Despite abundant evidence associating CD38 overexpression and CD4 T cell depletion in HIV infection, no causal relation has been investigated. To address this issue, a series of mechanisms are proposed, supported by evidence from different fields, by which CD38 overexpression can facilitate CD4 T cell depletion in HIV infection. According to this model, increased catalytic activity of CD38 may reduce CD4 T cells’ cytoplasmic nicotin‐amide adenine dinucleotide (NAD), leading to a chronic Warburg effect. This will reduce mitochondrial function. Simultaneously, CD38's (...) catalytic products ADPR and cADPR may be transported to the cytoplasm, where they can activate calcium channels and increase cytoplasmic Ca2+ concentrations, further altering mitochondrial integrity. These mechanisms will decrease the viability and regenerative capacity of CD4 T cells. These hypotheses can be tested experimentally, and might reveal novel therapeutic targets. (shrink)

In higher education, the conventional design of educational programs emphasises imparting knowledge and skills, in line with traditional Western epistemology. This emphasis is particularly evident in the design and implementation of many undergraduate programs in which bodies of knowledge and skills are decontextualised from the practices to which they belong. In contrast, the notion of knowledge as foundational and absolute has been extensively challenged. A transformation and pluralisation has occurred: knowledge has come to be seen as situated and localized into (...) various 'knowledges', and the status of the body has taken on renewed significance in epistemological debates. Rather than thinking of knowledge as transcending the body, the embodiment of knowledge has become a key factor in understanding the nature of knowledge and what it means to know. In this paper, we adopt a phenomenological perspective in exploring the notion of embodied knowing as it relates to higher education programs and, more specifically, the ways in which information and communication technologies (ICTs) are used in these programs. (shrink)

Esta obra se abre con una introducción histórica, no heleno ni eurocéntrica, en la que se reinterpretan los sistemas éticos en la historia mundial, hasta situar la problemática en la Modernidad dentro del sistema-mundo como proceso de globalización que simultáneamente excluye a la mayoría de la humanidad. En la primera parte se aborda una crítica a las morales formales (Kant, Rawls, Apel, Habermas) desde un principio material o de contenido con pretensión de universalidad; el deber de producir, reproducir y desarrollar (...) la vida humana en comunidad. El principio de factibilidad ética, por su parte, permite que el cumplimiento del acto, institución o sistema de eticidad pueda tener la pretensión de bondad. En la segunda parte, desde la imposibilidad de que dicho acto, institución o sistema de eticidad «buenos» pueda tener pretensión de perfección acabada, se descubren los que «sufren» en su corporalidad vulnerable la imposibilidad de vivir, el hecho de ser excluidos. Se trata de las víctimas, al decir de Marx, Horkheimer, Benjamin, Nietzsche, Freud o Lévinas. Desde las víctimas comienza propiamente el discurso de la Ética de la Liberación, en su nivel negativo material (deben poder vivir), en el principio discursivo crítico (deben poder participar en la argumentación), todo lo cual culmina en el principio crítico negativo de la factibilidad: el principio-liberación que inspira las transformaciones con pretensión de justicia. (shrink)

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction (...) force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment. (shrink)

Many conservatives endorse a defence of closed borders grounded in basic liberal rights such as the basic right of association. Some conservatives also endorse libertarian principles of legitimacy. It is not clear though that this sort of defence of closed borders is somehow coherent with these libertarian ideals. I argue that conservative libertarians of this kind must reject this defence of closed borders because either it collapses into a form of statism incoherent with libertarian principles of legitimacy, or into an (...) ideal precept without appeal regarding reality in the here and now that could only be applied to changing the very nature of the societies we know. As a result, at least conservative libertarians need to find a different source of justification for closed borders. (shrink)

Las fake news se suelen caracterizar como contenidos, de modo que prevalece el planteamiento semántico. Aquí se propone un enfoque pragmático, donde son actos comunicativos intencionales. Esto permite entender las fake news desde los actos locucionarios, ilocucionarios y perlocucionarios. Esta triple versión de intencionalidad comunicativa permite una mejor intelección de la mala información (misinformation) y de la desinformación (disinformation), que se refleja con claridad en el caso económico.Para mitigar o neutralizar los daños causados por las fake news en el tejido (...) social, se suele recomendar la contrastación de hechos (fact checking). La contribución de la Economía Experimental —y, en concreto, la aportación de Alvin Roth (Premio Nobel de Economía 2012)— puede ser especialmente relevante en dos direcciones: (a) la actividad económica y (b) la Economía como actividad entrelazada con otras. Esto supone el contrastar hechos partiendo de la intencionalidad en la actividad económica, en cuanto tal y en su nexo con otras actividades humanas. A este respecto, las fake news convergen con la toma de decisiones económicas, en cuanto que ambas están surcadas por la intencionalidad y, además, tienen lugar en un contexto donde adquieren un perfil orientado a fines. (shrink)

