Angiogenesis plays an essential role in tumor growth, invasion and metastasis. After initial pessimism about the usefulness of the antiangiogenic therapeutic approach for cancer, interest has increased in the development of antiangiogenic compounds after the first clinical approval of an antiangiogenic therapy. The anti‐vascular endothelial growth factor (VEGF) antibody bevacizumab has recently been approved for use in combination with chemotherapy for the treatment of metastatic colorectal and non‐small cell lung cancer patients. However, no survival benefit has been demonstrated in anti‐VEGF (...) monotherapy trials, probably due to the high complexity of tumor angiogenesis regulation. Experimental and clinical data, including the approval of the multitargeted drugs sunitinib and sorafenib, indicate that exciting results, including tumor regression, can be expected from the combined targeting of different pathways in the tumor angiogenesis scenario. Several obstacles, including the high cost of new molecular targeted drugs make this therapeutic approach difficult. BioEssays 29:1159–1168, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Perfectionism is a multidimensional construct with both positive and negative aspects. Recently, the concept of appearance-oriented perfectionism has been introduced, which is associated with body image dissatisfaction and weight and shape control behaviors. The Physical Appearance Perfectionism Scale is a 12-item two-factor instrument developed to assess this new dimension of perfectionism. The aim of the study is to validate the Spanish version of PAPS among a representative sample of 850 male university students in Spain. Exploratory and confirmatory factorial structure, internal (...) consistency, convergent and concurrent validity, and associated predictor variables analyses have been carried out. Results showed that the Spanish version of the PAPS maintains the original factor structure with all items and proves to be a reliable instrument. Physical appearance-oriented perfectionism is associated with general perfectionism, higher body dissatisfaction, Eating Disorders and Muscle Dysmorphia symptomatology, and compulsive exercise, particularly in the Worry about Imperfection subscale. These variables also act as predictors of physical appearance perfectionism. The use of the PAPS-S and the analysis of its subscales is recommended in the context of body image-related pathologies such as Eating Disorders and Muscle Dysmorphia. (shrink)

In higher education, the conventional design of educational programs emphasises imparting knowledge and skills, in line with traditional Western epistemology. This emphasis is particularly evident in the design and implementation of many undergraduate programs in which bodies of knowledge and skills are decontextualised from the practices to which they belong. In contrast, the notion of knowledge as foundational and absolute has been extensively challenged. A transformation and pluralisation has occurred: knowledge has come to be seen as situated and localized into (...) various 'knowledges', and the status of the body has taken on renewed significance in epistemological debates. Rather than thinking of knowledge as transcending the body, the embodiment of knowledge has become a key factor in understanding the nature of knowledge and what it means to know. In this paper, we adopt a phenomenological perspective in exploring the notion of embodied knowing as it relates to higher education programs and, more specifically, the ways in which information and communication technologies (ICTs) are used in these programs. (shrink)

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction (...) force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment. (shrink)

Las fake news se suelen caracterizar como contenidos, de modo que prevalece el planteamiento semántico. Aquí se propone un enfoque pragmático, donde son actos comunicativos intencionales. Esto permite entender las fake news desde los actos locucionarios, ilocucionarios y perlocucionarios. Esta triple versión de intencionalidad comunicativa permite una mejor intelección de la mala información (misinformation) y de la desinformación (disinformation), que se refleja con claridad en el caso económico.Para mitigar o neutralizar los daños causados por las fake news en el tejido (...) social, se suele recomendar la contrastación de hechos (fact checking). La contribución de la Economía Experimental —y, en concreto, la aportación de Alvin Roth (Premio Nobel de Economía 2012)— puede ser especialmente relevante en dos direcciones: (a) la actividad económica y (b) la Economía como actividad entrelazada con otras. Esto supone el contrastar hechos partiendo de la intencionalidad en la actividad económica, en cuanto tal y en su nexo con otras actividades humanas. A este respecto, las fake news convergen con la toma de decisiones económicas, en cuanto que ambas están surcadas por la intencionalidad y, además, tienen lugar en un contexto donde adquieren un perfil orientado a fines. (shrink)

