The study of intellectual humility is still in its early stages and issues of definition and measurement are only now being explored. To inform and guide the process of defining and measuring this important intellectual virtue, we conducted a series of studies into the implicit theory – or ‘folk’ understanding – of an intellectually humble person, a wise person, and an intellectually arrogant person. In Study 1, 350 adults used a free-listing procedure to generate a list of descriptors, one for (...) each person-concept. In Study 2, 335 adults rated the previously generated descriptors by how characteristic each was of the target person-concept. In Study 3, 344 adults sorted the descriptors by similarity for each person-concept. By comparing and contrasting the three person-concepts, a complex portrait of an intellectually humble person emerges with particular epistemic, self-oriented, and other-oriented dimensions. (shrink)

Current theories of breast cancer progression have been greatly influenced by the development and refinement of mouse transgenic and gene targeting technologies. Early transgenic mouse models confirmed the involvement of oncogenes, previously implicated in human breast cancer, by establishing a causal relationship between overexpression or activation of these genes and mammary tumorigenesis. More recently, the importance of genes located at sites of loss of heterozygosity in human breast cancer have been examined in mice by their targeted disruption via homologous recombination. (...) The union of these two approaches allows the generation of complex animal models that more accurately reflect the multistep nature of human breast cancer. This review will examine how the study of transgenic mice has increased our understanding of the molecular events responsible for oncogenic transformation of the mammary gland. BioEssays 22:554–563, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Business schools, and universities providing business education, from across the globe have increasingly engaged in responsible management education (RME), that is in embedding social, environmental and ethical topics in their teaching and research. However, we still do not fully understand the institutional pressures that have led to the adoption of RME, in particular concerning under-researched regions like Central and Eastern Europe (CEE). Hence, we undertook what is to our knowledge the most comprehensive study into the adoption of RME in CEE (...) to date (including 13 countries: Belarus, Bulgaria, Croatia, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Russia, Slovenia and Ukraine). We find that, with regard to RME, isomorphic pressures seem to shape teaching and research in different ways, which suggests that the idea of a holistic approach to RME, promoted by, for example, the Principles of Responsible Management Education (PRME), needs to be revisited; rather, different trajectories of organizational engagement may emerge for each principle. As a contribution to institutional theory, we discuss how a highly fragmented organizational field—like RME with its multiple dimensions—impacts on notions of actor centrality, where actors achieve centrality with regard to some dimensions of the field but fail to do so for others. In particular, we found that the European Union holds centrality in the area of RME teaching, but not in RME research. Our findings thus suggest that the concept of field centrality needs further clarification. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Asbestos-related illnesses contribute to the deaths of more than 100,000 people worldwide (ILO 2006) and the plight of sufferers of these illnesses has become a global ethical issue. A leading, Australian building products corporation, James Hardie, created a complex corporate structure that included the establishment of a “Victims Compensation Fund”, and moved its corporate headquarters to the Netherlands to reduce its liabilities. Hardie claimed that this move was tax minimization (Haigh 2006). In this study case, a number of ethical issues (...) provides the opportunity to discuss many business-society questions. These include the duties of the company towards a wide range of stakeholders affected in some way by Hardie’s earlier production of asbestos-related products and its subsequent responses to the question of compensation. (shrink)

In 1972, the young philosopher Peter Singer published "Famine, Affluence and Morality," which rapidly became one of the most widely discussed essays in applied ethics. Through this article, Singer presents his view that we have the same moral obligations to those far away as we do to those close to us. He argued that choosing not to send life-saving money to starving people on the other side of the earth is the moral equivalent of neglecting to save drowning children (...) because we prefer not to muddy our shoes. If we can help, we must--and any excuse is hypocrisy. Singer's extreme stand on our moral obligations to others became a powerful call to arms and continues to challenge people's attitudes towards extreme poverty. Today, it remains a central touchstone for those who argue we should all help others more than we do. As Bill and Melinda Gates observe in their foreword, in the age of today's global philanthropy, Singer's essay is as relevant now as it ever was. This attractively packaged, concise edition collects the original article, two of Singer's more recent popular writings on our obligations to others around the world, and a new introduction by Singer that discusses his current thinking. (shrink)

This reissue of his collection of early essays, Logico-Linguistic Papers, is published with a brand new introduction by Professor Strawson but, apart from minor ...

