Selective protein degradation maintains cellular homeostasis, but this process is disrupted in many diseases. Targeted protein degradation (TPD) approaches, built upon existing cellular mechanisms, are promising methods for therapeutically regulating protein levels. Here, we review the diverse palette of tools that are now available for doing so throughout the gene expression pathway and in specific cellular compartments. These include methods for directly removing targeted proteins via the ubiquitin proteasome system with proteolysis targeting chimeras (PROTACs) or dephosphorylation targeting chimeras (DEPTACs). Similar (...) effects can also be achieved through the lysosomal system with autophagy‐targeting chimeras (AUTACs), autophagosome tethering compounds (ATTECs), and lysosome targeting chimeras (LYTACs). Other methods act upstream to degrade RNAs (ribonuclease targeting chimeras; RIBOTACs) or transcription factors (transcription factor targeting chimeras; TRAFTACs), offering control throughout the gene expression process. We highlight the evolution and function of these methods and discuss their clinical implications in diverse disease contexts. (shrink)

Preterm birth is defined as delivery occurring before 37 weeks gestation.1 Infants born prematurely have increased risks of morbidity and mortality throughout life, especially during the first year. These risks increase as the gestational age at birth decreases.2 Additionally, there are significant racial and ethnic differences in preterm birth rates. In 2022, the rate of preterm birth among non-Hispanic black women was approximately 50% higher than that observed in non-Hispanic white women.1 The outcomes for these infants are also disparate–preterm birth (...) and low birth weight are the second-leading causes of infant mortality (deaths before 1 year of age). Notably, among preterm neonates, infants born to non-Hispanic black women have a mortality rate more than double that of infants born to non-Hispanic white mothers.3 Importantly, there is a small but significant group of neonates that can be classified as severely premature (those born <28 weeks). Infants born before 28 weeks have varied and uncertain outcomes. While this group accounts for only 0.4% of preterm births, it also accounts for 40% of deaths among preterm neonates.4 As noted by Romanis and Adkins, the advent of artificial amnion and placenta technology (AAPT) holds promise for its potential to address the physiologic complications and mortality risks of extreme prematurity by introducing amniotic substitutes that mimic in vivo placental oxygenation and substrate delivery. In contrast …. (shrink)

The philosophical difficulties presented by self-deception are vexed and multifaceted. One such difficulty is what I call the ‘doxastic problem’ of self-deception. Solving the doxastic problem involves determining whether someone in a state of self-deception that ∼p both believes that p and believes that ∼p, simply holds one or the other belief, or, as I will argue, holds neither. This final option, which has been almost entirely overlooked to-date, is what I call ‘ nondoxasticism ’ about self-deception. In this article, (...) I present a negative case for nondoxasticism according to which, in the paradigm case of self-deception, there is no explanatory need to attribute the self-deceived person either their undesired belief that p, or their desired belief that ∼p. Folk psychology is replete with concepts other than belief, and if we bear this in mind, it becomes clear that the explanatory roles for which the self-deceived person's purported beliefs have traditionally been enlisted can be comfortably filled without recourse to belief. (shrink)

This article takes as its starting point the central place given to contradiction by Hermann Goldschmidt in his book Contradiction Set Free, and it compares his approach with that of the philosopher Vladimir Jankélévitch. At the same time as Goldschmidt, Jankélévitch also assigned a central role to contradiction in thought, so much so that he often referred to his own philosophical method as “paradoxology.” For him, as for Goldschmidt, paradox is the driving force behind thought that is always on the (...) move. This article presents the main features of Jankélévitch’s paradoxology and illustrates it with two themes: forgiveness and Jewish identity. By highlighting this proximity between Goldschmidt’s approach and that of Jankélévitch, I suggest that they are both part of a more general movement in continental philosophy in the second half of the twentieth century, one of whose main challenges was to rethink philosophical rationality in depth. (shrink)

本书是罗根泽对诸子的哲学研究,包括《古史辨》第四册《诸子丛考》自序;战国前无私家著作说;由《墨子》引经推测儒墨两家与经书之关系;《墨子》探源等内容。.

