Before a cell divides into two daughter cells, it typically doubles not only its DNA, but also its mass. Numerous studies in cells ranging from yeast to mammals have shown that cellular growth, stimulated by nutrients and/or growth factor signaling, is a prerequisite for cell cycle progression in most types of cells. The textbook view of growth‐regulated cell cycles is that growth signaling activates the transcription of G1 Cyclin genes to induce cell proliferation, and also stimulates anabolic metabolism and cell (...) growth in parallel. However, genetic knockout tests in model organisms indicate that this is not the whole story, and new studies show that additional, “smarter” mechanisms help to coordinate the cell cycle with growth itself. Here we summarize recent advances in this field, and discuss current models in which growth signaling regulates cell proliferation by targeting core cell cycle regulators via non‐transcriptional mechanisms. (shrink)

We apply a paraconsistent strategy to reasoning about fractions.

Global climate change is complex to address. It will require people to interact publicly as well as set policy, as a crucial part of addressing it. To date, skills for effective public interaction—where such interactions even exist—do not measure up to the demands of such global complexity. Hierarchical complexity is used to analyze common forms of public talk and interaction. Its premises are applied to approaches to conduct public discourse, including postformal approaches. The Scale of Public Interactions is introduced and (...) indicates that Metasystematic stage approaches to climate change hold the most potential for addressing it. (shrink)

BackgroundVast sums are distributed based on grant peer review, but studies show that interrater reliability is often low. In this study, we tested the effect of receiving two short individual feedback reports compared to one short general feedback report on the agreement between reviewers.MethodsA total of 42 reviewers at the Norwegian Foundation Dam were randomly assigned to receive either a general feedback report or an individual feedback report. The general feedback group received one report before the start of the reviews (...) that contained general information about the previous call in which the reviewers participated. In the individual feedback group, the reviewers received two reports, one before the review period and one during the period. In the individual feedback group, the reviewers were presented with detailed information on their scoring compared with the review committee as a whole, both before and during the review period. The main outcomes were the proportion of agreement in the eligibility assessment and the average difference in scores between pairs of reviewers assessing the same proposal. The outcomes were measured in 2017 and after the feedback was provided in 2018.ResultsA total of 2398 paired reviews were included in the analysis. There was a significant difference between the two groups in the proportion of absolute agreement on whether the proposal was eligible for the funding programme, with the general feedback group demonstrating a higher rate of agreement. There was no difference between the two groups in terms of the average score difference. However, the agreement regarding the proposal score remained critically low for both groups.ConclusionsWe did not observe changes in proposal score agreement between 2017 and 2018 in reviewers receiving different feedback. The low levels of agreement remain a major concern in grant peer review, and research to identify contributing factors as well as the development and testing of interventions to increase agreement rates are still needed.Trial registrationThe study was preregistered at OSF.io/n4fq3. (shrink)

Despite growing awareness of the benefits of large-scale open access publishing, individual researchers seem reluctant to adopt this behavior, thereby slowing down the evolution toward a new scientific culture. We outline and apply a goal-directed framework of behavior causation to shed light on this type of behavioral reluctance and to organize and suggest possible intervention strategies. The framework explains behavior as the result of a cycle of events starting with the detection of a discrepancy between a goal and a status (...) quo and the selection of behavior to reduce this discrepancy. We list various factors that may hinder this cycle and thus contribute to behavioral reluctance. After that, we highlight potential remedies to address each of the identified barriers. We thereby hope to point out new ways to think about behavioral reluctances in general, and in relation to open access publishing in particular. (shrink)

Some of our reasons for action are grounded in the fact that the action in question is a means to something else we have reason to do. This raises the question as to which principles govern the transmission of reasons from ends to means. In this paper, we discuss the merits and demerits of a liberal transmission principle, which plays a prominent role in the current literature. The principle states that an agent has an instrumental reason to whenever -ing is (...) a means for him to do what he has intrinsic reason to do. We start by discussing the objection that this principle implies counterintuitive reason statements. We argue that attempts to solve this “too many reasons problem” by appealing to pragmatic strategies for debunking intuitions about so-called negative reason existentials are questionable. Subsequently, we discuss three important arguments in favor of Liberal Transmission, and argue that they fail to make a convincing case for this principle. In the course of the discussion, we also provide alternative, less liberal transmission principles. We argue that these alternative principles allow us to accommodate those phenomena that seem to support Liberal Transmission while avoiding its problems. (shrink)