Isaiah Berlin was one of the greatest thinkers of the twentieth century - a man who set ideas on fire. His defence of liberty and plurality was passionate and persuasive and inspired a generation. His ideas - especially his reasoned rejection of excessive certainty and political despotism - have become even more prescient and vital today.But who was the man behind such influential views? In Search of Isaiah Berlin tells the compelling story of a decades-long collaboration between Berlin and his (...) editor, Henry Hardy, who made it his vocation to bring Berlin's huge body of work into print. Hardy discovered that Berlin had written far more than people thought, much of it unpublished. As he describes his struggles with Berlin, who was almost on principle unwilling to have his work published, an intimate and revealing picture of the self-deprecating philosopher emerges. This is a unique portrait of a man who gave us a new way of thinking about the human predicament, and whose work had for most of his life remained largely out of view. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

Conjectures are made on the text of three passages in Tibullus, Books 1–2: 1.4.26 hastam … suam for crines … suos, 2.1.56 membra for bache, 2.4.60 aliis rebus for alias herbas.

Predatory grooming is a form of abuse most familiar from high-profile cases of sexual misconduct, for example, the Nassar case at Michigan State. Predatory groomers target individuals in a systematic effort to lead them into relationships in which they are vulnerable to exploitation. This is an example of a broader form of epistemic misconduct that Leydon-Hardy describes as epistemic infringement, where this involves the contravention of social and epistemic norms in a way that undermines our epistemic agency. In this chapter, (...) Leydon-Hardy looks at the distinctive epistemic harm caused by epistemic infringement. She argues that this harm cannot be understood simply as the victim’s having a false belief, or even as her being alienated from her belief-forming mechanisms. A deeper understanding of the harm caused by infringement shows that it stems from damage to one’s epistemic agency, and indeed, to one’s personhood. (shrink)

This study of the "radicalization" of psychiatry analyzes the writings of Laing, Foucault, Szasz, and Goffman, constructs a model for understanding mental illness, and emphasizes collective responsibility for the care of the mentally ill.

The presence of parents or other guardians (commonly termed ‘supervision’) and parental knowledge are factors that are both robustly negatively associated with a range of anti-social and risky behavioural outcomes such as adolescent crime. However, parental presence/supervision and parental knowledge are both (i) regularly used inaccurately as proxies for parental monitoring, (ii) poorly defined and operationalised, and (iii) rarely linked to negative behavioural outcomes with plausible mechanisms that adequately explain their association. These problematic aspects of the parental monitoring literature are (...) a barrier to research into adolescent outcomes and the varied role of parents. This theoretical paper facilitates solutions these problems by clarifying the concepts of parental presence, supervision and knowledge. This discussion delineates presence from supervision and knowledge from monitoring. It specifies how presence and knowledge are not parenting actions, and neither constitute parental monitoring. These concepts are clarified within the parameters of a recent framework of goal-directed parental action and parental monitoring. Doing so constitutes under-labouring that facilitates future discovery of their distinct and yet inter-related mechanisms of influence on adolescent action and development. These structured conceptual developments are also of benefit for our better future understanding of parenting and parental monitoring by providing a framework within which to re-situate existing empirical research findings. (shrink)

