Elliott Sober is both an empiricist and an instrumentalist. His empiricism rests on a principle called actualism, whereas his instrumentalism violates this. This violation generates a tension in his work. We argue that Sober is committed to a conflicting methodological imperative because of this tension. Our argument illuminates the contemporary debate between realism and empiricism which is increasingly focused on the application of scientific inference to testing scientific theories. Sober’s position illustrates how the principle of actualism drives a wedge between (...) two conceptions of scientific inference and at the same time brings to the surface a deep conflict between empiricism and instrumentalism. (shrink)