Many critics view Irigaray's work as an extension or deconstruction of a Lacanian paradigm. Few actually analyse it as a direct challenge to Lacanian concepts of symbolic subjectivity, and the consequent, alternative framework this would envisage. This article discusses a poss ible beyond the phallus, in relation to mediating concepts of the female imaginary and symbolic within her work, and an understanding of the female imaginary and symbolic within different feminist interpretations of the maternal imaginary and symbolic, arguing that the (...) imaginary is crucial in delineating a non-separatist cultural sublimation of female desire. Feminist revisions of the Oedipal by Jessica Benjamin and Kaja Silverman are examined in relation to the question of a maternal imagin ary and symbolic. Irigaray objects to Silverman's privileging of a Lacan ian concept of symbolic castration because it cannot negotiate between the literal relation to the body, and the metaphors and language of our cultural symbolic. Her female imaginary and symbolic provide this mediating link in direct challenge to the overly literal penis of Freud's castration complex and the essentially metaphorical nature of Lacan's phallus. Her mediation is related to the work of diverse psychoanalytic thinkers such as Andrew Samuels, Cornelius Castoriadis and Anthony Elliott. Returning to a feminist reading by Margaret Whitford, this article finally negates a Lacanian understanding of these structures and goes on to explore Irigaray's creative bodily imaginary, within two of her papers on analytic practice. Elaboration of a bodily and creative imaginary within the clinical setting can represent necessary mediation between real and symbolic and between the psyche and culture: this HISTORY OF THE HUMAN SCIENCES Vol. 10 No. 2 @ 1997 SAGE Publications (London, Thousand Oaks and New Delhi) pp. 41-60 [0952-6951(199705)10:2] mediation is personified through the hysteric, not through the Oedipal Law of the Father, which is finally the key question in culturally locat ing female desire, thereby connecting the theory of psychoanalysis with practice and with history. (shrink)

