IntroductionDeep brain stimulation is an effective treatment for advanced Parkinson’s disease with the targeting bilateral subthalamic nucleus or globus pallidus internus. So far, detailed studies on the efficacy of unilateral STN-DBS for motor symptoms have been reported, but few studies have been conducted on unilateral GPi-DBS.Materials and MethodsSeventeen patients with Parkinson’s disease who underwent unilateral GPi-DBS were selected. We conducted comparison analyses between scores obtained 6–42 months pre- and postoperatively using the following measurement tools: the Movement Disorder Society Unified Parkinson’s (...) Disease Rating Scale part III, the Hoehn and Yahr stage, the presence/absence of dyskinesia, Mini-Mental State Examination, Frontal Assessment Battery, Geriatric Depression Scale, levodopa equivalent dose, and cerebral blood flow by single photon emission computed tomography. Patient backgrounds were compared between four cohorts with favorable and unfavorable postoperative outcome.ResultsSignificant improvement was observed postoperatively in the following: total MDS-UPDRS Part III scores during the off period, contralateral scores, ipsilateral scores, and axial scores. Similarly, the Hoehn and Yahr stages during the off period, and GDS also showed significant decrease. In contrast, LED, MMSE, and FAB remained unchanged while the number of patients who scored positive for dyskinesia decreased by 40%. Abnormal cerebral blood flow preoperatively seen in the cerebral cortex had normalized in the total score-based good responder cohort. In the ipsilateral score-based good responder cohort, cerebral blood flow increased in the contralateral frontal lobe including in the premotor cortex, contralateral to the DBS. Compared to the poor responders, postoperative good responders demonstrated significantly higher preoperative MMSE scores.DiscussionUnilateral GPi-DBS therapy was effective in improving contralateral, ipsilateral, and axial motor symptoms of patients with advanced PD; in particular, it was found to be especially beneficial in PwPD whose cognitive function was unimpaired; the treatment efficacy rivaled that of bilateral counterparts up till at least 6 months postoperatively. Finally, normalization of preoperative abnormalities in cerebral blood flow and increased cerebral blood flow in the contralateral frontal lobe indicated the beneficial potential of this therapy on ipsilateral motor symptoms. (shrink)

Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)

ABSTRACTAnother individual’s gaze automatically shifts an observer’s attention to a location. This reflexive response occurs even when the gaze is presented subliminally over a short period. Another’s gaze also increases the preference level for items in the gaze direction; however, it was previously unclear if this effect occurs when the gaze is presented subliminally. This study showed that the preference levels for nonsense figures looked at by a subliminal gaze were significantly greater than those for items that were subliminally looked (...) away from. Targets that were looked at by a subliminal gaze were detected faster ; however, the participants were unable to detect the gaze direction. These results indicate that another individual’s gaze automatically increases the preference levels for items in the gaze direction without conscious awareness. (shrink)

In any nonstandard model of Peano arithmetic, the standard part is not first-order definable. But we show that in some model the standard part is definable as the unique solution of a formula , where P is a unary predicate variable.

We say that a subset A of M is implicitly definable in M if there exists a sentence $\phi$ in the language $\mathcal{L} \cup \{P\}$ such that A is the unique set with $ \models \phi$. We consider implicit definability of subfields of a given field. Among others, we prove the following: $\overline{\mathbb{Q}}$ is not implicitly $\emptyset$-definable in any of its elementary extension $K \succ \overline{\mathbb{Q}}$. $\mathbb{Q}$ is implicitly $\emptyset$-definable in any field K with tr.deg $_{\mathbb{Q}}K < \omega$. In a (...) field extension $\mathbb{Q} < K$ with K algebraically closed, $\mathbb{Q}$ is implicitly definable in K if and only if tr.deg $_{\mathbb{Q}}$ is finite. (shrink)

In this paper we define the notion of -linearity for and discuss interpretability (and noninterpretability) of -linear orders in structures and theories.