本书所编选的文章,是作者从事伦理学的教学和科研工作40多年来,在伦理道德建设方面潜心研究的成果。大体分为以下几个方面:伦理学基本理论研究、中国传统伦理思想研究、现实道德问题研究等。.

William James famously tells us that there are two main goals for rational believers: believing truth and avoiding error. I argues that epistemic consequentialism—in particular its embodiment in epistemic utility theory—seems to be well positioned to explain how epistemic agents might permissibly weight these goals differently and adopt different credences as a result. After all, practical versions of consequentialism render it permissible for agents with different goals to act differently in the same situation. -/- Nevertheless, I argue that epistemic consequentialism (...) doesn’t allow for this kind of permissivism and goes on to argue that this reveals a deep disanalogy between decision theory and the formally similar epistemic utility theory. This raises the question whether epistemic utility theory is a genuinely consequentialist theory at all. (shrink)

A rich literature has discussed what it is to respond to a reason, e.g., to believe or act on the basis of some consideration or another. In comparison, what it would be to respond to a second-order reason has been underexplored. Yet formulating an account of this is vital for maintaining the existence of second-order reasons in both the practical and epistemic domains. And indeed, there are reasons to doubt this is possible. For example, responding to second-order reasons is meant (...) to be different from simply coming to believe or act for a more richly described first-order reason but it's not clear what this would look like. This paper introduces an account of the second-order basing relation which meets these concerns. It therefore both develops our picture of second-order reasons and helps to defend their existence. (shrink)

According to a grand narrative that long ago ceased to be told, there was a seventeenth century Scientific Revolution, during which a few heroes conquered nature thanks to mathematics. This grand narrative began with the exhibition of quantitative laws that these heroes, Galileo and Newton for example, had disclosed: the law of falling bodies, according to which the speed of a falling body is proportional to the square of the time that has elapsed since the beginning of its fall; the (...) law of gravitation, according to which two bodies are attracted to one another in proportion to the sum of their masses and in inverse proportion to the square of the distance separating them -- according to his own preferences, each narrator added one or two quantitative laws of this kind. The essential feature was not so much the examples that were chosen, but, rather, the more or less explicit theses that accompanied them. First, mathematization would be taken as the criterion for distinguishing between a qualitative Aristotelian philosophy and the new quantitative physics. Secondly, mathematization was founded on the metaphysical conviction that the world was created pondere, numero et mensura, or that the ultimate components of natural things are triangles, circles, and other geometrical objects. This metaphysical conviction had two immediate consequences: that all the phenomena of nature can be in principle submitted to mathematics and that mathematical language is transparent; it is the language of nature itself and has simply to be picked up at the surface of phenomena. Finally, it goes without saying that, from a social point of view, the evolution of the sciences was apprehended through what has been aptly called the "relay runner model," according to which science progresses as a result of individual discoveries. Grand narratives such as this are perhaps simply fictions doomed to ruin as soon as they are clearly expressed. In any case, the very assumption on which this grand narrative relies can be brought into question: even in the canonical domain of mechanics, the relevant epistemological units crucial to understanding the dynamics of the Scientific Revolution are perhaps not a few laws of motion, but a complex set of problems embodied in mundane objects. Moreover, each of the theses just mentioned was actually challenged during the long period of historiographical reappraisal, out of which we have probably not yet stepped. Against the sharp distinction between a qualitative Aristotelian philosophy and the new quantitative physics, numerous studies insist that Rome wasn't built in a day, so to speak. Since Antiquity, there have always been mixed sciences; the emergence of pre-classical mechanics depends on both medieval treatises and the practical challenges met by Renaissance engineers. It is indeed true that, for Aristotle, mathematics merely captures the superficial properties of things, but the Aristotelianisms were many during the Renaissance and the Early Modern period, with some of them being compatible with the introduction of mathematics in natural philosophy. In addition, the gap between the alleged program of mathematizing nature and its effective realization was underlined as most natural phenomena actually escaped mathematization; at best they were enrolled in what Thomas Kuhn began to rehabilitate under the appellation of the "Baconian sciences," i.e., empirical investigations aiming at establishing isolated facts, without relating them to any overarching theory. Hence, mathematization of nature cannot pretend to capture a historical fact: at most, it expresses an indeterminate task for generations to come. On top of these first two considerations, and against the thesis of the neutrality of the mathematical language, it was urged that mathematics is not "only a language" and that, exactly as other symbolic means or cognitive tools, it has its own constraints. For example, it has been thoroughly explained that the Euclidean theory of proportions both guides and frustrates the Galilean analysis of motion; its shortages were particularly clear with respect to the expression of continuity, which is crucial in the case of motion. Consequently, when calculus was invented and applied to the analysis of motion, it was not a transposition that left things as they stood. Even more clearly than in the case of a translation from one natural language to another, the shift from one symbolic language to another entails that certain possibilities are opened while others are closed. The cognitive constraints imposed by established mathematical theories, as seen in the theory of proportions or calculus, were not the only ones to be studied in relation to mathematization. Certain schemes dependent on the grammar of natural languages, e.g., the scheme of contrariety, or certain symbolic means of representation, e.g. geometrical diagrams and numerical tables, were also subject to such scrutiny. Lastly, it was insisted that, even if we concede the existence of scientific geniuses, mathematics is largely produced by intellectual communities and embedded within social practices. More attention was consequently paid to the forms of communication in given mathematical networks, or to the teaching of the discipline in, for example, Jesuit colleges and universities. The set of mathematical practices specific to specialized craftsmen, highly-qualified experts and engineers began to be studied in its own right. All these reflections may have helped us change our perspectives on the question of mathematization. It seems, however, that they were instead set aside, both because of a general distrust towards sweeping narratives that are always subject to the suspicion that they overlook the unyielding complexity of real history, and because of a shift in our interests. The more obscure and idiosyncratic they are, an alchemist, a patron of the sciences or a lunatic collector is nowadays honored in journals of the history of sciences. As for the general issues involved in the question of mathematization, they are rejected as obsolete, or reserved for specialized journals in the history of mathematics. Consequently, before presenting the essays of this fascicle, I would like to say a few words in favor of a renewed study of the forms of mathematization in the history of the early sciences. (shrink)