The development of nuclear energy technologies in the second half of the 20th century came with great hopes of rebuilding nations recovering from the devasta-tion of the Second World War or recently released from colonial rule. In coun-tries like France, India, the USA, Canada, Russia, and the United Kingdom, nuclear energy became the symbol of development towards a modern and technologically advanced future. However, after more than six decades of experi-ence with nuclear energy production, and in the aftermath of the (...) Fukushima nuclear disaster, it is safe to say that nuclear energy production is not without its problems.Some of these problems have their origins in the very materiality of the technolo-gies involved. For example, not only does the use of highly radioactive materials give rise to risks for the current generation (e.g., in the potential for disaster when reactors melt down) but high-level radioactive waste from nuclear energy production presents a serious intergenerational problem for which an acceptable final solution or its implementation remains elusive. Moreover, nuclear energy technologies have specific social and political consequences. For example, they have been said to be authoritarian technologies (Winner, 1980), requiring cen-tralized authority, secrecy, and technocratic decision-making. While some of these problems could have been foreseen before nuclear energy technologies were introduced, others only arose after these technologies were already integrated into the social and infrastructural fabric of our lives. Addition-ally, new technologies (e.g., Generation III, III+ and IV reactors) are still being developed, bringing with them new and uncertain hazards and risks. Ignorance and uncertainty about the possible deleterious effects of introducing a new technology are inevitable, especially if the technology is complex, large time-scales are involved, or risks depend on social or political factors unforeseen in the design stage. However, this should not deter us from developing and intro-ducing new technologies. Rather, it should motivate us to organize these ‘exper-iments’ with new technologies in society in such a way that we can learn about their possible hazards and risks as effectively and responsibly as possible (van de Poel, 2011, 2015). In this way, it is possible to minimize risks and avoid unwant-ed moral, social or political developments. However, organizing such experi-ments responsibly also means that one could come to the conclusion that continuing an experiment is no longer responsible or desirable. Should we be prepared for such a scenario, and if so, how could we do that? One possible strategy to tackle this issue is that the technology and its introduction should be reversible. The aim of this thesis is to further explore this strategy by answering the following main research question (RQ) and accompanying subquestions (SQ):RQ: What are the implications of reversibility for the responsible develop-ment and implementation of nuclear energy technologies?SQ1: Under what conditions can nuclear energy technologies be considered reversible?SQ2: Why should nuclear energy technologies be reversible?SQ3: If so, how could the reversibility of nuclear energy technologies be achieved?After the introductory chapter 1, the chapters that form the main body of this dissertation each provide a distinct contribution to answering the three subques-tions and, by extension, the main research question. Guided by three historical case studies of nuclear energy technology development (i.e., India, France and the USA), chapter 2 answers the first subquestion by formulating the two condi-tions under which it can be considered reversible, i.e., 1) the ability to stop the further development and deployment of a that technology in society, and 2) the ability to undo the undesirable outcomes (material, institutional or symbolic) of the development and deployment of the technology. Chapter 3 subsequently tackles the second subquestion by establishing the general desirability of technological reversibility by virtue of its relation to responsibility in Emmanuel Levinas’ ethical phenomenology. It argues that technology development is a legitimate response to responsibility but inevitably falls short of the responsibility that inspires it, incessantly calling for technological and political change in the process. Having thus argued that nuclear energy technologies should ideally be reversible, chap-ters 4 and 5 work towards specific strategies to achieve technological reversibil-ity. Chapter 4 first investigates the processes that make it difficult to stop the further development and implementation of a nuclear energy technology in society, thus provid-ing input on how to fulfill the first condition for the reversibility of nuclear energy technologies. To do so, it presents a phenomenological perspective on technology and its adoption based on the work of Alfred Schutz. It also explores different ways in which technology adoption drives the processes of path depend-ence towards technological lock-in. Chapter 5 examines the history of geological disposal of high-level radioactive waste in the USA. It identifies a number of concrete policy pitfalls that could lead to lock-in and that should consequently be avoided. It also presents a number of general design strategies that could facilitate the undoing of undesirable consequences of a technology, thus providing input on how to fulfill the second condition for the reversibility of nuclear energy technol-ogies.Chapter 6 summarizes the central findings of the thesis and explains how these help to answer the research questions. On top of this, it reflects on a number of complications connected to reversibility considerations. Based on this, it is concluded that the question of irreversibility and reversibility is context- and technology-specific and a matter of degree. The chapter concludes with a reflec-tion on generalizations and limitations of the results. Finally, chapter 7 discusses the implications of this dissertation’s results for responsibly experimenting with nuclear energy technologies in society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:“First the Bow is Bent in Study …” Dominican Education before 1350 by M. Michèle MulchaheyJohn InglisM. Michèle Mulchahey. “First the Bow is Bent in Study …” Dominican Education before 1350. Studies and Texts, vol. 132. Toronto: Pontifical Institute of Medieval Studies, 1998. Pp. xxi + 618. Cloth, $110.00.In his The Setting of the Summa theologiae of Saint Thomas, Leonard Boyle represents one of the more interesting directions (...) in the recent historiography of Latin medieval philosophy (Toronto: Pontifical Institute of Mediaeval Studies, 1982). His claim is that if we are to understand Aquinas, we need to pay closer attention to the Dominican intellectual context. With a focus on the moral component of Aquinas’s Summa theologiae, Boyle establishes that Aquinas did not converse alone with Aristotle and Averroes in some philosophical ivory tower as historians often imply, but that he wrote and disputed in light of Dominican goals. This point helps to clarify the context of Aquinas’s texts—a type of historical context not found in the standard philosophical accounts. In the book under review, the first detailed history of Dominican medieval education, M. Michèle Mulchahey supplies a more extended treatment of this intellectual context.Commonly, intellectuals in the high middle ages are presented as spending their lives at universities studying philosophy, conducting disputations, and lecturing on the Sentences of Peter the Lombard. Anthony Kenny and Jan Pinborg present such a picture in their helpful contribution to The Cambridge History of Later Medieval Philosophy ([Cambridge: Cambridge University Press, 1982], 11–42). Mulchahey argues that this sort of picture is rather simplistic when applied to the Dominican intellectual life. From the early years of the order, there was to be a “doctor” in each and every local Dominican house (132). One of Mulchahey’s more interesting conclusions is that the schools associated with these local houses were more advanced than has often been thought. For example, each house was to include lectures on the Sentences of Peter the Lombard and on Scripture, that is, on the very texts which historians commonly associate only with the universities (134–136). Furthermore, disputations were conducted frequently at local houses (134, 167) and by the middle of the thirteenth century, the works of Aristotle were often taught (220). Her point is that if we are to understand the intellectual world in which a Dominican like Aquinas spent his life, then we need to be clear about this context and not just about that of the universities.Even at the university, Dominicans studied and lectured at Dominican houses and not at institutions of the secular clergy. For instance, even when Aquinas was a Bachelor of the Sentences and a Master of the Sacred Page at the University of Paris, he lived and taught at the Dominican convent according to the distinct traditions and practices [End Page 361] of the order. Furthermore, select Dominican schools of higher learning, including those associated with universities, produced teachers for local Dominican communities. Mulchahey argues convincingly that the structures of Dominican education came to exist from the bottom up within a Dominican context and not as an extension of the statutes of the universities (351–378).This Dominican context helps to provide a response to an objection that John Jenkins raises to Boyle’s view of the audience of Aquinas’s Summa theologiae—an issue that has important implications for how to read this work. Boyle argued that the Summa arose out of the pastoral needs of ordinary Dominicans and reflects this institutional purpose. Jenkins “rejects” this claim, arguing that Aquinas’s text is so dense and conceptually difficult that it could only have been written for those who were prepared to study the Sentences of Peter the Lombard at the University of Paris. (See John I. Jenkins, Knowledge and faith in Thomas Aquinas [Cambridge: Cambridge University Press, 1997], 81, 89–90.) Mulchahey provides important support for Boyle’s view by establishing that it was the policy of the order to prepare ordinary Dominicans to study the Sentences of Peter the Lombard at the local houses. At a time when there were few universities, the Dominicans established hundreds of sites of higher education at... (shrink)

