Nurses practising in mental health are faced with challenging decisions concerning confidentiality if a patient is deemed a potential risk to self or others, because releasing pertinent information pertaining to the patient may be necessary to circumvent harm. However, decisions to withhold or disclose confidential information that are inappropriately made may lead to adverse outcomes for stakeholders, including nurses and their patients. Nonetheless, there is a dearth of contemporary research literature to advise nurses in these circumstances. Cognitive Continuum Theory presents (...) a single‐system intuitive‐analytical approach to examining and understanding nurse cognition, analogous to the recommended single‐system approach to decision‐making in mental health known as structured clinical judgement. Both approaches incorporate cognitive poles of wholly intuition and analysis and a dynamic continuum characterised by a ‘common sense’ blending of intuitive and analytical cognition, whereby cues presented to a decision‐maker for judgement tasks are weighed and assessed for relevance. Furthermore, Cognitive Continuum Theory promotes the importance of determining pattern recognition and functional relations strategies, which can be used to understand the operationalisation of nurse cognition. (shrink)

Humanity stands at a precipice. -/- Our species could survive for millions of generations — enough time to end disease, poverty, and injustice; to reach new heights of flourishing. But this vast future is at risk. With the advent of nuclear weapons, humanity entered a new age, gaining the power to destroy ourselves, without the wisdom to ensure we won’t. Since then, these dangers have only multiplied, from climate change to engineered pandemics and unaligned artificial intelligence. If we do not (...) act fast to reach a place of safety, it may soon be too late. -/- The Precipice explores the science behind the risks we face. It puts them in the context of the greater story of humanity: showing how ending these risks is among the most pressing moral issues of our time. And it points the way forward, to the actions and strategies we can take today to safeguard humanity’s future. (shrink)

Necessitarian accounts of the laws of nature meet an apparent difficulty: for them, counterlegal conditionals, despite appearing to be substantive, seem to come out as vacuous. I argue that the necessitarian may use the presuppositions of counterlegal discourse to explain this. If the typical presupposition that necessitarianism is false is made explicit in counterlegal utterances, we obtain sentences such as 'If it turns out that the laws of nature are contingent, then if the laws had been otherwise, then such and (...) such would have been the case', which are non-vacuous and very often true. This goes a long way towards resolving the difficulty for necessitarianism. (shrink)

We think we know what healers do: they build on patients' irrational beliefs and treat them in a 'symbolic' way. If they get results, it's thanks to their capacity to listen, rather than any influence on a clinical level. At the same time, we also think we know what modern medicine is: a highly technical and rational process, but one that scarcely listens to patients at all. In this book, ethnopsychiatrist Tobie Nathan and philosopher Isabelle Stengers argue that this commonly (...) posed opposition between traditional and modern medicine is misleading. They show instead that healers are interesting precisely because they don't listen to patients, using techniques of 'divination' rather than 'diagnosis'. Healers construct genuine therapeutic strategies by identifying the origins of symptoms in external forces, outside of the mind of the sufferer, and in this regard African healers are virtuosos. Though it may claim otherwise, modern medicine, for its part, is characterised by empiricism rather than rationality. What appears to be the pursuit of rationality is ultimately only a means to dismiss and exclude other forms of treatment. Blurring the distinctions between traditional and modern practices and drawing on perspectives from across the globe, this ethnopsychiatric manifesto encourages us to think in radically new ways about illness, challenging accepted notions on the relationship between sufferer and symptom. It will be of great interest to those working in medicine and healthcare, as well as anthropologists, social scientists and those in the humanities more broadly. (shrink)

Settler colonialism is structured in part according to the principle of civilizational progress yet the roots of this doctrine are not well understood. Disparate ideas of progress and practices related to colonial dispossession and domination can be traced back to the Enlightenment, and as far back as ancient Greece, but there remain unexplored logics and continuities. I argue that civilizational progress and settler colonialism are structured according to the opposition between politics governed by reason or faith and the figure of (...) the child as sinful or bestial. Thus, it is not contingent, but rather necessary that justificatory frameworks of European empire and colonialism depict Indigenous peoples as children. To illustrate how the theoretical link between Indigenous peoples and children emerges not as a simple analogy, but rather, as the source of the premodern/modern and savage/civilized binaries, I trace the various historical iterations of the political/childhood opposition through the classical, medieval, enlightenment, and modern eras. I show how the model of civilizational progress from a premodern and savage state of childhood continues to serve as the model for settler colonial exclusion and domination of Indigenous peoples. (shrink)

