During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen‐induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined (...) by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb‐group proteins and chromatin accessibility. (shrink)

Apathy and depression are frequently observed as behavioral and psychological symptoms of dementia, respectively, and are important for ensuring adequate care. This study aims to explore effective non-pharmacological interventions for apathy and depression with mild cognitive impairment and dementia. Five search engines including PubMed, Scopus, CINAHL, PsycInfo, and Web of Science were used to extract relevant studies. Inclusion criteria were studies that involved participants who were diagnosed with MCI or dementia, included quantitative assessments of each symptom, and employed randomized controlled (...) trials. Twenty studies were extracted, with interventions have been conducted in care facilities, the community, and hospitals. Participants in many studies had MCI or mild-to-moderate dementia but were not diagnosed with the subtypes of dementia. Few studies had set apathy and depression as the primary outcomes of non-pharmacological interventions. The findings suggested that emotional and stimulation-oriented approaches to apathy and depression would be useful for people with MCI or mild-to-moderate dementia. It would be helpful for therapists to assess the clinical features of the target symptoms for selecting suitable interventions. Additionally, increasing the number of randomized controlled trials focusing on apathy or depression as primary outcomes would offer a more definite conclusion for future systematic reviews. (shrink)

According to Dignāga, the word “cow” makes one understand all cows in a general form by excluding non-cows. However, how does one understand the non-cows to be excluded? Hattori answers as follows: “On perceiving the particular which is endowed with dewlap, horns, a hump on the back, and so forth, one understands that it is not a non-cow, because one knows that a non-cow is not endowed with these attributes.” Hattori regards observation of a dewlap, etc. as the cause of (...) excluding non-cows. Akamatsu presents a view similar to Hattori’s. Tanizawa, however, criticises Akamatsu by pointing out that then the apohavādin would have accepted positive elements such as a dewlap as defining characteristics of a cow. Stating that X is not a cow because it is not endowed with a dewlap, etc., amounts to accepting that the dewlap, etc. are the defining characteristics of a cow. Instead of a real universal cowness the apohavādin would have accepted a dewlap, etc. Akamatsu’s understanding of apoha, if it was correct, implies Tanizawa, would destroy the essence of the Buddhist theory of apoha. Continuing the view of Hattori and Akamatsu, Yoshimizu recently published two articles on Dignāga’s theory of apoha. He claims that “the word “cow” excludes all horses by virtue of the fact that horns are never seen on them.” Thus, “the word “cow” can exclude all of them collectively by virtue of the fact that none of them has all the members of the set of characteristics that form the worldly definition of “cow”.” Horns, one of the characteristic features of cows, are indeed mentioned by Dignāga in PS 5:43. Yoshimizu understands Dignāga’s semantics as being parallel to the modern semantics of componential analysis. A question arises: what does Dignāga, the founder of the Buddhist theory of apoha, really think regarding this issue? The present article sheds light on the incompatibility of the two interpretations by investigating the relevant source texts. It further shows that the issue Tanizawa deals with was already discussed by Dignāga. Examining Dignāga’s discussions shows that Tanizawa is right in his understanding of apoha. The interpretation by Hattori and other scholars is not supported by Dignāga’s text. The present conclusion is also supported by Mādhava, Uddyotakara and Kumārila. None of them assumes Dignāga’s theory to be as Hattori, etc. take it. (shrink)

Following Dharmakīrti’s interpretation, PS I 9ab has been understood as stating a view common to both Sautrāntikas and Yogācāras, i.e. a view that self-awareness is the result of a means of valid cognition. It has also been understood that Dignāga accepts two different views attributed to Sautrāntikas with regard to pramāṇaphala: in PS ad I 8cd he regards the cognition of an external object as the result; in PS ad I 9ab–cd he alternatively presents another view that self-awareness is the (...) result. Dignāga’s text, however, does not support these interpretations. Rather it contradicts them. In fact Dignāga presupposes a single view, and not two, attributed to Sautrāntikas, a view that the cognition of an external object is the result. In I 9ab he is presenting an alternative view that is attributed only to Yogācāras, i.e. a view that is not common to Sautrāntikas. Althogh the Sautrāntika sākāravāda essentially has an internal structure, Dignāga presupposes that an external object can be regarded as the object of cognition because it is similar to the image of object. He assumes that the objects of pramāṇa and phala, both being external objects, are identical. Criticizing Dignāga’s claim that bāhyārthajñāna is the phala, Kumārila points out that there is a serious gap between the objects of pramāṇa and phala. Consequently Dharmakīrti has to admit that even in the Sautrāntika view an external object is not directly cognized and instead proposes as the second view of Sautrāntikas that svasaṃvitti is the phala. At the same time he reinterprets Dignāga and defends from Kumārila’s criticism by introducing the two different levels. When investigating the real nature, i.e. in the paramārtha level, svasaṃvitti is the phala, whereas in the upacāra level, bāhyārthajñāna or bāhyārthaniścaya is the phala. Thus, Dharmakīrti avoids Kumārila’s criticism of Dignāga. Kumārila triggers Dharmakīrti’s new introduction of the second view of Santrāntikas that svasaṃvitti is the phala. (shrink)

In his paper “Non-human moral status: problems with phenomenal consciousness,” Joshua Shepherd emphasized an objectivist understanding of welfare to establish the moral status of non-human entities...

v. 1. A critical edition of Mimamsa-Slokavarttika ad 1.1.2 (Codanasutra) -- v. 2. An annotated translation of Mimamsa-Slokavarttika ad 1.1.2 (Codanasutra).

