This essay focuses on the categerial expression of the metaphysics of ecstatic naturalism and the theology of deep pantheism. Naturalism, the theory that nature is all that there is, becomes the ecstatic form by stressing the continual fissuring between nature naturing and its potencies and nature natured seen as the innumerable orders of the world. Deep pantheism critiques the dualism of supernatural theism as well as the half-way theology of panentheism. Further, deep pantheism is “deep” because it focuses on the (...) churning abyss of the unconscious of nature and it’s archetypal potencies. (shrink)

On Indic philosophy with special reference to Gujaratis (Indic people) and Gujarat, India.

Comparative and analytical study of renunciation in Indic philosophy and religion.

Exhaustive study on the philosophy of R̥gveda, Hindu canonical text.

Dictionary of concepts of Indian philosophy.

The Institutional Animal Care and Use Committee is entrusted with assessing the ethics of proposed projects prior to approval of animal research. The role of the IACUC is detailed in legislation and binding rules, which are in turn inspired by the Three Rs: the principles of Replacement, Reduction, and Refinement. However, these principles are poorly defined. Although this provides the IACUC leeway in assessing a proposed project, it also affords little guidance. Our goal is to provide procedural and philosophical clarity (...) to the IACUC without mandating a particular outcome. To do this, we analyze the underlying logic of the Three Rs and conclude that the Three Rs accord animals moral standing, though not necessarily “rights” in the philosophical sense. We suggest that the Rs are hierarchical, such that Replacement, which can totally eliminate harm, should be considered prior to Reduction, which decreases the number of animals harmed, with Refinement being considered last. We also identify the need for a hitherto implicit fourth R: Reject, which allows the IACUC to refuse permission for a project which does not promise sufficient benefit to offset the pain and distress likely to be caused by the proposed research. (shrink)

In recent years, the established paradigm of the three Rs of animal research—refinement, replacement, and reduction—has come under scrutiny. A crucial weakness in use of the three Rs is uncertainty about how they should be prioritized. Events like pandemics have the power to alter the research landscape, fast‐tracking innovation and setting new precedents. Existential threats can raise perceptions of social benefit and can lower animal‐welfare thresholds. The rush to develop new research models may also undermine progress in reducing or replacing (...) animal models. By circumventing the barrier posed by animal models that are poorly matched to human conditions, new technologies like CRISPR can enhance the refinement component while undermining reduction and replacement. This pandemic has exposed the need for an urgent review of the efficacy of the three Rs, with the potential to establish a new set of protocols for animal research, both inside and beyond the context of an emergency. (shrink)