For thirty years, Peter Singer's Practical Ethics has been the classic introduction to applied ethics. For this third edition, the author has revised and updated all the chapters and added a new chapter addressing climate change, one of the most important ethical challenges of our generation. Some of the questions discussed in this book concern our daily lives. Is it ethical to buy luxuries when others do not have enough to eat? Should we buy meat from intensively reared animals? (...) Am I doing something wrong if my carbon footprint is above the global average? Other questions confront us as concerned citizens: equality and discrimination on the grounds of race or sex; abortion, the use of embryos for research and euthanasia; political violence and terrorism; and the preservation of our planet's environment. This book's lucid style and provocative arguments make it an ideal text for university courses and for anyone willing to think about how she or he ought to live. (shrink)

The relationship of part to whole is one of the most fundamental there is; this is the first and only full-length study of this concept. This book shows that mereology, the formal theory of part and whole, is essential to ontology. Peter Simons surveys and criticizes previous theories, especially the standard extensional view, and proposes a more adequate account which encompasses both temporal and modal considerations in detail. 'Parts could easily be the standard book on mereology for the next (...) twenty or thirty years.' Timothy Williamson, Grazer Philosophische Studien. (shrink)

Confirmation bias is one of the most widely discussed epistemically problematic cognitions, challenging reliable belief formation and the correction of inaccurate views. Given its problematic nature, it remains unclear why the bias evolved and is still with us today. To offer an explanation, several philosophers and scientists have argued that the bias is in fact adaptive. I critically discuss three recent proposals of this kind before developing a novel alternative, what I call the ‘reality-matching account’. According to the account, confirmation (...) bias evolved because it helps us influence people and social structures so that they come to match our beliefs about them. This can result in significant developmental and epistemic benefits for us and other people, ensuring that over time we don’t become epistemically disconnected from social reality but can navigate it more easily. While that might not be the only evolved function of confirmation bias, it is an important one that has so far been neglected in the theorizing on the bias. (shrink)

This chapter provides an introduction to higher-order metaphysics as well as to the contributions to this volume. We discuss five topics, corresponding to the five parts of this volume, and summarize the contributions to each part. First, we motivate the usefulness of higher-order quantification in metaphysics using a number of examples, and discuss the question of how such quantifiers should be interpreted. We provide a brief introduction to the most common forms of higher-order logics used in metaphysics, and indicate a (...) number of questions which can be raised in such systems using logical vocabulary alone. Using a further example, we return to applications of higher-order logics in metaphysics. We also mention key developments in the history of higher-order logic as it pertains to metaphysics. Finally, we mention certain arguments which have been raised against the use of higher-order logic, and some ways of responding to them. (shrink)

Acknowledgments 1. Culture Is Essential 2. Culture Exists 3. Culture Evolves 4. Culture Is an Adaptation 5. Culture Is Maladaptive 6. Culture and Genes Coevolve 7. Nothing about Culture Makes Sense except in the Light of Evolution.

Introduction: our environment is out of control -- The foundation: your environment shapes you -- Every hero is the product of a situation : understanding the proximity effect -- How your environment shapes you : the myth of willpower -- Use positive-stress environments to promote change -- Create enriched environments : the key of "forcing functions" to promote change -- More than good intentions : how to adapt to new and difficult environments -- Grow into your goals : outsource your (...) motivation to high pressure environments -- Optimal environments for rapid learning : shortcuts to success -- Rotate your environments : change it up based on the work you're doing -- Find unique collaborations : design your world through transformational relationships -- Never forget where you came from : remember the environment where you began -- Pse rejuvinating environments to promote recovery and growth -- Establish your value system : the clearer you get, the more successful you'll be -- Remove everything that conflicts with your values : how to make tough choices -- Change your defaults : outsource your behavior to your environment -- Create triggers to prevent self-sabotage : putting failure-planning to work -- Shock your routine : the power of regular sabbaticals -- Reset your body and brain every week: the power of a fast -- Designate a sacred space : create an environment to stay on course -- Conclusion: no matter where you are, you can change -- Acknowledgments -- Index -- About the author. (shrink)

A complete system of classical Aristotelian logic intended for honors high school and college.

