Objective: To clarify whether long time constant is useful for detecting the after-slow activity of epileptiform discharges : sharp waves and spikes and for differentiating EDs from sharp transients.Methods: We employed 68 after-slow activities preceded by 32 EDs and 36 Sts from 52 patients with partial and generalized epilepsy defined by visual inspection. High-frequency activity associated with the apical component of EDs and Sts was also investigated to endorse two groups. After separating nine Sts that were labeled by visual inspection (...) but did not fulfill the amplitude criteria for after-slow of Sts, 59 activities were analyzed about the total area of after-slow under three TCs.Results: Compared to Sts, HFA was found significantly more with the apical component of EDs. The total area of after-slow in all 32 EDs under TC 2 s was significantly larger than those under TC 0.3 s and 0.1 s. Conversely, no significant differences were observed in the same parameter of 27 Sts among the three different TCs. Regarding separated nine Sts, the total area of after-slow showed a similar tendency to that of 27 Sts under three different TCs.Significance: These results suggest that long TC could be useful for selectively endorsing after-slow of EDs and differentiating EDs from Sts. These findings are concordant with the results of the HFA analysis. Visual inspection is also equally good as the total area of after-slow analysis. (shrink)

Valuable insights into eukaryotic regulatory circuits can emerge from studying interactions of bacterial pathogens such as Helicobacter pylori with host tissues. H. pylori uses a type IV secretion system (T4SS) to deliver its CagA virulence protein to epithelial cells, where much of it becomes phosphorylated. CagA's phosphorylated and non‐phosphorylated forms each interact with host regulatory proteins to alter cell structure and cell fate. Kwok and colleagues1 showed that CagA destined for phosphorylation is delivered using host integrin as receptor and H. (...) pylori's CagL protein as an integrin‐specific adhesin, and that CagL–integrin‐binding activates the kinase cascade responsible for CagA phosphorylation. This research contributes to understanding infectious disease and the control of cell fates. BioEssays 30:515–520, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This study investigated the effect of Mahjong, which is a table game played by three or four players and involves intellectual activity, on the intelligence quotient of children. The participants were children between the age of 6 and 15 years, and their IQ was assessed immediately after enrolling in children's Mahjong classes and 1 year after the enrollment using the Wechsler Intelligence Scale for Children Fourth Edition. Twenty children were included in the analysis. Their mean age at the time of (...) the initial evaluation was 9 years and 6 months. In addition, we conducted a 1-year post-examination. The change in the IQ of this group was compared to that of a historical control group with a similar age range and test–retest interval. The mean overall full-scale IQ of the 20 children during the initial and post-1-year examinations was 106.05 and 113.75, respectively, and showed a statistically significant increase. Based on the subscale index, the verbal comprehension index and processing speed index scores both showed a statistically significant increase from 100.6 to 106.75 and from 108.05 to 119.05, respectively. The PSI of the children included in the analysis showed a statistically significant increase compared to the historical control group. This study suggests that children who participate in Mahjong classes during their childhood have increased PSI scores of WISC-IV. (shrink)

Recently, many opportunities have emerged to use the Internet in daily life and classrooms. However, with the growth of the World Wide Web (Web), it is becoming increasingly difficult to find target information on the Internet. In this study, we explore a method for developing the ability of users in information seeking on the Web and construct a search process feedback system supporting reflective activities of information seeking on the Web. Reflection is defined as a cognitive activity for monitoring, evaluating, (...) and modifying one's thinking and process. In the field of learning science, many researchers have investigated reflective activities that facilitate learners' problem solving and deep understanding. The characteristics of this system are: (1) to show learners' search processes on the Web as described, based on a cognitive schema, and (2) to prompt learners to reflect on their search processes. We expect that users of this system can reflect on their search processes by receiving information on their own search processes provided by the system, and that these types of reflective activity helps them to deepen their understanding of information seeking activities. We have conducted an experiment to investigate the effects of our system. The experimental results confirmed that (1) the system actually facilitated the learners' reflective activities by providing process visualization and prompts, and (2) the learners who reflected on their search processes more actively understood their own search processes more deeply. (shrink)

世界とは何かという壮大なテーマに気鋭の哲学者がせまる知的刺激あふれる一冊。事実とは何なのか?いま自分が見ているものと隣人が見ているものは同じものなのか?人と人とのコミュニケーションはどのようにして成り 立つのか?...新たなものの見方や考え方を模索し、社会で直面するさまざまな課題を解くカギを探ります。.

