The present paper attempts to highlight the strategy of regional specialisation for technological innovation in R&D laboratories. The paper makes a proposition that regional specialisation should be recognised as a strategic initiative for technology development in R&D laboratories. The rationale for this strategic initiative has been substantiated with the help of illustrations from the cases of technology development efforts taken up in different laboratories in the country under the Council of Scientific and Industrial Research (CSIR), India. In this direction, CSIR (...) and other centres of excellence have played a pioneering role in the development of various industrial clusters and artisan concentrations in different parts of the country. The implications of adoption or otherwise of this strategy initiative for technological innovation in R&D laboratories have been discussed. (shrink)