Ethical Issues in Translational Research

Perspectives in Biology and Medicine 53 (4):517-533 (2010)
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Translational research is a main focus of current health policy (Albani and Prakken 2009; PLoS Medicine 2008). Translation of biomedical research knowledge to effective clinical treatment is essential to the public good (Lavis et al. 2003). Only 5% of basic science studies showing significant therapeutic promise are successfully translated into clinical application (Contopoulos-Ioannidis, Ntzani, and Ionannidis 2003; FDA 2004). As Hall (2001) observes, this is a problem: "When too many important discoveries lie dormant, the public good suffers" (p. G1127). Recent health policy initiatives intended to foster the translation of basic science into clinical advances must consider the unique bioethical issues raised by ..



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