I present a notion of invariance under arbitrary surjective mappings for operators on a relational finite type hierarchy generalizing the so-called Tarski-Sher criterion for logicality and I characterize the invariant operators as definable in a fragment of the first-order language. These results are compared with those obtained by Feferman and it is argued that further clarification of the notion of invariance is needed if one wants to use it to characterize logicality.

I present a notion of invariance under arbitrary surjective mappings for operators on a relational finite type hierarchy generalizing the so-called Tarski-Sher criterion for logicality and I characterize the invariant operators as definable in a fragment of the first-order language. These results are compared with those obtained by Feferman and it is argued that further clarification of the notion of invariance is needed if one wants to use it to characterize logicality.

This paper advocates for the normative role of logic in reasoning. I offer a response, anchored in an externalist perspective, to two fronts of attack against the normativity thesis, namely Harman’s sceptical challenge and the accusation of naturalistic fallacy. On the one hand, I rework dialogical bridge principles and show that such principles satisfy adequacy criteria to deal with Harman’s challenge. On the other hand, I argue that it is possible to derive normative consequences from logical facts. This is because (...) argumentative interactions among agents involve the acceptance of constitutive rules that entail obligations. Hence, since logical rules can be seen as constitutive of the social practice of reasoning, they create prescriptions for reasoning. Bridge principles make those obligations and prohibitions explicit. (shrink)

En este artículo, abordo la disputa entre normativismo y descriptivismo centrándome en el problema del arbitraje. Para esto, propongo acercar a esta disputa la discusión sobre el problema del colapso que se ha dado recientemente en el marco de la filosofía de la lógica. Mi propuesta sostiene, por un lado, que el razonamiento humano, en cuanto práctica social, es una actividad esencialmente normada y, por otro lado, que los sistemas formales que se toman de referencia en la psicología del razonamiento (...) son el resultado de diversos procesos de equilibrio reflexivo. Esto permite defender el rol normativo de los sistemas formales como estándar para el razonamiento humano. Además, sostengo que la adecuación de un sistema formal está signada por los contextos específicos de razonamiento. Así, defiendo un pluralismo normativo respecto de los sistemas formales de inferencia en el marco de los estudios empíricos sobre el razonamiento humano. (shrink)

Resumen: El artículo a través de un esfuerzo teórico-epistémico e histórico, busca dar cuenta de la relevancia del género documental audiovisual, como referente en la construcción de realidad y memoria social, abocándonos específicamente al desarrollo del documental en Chile. Para ello, se argumenta sobre las problemáticas que acarrea la identificación de este tipo de realizaciones audiovisuales y, una vez zanjada dicha cuestión, se alude a la fuerza revitalizadora que alcanza como reflejo de una sociedad, su reconstrucción del pasado, su valorización (...) del presente y su proyección con visión de futuro. Es decir, el documental como posibilidad de intervenir en lo que percibimos como real, siendo necesario profundizar algunas nociones como verdad; objetividad y subjetividad; realidad y memoria social, entre otras cuestiones de importancia. Todo este recorrido histórico y epistemológico es apoyado en la fenomenología y la hermenéutica, en virtud de indagar en el género documental desde la experiencia chilena.: The article, through a theoretical-epistemic and historical effort, seeks to account for the relevance of the audio-visual documentary genre, as a reference in the construction of reality and social memory, focusing specifically on the development of documentary in Chile. For this, it is argued about the problems that the identification of this type of audio-visual realizations entails, and once this question is settled, it is alluded to the revitalizing force that it achieves as a reflection of a society, its reconstruction of the past, its valorisation of the present and its projection with vision of the future. That is, the documentary as a possibility to intervene in what we perceive as real, being necessary to deepen some notions as truth; objectivity and subjectivity; reality and social memory, among other important issues. All this historical and epistemological journey is supported in phenomenology and hermeneutics, by virtue of investigating the documentary genre from the Chilean experience. (shrink)

