This paper examines the construction of maternal responsibility in transgenerational epigenetics and its implications for pregnant women. Transgenerational epigenetics is suggesting a link between maternal behaviour and lifestyle during pregnancy and the subsequent well-being of their children. For example, poor prenatal diet and exposure to maternal distress during pregnancy are linked to epigenetic changes, which may cause health problems in the offspring. In this field, the uterus is seen as a micro-environment in which new generations can take shape. Because epigenetics (...) concerns how gene expression is influenced by the social realm, including a range of environmental conditions such as stress, diet, smoking, exercise, exposure to chemicals, pollution, and environmental hazards, the research findings in this area have direct policy relevance. For policy makers, rather than controlling this complex range of determinants of health, isolating and targeting maternal body and responsibilising mothers for the control of this micro-environment might seem feasible. Yet, examining the maternal body in isolation as a powerful environment to shape the health of next generations not only responsibilises women for the environment that they cannot control but also makes them a target for intrusive and potentially exploitative biomedical interventions. Even though ‘social factors’ are increasingly considered in epigenetics writing, the phrase is usually taken as self-explanatory without much elaboration. Drawing on the Covid-19 pandemic, this paper moves the current debate forward by providing consolidated examples of how individuals, including pregnant women, have little control over their environment and lifestyle. As evidenced by the pandemic’s disproportionate effects on people with low socioeconomic or poor health status, some pregnant women bore considerable physical and psychological stress which combined with other stress factors such as domestic violence. (shrink)

本书延续卷一内容,继续探讨自由主义政治哲学的核心问题。从论和史两个维度,从创办近十年,今年三月刚好出满二十期,并在中文世界中享有声誉的《政治与社会哲学评论》中选取十余篇文章,组成专集卷二。.

Human heritable genome editing (HHGE) involves editing the genes of human gametes and/or early human embryos. Whilst ‘identity’ is a key concept underpinning the current HHGE debate, there is a lack of inclusive analysis on different concepts of ‘identity’ which renders the overall debate confusing at times. This paper first contributes to reviewing the existing literature by consolidating how ‘identity’ has been discussed in the HHGE debate. Essentially, the discussion will reveal an ontological and empirical understanding of identity when different (...) types of identity are involved. Here, I discuss genetic, numerical, qualitative and narrative and how each of them is relevant in the HHGE context. Secondly, given the different types of identity, the paper explores how we could navigate these different interpretations of identity in a way that promotes an inclusive and informed discussion between primary stakeholders and the general public in the HHGE debate. Here, I argue for and refine a multi-faceted concept of identity as a suitable framework for discussing the ethical and societal implications of HHGE because it not only could integrate different understandings of identity but also highlight the interconnectedness between these different understandings. (shrink)

Many studies demonstrate that people form their first impression of a stranger based on facial appearance, and these impressions influence their subsequent decisions and behaviors. However, much less research has examined the factors that moderate the accuracy of first impressions based on a photo of face. The present study included three experiments to explore gender differences in the accuracy of impressions based on faces. The results showed that people judge facial attractiveness more accurately for female faces than for male faces (...) while giving more accurate wealth judgments for male faces than for female faces. Interestingly, although we did not find a significant correlation between confidence ratings and the accuracy of wealth rating, we recognized a significant moderate correlation between confidence ratings and the accuracy of attractiveness ratings when female participants rated male faces. To our knowledge, the present study is the first to reveal gender biases in the accuracy of impression judgments based on facial appearance. These findings imply a significant influence of traditional gender roles on accurate facial judgments. (shrink)

Using a data set of 30 authentic institutional emails written by Chinese college students to their native English teacher, this article investigates the frequency and combinations of apology strategies used by English as a Foreign Language learners in natural contexts. Drawing on the coding framework adapted from previous studies, this article carries out a fine-grained analysis of apology behaviors of Chinese EFL learners when they offended their teacher for various reasons. Results revealed that the most frequently used strategy was illustrative (...) force indicating devices, and “IFIDs + taking on responsibility” ranked the most frequent combination. Among IFID sub-strategies, an expression of regret had the highest frequency. In addition, a new strategy—request for a chance to repair—was identified, which was used by Chinese learners to show their respectful and pious attitude when a more serious offense was made to their teacher. Findings from the study indicate that Chinese EFL learners tend to use culture-specific apology strategies in academic contexts. This study has pedagogical implications for EFL pragmatics instruction in Chinese contexts and also second language pragmatics instruction tailored for native Chinese learners in English-speaking countries. (shrink)