As we understand them, dispositions are relatively uncontroversial 'predicatory' properties had by objects disposed in certain ways. By contrast, powers are hypothetical 'ontic' properties posited in order to explain dispositional behaviour. Chapter 1 outlines this distinction in more detail. Chapter 2 offers a summary of the issues surrounding analysis of dispositions and various strategies in contemporary literature to address them, including one of our own. Chapter 3 describes some of the important questions facing the metaphysics of powers including why they're (...) worth positing, and how they might metaphysically explain laws of nature and modality. (shrink)

Drawing on theoretical arguments from the psychology discipline, we investigate the implications of employee entitlement in organizational settings. Specifically, we utilize workplace engagement theory to suggest that due to their skewed sense of deservingness, employees high in entitlement are less likely to experience workplace engagement. Furthermore, the negative relationship between employee entitlement and workplace engagement is strengthened when ethical leadership is low, yet mitigated when ethical leadership is high. Finally, we predict that under conditions of low ethical leadership, reductions in (...) engagement explain why employee entitlement results in hindered job performance. This mediated effect does not hold when ethical leadership is high. We tested our theoretical model utilizing field data from employees and their direct supervisors in the financial services industry. Our results support our theoretical model. Theoretical and practical implications are discussed. (shrink)

The Church-Turing Thesis is widely regarded as true, because of evidence that there is only one genuine notion of computation. By contrast, there are nowadays many different formal logics, and different corresponding foundational frameworks. Which ones can deliver a theory of computability? This question sets up a difficult challenge: the meanings of basic mathematical terms are not stable across frameworks. While it is easy to compare what different frameworks say, it is not so easy to compare what they mean. We (...) argue for some minimal conditions that must be met if two frameworks are to be compared; if frameworks are radical enough, comparison becomes hopeless. Our aim is to clarify the dialectical situation in this bourgeoning area of research, shedding light on the nature of non-classical logic and the notion of computation alike. (shrink)

Some authors have called for increased research on various forms of geoengineering as a means to address global climate change. This paper focuses on the question of whether a particular form of geoengineering, namely deploying sulfate aerosols in the stratosphere to counteract some of the effects of increased greenhouse gas concentrations, would be a just response to climate change. In particular, we examine problems sulfate aerosol geoengineering (SAG) faces in meeting the requirements of distributive, intergenerational, and procedural justice. We argue (...) that SAG faces obstacles to meeting the requirements of all three considered kinds of justice, because its impacts can harm some persons and communities much more than others; it poses serious risks to future generations; and SAG is especially prone to unilateral implementation. While we do not claim that SAG ought not to be implemented, we argue that it is the responsibility of proponents of SAG to recognize and address these ethical obstacles before advocating its implementation. (shrink)

The fairy tale The Three Princes of Serendip can be taken to be allegorical of not only chance discovery (serendipity) but of other aspects of scientific discovery as well. Just as Horace Walpole coined serendipity, so can the term bahramdipity be derived from the tale and defined as the cruel suppression of a serendipitous discovery. Suppressed, unpublished discoveries are designated nulltiples. Several examples are presented to make the case that bahramdipity is an existent aspect of scientific discovery. Other examples of (...) non-ideal scientific research and discovery are provided in order to contrast and clarify the meaning and use of bahramdipity. Additional allegories of scientific discovery are taken from the tale and a hope for the strengthening of scientific integrity is expressed. (shrink)

The deliberative systems approach is a recent innovation within the tradition of deliberative democratic theory. It signals an important shift in focus from the political legitimacy produced within isolated and formal sites of deliberation (e.g., Parliament or deliberative mini-publics), to the legitimacy produced by a number of diverse interconnected sites. In this respect, the deliberative systems (DS) approach is better equipped to identify and address defects arising from the systemic influences of power and coercion. In this article, I examine one (...) of the least explored and least understood defects: the exclusion of non-speaking political actors generated by the uniform privileging of speech in all sites within a system. Using the examples of prefigurative protest, Indigenous refusal to deliberate, and the non-deliberative agency of disabled citizens, I argue that the DS approach allows theorists to better understand forms of domination related to the imposition of speech on those who are either unwilling or unable to speak. (shrink)

I describe three extant attempts to identify the global external symmetries within a Humean framework with theorems of some or other deductive systematization of the world, respectively, the best system, a meta-best system and a maximally simple system. Each has merits, but also serious flaws. Instead, I propose a view of global external symmetries as consequences of the structure of Humean-consistent world-making relations.