According to epistemic reductionism about practical reasons, facts about practical reasons can be reduced to facts about evidence for ought-judgements. We argue that this view misconstrues practical conflicts. At least some conflicts between practical reasons put us in a position to know that an action ϕ is optional, i.e. that we neither ought to perform nor ought to refrain from performing the action. By understanding conflicts of practical reasons as conflicts of evidence about what one ought to do, epistemic reductionism (...) fails to account for this. In conflict cases in which ϕ-ing is optional, epistemic reductionism suggests that we have equally strong evidence for and against assuming that we ought to ϕ, and thus cannot be in a position to know that it is not the case that we ought to ϕ. This is a serious flaw. (shrink)

Some critical reactions hardly give clues to the arguer as to how to respond to them convinc-ingly. Other critical reactions convey some or even all of the considerations that make the critic critical of the arguer’s position and direct the arguer to defuse or to at least contend with them. First, an explication of the notion of a critical reaction will be provided, zooming in on the degree of ‘directiveness’ that a critical reaction displays. Second, it will be examined whether (...) and to what extent there is a normative requirement to strive after criticism that is more than minimally directive. In this paper, it is hypothesized that the com-petitiveness inherent in critical discussion must be mitigated by making the opponent responsible for providing her counterconsiderations, if available, thus assisting the proponent in developing an argumenta-tive strategy that defuses them. (shrink)

Eugenics: Then and now Content Type Journal Article DOI 10.1007/s11016-010-9477-1 Authors Staffan Müller-Wille, ESRC Centre for Genomics in Society, Byrne House, University of Exeter, Exeter, EX4 4PJ UK Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

The relevance of metamathematical researches for philosophy of math- ematics is an indubitable matter. In the paper I shall speak about impli- cations of metamathematics for general philosophy, especially for classical epistemological problems. Let us start with a historical observation con- cerning Hilbert's programme, the rst research programme in metamathe- matics as a separate study of formal systems. This programme was strongly in uence by epistemological considerations. In fact, Hilbert wanted to se- cure all classical mathematics against inconsistencies and this (...) aim had be achieved with the help of nitary consistency proof. Hilbert's claim is like the Cartesian project of reduction of all concepts to clarae et distinctae ideae. The epistemological commitment of original Hilbert's programme may be treated as a prelim- inary heuristic motivation for looking for epistemological implications of metamathematical results. It seems reasonable to examine in this respect three so-called limitative theorems: the rst Godel's incompleteness theo- rem , the second Godel's incom- pleteness theorem consistency of S, cannot be proved in S, providing that S is consistent) and Tarski's undenability theorem ; \S" stands for formal system containing elementary number theory. From the above-mentioned theorems we obtain an important, from philosophical point of view, conclusion: semantics of S cannot be expressed in S. Now, I shall present three applications of limitative theorems to the analysis of classical epistemological problems. (shrink)

Stephenson (2022) has argued that Kant’s thesis that all transcendental truths are transcendentally a priori knowable leads to omniscience of all transcendental truths. His arguments depend on luminosity principles and closure principles for transcendental knowability. We will argue that one pair of a luminosity and a closure principle should not be used, because the closure principle is too strong, while the other pair of a luminosity and a closure principle should not be used, because the luminosity principle is too strong. (...) Stephenson’s argument also depends on a factivity principle for transcendental knowability, which we will argue to be false. (shrink)

1. Die erste Hälfte des Kommentars, mit Ausnahme der Kapitel über die Weltseele.

'What is real?' has been one of the key questions of philosophy since its beginning in antiquity. But it is not just a question that philosophers ask. This Very Short Introduction discusses what reality is by looking at a variety of arguments, theories, and thought-experiments from philosophy, physics, and cognitive science.