This book examines the philosophical foundations of the realist view of the progress of science as cumulative. It is a view that has recently been faced with a number of powerful attacks in which successive scientific theories are seen, not as extending their scope and honing their explanations, but as incommensurable. There is, it is held, in principle no way of establishing that they are about the same things. From the voluminous literature on the topic, Dr Smith has selected relevantly (...) and incisively and his exposition of the contending arguments is vigourous and clear, without undue technicality. As an explication and defence of realism it will interest all those concerned with this basic question in the philosophy of science and the philosophy of language. (shrink)

This book reformulates the sociological subdiscipline known as the sociology of knowledge. Knowledge is presented as more than ideology, including as well false consciousness, propaganda, science and art.

Ohne Rücksicht auf disziplinäre Schranken bringt dieses Buch verschiedene nicht-reduktionistische Lerntheorien miteinander ins Gespräch. In einem offenen Diskurs, der die Konzepte zueinander in Beziehung setzt, werden die unterschiedlichen Perspektiven kritisch abgewogen und hinsichtlich ihrer Stärken und Schwächen diskutiert.

Delo se loteva vprašanja aktualnosti pojma subjekta v filozofiji in politiki skozi analizo tistih avtorjev, ki so ga domnevno najbolj radikalno pokopali: pokaže, da vznik radikalno novega in problematika subjekta zavzema osrednje mesto v Deleuzovi filozofiji, kakor tudi v Lyotardovi pozni misli posvečeni praznini, v Foucaultovi obravnavi biopolitike in biooblasti, v delu Negrija in Hardta o Imperiju, ter nazadnje v Badioujevi predelavi temeljnih filozofskih kategorij biti, resnice in subjekta, na osnovi katerih je dandanes znova možna renesansa filozofije. Ta ima po (...) Badiouju štiri razsežnosti, ki se v delu Vznik subjekta nenehno prepletajo: »V osnovi želja filozofije implicira razsežnost upora: ni filozofije brez nezadovoljstva mišljenja v njegovem soočenju s svetom, kakršen je. Pa vendar želja filozofije vključuje tudi logiko: to je, prepričanje v moč argumenta in uma.«. (shrink)

En el escrito Vorläufige Thesen zur Refomation der Philosophie, Ludwig Feuerbach atribuye a Spinoza la autoría de la filosofía especulativa. A la zaga queda Schelling, considerado por Feuerbach únicamente como el restaurador de la misma. En la secuencia establecida por éste, Hegel sería, por su parte, solo un elemento más en la constitución de la filosofía especulativa, aunque tiene el mérito de completar tal sistema de pensamiento. En el presente artículo pretendo determinar en qué medida el autor de esta filosofía (...) se halla presente en el que la consuma. Esbozaré la forma y grado de esa presencia poniendo el foco en un aspecto nuclear, que, al mismo tiempo, servirá de guía del trabajo aquí propuesto: la negación. (shrink)

Members of the field of philosophy have, just as other people, political convictions or, as psychologists call them, ideologies. How are different ideologies distributed and perceived in the field? Using the familiar distinction between the political left and right, we surveyed an international sample of 794 subjects in philosophy. We found that survey participants clearly leaned left (75%), while right-leaning individuals (14%) and moderates (11%) were underrepresented. Moreover, and strikingly, across the political spectrum, from very left-leaning individuals and moderates to (...) very right-leaning individuals, participants reported experiencing ideological hostility in the field, occasionally even from those from their own side of the political spectrum. Finally, while about half of the subjects believed that discrimination against left- or right-leaning individuals in the field is not justified, a significant minority displayed an explicit willingness to discriminate against colleagues with the opposite ideology. Our findings are both surprising and important, because a commitment to tolerance and equality is widespread in philosophy, and there is reason to think that ideological similarity, hostility, and discrimination undermine reliable belief formation in many areas of the discipline. (shrink)