Gene expression network is also a type of complex network. It is challenging to analyze the gene expression network through relevant knowledge and algorithms of a complex network. In this paper, the existing characteristics of genes are analyzed from various indexes of the gene expression network to analyze key genes and TOP genes. Firstly, gene chip data are screened, gene data with obvious characteristics are selected, and relevant clustering characteristics are analyzed. Then, the complex gene network structure is established, and (...) gene networks with different threshold shapes and different sizes are selected. Finally, the relevant indexes and PR values after the PageRank algorithm are analyzed for complex networks under different thresholds, thus establishing the TOP gene and PR sequence. (shrink)

Migraine is a chronic and idiopathic disorder leading to cognitive and affective problems. However, the neural basis of migraine without aura is still unclear. In this study, dynamic amplitude of low-frequency fluctuations analyses were performed in 21 patients with migraine without aura and 21 gender- and age-matched healthy controls to identify the voxel-level abnormal functional dynamics. Significantly decreased dALFF in the bilateral anterior insula, bilateral lateral orbitofrontal cortex, bilateral medial prefrontal cortex, bilateral anterior cingulate cortex, and left middle frontal cortex (...) were found in patients with migraine without aura. The dALFF values in the anterior cingulate cortex were negatively correlated with pain intensity, i.e., visual analog scale. Finally, support vector machine was used to classify patients with migraine without aura from healthy controls and achieved an accuracy of 83.33%, sensitivity of 90.48%, and specificity of 76.19%. Our findings provide the evidence that migraine influences the brain functional activity dynamics and reveal the neural basis for migraine, which could facilitate understanding the neuropathology of migraine and future treatment. (shrink)

BackgroundThe neural activity of irritable bowel syndrome patients in the resting state without any intervention has not been systematically studied. The purpose of this study was to compare the resting-state brain functions of IBS patients with healthy controls.MethodsThe published neuroimage studies were obtained from electronic databases including PubMed, EMBASE, PsycINFO, Web of Science Core, CNKI Database, Wanfang Database, VIP Database, and CBMdisc. Search dates were from inception to March 14th, 2022. The studies were identified by the preidentified inclusion and exclusion (...) criteria. Two independent reviewers compiled the studies and evaluated them for quality and bias.ResultsAltogether 22 fMRI studies were included in this review. The risk of bias of the included studies was generally low. The findings indicated that in IBS patients, increased or decreased brain areas were mostly associated with visceral sensations, emotional processing, and pain processing. According to brain network research, IBS may exhibit anomalies in the DMN, CEN, and emotional arousal networks. The fluctuations in emotion and symptoms in IBS patients were associated with alterations in the relevant brain regions.ConclusionThis study draws a preliminary conclusion that there are insufficient data to accurately distinguish the different neurological features of IBS in the resting state. Additional high-quality research undertaken by diverse geographic regions and teams is required to reach reliable results regarding resting-state changed brain regions in IBS. (shrink)

The sizes of individual data files have steadily increased along with rising demand for customized services, leading to issues such as low efficiency of web-based geographical information system -based data compression, transmission, and rendering for rich Internet applications in complicated visualization systems. In this article, a WebGIS-based technical solution for the efficient transmission and visualization of meteorological big data is proposed. Based on open-source technology such as HTML5 and Mapbox GL, the proposed scheme considers distributed data compression and transmission on (...) the server side as well as distributed requests and page rendering on the browser side. A high-low 8-bit compression method is developed for compressing a 100 megabyte file into a megabyte-scale file, with a compression ratio of approximately 90%, and the recovered data are accurate to two decimal places. Another part of the scheme combines pyramid tile cutting, concurrent domain name request processing, and texture rendering. Experimental results indicate that with this scheme, grid files of up to 100 MB can be transferred and displayed in milliseconds, and multiterminal service applications can be supported by building a grid data visualization mode for big data and technology centers, which may serve as a reference for other industries. (shrink)

