is that holding elected politicians to account for policies treated as divisive ends in themselves has become easier—but that holding them accountable for policies intended as means to the achievement of consensual ends has become harder. (shrink)

This paper generalizes the simple regret model by Bell in Operations Research 30(5), 961-981 and Loomes and Sugden in The Economic Journal 92(368), 805-824 to cope with the situation in which decision outcomes are multi-attributed. We propose a model that combines the simple regret model for ex ante preferences and the additive difference representation for ex post preferences. We first present a necessary and sufficient axiomatization of our model in Savage’s framework. The proposed model is composed of three types of (...) functions. One is a value function for each attribute. The others are attribute-dependent and holistic regret-rejoicing functions that capture trade-offs among value-differences of chosen and forgone outcomes for each attribute and among all attributes, respectively. We then provide constructive procedures for those functions and methods for consistency checks of the procedures. We, finally, conduct an experiment to estimate those functions in the two attributes case by means of the constructive procedure and give an application of the model and our findings. (shrink)

頽廃に至っても、いまだ発現する偶然への希望はある。しかし、頽廃、すなわち消尽に至るならば、無と慨嘆の現実しかありえない。希望の存立自体、五分の可能性に生きる偶然なのである。.

This paper examines how British war veterans fold together war time and post war experiences in practices of remembering and reconciliation. We examine these practices as networks of association between British ex-servicemen (veterans) and the people, places and circumstances associated with their experiences as prisoners in Japan during WW2. We focus on the experience of World War 2 British ex-servicemen (veterans) who were prisoners of war in Far East. During their period of captivity they worked to build Thai-Burma Railway before (...) transfer to a copper mine in Japan. Some 50 years later they participated in a "reconciliation trip" to Japan. We discuss two related issues. First, how and in what ways are the post war lives and war time experiences of these veterans gathered up in the emergent collectivity of such practices? In other words in what ways do these practices emerge and sustain themselves as a process of collection and dispersion of circulating reference in networks of association between people places and things. Second, we examine how accounts of redemption (claims to the consequences of experience as being other than you would expect them to be) create the basis for emergent forms of agency and settlement in expanding networks of remembering and reconciliation. (shrink)

A real but typical case of identity fraud is used to open up the complex web of identification systems in Brazil. It is argued that identification has two poles related to the nature of citizenship—repression and inclusion—and that reactions from citizens to new identification schemes can be attributed to how they view the purpose of the cards in these terms. In Brazil, a sense of inclusion and citizenship based on a fear of anonymity and exclusion predominates leading to widespread support (...) amongst even critics of state activities. However, this may be undermined by the lack of state preparation for an information society, particularly the absence of meaningful data protection laws. (shrink)

Do people tend to disagree over political issues because of conflicting values? Or do they disagree about which policies will most effectively promote shared values? In a previous article, I argued that the issues most people think are most important tend to fall into the latter category. On the issues of greatest importance to the mass public, most citizens agree about the ends that are desirable, but disagree about which policy means would best effectuate those ends. Consequently, disputes about facts—disputes (...) about the actual effects of proposed public policies—lie at the heart of the most important divisions in contemporary American public opinion. However, people do not necessarily interpret their political disagreements this way. If they fail to recognize that facts that they see as self-evident are disputed by their opponents, they may see their opponents as having different values, since there could be few other explanations for their opponents' disagreement with them. However, evidence that disagreements about facts are really driving public opinion can be found by using conditional surveys, which ask respondents if they would support a given policy if they believed that it would cause specific negative consequences. (shrink)

The present article is based on a interview with a Japanese experienced caregiver who specializes in patients with amyotrophic lateral sclerosis, which generally leads to the locked-in syndrome. Professional caregivers for ALS patients with ventilator experience two particular temporalities in their practice. First, they must monitor the patient continuously during a seven-hour stay. Because a single problem in the ventilator can have fatal consequences, the care of an ALS patient with a ventilator requires long periods of sustained concentration. Second, trying (...) to understand the signs of a patient with a ventilator sometimes requires three hours to go through ten alphabets. In addition to the huge effort that such communication requires, caregivers must complete the meaning of the signs with their imagination: the ten alphabets are not sufficient to understand what the patient really wants to say. This imaginative capacity, however, is based on a long relationship, which started when the patient was still able to speak and move. That is why, as this article will show, even when a patient has entered total LIS, the caregiver can continue to realize his or her wishes. (shrink)

Do people tend to disagree over political issues because of conflicting values? Or do they disagree about which policies will most effectively promote shared values? In a previous article, I argued that the issues most people think are most important tend to fall into the latter category. On the issues of greatest importance to the mass public, most citizens agree about the ends that are desirable, but disagree about which policy means would best effectuate those ends. Consequently, disputes about facts—disputes (...) about the actual effects of proposed public policies—lie at the heart of the most important divisions in contemporary American public opinion. However, people do not necessarily interpret their political disagreements this way. If they fail to recognize that facts that they see as self-evident are disputed by their opponents, they may see their opponents as having different values, since there could be few other explanations for their opponents' disagreement with them. However, evidence that disagreements about facts are really driving public opinion can be found by using conditional surveys, which ask respondents if they would support a given policy if they believed that it would cause specific negative consequences. (shrink)

In studies publishing identifying personal information, obtaining consent is regarded as necessary, as it is impossible to ensure complete anonymity. However, current journal practices around specific points to consider when obtaining consent, the contents of consent forms and how consent forms are managed have not yet been fully examined. This study was conducted to identify potential issues surrounding consent to publish identifying personal information.

