Mutant sequences as probes of protein folding mechanisms

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Bioessays 6 (6):254-257 (1987)
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Abstract

Mutagenesis makes it possible to examine the effect of amino acid replacements on the folding and stability of proteins. The evaluation of kinetic and equilibrium folding data using reaction coordinate diagrams allows one to determine the roles that single amino acids play in the folding mechanism.

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10.1002/bies.950060603

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