The purpose of professional education programs is to prepare aspiring professionals for the challenges of practice within a particular profession. These programs typically seek to ensure the acquisition of necessary knowledge and skills, as well as providing opportunities for their application. While not denying the importance of knowledge and skills, this paper reconfigures professional education as a process of becoming. Learning to become a professional involves not only what we know and can do, but also who we are (becoming). It (...) involves integration of knowing, acting, and being in the form of professional ways of being that unfold over time. When a professional education program focuses on the acquisition and application of knowledge and skills, it falls short of facilitating their integration into professional ways of being. In addition, through such a focus on epistemology (or theory of knowing), ontology (or theory of being) is overlooked. This paper explores what it means to develop professional ways of being where the focus is becoming, not simply knowing as an end in itself. (shrink)

En 1993 y 2012 la poeta irlandesa Mary O’Malley publicó Valparaiso y Where the Rocks Float que edificó alrededor de la figura del mar y de la zona costera irlandesa donde nació. En ambas colecciones, la figura del mar se transforma en un potente agente activo que denuncia el rol de la mujer en la sociedad irlandesa y la explotación de los espacios azules con fines de consumo. Utilizando el análisis de Donna Haraway en Manifiesto cíborg (1985), este artículo analizará (...) una selección de textos de ambos poemarios para estudiar el vínculo entre mujer y mar como agentes activos contra la opresión patriarcal y la explotación capitalista. (shrink)

There is a peak in peer victimization during middle childhood, with multiple negative consequences. Parental use of corporal punishment and child aggression are the most widely studied predictors of this phenomenon. The aim of the present study was to analyze whether parental use of corporal punishment affects peer victimization through child aggression. This mediation model was explored for both mothers and fathers and for both physical and relational forms of aggression and peer victimization. Furthermore, we also analyzed whether the mediation (...) models were moderated by the sex of the child. Participants were 234 third graders. Child aggression and victimization were measured by peers using the Mini Direct Indirect Aggression Inventory. Independent measures of mother’s and father’s use of corporal punishment were obtained from a PCA of items from the Parental Styles and Dimensions Questionnaire. Conditional process modeling was carried out using a macro for SPSS developed by Hayes. Results indicated that aggression mediated the relation of parental corporal punishment to peer victimization. Some interesting moderating effects of sex in this mediation model were found; specifically, physical, and relational aggression mediated the relation of maternal corporal punishment to peer victimization only in boys. Few studies to date have addressed the connection between aggressive behavior and peer victimization as outcomes of corporal punishment, taking into consideration the role of parent’s and child’s sex, and both physical and relational forms of aggression and victimization during childhood. (shrink)

The aim of this paper is to explore the peculiar case of infectious logics, a group of systems obtained generalizing the semantic behavior characteristic of the -fragment of the logics of nonsense, such as the ones due to Bochvar and Halldén, among others. Here, we extend these logics with classical negations, and we furthermore show that some of these extended systems can be properly regarded as logics of formal inconsistency and logics of formal undeterminedness.

This paper attempts to answer whether the property of “efficacy” can be attributed to constitutive rules. In particular, according to Di Lucia, I will point out some problems that the “semantic conception of efficacy” has concerning constitutive and regulative rules. Then, the main goal of the paper will be to reflect on the possibility of the efficacy of constitutive rules by means of a complex case that the semantic conception seems to disregard: The case of the cheater. Does the action (...) of the cheater show the inefficacy of constitutive rules? Does she play the game while breaking the rule? Can the semantic conception of efficacy explain this situation, or do we need a more flexible concept of efficacy that takes nomotropism into account? These are some of the questions I will try to answer. (shrink)

Ample attention is being paid in the higher education literature to promoting active learning among students. However, critical examination of educational purposes and ends is largely lacki...

El vocabulario en los niños con Trastorno del Desarrollo del Lenguaje (TDL) o con Retraso del Lenguaje (RL) es más pobre que en los niños con un desarrollo típico del lenguaje, por lo que se pretende conocer qué diferencias existen entre ellos. Han participado 66 infantes entre 3 y 5 años; se ha valorado que vocabulario conocen, se ha determinado que tienen menos vocabulario (52%) que sus homónimos (69%), a excepción de la categoría de transportes, en la que tienen los (...) mismos resultados. Finalmente, se determina el listado de categorías que más necesitan trabajar los niños con RL o TDL. (shrink)

Emotions are an integral part of human cognition and they guide not only our understanding of the world but also our actions within it. As such, whether we soothe or flame an emotion is not inconsequential. Recent work in conversational AI has focused on responding empathetically to users, validating and soothing their emotions without a real basis. This AI-aided emotional regulation can have negative consequences for users and society, tending towards a one-noted happiness defined as only the absence of "negative" (...) emotions. We argue that we must carefully consider whether and how to respond to users' emotions. (shrink)

