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  1. Beyond structure: do intermediate filaments modulate cell signalling?Jesus M. Paramio & José L. Jorcano - 2002 - Bioessays 24 (9):836-844.
    Intermediate filament (IF) proteins form the largest family of cytoskeletal proteins in mammalian cells. The function of these proteins has long been thought to be only structural. However, this single function does not explain their diverse tissue‐ and differentiation‐specific expression patterns. Evidence is now emerging that IF also act as an important framework for the modulation and control of essential cell processes, in particular, signal transduction events. Here, we review the most recent developments in this growing and exciting new field. (...)
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  • Is spinal muscular atrophy the result of defects in motor neuron processes?Michael Briese, Behrooz Esmaeili & David B. Sattelle - 2005 - Bioessays 27 (9):946-957.
    The hereditary neurodegenerative disease spinal muscular atrophy (SMA) with childhood onset is one of the most common genetic causes of infant mortality. The disease is characterized by selective loss of spinal cord motor neurons leading to muscle atrophy and is the result of mutations in the survival motor neuron (SMN) gene. The SMN protein has been implicated in diverse nuclear processes including splicing, ribosome formation and gene transcription. Even though the genetic basis of SMA is well understood, it is not (...)
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