This study investigated a conceptual model by testing how parental romantic relationships influenced the depressive symptoms of grown-up children and whether the constructive communication patterns of grown-up children and romantic relationships played mediation effects within it. A total of 421 Chinese participants were enrolled in the study. The level of depressive symptoms, romantic relationship satisfaction and closeness, couple communication patterns, and parental romantic relationships were measured via self-report questionnaires. According to the results, the structural equation modeling analysis verified that the (...) severity of participants’ depressive symptoms was negatively associated with the parental romantic relationship and that the association was mediated by participants’ constructive communication patterns and their own romantic relationships. Furthermore, compared with nondepressed participants, depressed participants were less satisfied with their parental romantic relationships, exhibited fewer constructive communication patterns, and were more distant and unsatisfied with current romantic relationships. (shrink)

本书分上下册,主要内容包括格言联壁,交友论,小窗幽记,安得长者言,菜根潭,围炉夜话,六事箴言,居官格言三十三条.

本书对作为一个整体性概念的生命科技犯罪及其刑法应对策略进行了研究,并详细地针对基因犯罪、辅助生殖犯罪、器官移植犯罪、人体实验犯罪以及美容整形犯罪等具体形式及其刑法应对策略加以探讨。.

本书以改革的精神,在坚持唯物辩证法基本原理的基础上,对唯物辩证法的叙述有新的突破,还分设专题剖析了40多个现实问题。.

本书主要介绍了先秦、汉代、宋代、近代四个时期传统义利思想的历史发展及中国传统义利思想对日本义利观的影响。.

本书受教育部2004年哲学社会科学研究重大课题攻关项目“当代科学哲学的发展趋势研究”(04JZD0004)、国家社会科学基金项目“测量难题的模态解释——量子力学前沿中的哲学问题”(05CZX008)和 教育部人文社会科学重点研究基地——山西大学科学技术哲学研究中心基金资助.

本書從多維度研究了國外意識形態新變化，即從傳統意識形態的新變化、當代新出現的意識形態、社會主義意識形態的新發展、蘇共意識形態的終結及其原因等維度，對當代國外意識形態從實踐到理論、從宏觀到微觀、從內容到 形式、從類型到結構、從特徵到功能、從存在方式到傳播方式、從形成機制到作用機制、從研究視角到研究方法等方面進行較全面的研究，分析了國外意識形態新變化對我國主流意識形態建設的影響、挑戰與啟迪，並對我國社會 主義意識形態建設策略提出建議。.

Yidali si xiang jia Weike de "Xin ke xue" de zhong yao xing bu xia yu Daerwen de "Wu zhong qi yuan", shi mei xue jia Zhu Guangqian wan nian tou ru zui duo jing li wan cheng de yi bu zhong liang ji yi zuo. Zhu Guangqian zai fan yi de tong shi, hai dui "Xin ke xue" jin xing le shen ru yan jiu. zai ben shu zhong, Zhu Guangqian xian shi e yao jie shao le "Xin ke (...) xue" de jing sui, ren wei Weike yan jiu li shi shi qiang diao qiong ben qiu yuan, yi bu luo zi ran fa wei qi dian, lun zheng ren lei ji she hui zhi du de fa zhan; hou you tou shi Weike de shi xue he mei xue, fen xi le wei ke dui xi fang zhe xue de ge xin he Zhongguo mei xue de ju da ying xiang, bing dai chu le Zhu Guangqian zi ji dui zi you ji ren dao zhu yi de zhui qiu. (shrink)

Ben cheng guo yi li lun jia gou er fei li shi xu shu de jiao du yan jiu zao qi ru jia de wang ba zhi bian, zong jie wang dao ba dao de zhu yao nei rong, shu li wang ba zhi bian suo guan zhu de si xiang zhu ti, fen xi qi si xiang luo ji jia gou, tan jiu wang ba zhi bian zai Zhongguo chuan tong zheng zhi zhe xue ji Zhongguo chuan tong she (...) hui zhong di ying xiang he yi yi, bing yi xian dai zheng zhi zhe xue de shi jiao fen xi qi li lun de shi wa jue wang ba zhi bian de ji ji yi yi. (shrink)