In this paper, I argue that the term kinêsis bears different connotations when associated with two different Plotinian hypostases in the Enneads: Intellect and Soul1. I propose an interpretation of this term as intellectual movement when it is associated with the Intellect and spatial movement when it is associated with the Soul.In the first section, I evaluate the meaning of kinêsis in reference to the hypostasis Intellect. In the second section, I turn to a critical examination of kinêsis associated with (...) the hypostasis Soul, emphasising the conceptual complexity of the term. I develop my interpretation on the distinction between kinêsis tês ousias and kinêsis pros ousias, translating the former as ‘movement of the hypostasis’ and the latter as ‘movement from the hypostasis.’ On this revised reading, I conclude that kinêsis in Plotinus is a context-dependent concept that alters its significance according to the hypostasis and introductory locution (‘tês’ or ‘pros’) with which it is associated. I conclude by linking Plotinian henology with Platonic and Aristotelian doctrines to illuminate an ongoing conversation between Plotinian metaphysics and Platonic and Aristotelian concepts of movement. (shrink)

La investigación presentada explora el método Painting Dialogues, llevado a cabo en la Universidad de Cádiz, durante la estancia postdoctoral de su creadora, Małgorzata Karczmarzyk, con estudiantes de Educación Infantil.A partir de la experiencia de creación compartida y del análisis y reflexión conjunta de la huella gráfica originada a modo de cartografía, el diálogo pictórico se presenta como proceso clave de aprendizaje. Esta forma de comunicación ayuda a comprender e interiorizar el conocimiento, potenciando la expresividad, la sensorialidad, la intuición, la (...) confianza y la escucha hacia uno mismo y hacia el otro. (shrink)

En el imaginario del anime contemporáneo de ciencia ficción encontramos algunos ejemplos claros de una reinterpretación de la relación entre ser humano y tecnología en términos no-clásicos. La filosofía de la individuación de Gilbert Simondon, con su crítica radical al individualismo y al sustancialismo, y en especial su filosofía de la técnica, centrada en la denuncia del olvido cultural de los aspectos humanos de la técnica, ofrecen una clave filosófica idónea para la exploración de ese imaginario. Mediante la aplicación de (...) los conceptos desarrollados por Simondon en sus análisis del modo de existencia de los objetos técnico a los animes Akira, Evangelion, Ghost in The Shell y Serial Experiments Lain, muestro que existe en ellos una visión coherente e innovadora de la relación entre humanidad y técnica, que coincide en muchos aspectos con las críticas y propuestas elaboradas por el mismo Simondon. Los más importantes de estos aspectos se relacionan con la idea de la extensión tecnológica de lo humano y con los grados de integración o separación existentes entre el dominio de lo técnico y el de la espiritualidad y la religión. (shrink)

This text proposes an interpretation of the work of Franklin Leopoldo e Silva based on the reading of some of his numerous published articles and books, without neglecting the classes and guidance received from the stage of Scientific Initiation to Postdoctoral studies. Precisely, by highlighting the importance of three thinkers widely studied by Professor Franklin – Berkeley, Bergson and William James –, we suggest that at the heart of this philosophical experience there would be a constant: empiricism. Whether in the (...) classical or radical version, the line we draw in this multiplicity reveals an openness to concrete empiricism. (shrink)

Alba María Laredo Delgado y Darío Méndez Salcedo Facultad de Psicología, Universidad de Granada, España La comunicación entre dos personas … Read More →.

Los años treinta y cuarenta vieron surgir en Antioquia un arte americanista y nacionalista, de carácter social, cuyos principales representantes fueron Pedro Nel Gómez, Carlos Correa y Débora Arango. El artículo explora el enfrentamiento conceptual entre los partidarios del muralismo mexicano, fundamentados en la estética marxista, y los partidarios de un arte moderno internacional, opuesto a todo contenido ideológico, liderados en Colombia por la crítica de arte Marta Traba. La discusión será abordada en tres fases: los años de apogeo del (...) arte social (1934-1950), su momento de crisis (1950-1960), y la revisión actual de la historia del arte en Colombia. (shrink)