Following our [6], though with somewhat different methods here, further variants of Goodstein sequences are introduced in terms of parameterized Ackermann–Péter functions. Each of the sequences is shown to terminate, and the proof-theoretic strengths of these facts are calibrated by means of ordinal assignments, yielding independence results for a range of theories: PRA, PA,$\Sigma ^1_1$-DC$_0$, ATR$_0$, up to ID$_1$. The key is the so-called “Hardy hierarchy” of proof-theoretic bounding finctions, providing a uniform method for associating Goodstein-type sequences with parameterized normal (...) form representations of positive integers. (shrink)

In this short but meaty book, Peter Unger questions the objective answers that have been given to central problems in philosophy. As Unger hypothesizes, many of these problems are unanswerable, including the problems of knowledge and scepticism, the problems of free will, and problems of causation and explanation. In each case, he argues, we arrive at one answer only relative to an assumption about the meaning of key terms, terms like "know" and like "cause," even while we arrive at (...) an opposite answer relative to quite different assumptions, but equally arbitrary assumptions, about what the key terms mean. (shrink)

This comprehensive and important volume includes contributions by activists, journalists, lawyers and scholars from twenty-one countries. The essays map the directions the movement for women's rights is taking--and will take in the coming decades--and the concomittant transformation of prevailing notions of rights and issues. They address topics such as the rapes in former Yugoslavia and efforts to see that a War Crimes Tribunal responds; domestic violence; trafficking of women into the sex trade; the persecution of lesbians; female genital mutilation; and (...) reproductive rights. (shrink)

What is narrative? What is distinctive about the great literary narratives? In virtue of what is a narrative fictional or non-fictional? In this important new book Peter Lamarque, one of the leading philosophers of literature at work today, explores these and related questions to bring new clarity and insight to debates about narrative in philosophy, critical theory, and narratology.

How do we go about weighing evidence, testing hypotheses, and making inferences? The model of " inference to the best explanation " -- that we infer the hypothesis that would, if correct, provide the best explanation of the available evidence--offers a compelling account of inferences both in science and in ordinary life. Widely cited by epistemologists and philosophers of science, IBE has nonetheless remained little more than a slogan. Now this influential work has been thoroughly revised and updated, and features (...) a new introduction and two new chapters. Inference to the Best Explanation is an unrivaled exposition of a theory of particular interest in the fields both of epistemology and the philosophy of science. (shrink)

Narrative thinking -- Narrative thinking about one's past -- Grief : a case study -- Narrative thinking about one's future -- Self-forgiveness : a case study -- The narrative sense of self -- Narrative, truth, life, and fiction.

Aristotle maintains that every man has, or should have, a single end, a target at which he aims. The doctrine is stated in E.N. I 2. ‘If, then, there is some end of the things we do which we desire for its own sake, and if we do not choose everything for the sake of something else, clearly this must be the good and the chief good. Will not the knowledge of it, then, have a great influence on life? Shall (...) we not, like archers who have a mark to aim t, be more likely to hit upon what is right?’. Aristotle does not here prove, nor need we understand him as claiming to prove, that there is only one end which is desired for itself. He points out correctly that, if there are objects which are desired but not desired for themselves, there must be some object which is desired for itself. The passage further suggests that, if there were one such object and one only, this fact would be important and helpful for the conduct of life. (shrink)

In this paper I discuss Plato's conception of expertise as a part of the Platonic theory of a good, successful life (eudaimonia). In various Platonic dialogues, Socrates argues that the good life requires a certain kind of knowledge that guides all our good, beneficial actions: the “knowledge of the good and bad”, which is to be acquired by “questioning ourselves and examining our and others’ beliefs”. This knowledge encompasses the particular knowledge of how to recognize experts in a given technical (...) domain. The central element in Socrates’ account of an expert is what I call the truth-and-caring criterion: an expert has to make seeking the truth and avoiding (avoidable) error her supreme epistemic goal and she has to make caring for common goods the supreme goal of practising her expertise. (shrink)