The binary between the figure of the child and the fully human being is invoked with regularity in analyses of race, yet its centrality to the conception of race has never been fully explored. For most commentators, the figure of the child operates as a metaphoric or rhetorical trope, a non-essential strategic tool in the perpetuation of White supremacy. As I show in the following, the child/human binary does not present a contingent or merely rhetorical construction but, rather, a central (...) feature of racialization. Where Black peoples are situated as objects of violence it is often precisely because Blackness has been identified with childhood and childhood is historically identified as the archetypal site of naturalized violence and servitude. I proceed by offering a historical account of how Black peoples came to inherit the subordination and dehumanization of European childhood and how White youth were subsequently spared through their partial categorization as adults. (shrink)

Shamatha, Transcendental, and Stillness Meditation are said to aim for “contentless” experiences, where mental content such as thoughts, perceptions, and mental images is absent. Silence is understood to be a central feature of those experiences. The main source of information about the experiences is texts by experts from within the three traditions. Previous research has tended not to use an explicit scientific method for selecting and reviewing expert texts on meditation. We have identified evidence synthesis as a robust and transparent (...) method that is suitable for this purpose. In this paper we use evidence synthesis based on expert texts to examine silence/quietness as a feature of the contentless experiences in the three practices. Objective criteria were used to select a sample of 135 expert texts. A database containing the expert descriptions of the meditation techniques and experiences was produced by extracting the relevant material from the publications and coding that material to differentiate individual features. The database, which forms part of the supplementary material for this paper, identifies each feature of the contentless experiences referred to in the expert texts, including silence/quietness. Our key finding is that the experts indicate silence/quietness has a particular connection with stillness, and the absence of concepts, mental activity/noise, thoughts, and disturbance. Further analysis leads to the following insights. The silence/quietness reflects the absence of thoughts and sounds, and this fits neatly with a conception of silence/quietness as the absence of internal and external noise. In some cases the terms silence and quietness may also reflect the absence of other disturbances such as non-auditory perceptions, mental images, and negative feelings. That would fit with a conception of silence/quietness as complete calm or absence of disturbance. It is not clear from the expert texts how silence/quietness is distinct from other features such as stillness that also reflect the absence of disturbances. As a separate matter, silence/quietness has connections with all the other features of the contentless experiences, but the closeness of the connections varies. Our work uncovers fine distinctions and ambiguities which lead to new research questions that can be explored in future studies. (shrink)

What sense, if any, does it make to speak of God? This question, of such vital importance to religious commitment, occupies an important place in discussion among Anglo-American philosophers of religion whose orientation is logical analysis. ‘Metatheological scepticism’ is the view that denies the intelligibility of religious discourse, derived from a theory of meaning which holds that a sentence has cognitive significance only if it makes a statement that is conclusively verifiable on empirical grounds. Dr Heimbeck’s argument for the cognitive (...) nature of religious discourse is twofold. First, he shows that such discourse can qualify as cognitively significant without having to satisfy the verification requirement. Secondly, he shows that it does in fact satisfy such a requirement because it is firmly rooted in the empirical realm. Originally published in 1969, this book, for teachers and students of philosophy of religion, is both easily comprehensible and highly readable, although the discussion of philosophical and theological points is conducted at an advanced level. (shrink)

A poor understanding of probability may lead people to misinterpret every day coincidences and form anomalistic beliefs. We investigated the relationship between anomalistic beli...

Subpart B of 45 Code of Federal Regulations Part 46 (CFR) identifies the criteria according to which research involving pregnant women, human fetuses, and neonates can be conducted ethically in the United States. As such, pregnant women and fetuses fall into a category requiring “additional protections,” often referred to as “vulnerable populations.” The CFR does not define vulnerability, but merely gives examples of vulnerable groups by pointing to different categories of potential research subjects needing additional protections. In this paper, I (...) assess critically the role of this categorization of pregnant women involved in research as “vulnerable,” both as separate entities and in combination with the fetuses they carry. In particular, I do three things: (1) demonstrate that pregnant women qua pregnancy are either not “vulnerable” according to any meaningful definition of that term or that such vulnerability is irrelevant to her status as a research participant; (2) argue that while a fetus may be vulnerable in terms of dependency, this categorization does not equate to the vulnerability of the pregnant woman; and (3) suggest that any vulnerability that appends to women is precisely the result of federal regulations and dubious public perceptions about pregnant women. I conclude by demonstrating how this erroneous characterization of pregnant women as “vulnerable” and its associated protections have not only impeded vital research for pregnant women and their fetuses, but have also negatively affected the inclusion of all women in clinical research. (shrink)

