Abstract

Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed. (Published Online November 9 2006).