The Natural Philosophy of Jan Bayer The main focus of this study is a reconstruction of the natural philosophy of the early modern Prešov's scholar Jan (Johannes) Bayer (1630–1674), with special regard to its Mosaic profile. After a critical reading of the research done on Bayer up to this point, the author concludes that Bayer’s natural-philosophical work, as such, has not yet been satisfactorily analyzed, nor has its connection to its supposedly two most important sources, Francis Bacon and Jan Amos (...) Comenius, been sufficiently explored. The study therefore concentrates on a critical analysis of Bayer’s interpretation of creation and his natural history, which are then both situated in the philosophical context of their time. The author then notes that although Bayer’s project of erecting an original and on the (especially Aristotelian) tradition independent Mosaic natural philosophy ended in failure, the thinker’s work can be assessed as a valuable attempt to synthesize Baconian and Comenian motifs while at the same time reflecting broader intellectual contexts of the period. (shrink)

El objetivo de este ensayo es presentar las líneas principales del pensamiento de Jan Patočka que conducen a una fenomenología metafísica. Su intento de revisión fenomenológica conduce al proyecto de una historia de la ontología de la sujetividad. Si dentro de este escenario se puede hablar de una apertura del ser y del mundo, esta apertura se produce también en el sujeto maduro que encuentra el absoluto en el interior de sí mismo. La intencionalidad permanece siempre como motor de la (...) comprensión fenomenológica que en Patočka se abre a todos los elementos naturales asumiendo los caracteres de una universalización teórica. La nueva fenomenología metafísica pensada por Patočka transmite tres leitmotiv comunes: apertura, posibilidad y libertad.The aim of this essay is to present the main features of Jan Patočka’s thought which lead to a metaphysical phenomenology. His phenomenological revision realizes an history of subject’s ontology. Inside this scenario an open-ing of being and world happens and the same opening could be found in the adult subject who encounters the absolute inside himself. Intentionality remains the key of phenomenological comprehension which in Patočka includes all natural elements and assumes the character of a theoretical universalization. The new metaphysical phenomenology suggested by Patočka conveys three leitmotiv: opening, possibility and freedom. (shrink)

In the mathematics education research literature, there is a growing body of scholarship on how mathematicians practice their craft. The purpose of this chapter is to survey some of this literature and explain how it can contribute to the philosophy of mathematical practice. We first describe how mathematics educators use empirical methodologies to investigate the behaviors of mathematicians and argue that findings from these studies can inform the philosophy of mathematical practice. We then illustrate this by summarizing research on mathematicians’ (...) understandings and mathematicians’ proof reading. (shrink)

On several levels, there is now a debate whether the concept of God can be made compatible with modern science. In an attempt to elucidate this debate, I give an account of my own experiences from writing a book on the foundation of quantum mechanics. In my opinion, one can give two independent arguments for the existence of God by taking as departure an epistemic (knowledge-based) interpretation of quantum theory. However, I also argue that any religious belief should be the (...) result of an existential choice governed by each person’s own context (history and culture). In particular, I give my account of Christianity as a religion connected to our western culture, how one as a scientist can relate to the relevant dogmas. (shrink)

The well known Bell experiment with two actors Alice and Bob is considered. First the simple deduction leading to the CHSH inequality under local realism is reviewed, and some arguments from the literature are recapitulated. Then I take up certain background themes before I enter a discussion of Alice’s analysis of the situation. An important point is that her mind is limited by the fact that her Hilbert space in this context is two-dimensional. General statements about a mind’s limitation during (...) a decision process are derived from recent results on the reconstruction of quantum theory from conceptual variables. These results apply to any decision situation. Let all the data from the Bell experiment be handed over to a new actor Charlie, who performs a data analysis. But his mind is also limited: He has a four-dimensional Hilbert space in the context determined by the experiment. I show that this implies that neither Alice nor Charlie can have the argument leading to the CHSH inequality as a background for making decisions related to the experiment. Charlie may be any data analyst, and he may communicate with any person. It is argued that no rational person can be convinced by the CHSH argument when making empirical decisions on the Bell situation. (shrink)