Contentless experience involves an absence of mental content such as thought, perception, and mental imagery. In academic work it has been classically treated as including states like those aimed for in Shamatha, Transcendental, and Stillness Meditation. We have used evidence synthesis to select and review 135 expert texts from within the three traditions. In this paper we identify the features of contentless experience referred to in the expert texts and determine whether the experiences are the same or different across the (...) practices with respect to each feature. We identify 65 features reported or implied in one or more practices, with most being reported or implied in all three. While there are broad similarities in the experiences across the traditions, we find that there are differences with respect to four features and possibly many others. The main difference identified is that Shamatha involves substantially greater attentional stability and vividness. Another key finding is that numerous forms of content are present in the experiences, including wakefulness, naturalness, calm, bliss/joy, and freedom. The findings indicate that meditation experiences described as contentless in the academic literature can in fact involve considerable variation, and that in many and perhaps most cases these experiences are not truly contentless. This challenges classical understandings in academic research that in these so-called contentless experiences all content is absent, and that the experiences are therefore an identical state of _pure consciousness_ or consciousness itself. Our assessment is that it remains an open question whether the experiences aimed for in the three practices should be classed as pure consciousness. Implications of our analysis for neuroscientific and clinical studies and for basic understandings of the practices are discussed. (shrink)

In this article, I outline the major themes of ‘anti-theodicy’. Anti-theodicy is characterised as a reaction, as rejection, against traditional solutions to the problem of evil and against the traditional formulations of the problem of evil to which those solutions respond. I detail numerous ‘moral’ anti-theodical objections to theodicy, illustrating the central claim of anti-theodicy: Theodicy is morally objectionable. I also detail some ‘non-moral’ anti-theodical objections, illustrating the second major claim of anti-theodicy: Traditional formulations of the problem of evil are (...) conceptually misguided. My focus remains on the analytic philosophical tradition throughout, but I briefly allude to the rich theological tradition of anti-theodicy. Although we should recognise the significant degree of diversity amongst anti-theodical arguments and the philosophical views of their proponents, this article should serve to illustrate the general theme: ‘Theodicies mediate a praxis that sanctions evil.’. (shrink)

Many philosophers have objected to Kant’s account of duties regarding non-human nature, arguing that it does not ground adequate moral concern for non-human natural entities. However, the traditional interpretation of Kant on this issue is mistaken, because it takes him to be arguing merely that humans should abstain from animal cruelty and wanton destruction of flora solely because such actions could make one more likely to violate one’s duties to human beings. Instead, I argue, Kant’s account of duties regarding nature (...) grounds much stronger limitations on how humans may treat non-human animals and flora, since such duties are rooted in the imperfect duty to increase one’s own moral perfection. This duty proscribes actions affecting non-human nature that decrease one’s moral perfection, such as those that cause organisms unnecessary harm. Moreover, the duty to moral perfection prescribes (but does not strictly require) actions affecting non-human nature that increase one’s moral perfection, such as those that benefit organisms. Given this interpretation, I show that, contrary to a widely held view, Kant’s moral philosophy can ground a coherent and robust approach to environmental ethics. (shrink)

It is often claimed that from the moment of conception embryos have the same moral status as adult humans. This claim plays a central role in many arguments against abortion, in vitro fertilization, and stem cell research. In what follows, I show that this claim leads directly to an unexpected and unwelcome conclusion: that natural embryo loss is one of the greatest problems of our time and that we must do almost everything in our power to prevent it. I examine (...) the responses available to those who hold that embryos have full moral status and conclude that they cannot avoid the force of this argument without giving up this key claim. (shrink)

In this book, Toby Svoboda develops and defends a Kantian environmental virtue ethic, challenging the widely-held view that Kant's moral philosophy takes an instrumental view toward nature and animals and has little to offer environmental ethics. On the contrary, Svoboda posits that there is good moral reason to care about non-human organisms in their own right and to value their flourishing independently of human interests, since doing so is constitutive of certain virtues. Svoboda argues that Kant’s account of indirect (...) duties regarding nature can ground a compelling environmental ethic: the Kantian duty to develop morally virtuous dispositions strictly proscribes unnecessarily harming organisms, and Svoboda argues that this duty compels us to act in ways that benefit non-human organisms, given that doing so can enhance one’s virtues. Svoboda’s argument engages the recent literature on environmental virtue and provides an original argument for an environmental virtue ethic firmly rooted in Kant’s moral philosophy. (shrink)