Dogs and cats have been domesticated through different processes. Dogs were the first domesticated animals, cooperating with humans by hunting and guarding. In contrast, cats were domesticated as predators of rodents and lived near human habitations when humans began to settle and farm. Although the domestication of dogs followed a different path from that of cats, and they have ancestors of a different nature, both have been broadly integrated into—and profoundly impacted—human society. The coexistence between dogs/cats and humans is based (...) on non-verbal communication. This review focuses on “gaze,” which is an important signal for humans and describes the communicative function of dogs’ and cats’ eye-gaze behavior with humans. We discuss how the function of the gaze goes beyond communication to mutual emotional connection, namely “bond” formation. Finally, we present a research approach to multimodal interactions between dogs/cats and humans that participate in communication and bond formation. (shrink)

IntroductionPrevious studies on metacognitive ability were explored using self-report questionnaires that are difficult to adequately measure and evaluate when the capacity for self-reference is undeveloped. This study aimed to validate the Congruency-based Metacognition Scale to measure metacognition and the feeling of confidence abilities and to investigate the development of metacognition during adolescence.MethodsThe CMS was administered to 633 child–parent pairs in Japan. The CMS metacognition score was assessed based on congruency scores between the self-report of the child from a third-person perspective (...) and the parent’s report from the first-person perspective. The CMS self-judgment accuracy score was assessed by the congruency scores between the children’s self-report from the 1PP and 3PP. For both measures, the more distant the 3PP on the self-report was from the 1PP on the parent’s report and child self-report means low ability. An exploratory factor analysis was conducted to examine construct validity and then a confirmatory factor analysis was used. Criterion validity was examined by calculating Pearson’s correlation coefficients with scores on the Beck Cognitive Insight Scale and Autism Quotient. We used intraclass correlation and Cronbach’s alpha to examine the test–retest and internal consistency reliability.ResultsBased on the results of the EFA and CFA, we adopted one factor structure with five items. The CMS metacognition and CMS self-judgment accuracy showed evidence criterion validity, exhibiting significant correlations with the BCIS self-reflectiveness and self-certainty scores, respectively. Regarding to the AQ, only the CMS metacognition score had significant correlations with the social skills and total scale score. The test–retest reliability showed adequate. Adolescents were found to have significantly lower metacognitive ability compared to young adults.ConclusionCMS could be a valid and reliable measure to examine metacognitive abilities for adolescents. (shrink)

This study aimed to investigate whether the effect of mental practice can be enhanced by providing neurofeedback based on transcranial magnetic stimulation -induced motor evoked potentials. Twenty-four healthy, right-handed subjects were enrolled in this study. The subjects were randomly allocated into two groups: a group that was given correct TMS feedback and a group that was given randomized false TMS feedback. The subjects imagined pushing the switch with just timing, when the target circle overlapped a cross at the center of (...) the computer monitor. In the Real-FB group, feedback was provided to the subjects based on the MEP amplitude measured in the trial immediately preceding motor imagery. In contrast, the subjects of the Sham-FB group were provided with a feedback value that was independent of the MEP amplitude. TMS was applied when the target, moving from right to left, overlapped the cross at the center of the screen, and the MEP amplitude was measured. The MEP was recorded in the right first dorsal interosseous muscle. We evaluated the pre-mental practice and post-mental practice motor performance in both groups. As a result, a significant difference was observed in the percentage change of error values between the Real-FB group and the Sham-FB group. Furthermore, the MEP was significantly different between the groups in the 4th and 5th sets. Therefore, it was suggested that TMS-induced MEP-based neurofeedback might enhance the effect of mental practice. (shrink)