This paper advocates for the normative role of logic in reasoning. I offer a response, anchored in an externalist perspective, to two fronts of attack against the normativity thesis, namely Harman’s sceptical challenge and the accusation of naturalistic fallacy. On the one hand, I rework dialogical bridge principles and show that such principles satisfy adequacy criteria to deal with Harman’s challenge. On the other hand, I argue that it is possible to derive normative consequences from logical facts. This is because (...) argumentative interactions among agents involve the acceptance of constitutive rules that entail obligations. Hence, since logical rules can be seen as constitutive of the social practice of reasoning, they create prescriptions for reasoning. Bridge principles make those obligations and prohibitions explicit. (shrink)

En este artículo, abordo la disputa entre normativismo y descriptivismo centrándome en el problema del arbitraje. Para esto, propongo acercar a esta disputa la discusión sobre el problema del colapso que se ha dado recientemente en el marco de la filosofía de la lógica. Mi propuesta sostiene, por un lado, que el razonamiento humano, en cuanto práctica social, es una actividad esencialmente normada y, por otro lado, que los sistemas formales que se toman de referencia en la psicología del razonamiento (...) son el resultado de diversos procesos de equilibrio reflexivo. Esto permite defender el rol normativo de los sistemas formales como estándar para el razonamiento humano. Además, sostengo que la adecuación de un sistema formal está signada por los contextos específicos de razonamiento. Así, defiendo un pluralismo normativo respecto de los sistemas formales de inferencia en el marco de los estudios empíricos sobre el razonamiento humano. (shrink)

Resumen: El artículo a través de un esfuerzo teórico-epistémico e histórico, busca dar cuenta de la relevancia del género documental audiovisual, como referente en la construcción de realidad y memoria social, abocándonos específicamente al desarrollo del documental en Chile. Para ello, se argumenta sobre las problemáticas que acarrea la identificación de este tipo de realizaciones audiovisuales y, una vez zanjada dicha cuestión, se alude a la fuerza revitalizadora que alcanza como reflejo de una sociedad, su reconstrucción del pasado, su valorización (...) del presente y su proyección con visión de futuro. Es decir, el documental como posibilidad de intervenir en lo que percibimos como real, siendo necesario profundizar algunas nociones como verdad; objetividad y subjetividad; realidad y memoria social, entre otras cuestiones de importancia. Todo este recorrido histórico y epistemológico es apoyado en la fenomenología y la hermenéutica, en virtud de indagar en el género documental desde la experiencia chilena.: The article, through a theoretical-epistemic and historical effort, seeks to account for the relevance of the audio-visual documentary genre, as a reference in the construction of reality and social memory, focusing specifically on the development of documentary in Chile. For this, it is argued about the problems that the identification of this type of audio-visual realizations entails, and once this question is settled, it is alluded to the revitalizing force that it achieves as a reflection of a society, its reconstruction of the past, its valorisation of the present and its projection with vision of the future. That is, the documentary as a possibility to intervene in what we perceive as real, being necessary to deepen some notions as truth; objectivity and subjectivity; reality and social memory, among other important issues. All this historical and epistemological journey is supported in phenomenology and hermeneutics, by virtue of investigating the documentary genre from the Chilean experience. (shrink)

The act of iudicare hostes (‘declare public enemy’) was a formal pronouncement of the Roman Senate, voted for the first time in 88 BCE following a proposal by L. Cornelius Sulla after his first march on Rome. Legal historians have generally interpreted it as an emergency measure intended to preserve legality in a situation of civil strife and viewed it as a consistently defined institutional framework throughout the final decades of the Republic. Through an analysis of Sulla’s performative political communication, (...) before, during and in the immediate aftermath of the march, this paper argues that the act of judging (iudicare) someone a public enemy (hostis publicus) was first deployed as a political action, void of legal effects. Later instances of iudicare suggest that this act underwent a process of institutionalization after 63 BCE. (shrink)