Part–whole causation is the thesis that some causes are part of their effects. PWC has been objected to because of its incompatibility with the criterion that causes not be spatially included within their effects and the criterion that causes and effects are ontologically distinct in some sense. This paper serves to undermine the sufficiency of these ways of objecting to PWC by showing that for each criterion either cause-effect relationships need not satisfy it or part–whole relationships can. A case-study of (...) the collapse of Bridge 9340 is employed to facilitate the discussion. (shrink)

Part–whole causation (PWC) is the thesis that some causes are part of their effects. PWC has been objected to because of its incompatibility with the criterion that causes not be spatially included within their effects and the criterion that causes and effects are ontologically distinct in some sense. This paper serves to undermine the sufficiency of these ways of objecting to PWC by showing that for each criterion either cause-effect relationships need not satisfy it or part–whole relationships can. A case-study (...) of the collapse of Bridge 9340 is employed to facilitate the discussion. (shrink)

The emerging field of comparative political theory (CPT) seeks to expand our understanding of politics through intercultural dialogues between diverse systems of political thought. CPT acknowledges diverse modes of political understanding, yet the field is still methodologically focused on textual forms of political practice and learning. I argue that the privileging of political literature in CPT has been inherited from orthodox political theory and the history of political thought and that the prioritizing of text over oral and enactive practices places (...) constraints on intercultural dialogue. First, methodological focus on texts inhibits dialogue with Indigenous traditions that do not prioritize text in the same way or to the same extent in the reproduction of political culture. Second, the incorporation of oral traditions tends to conflate orality with text in ways that obfuscate the contribution of enactive performance. One result of these methodological oversights is that CPT risks recapitulating some of the historical exclusionary logics that it seeks to overcome. (shrink)

In contentless experience there is an absence of mental content such as thought, perception, and mental imagery. The path to contentless experience in meditation can be taken to comprise the meditation technique, and the experiences on the way to the contentless “goal-state/s”. Shamatha, Transcendental, and Stillness Meditation are each said to access contentless experience, but the path to that experience in each practice is not yet well understood from a scientific perspective. We have employed evidence synthesis to select and review (...) 135 expert texts from those traditions. In this paper we describe the techniques and interim-states based on the expert texts and compare them across the practices on key dimensions. Superficially, Shamatha and Transcendental Meditation appear very different to Stillness Meditation in that they require bringing awareness to a meditation object. The more detailed and systematic approach taken in this paper indicates that posturally Shamatha is closer to Stillness Meditation, and that on several other dimensions Shamatha is quite different to both other practices. In particular, Shamatha involves greater measures to cultivate attentional stability and vividness with respect to an object, greater focusing, less tolerance of mind-wandering, more monitoring, and more deliberate doing/control. Achieving contentless experience in Shamatha is much slower, more difficult, and less frequent. The findings have important implications for taxonomies of meditation and for consciousness, neuroscientific, and clinical research/practice, and will provide new and useful insights for meditation practitioners. (shrink)

In this report I provide an introduction to the burgeoning field of hypercomputation – the study of machines that can compute more than Turing machines. I take an extensive survey of many of the key concepts in the field, tying together the disparate ideas and presenting them in a structure which allows comparisons of the many approaches and results. To this I add several new results and draw out some interesting consequences of hypercomputation for several different disciplines.

It is often said that there are three great traditions of normative ethics: consequentialism, deontology and virtue ethics. Each is based around a compelling intuition about the nature of ethics: that what is ultimately important is that we produce the best possible outcome, that ethics is a system of rules which govern our behaviour, and that ethics is about living a life that instantiates the virtues, such as honesty, compassion and loyalty. This essay is about how best to interpret consequentialism. (...) I show that if we take consequentialism beyond the assessment of acts, using a consequentialist criterion to assess decision making, motivation, and character, then the resulting theory can also capture many of the intuitions about systems of moral rules and excellences of character that lead people to deontology and virtue ethics. I begin by considering the argument that consequentialism is self-defeating because its adoption would produce bad outcomes. I take up the response offered by the classical utilitarians: when properly construed, consequentialism does not require us to make our decisions by a form of naïve calculation, or to be motivated purely by universal benevolence. Instead it requires us to use the decision procedure that will produce the best outcome and to have the motives that lead to the best outcome. I take this idea as my starting point, and spend the thesis developing it and considering its implications. I demonstrate that neither act-consequentialism nor rule-consequentialism has the resources to adequately assess decision making and motivation. I therefore turn to the idea of global consequentialism, which assesses everything in terms of its consequences. I then spend the greater part of the essay exploring how best to set up such a theory and how best to apply it to decision making and motivation. I overcome some important objections to the approach, and conclude by showing how the resulting approach to consequentialism helps to bridge the divide between the three traditions. (shrink)

