A new road map for design is emerging out of interdisciplinary research across biology and design. Whilst in the second part of the twentieth century, the emergence of the digital realm altered and radically challenged conventional design and manufacturing processes, the beginning of the twenty-first century marks a strong shift towards the amalgamation of the binary code with biological systems. With advances in synthetic biology, we can now ‘biofabricate’ like Nature does. By tinkering and altering the DNA code or the (...) environment of growth of living organisms, we can effectively ‘design’ and grow new biomaterials. The role of design is shifting from working with inanimate matter such as plastic and metals to making with animate living entities such as mycelium, yeast and bacteria. This paradigm shift promises to open up new possibilities for biofabricating future intelligent materials as well as for engaging with new sustainable processes. This paper examines strategies and tools for designing with living systems and proposes a framework for design to engage with our future bio-materiality. From biofabrication experiments to synthetic biology propositions, the paper will investigate a series of design artifacts that explores strategies such as co-designing with natural organisms or actuating a new synthetic nature and develop a critique of how biodesign can help shifting towards the crafting of a future sustainable intelligent bio-materiality. (shrink)