At the end of the eighteenth century and beginning of the 19th, Spain and the Italian States contributed to the development of European agricultural science and the improvement of manufacturing. They collaborated with each other and reworked the most advanced models of France, Central Europe and Great Britain. Despite their somewhat less prosperous economic status, they demonstrated great originality in research and experimentation. In this process, botanical knowledge served as a starting point for a new epistemological path. Through three case (...) studies – the botanists Antonio José Cavanilles and Domenico Nocca, and the agriculturist Filippo Re – my article analyses how Spanish and Italian naturalists and learned individuals contributed to forming the concept of ‘economic botany’ through the exchange of seeds, plant specimens, books, journals, and – more in general – opinions, becoming germinal forces in a large transnational network. (shrink)