In sexually reproducing organisms maintenance of germ stem cell immortality is fundamental for transmitting genetic material to future generations. While previous research has mainly considered intrinsic regulatory mechanisms in the germline, our recent study has found a direct contribution of somatic cells in preserving germline immortality via the somatically expressed endoribonuclease ENDU‐2 in Caenorhabditis elegans. We have identified ENDU‐2 as a secreted protein that can be taken up by the germline. Here, we discuss how ENDU‐2 might uncouple its RNA‐binding and (...) RNA‐cleavage activities to control gene expression via either an endoribonuclease dependent or an independent way. We also speculate on a possible functional conservation of its mammalian homologs in mediating cell‐cell communication as well as its potential significance in understanding human pathogenesis such as cancer development. (shrink)