Scientific heritage can be found in every teaching and research institution, large or small, from universities to museums, from hospitals to secondary schools, from scientific societies to research laboratories. It is generally dispersed and vulnerable. Typically, these institutions lack the awareness, internal procedures, policies, or qualified staff to provide for its selection, preservation, and accessibility. Moreover, legislation that protects cultural heritage does not generally apply to the heritage of science. In this paper we analyse the main problems that make scientific (...) heritage preservation so difficult to address. We discuss the concept and present existing preservation tools, including recent surveys, legislation, policies, and innovative institutional approaches. We briefly analyse two recent initiatives for the preservation of scientific heritage, at the Universities of Lisbon and Cambridge. (shrink)