Abstract
We propose to replace the present, 400 years-old scientific world picture with an updated, essentially complete model describing the architecture of the Universe. We show that three levels of reality, namely: phenomena, laws and first principles, together form the Universe. Moreover, on the basis of observable behaviour, phenomena, laws and principles can be classified into three fundamentally different branches of natural sciences: physical, biological and psychological. It is shown that the first principles have an ultimate role in the Universe, concentrating the governing potential of the Universe in a most elegant, comprehensive and fundamental manner. We define life and introduce the first principle of biology, i.e. the Bauer principle and show that it is the most fundamental of all the three first principles of the Universe. We consider the similarities and differences of our biological principle in comparison to the onto-poietic principle of Anna-Teresa Tymieniecka. With the help of the three first principles of natural sciences, we present arguments indicating the ultimate basis of the long awaited universal science that has a determining role for the development and perspectives of sciences, philosophy, religion, art, and the future of civilization.