In this article we assess the general claim that Durkheimian sociology has reactionary, fascist, or totalitarian affinities, and the specific claim that Marcel Déat’s Durkheimian background was a significant factor in his becoming a Nazi sympathizer. We do so by comparing the different trajectories of the interwar generation of young Durkheimians and find that only one, i.e. Déat, can be said to have become fascist. Indeed, what characterizes this generation of Durkheimians is the variety of the ways in which they (...) responded to the crises of the interwar years, both politically and scientifically. Nonetheless, most remained on the political left, and during the war many younger members of the Durkheimian group either fled the country or were involved in the French Resistance. As the only personal link between the Durkheimian group and fascism, Déat’s career is of particular interest. Instead of Déat’s being an orthodox Durkheimian, his successive engagements embody the intellectual fragmentation and heterodoxy characteristic of the interwar generation. We outline Déat’s career by foregrounding the conjunctural and dispositional factors that we believe point toward a more plausible explanation of Déat’s transformation than does an internalist history-of-ideas approach according to which his political evolution can be explained by reference to an underlying intellectual continuity. Déat’s fascism is better explained by the repeated frustration of his political and intellectual ambitions that ultimately led to a fateful accommodation with Nazi power than by any tendency inherent to Durkheimian sociology. (shrink)

The recent declaration of the largest municipal bankruptcy in US history has propelled Detroit’s plight into the international spotlight. Though a victim of the general decline of US manufacturing, drawing on Thomas Sugrue’s pioneering work I argue that Detroit’s crisis is better understood as a specifically urban crisis. The city’s concentrated poverty and desolation and its fiscal straits are not reducible to broader economic trends, nor are they exclusively the product of political mismanagement. Rather, they are the outcome of a (...) long history of economic decentralization and racial segregation, made worse by a politico-administrative arrangement that distributes wealth and services unequally across the metropolitan area. By imposing municipal austerity, Detroit’s bankruptcy is unlikely to do much to address these fundamental inequalities. Any plan to revitalize the city must move beyond boosterism and tackle head on the problems of racial and economic segregation that continue to affect Detroit’s 700,000 residents. (shrink)

As social, locative, and mobile media render the intimate public and the public intimate, this volume interrogates how this phenomenon impacts art practice and politics. Contributors bring together the worlds of art and media culture to rethink their intersections in light of participatory social media. By focusing upon the Asia-Pacific region, they seek to examine how regionalism and locality affect global circuits of culture. The book also offers a set of theoretical frameworks and methodological paradigms for thinking about contemporary art (...) practice more generally. (shrink)

Human brain organoids are three-dimensional masses of tissues derived from human stem cells that partially recapitulate the characteristics of the human brain. They have promising applications in many fields, from basic research to applied medicine. However, ethical concerns have been raised regarding the use of human brain organoids. These concerns primarily relate to the possibility that brain organoids may become conscious in the future. This possibility is associated with uncertainties about whether and in what sense brain organoids could have consciousness (...) and what the moral significance of that would be. These uncertainties raise further concerns regarding consent from stem cell donors who may not be sufficiently informed to provide valid consent to the use of their donated cells in human brain organoid research. Furthermore, the possibility of harm to the brain organoids raises question about the scope of the donor’s autonomy in consenting to research involving these entities. Donor consent does not establish the reasonableness of the risk and harms to the organoids, which ethical oversight must ensure by establishing some measures to mitigate them. To address these concerns, we provide three proposals for the consent procedure for human brain organoid research. First, it is vital to obtain project-specific consent rather than broad consent. Second, donors should be assured that appropriate measures will be taken to protect human brain organoids during research. Lastly, these assurances should be fulfilled through the implementation of precautionary measures. These proposals aim to enhance the ethical framework surrounding human brain organoid research. (shrink)

「士農工商は天下を治めるたすけとなる」―江戸期、都市化・経済化の流動的な波の中で、人々の生のつながりの公共的意義を説いた梅岩。広範な影響を及ぼしたその心学は、人々に希望を与え、世界のすべての存在が共に 幸福になることをめざす創造的・運動的な営みであった。.

仁斎にとっての「学問」とは、世界の見え方を刷新させるものである。そして、そのような「学問」の道を開いたのが孔子であった。.