Climate change threatens to infringe the human rights of many. Taking an optimistic stance, climate engineering might reduce the extent to which such rights are infringed, but it might also bring about other rights infringements. This Forum, leading off the special issue on climate engineering governance, engages three scholars in a discussion of three core issues at the intersection of human rights and climate engineering. The Forum is divided into three sections, each authored by a different scholar and discussing a (...) distinct aspect of this relationship. First, Toby Svoboda gives an overarching view of three competing approaches to human rights, grounded in philosophy; then, Holly Jean Buck looks at lessons from how the climate migration conversation brings a human rights approach to a climate policy issue; and finally, Pablo Suarez illustrates how a humanitarian approach to climate engineering works with a human rights framework. The conclusion of the Forum draws together points of overlap across the three sections and suggests a path forward for policy and research on this topic. Together, the sections show that climate engineering, should it materialize, will pose novel human rights challenges, and may well force reconsideration of how human rights are applied as a guide to action. (shrink)

This paper appeals to certain popular doctrines about human welfare and morality to offer a new response to the problem of hell. In particular, I contend that the combination of desire satisfactionism, a subjective theory about welfare, with an objective theory of morality leads to a surprisingly intuitive and compelling argument for the consistency of the post-mortem punishment of people in hell with the existence of an omniperfect God. In fact, under these conditions, the existence of such a divine being (...) may actually require that there be at least some type of hell/post-mortem punishment. Finally, I suggest that positing the existence of hell can strengthen desire satisfactionism against an objection tied to base or immoral desires. (shrink)

This paper develops two ideas with respect to dispositional properties: (1) Adapting a suggestion of Sungho Choi, it appears the conceptual distinction between dispositional and categorical properties can be drawn in terms of susceptibility to finks and antidotes. Dispositional, but not categorical properties, are not susceptible to intrinsic finks, nor are they remediable by intrinsic antidotes. (2) If correct, this suggests the possibility that some dispositions—those which lack any causal basis—may be insusceptible to any fink or antidote. Since finks and (...) antidotes are a major obstacle to a conditional analysis of dispositions, these dispositions that are unfinkable may be successfully analysed by the conditional analysis of dispositions. This result is of importance for those who think that the fundamental properties might be dispositions which lack any distinct causal basis, because it suggests that these properties, if they exist, can be analysed by simple conditionals and that they will not be subject to ceteris paribus laws. (shrink)

The orthodox view of the metaphysics of desert is that desert is a triadic relation that obtains between a subject, an object and a desert base. Not only is this view lacking in motivation, but conceiving of the desert base as part of the desert relation renders the concept of desert incoherent. Instead, desert should be thought of as a dyadic relation between a subject and an object, where desert bases are simply the grounds for dyadic desert facts.

As a direct consequence of the sophisticated arrangement of its intrinsic neurons, the gastrointestinal tract is unique among peripheral organs, in its ability to mediate its own reflexes. Neurons of the enteric nervous system are intimately associated with enteric glial cells. These supporting cells do not resemble Schwann cells, the glial cell found in all other parts of the peripheral nervous system, but share many similarities with astrocytes of the central nervous system. Ablation of enteric glial cells in adult transgenic (...) mice has demonstrated that these cells are essential to maintain the integrity of the small intestine. Acute loss of enteric glial cells induces massive pathological changes with similarities to necrotizing enterocolitis (NEC) and early Crohn's disease. These human conditions share some mechanistic similarities. Identification of enteric glial cell dysfunction/loss as sufficient to induce necrotic/inflammatory bowel disease may be important to understand the pathogenesis of both NEC and Crohn's disease. BioEssays 24:130–140, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

A comprehensive look at photography's most dynamic era, this book surveys the rich variety of innovation that characterised the 1930s, exploring the aesthetic and cultural achievements of leading photographers and mapping the impact on the ...

The paintings, murals, and graphics of Ben Shahn have made him one of the most heralded American artists of the 20th century, but during the 1930s he was among the America's premier photographers. This book presents 100 photographs from his most ambitious FSA project, a study of small-town life in the Depression.