Contra la opinión generalizada de que la "mímesis" deja de ser un paradigma del arte a partir del siglo XVIII, este artículo, inspirado en una idea general de Gadamer, intenta mostrar su vigencia apoyándose para ello en una revisión de los textos griegos fundadores de la teoría y en otras fuentes que dan fe de la evolución del concepto en la estética occidental. Muy lejos de la desfiguración moderna, que lo redujo a la simple copia de apariencias sensibles, el concepto (...) original de "mímesis" alude a un hacer paralelo con la naturaleza: se fundamenta, por un lado, en la noción pitagórica del orden universal presente en el movimiento de los cuerpos celestes, así como en el alma humana y en la belleza de las obras de arte, y, por otro, en la noción aristotélica de "reconocimiento" como un volver a conocer que deja de lado todo lo inesencial. (shrink)

The study of agriculture in ancient societies is of vital importance for the understanding of their ecological basis. This article discusses data gathered from Alonso de Molina's dictionary, published in Mexico City in 1571. Molina's information on soil, rain, plants, technology, and human labor applied to agricultural activities gives a picture of the complexity of the several native agricultural systems practiced at that time. Since the Sixteenth Century, native agriculture was impacted by the introduction of new plants, animals, agricultural equipment, (...) and techniques from the Old World. A combination of the two agricultural models conform a new Mexican model of agriculture along the Colonial times. The knowledge of Sixteenth Century agricultural systems is fundamental for the understanding of the history and the conformation of contemporary agro-ecosystems. Recent studies on ecology and social anthropology agree on the necessity to take into account historical data for the discussion of ecological sustainability. (shrink)

During the last decades the question of defining life has gained increased interest but, at the same time, the difficulty in reaching consensus on a possible answer has led many to skeptical positions. This, in turn, has raised a wider debate about why defining life is so hard and controversial. Such a debate introduces additional aspects to be considered, like the role and nature of a definition of life itself. In this paper, we will focus on those aspects, arguing that (...) progress can be made if we conceive definitions of life as open heuristic tools that contribute to develop specific research strategies in the biological sciences and, more generally, to increase our understanding of life’s complexity. In contrast with pragmatic or operationalist approaches, we will defend that definitions of life comprise a set of ontological assumptions, together with an inherent unifying vocation, so they should be subject to comparison and critical assessment, closely related to the success or failure of the corresponding research programs, but also to the success or failure in establishing well-grounded interconnections among the latter. We consider that the search for a more coherent, integrated and generalized theory of biology cannot be pursued without keeping an empirical standpoint, and the exercise of defining life should not be taken as an obstacle but as a valuable instrument to achieve that goal. (shrink)

This article offers a philosophical-empirical account of embodied skilful performance in the practice of plant biotechnology. Drawing on the work of Merleau-Ponty and others, we elaborate how skilful performance emerges from and through reciprocal relations encompassing the body-in-the-world and the world-in-the-body. The contribution of this article lies in offering an account of skilful performance that is attentive to a perceiving, motile, feeling body entwined with world. In genetically modifying plants, scientists direct their senses of touch and vision to manipulating plant (...) materials and matter, ‘reading’ subtle changes in tissue cultures, plantlets and so on. In rhythmic movements, they extend their bodies through skilful use of complex equipment, while calling on ‘intuition’ to guide their work. Skilful performance, then, relies on our lived body that is not merely a physical object among other objects, nor a passive instrument for the mind, but dynamic and inescapably entwined with people and things in a world in flux. Bringing to the fore how perceiving, motile, feeling bodies are implicated in skilful performance has significant implications for education and workplace training. (shrink)

Según Julián Marías, fue Ortega, en 1914, quien hizo el primer uso filosófico de la palabra griega _alétheia_ con el significado de descubrimiento o iluminación: se trata de una innovación significativa porque Ortega introdujo una acepción nueva, sirviéndose de esa palabra, para superar la idea, que le parecía inaceptable, de que la verdad tenga que ser adecuación. Después de Ortega, los demás filósofos, a partir de 1927 con Heidegger, no saben de dónde procede la interpretación etimológica que ellos dan como (...) obvia para sus reflexiones filosóficas sobre la verdad. En realidad no hay textos griegos claros que interpreten el concepto de _alétheia_ ni etimológica ni filosóficamente. Julián Marías descubrió la más antigua discusión etimológica en el lingüista y filósofo Teichmüller (1879), de la cual se sirvió Ortega en fecha tan temprana como 1914 para hacer la primera interpretación filosófica de esa palabra. A pesar de ello, se ha hecho general la creencia de que fue Heidegger el primero que trató sobre la verdad como _alétheia_ en contraposición a lo que denomina _concepto tradicional de la verdad._. (shrink)