PurposeThis study aimed to investigate whether oxygenated hemoglobin generated during a motor imagery task is associated with the motor learning level of the task.MethodsWe included 16 right-handed healthy participants who were trained to perform a ball rotation task. Hemodynamic brain activity was measured using near-infrared spectroscopy to monitor changes in oxy-Hb concentration during the BR MI task. The experimental protocol used a block design, and measurements were performed three times before and after the initial training of the BR task as (...) well as after the final training. The BR count during training was also measured. Furthermore, subjective vividness of MI was evaluated three times after NIRS measurement using the Visual Analog Scale.ResultsThe results showed that the number of BRs increased significantly with training. VAS scores also improved with training. Furthermore, oxy-Hb concentration and the region of interest showed a main effect. An interaction was confirmed, and it was ascertained that the change in oxy-Hb concentrations due to training was different for each ROI. The most significant predictor of subjective MI vividness was supplementary motor area oxy-Hb concentration.DiscussionHemodynamic brain activity during MI tasks may be correlated with task motor learning levels, since significant changes in oxy-Hb concentrations were observed following initial and final training in the SMA. In particular, hemodynamic brain activity in the SMA was suggested to reflect the MI vividness of participants. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Japan Unbound: A Volatile Nation's Quest for Pride and PurposeDaniel A. MetrauxJapan Unbound: A Volatile Nation's Quest for Pride and Purpose. By John Nathan. Boston: Houghton Mifflin Company, 2004.Immediately after my return from an eight-day visit to Japan in late March 2004, I happened upon a long article in the New York Times (March 27, 2004, p. A4) featuring Hitomi Kanehara, a twenty-year-old author of a novel (...) about her post-bubble generation. Her portrait of a radically changing society in Japan reflects what I learned from two dozen interviews with Japanese friends and colleagues over the course of my visit.The Times article praised Kanehara for the portrait of young people in Japan since the 1990 collapse of Japan's "bubble economy" of the 1970s and 1980s:It is a world of "freeters," young Japanese surviving on part-time jobs and unconcerned with their future; of unsentimental sex and a profound inability to communicate verbally; a world in which a killing is viewed with amorality. The institutions that built postwar Japan—the family, school and companies—are noticeable by their absence. In a nation known for its social cohesion, the characters have no interest in playing a role in society, but only in finding personal satisfaction among themselves. Unlike Japanese in, say, their 30s, the characters in the novel are not disillusioned at Japanese society, since they had few expectations to begin with. "There are many people who don't expect anything from society," Ms. Kanehara says. "That's precisely why they are looking inward or to people [End Page 678] closest to them. I never knew the bubble era, so my way of looking at things can't help being different. Since I was born, I've never experienced a time of prosperity. Without my being aware, it's possible that my writing reflects the era."The Japan that I observed ever so briefly in March 2004 after a four-year absence is a society that is undergoing revolutionary changes in values and behavior in every sphere of life from education and popular culture to business and government. The result is a process that is radically changing the Japanese cultural landscape, making it a place vastly different from its traditional and even recent past.This view of Japan is carefully chronicled in John Nathan's most recent work, Japan Unbound: A Volatile Nation's Quest for Pride and Purpose. Nathan, the Takashima Professor of Japanese Cultural Studies at the University of California at Santa Barbara and author of highly praised books on Mishima Yukio and Sony, explores many facets of contemporary Japanese society ranging from education and families to business, politics, and foreign relations.Nathan analyzes a nation experiencing dramatic change as Japan moves away from many of its traditional values toward a very uncertain future. A long and demeaning recession has weakened the foundations of the traditional family system and has contributed to the rapid rise of divorce and an increase in the physical abuse of children by their families. The recession has contributed to the weakening of the bond between Japan's corporations and their employees, who are losing their right to lifetime employment. More and more Japanese are growing skeptical of their nation's dependant relationship of over a half-century with the United States, and nationalistic and xenophobic books are climbing up the best-seller list.One matter that Nathan discusses brilliantly is the traumatic breakdown of order and cohesion in Japan's primary and secondary schools and the increasingly rebellious nature of Japanese youth. He writes about riotous conditions in classrooms in a country once famous for respectful children. His best chapter depicts chaos in the classroom, where teachers across the country have simply lost control of their students. Disruptive students rule the roost, bringing intolerable disorder and engaging in physical attacks on other students as well as teachers and administrators. Nathan writes:Classroom breakdown is only part of a larger crisis of anger and withdrawal that has bewildered parents and educators.... In the United States, suspension is a legal option; in Japan suspension and expulsion are taboo under any circumstances. Promotion is based... (shrink)