The purpose of professional education programs is to prepare aspiring professionals for the challenges of practice within a particular profession. These programs typically seek to ensure the acquisition of necessary knowledge and skills, as well as providing opportunities for their application. While not denying the importance of knowledge and skills, this paper reconfigures professional education as a process of becoming. Learning to become a professional involves not only what we know and can do, but also who we are (becoming). It (...) involves integration of knowing, acting, and being in the form of professional ways of being that unfold over time. When a professional education program focuses on the acquisition and application of knowledge and skills, it falls short of facilitating their integration into professional ways of being. In addition, through such a focus on epistemology (or theory of knowing), ontology (or theory of being) is overlooked. This paper explores what it means to develop professional ways of being where the focus is becoming, not simply knowing as an end in itself. (shrink)

En 1993 y 2012 la poeta irlandesa Mary O’Malley publicó Valparaiso y Where the Rocks Float que edificó alrededor de la figura del mar y de la zona costera irlandesa donde nació. En ambas colecciones, la figura del mar se transforma en un potente agente activo que denuncia el rol de la mujer en la sociedad irlandesa y la explotación de los espacios azules con fines de consumo. Utilizando el análisis de Donna Haraway en Manifiesto cíborg (1985), este artículo analizará (...) una selección de textos de ambos poemarios para estudiar el vínculo entre mujer y mar como agentes activos contra la opresión patriarcal y la explotación capitalista. (shrink)

There is a peak in peer victimization during middle childhood, with multiple negative consequences. Parental use of corporal punishment and child aggression are the most widely studied predictors of this phenomenon. The aim of the present study was to analyze whether parental use of corporal punishment affects peer victimization through child aggression. This mediation model was explored for both mothers and fathers and for both physical and relational forms of aggression and peer victimization. Furthermore, we also analyzed whether the mediation (...) models were moderated by the sex of the child. Participants were 234 third graders. Child aggression and victimization were measured by peers using the Mini Direct Indirect Aggression Inventory. Independent measures of mother’s and father’s use of corporal punishment were obtained from a PCA of items from the Parental Styles and Dimensions Questionnaire. Conditional process modeling was carried out using a macro for SPSS developed by Hayes. Results indicated that aggression mediated the relation of parental corporal punishment to peer victimization. Some interesting moderating effects of sex in this mediation model were found; specifically, physical, and relational aggression mediated the relation of maternal corporal punishment to peer victimization only in boys. Few studies to date have addressed the connection between aggressive behavior and peer victimization as outcomes of corporal punishment, taking into consideration the role of parent’s and child’s sex, and both physical and relational forms of aggression and victimization during childhood. (shrink)

The topic of the present reflection is Christian religious belief. Specifically, we will use Husserlian tools in order to examine the positional nature of this particular type of belief. We will be less interested in the question concerning the success conditions of this experience and more in its noetic structure. According to our proposal, to believe by faith supposes (although it is not exhausted by) accepting the existence of mundane evidence speaking against this fundamental belief. The believer acknowledges the existence (...) of this contradicting en-doxical basis and nevertheless believes what she believes. We will refer to this simultaneous movement of accepting and cancelling as the concessive structure of the religious attitude. The para-doxical movement of experiencing conflicting evidence as being subjectively ineffective is a key component of this attitude. At least some inchoative conflict with the world is required in order for the religious belief to be religious. Lastly, we will try to show that, with a distinctive terminology, the idea that the Christian religious attitude involves a conflict between subjectivity and world is present not only in Kierkegaard but also in phenomenological figures like Scheler and even Husserl. (shrink)

In this paper I attempt to bring together (at least) two very different debates: one on justice, mercy and particularity, the other on the play of exclusionary reasons. My aim is to show how the discussion of the uneasy co-existence of justice and mercy pivots on the question of particularity. And, secondly, that the debate on exclusionary reasons can show us why law may fail to do justice in this context.