Future practitioners of sustainable agriculture and agroecology must have the capacity to address the wicked problems in the food system to make progress toward sustainability. Undergraduate sustainable agriculture students from a variety of backgrounds may struggle with the question, is the challenging and complex work of addressing wicked problems of agroecology for me? Our case study investigated sociocultural tensions associated with identity encountered when wicked problems teaching units were integrated into the Advanced Practices of Sustainable Agriculture course at a large, (...) Midwestern Land Grant University. The research and course employed a four-part framework that focused on attending to individual needs and identities, facilitating practice-based and community-based learning, engaging in problems situated in regional contexts, and supporting awareness of local and global political and ecological issues. Researchers used a community of practice theoretical lens, and focused on the sociocultural tensions that may have impacted individual and community identity formation. Two wicked problems teaching units are described by drawing upon documentation and audio recordings from planning meetings, course sessions, student and instructor interviews, and course artifacts. Vignettes were constructed to situate four interrelated types of sociocultural tensions encountered by instructors and students. These tensions reflected forces at the individual, community, local, and global levels which interact to influence learners’ capacity to become full participants in sustainable agriculture. The study fills a gap related to affective dimensions of learning like identity in agroecology education. Dilemmas and implications related to identity, pedagogy, and epistemology are discussed. (shrink)

Behind the phase of cognition analysed by Husserl, there is a phase of affection. In this phase, there are significant mental disorders occurring. Similar to the way in which the phase of cognition is divided into reference, meaning (referent), and representation of words (classification according to Husserl's theory of meaning), the phase of affection is also divided into reference, “meaning,” and figure as sphere of “meaning”. The situation as a reference can allow various predications to form different explanations, i.e. different (...) states of affairs. From the point of view of affection, this reference has another role. The affection of a situation obliges us to produce bodily “meanings,” which is a sign of health. Mental disorders can be described as some distortion in the phase of affection. Healing in this regard occurs through the restoration of creativity for “meanings” which assume the situation. (shrink)

The “phenomenological” method according to Emmanuel Lévinas consists of two steps: first, reducing the said (le dit) to the saying (le dire); and second, “hyperbole” in his own words. Reducing the said to the saying, in itself, means in this context of the methodology a method to escape from ontology and cognitive philosophy, and to discover the dimension of inter-human facticity. In the second step of “hyperbole”, Lévinas outlines the horizon of this inter-human facticity as that of affectivity. In this (...) horizon (of ethics), the self is defined as phenomena containing the affectivity related to the two extreme situations: personal (physical and mental) suffering and that of the other. Ultimately, the death of the other person and a person’s own possible death limit the internal structure of this horizon. (shrink)

Agger, Ben, Critical Social Theories - An Introduction (reviewed by Thomas Murakami).

How can we effectively promote the public’s prevention of coronavirus disease 2019 infection? Jordan et al. found with United States samples that emphasizing either self-interest or collective-interest of prevention behaviors could promote the public’s prevention intention. Moreover, prosocially framed messaging was more effective in motivating prevention intention than self-interested messaging. A dual consideration of both cultural psychology and the literature on personalized matching suggests the findings of Jordan et al. are counterintuitive, because persuasion is most effective when the frame of (...) the message delivered and the recipient of the message are culturally congruent. In order to better understand the potential influence of culture, the current research aimed to replicate and extend Jordan et al. findings in the Japanese context. Specifically, we examined the question whether the relative effectiveness of the prosocial appeal is culturally universal and robust, which types of ‘others’ especially promote prevention intention, and which psychological mechanisms can explain the impact of messaging on prevention intention. In Study 1, we confirmed that self-interested framed, prosocially framed, and the combination of both types of messaging were equally effective in motivating prevention intention. In Study 2, we found that family-framed messaging also had a promoting effect similar to that from self-interested and prosocial appeals. However, the relative advantage of prosocial appeals was not observed. Further, a psychological propensity relevant to sensitivity to social rejection did not moderate the impact of messaging on prevention intention in both studies. These results suggest that since engaging in the infection control itself was regarded as critical by citizens after public awareness of COVID-19 prevention has been sufficiently heightened, for whom we should act might not have mattered. Further, concerns for social rejection might have had less impact on the prevention intentions under these circumstances. These results suggest that the relative advantage of a prosocial appeal might not be either culturally universal or prominent in a collectivistic culture. Instead, they suggest that the advantages of such an appeal depends on the more dynamic influence of COVID-19 infection. (shrink)

This paper seeks to demonstrate the structural difference in communication of schizophrenia and autism. For a normal adult, spontaneous communication is nothing but the transmission of phantasía (thought) by means of perceptual objects or language. This transmission is first observed in a make-believe play of child. Husserl named this function “perceptual phantasía,” and this function presupposes as its basis the “internalized affection of contact” (which functions empirically in eye contact, body contact, or voice calling me). Regarding autism, because of the (...) innate lack of affection of contact, intersubjective perceptual phantasía does not occur spontaneously. Consequently, autistics do not engage in make-believe play but in stereotyped and solipsistic play. Without the formation of perceptual phantasía, there is no differentiation between phantasía and perception. For this reason, people with Asperger's syndrome consider conversation not an immediate communication of thought but a logical transmission of concepts. Schizophrenia is characterized by a distortion in the internalized affection of contact, resulting in a disturbance of perceptual phantasía, and this later is covered by various symptoms—for example, delusion as a pathological kind of communication of thought. This delusion is based on the pathological internalized affection of contact represented by a terrifying Other. (shrink)

A few findings from our laboratory are provided as evidence favoring “isomrphism” in filling-in. One is the responsivity of macaque-cortical area V1 cells to a stimulus designed for surface filling-in at the blind spot. Another is a phenomenological observation of motion aftereffect confined within a filled-in surface at the blind spot. Our recent study on the monkey's perception of surface filling-in at a scotoma is also mentioned.