This article considers the implications of the early development of London Zoo. It gives insight into the differences between the ideal image of the zoo, the real situation under which the zoo was managed, and popular perceptions of the zoo. The discussion explores three areas: the heterogeneous audience of the zoo, the aestheticization of the zoo and its animal displays, and the pedagogy of observing nonhuman animals in the zoo. The zoo's ideals confronted various difficulties, while the pedagogy of zoo (...) visits, which developed within a frame of natural theology, was subject to various applications. The article argues that these differences were not evidence of the zoo's failure to consolidate its ideological backbone in Victorian society. It concludes that such divergence characterized the zoo's unique capacity both to evoke and to receive competing ideals, anxieties and criticism. (shrink)

Molecular and biochemical analysis of the biogenesis of peroxisomes has made rapid progress in recent years. Research on the mechanism of targeting of peroxisomal proteins has revealed that many, but not all, peroxisomal proteins have a conserved tripeptide motif in their carboxy‐terminal portions which is required for entry into peroxisomes; the topogenic signal mechanism thus differs in these instances from those employed in mitochondria and endoplasmic reticulum. Other factors involved in peroxisome biogenesis are also coming to light.

The paper attempts to construct a global model of a social contract using well-known metaphors of two great philosophers: Jean-Jacques Rousseau and John Locke. By modelling a global social contract, I mean the formulation of a social contract using two sets of data: one is global citizens' preferences about values and norms while the other is sovereign states' participation in multilateral treaties. Both Rousseau and Locke formulate their versions of social contract theories in the national context of eighteenth-century Europe. This (...) paper tries my hands on extending their theories to the global context. This paper attempts to link empirically the relationship between global citizens' preferences as gauged by the World Values Survey and sovereign states' participation in 120 multilateral treaties deposited to the United Nations. To see the link between citizens and treaties (quasi-legislative outcomes, sort of), dimensional similarities of the cosmos of citizens' preference and the cosmos of sovereign states' willingness to join multilateral treaties are examined. Once done, all the sovereign states are located in each of the two cosmoses, citizens and states, and the correlation coefficients between them are measured. Based on these empirical results, the nature of the global quasi-legislative process is clarified. Conclusions and implications are drawn. (shrink)

「意識のクオリア」も五感も、すべては錯覚だった。「心は脳が作り上げた幻想である」ことを述べた著者が、自己意識や五感が錯覚であることに的を絞って説明。.

闇斎門下の個性豊かな諸家の事跡を通して、垂加神道の史的展開を検討すると共に、『日本書紀』神代巻の解釈に見える思想の根幹を明らかにする。.

The paper explores the logical strength of Isbell's zig‐zag theorem using the framework of reverse mathematics. Working in, we show that is equivalent to Isbell's zig‐zag theorem for countable monoids: If B is a monoid extension of A, then is dominated by A if and only if b has a zig‐zag over A. Our proof of Isbell's zig‐zag theorem avoids use of strong comprehension axioms common in traditional proofs. We also analyze the strength of theorems concerning binary relations.

Modal realism -- Time, space, world -- Existence -- Actuality -- Modal realism and modal tense -- Transworld individuals and their identity -- Existensionalism -- Impossibility -- Proposition and relief -- Fictional worlds -- Epistemology.

This book constitutes the thoroughly refereed joint post-proceedings of three international workshops organized by the Japanese Society for Artificial Intelligence, held in Tokyo, Japan in June 2006 during the 20th Annual Conference JSAI 2006. The volume starts with eight award winning papers of the JSAI 2006 main conference that are presented along with the 21 revised full workshop papers, carefully reviewed and selected for inclusion in the volume.

We introduce several concepts concerning the indiscernibility of trees. A tree is by definition an ordered set such that, for any a∈O, the initial segment {b∈O:b (...) A of the form η∈O, where O is a tree, and aη labeled by η is an element in M. Such a set A is also called a tree in this paper. We study the indiscernibility of trees A in general settings and apply the obtained results to the study of unstable theories. (shrink)

Sherlock Holmes is a fictional individual. So is his favorite pipe. Our pre-theoretical intuition says that neither of them is real. It says that neither of them really, or actually, exists. It also says that there is a sense in which they do exist, namely, a sense in which they exist “in the world of” the Sherlock Holmes stories. Our pre-theoretical intuition says in general of any fictional individual that it does not actually exist but exists “in the world of” (...) the relevant fiction. I wish to defend this pretheoretical intuition. To do so, I need to defend two claims: that fictional individuals do not actually exist, and that they exist “in the world of” the relevant fiction. The aim of this paper is to defend the first claim. (shrink)