This paper attempts to answer whether the property of “efficacy” can be attributed to constitutive rules. In particular, according to Di Lucia, I will point out some problems that the “semantic conception of efficacy” has concerning constitutive and regulative rules. Then, the main goal of the paper will be to reflect on the possibility of the efficacy of constitutive rules by means of a complex case that the semantic conception seems to disregard: The case of the cheater. Does the action (...) of the cheater show the inefficacy of constitutive rules? Does she play the game while breaking the rule? Can the semantic conception of efficacy explain this situation, or do we need a more flexible concept of efficacy that takes nomotropism into account? These are some of the questions I will try to answer. (shrink)

Ample attention is being paid in the higher education literature to promoting active learning among students. However, critical examination of educational purposes and ends is largely lacki...

La decouverte de plus en plus profonde de la signification du christianisme a transforme la pensee de Fichte. Reciproquement, Fichte s'engage dans la voie d'une transformation du christianisme, au sens d'une metamorphose de la croyance en vision; il saisit la foi comme un stade imparfait de la science et souligne que seule cette derniere est a meme de supprimer l'exteriorite de l'Absolu. Le present ouvrage allie les points de vue genetique et systematique. De ses cinq parties, les quatre premieres exposent, (...) en suivant l'ordre chronologique, l'evolution de la theorie fichteenne du christianisme, depuis les textes prekantiens jusqu'a la Doctrine de l'Etat de 1813. La longue cinquieme partie, structuree thematiquement plutot que chronologiquement, est reservee non seulement a la reprise synthetique, mais aussi a la confrontation critique. Elle examine les differents aspects de la conception fichteenne du christianisme, notamment sa position a l'egard du Nouveau Testament, de la dogmatique, de la morale et de la mystique chretiennes. (shrink)

v. 1. pt. 1. Rationalisme, empirisme et crise des croyances au XVIIe siècle -- v. 1. pt. 2. Le procès du Christianisme dans la pensée du XVIIIe siècle -- v. 1. pt. 3. La philosophie de la religion chrétienne chez Kant et les postkantiens -- v. 1. pt. 4. La critique du Christianisme au XIXe siècle -- v. 2. pt 5. Philosophie chrétienne, philosophie du Christianisme au XIXe siècle -- v. 2. pt. 6. Vingtième XVIIe siècle. Index.

El vocabulario en los niños con Trastorno del Desarrollo del Lenguaje (TDL) o con Retraso del Lenguaje (RL) es más pobre que en los niños con un desarrollo típico del lenguaje, por lo que se pretende conocer qué diferencias existen entre ellos. Han participado 66 infantes entre 3 y 5 años; se ha valorado que vocabulario conocen, se ha determinado que tienen menos vocabulario (52%) que sus homónimos (69%), a excepción de la categoría de transportes, en la que tienen los (...) mismos resultados. Finalmente, se determina el listado de categorías que más necesitan trabajar los niños con RL o TDL. (shrink)

Providing the first English translation of Análisis del ser del mexicano, this book features a full biography of Uranga, a detailed overview of the translated text, and discussion of Uranga's relevance to contemporary debates in the phenomenology of culture, the philosophy of liberation, Latin American philosophy and phenomenology itself. Reading Uranga's brilliant words expertly translated and introduced by Carlos Alberto Sánchez finally allows us to understand why this Mexican philosopher is considered one of the most fearless and original thinkers of (...) the 20th century. (shrink)

What are the Early Memoranda?1 When were they written? What are their sources? What is their purpose and their relation to Hume's works? These questions, usually addressed separately, are in fact tightly interwoven: they require an articulated response that embraces them all. Our response could be summarised as follows: far from being current reading notes, or even less the exhaustive diary of Hume's intellectual experience, the Early Memoranda are most likely second-tier texts, or—as James Harris recently conjectured—"notes taken from notes."2 (...) More generally, the Memoranda, with some possible exceptions, are the result of a selection between those "loose bits of paper" and "uncorrect thoughts"3 which Hume began to... (shrink)

Emotions are an integral part of human cognition and they guide not only our understanding of the world but also our actions within it. As such, whether we soothe or flame an emotion is not inconsequential. Recent work in conversational AI has focused on responding empathetically to users, validating and soothing their emotions without a real basis. This AI-aided emotional regulation can have negative consequences for users and society, tending towards a one-noted happiness defined as only the absence of "negative" (...) emotions. We argue that we must carefully consider whether and how to respond to users' emotions. (shrink)

