Biological markers: Search for villains in psychiatry

Journal of Mind and Behavior 25 (3):213-226 (2004)
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Abstract

The article explores the influence of unproven specificity of pathogenesis manifested in clinical psychiatry and research. A selected literature review of studies attempting to identify a biological marker is presented. To date, the search for a biological marker to establish a psychiatric diagnosis has been unsuccessful. Clinical settings and programs are described which seem to be driven by psychological issues, one such example being the search for villains. Thus, specific assumptions about etiology affect therapy technique and treatment planning and may be disadvantageous to patient care. Biological and psychological development in all of its phases is subject to a diverse range of perturbations, intrinsic as well as extrinsic. A flexible, balanced view is called for before specificity is extended to general theories, which, in turn, affect therapy and treatment settings

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