In this paper, I argue that the term kinêsis bears different connotations when associated with two different Plotinian hypostases in the Enneads: Intellect and Soul1. I propose an interpretation of this term as intellectual movement when it is associated with the Intellect and spatial movement when it is associated with the Soul.In the first section, I evaluate the meaning of kinêsis in reference to the hypostasis Intellect. In the second section, I turn to a critical examination of kinêsis associated with (...) the hypostasis Soul, emphasising the conceptual complexity of the term. I develop my interpretation on the distinction between kinêsis tês ousias and kinêsis pros ousias, translating the former as ‘movement of the hypostasis’ and the latter as ‘movement from the hypostasis.’ On this revised reading, I conclude that kinêsis in Plotinus is a context-dependent concept that alters its significance according to the hypostasis and introductory locution (‘tês’ or ‘pros’) with which it is associated. I conclude by linking Plotinian henology with Platonic and Aristotelian doctrines to illuminate an ongoing conversation between Plotinian metaphysics and Platonic and Aristotelian concepts of movement. (shrink)

La investigación presentada explora el método Painting Dialogues, llevado a cabo en la Universidad de Cádiz, durante la estancia postdoctoral de su creadora, Małgorzata Karczmarzyk, con estudiantes de Educación Infantil.A partir de la experiencia de creación compartida y del análisis y reflexión conjunta de la huella gráfica originada a modo de cartografía, el diálogo pictórico se presenta como proceso clave de aprendizaje. Esta forma de comunicación ayuda a comprender e interiorizar el conocimiento, potenciando la expresividad, la sensorialidad, la intuición, la (...) confianza y la escucha hacia uno mismo y hacia el otro. (shrink)

En el imaginario del anime contemporáneo de ciencia ficción encontramos algunos ejemplos claros de una reinterpretación de la relación entre ser humano y tecnología en términos no-clásicos. La filosofía de la individuación de Gilbert Simondon, con su crítica radical al individualismo y al sustancialismo, y en especial su filosofía de la técnica, centrada en la denuncia del olvido cultural de los aspectos humanos de la técnica, ofrecen una clave filosófica idónea para la exploración de ese imaginario. Mediante la aplicación de (...) los conceptos desarrollados por Simondon en sus análisis del modo de existencia de los objetos técnico a los animes Akira, Evangelion, Ghost in The Shell y Serial Experiments Lain, muestro que existe en ellos una visión coherente e innovadora de la relación entre humanidad y técnica, que coincide en muchos aspectos con las críticas y propuestas elaboradas por el mismo Simondon. Los más importantes de estos aspectos se relacionan con la idea de la extensión tecnológica de lo humano y con los grados de integración o separación existentes entre el dominio de lo técnico y el de la espiritualidad y la religión. (shrink)

Alba María Laredo Delgado y Darío Méndez Salcedo Facultad de Psicología, Universidad de Granada, España La comunicación entre dos personas … Read More →.

This article aims to present four case studies of the different responses to governmental measures to fight the COVID-19 pandemic by supreme and constitutional courts, especially in cases of jurisdictions that have been facing democratic erosion. The spread of the COVID-19 pandemic demanded immediate public policies and other political decisions from the branches of government. Executive authorities were the main actors in effecting constitutional public health norms. The expectation was that they will abide by the rule of law in fulfilling (...) their duties; that has not been the case under governments that promoted democratic erosion. The different contexts of the threats posed to the constitutional democracies led populist and illiberal leaders to opportunistically either try to—and then be contained by courts—or effectively consolidate the expansion of powers under the conditions of the pandemic. Concentrating on four jurisdictions (the USA, Hungary, El Salvador, and Brazil), the article demonstrates that courts can effectively work as bulwarks against waves of democratic erosion, especially in situations of stress, as it was the case in the global COVID-19 pandemic. This hypothesis is also proven by episodes in which courts did not sufficiently operate to curb illiberalism because they were already captured. The analyses enable classifying the court’s responses to the COVID-19 executive measures in a threefold pattern: deferential, restrictive, and of forced capitulation. (shrink)