Many views rely on the idea that it can never be rational to have high confidence in something like, “P, but my evidence doesn’t support P.” Call this idea the “Non-Akrasia Constraint”. Just as an akratic agent acts in a way she believes she ought not act, an epistemically akratic agent believes something that she believes is unsupported by her evidence. The Non-Akrasia Constraint says that ideally rational agents will never be epistemically akratic. In a number of recent papers, the (...) Non-Akrasia Constraint has been called into question. The goal of this paper is to defend it... for the most part. (shrink)

What determines qualitative sameness and difference? This book explores four principal accounts of the ontological basis of properties, including universals, trope theory, resemblance nominalism, and class nominalism, considering the assumptions and ontolological commitments which are required to make each into a plausible account of properties. -/- The latter half of the book investigates the applications of property theory and the different conceptions of properties which might be adopted with these in mind: first, the possibility and desirability of individuating properties, and (...) the distinction between sparse and abundant conceptions of properties; second, the distinction between intrinsic and extrinsic properties; third, the relationship between properties and their causal powers, and whether this is necessary or contingent; fourth, the relationship between properties and causation, modality, and laws of nature; finally, whether properties exist objectively, and if they do, what our epistemic position is with respect to such entities. (shrink)

Philosophical discussion on control has largely centred around control over our actions and beliefs. Yet this overlooks the question of whether we also have control over the reasons for which we act and believe. To date, the overriding assumption appears to be that we do not, and with seemingly good reason. We cannot choose to act for a reason and acting-for-a-reason is not itself something we do. While some have challenged this in the case of reasons for action, these claims (...) seem especially untenable regarding believing for a reason. And extending the scope of control in this way also faces the threat of regress. In the face of this orthodoxy, the present paper argues that we do in fact have control over both believing and acting for a particular reason. It also starts to develop an account of the way in which this would be possible. Given the broad importance of understanding control and agency, this paper bears on a number of topics in epistemology, the philosophy of mind, and ethics. (shrink)

We debate whether permissivism is true. We start off by assuming an accuracy-oriented framework, and then discuss metaepistemological questions about how our epistemic evaluations promote accuracy.

Many studies in Western societies show a pattern of discriminative grandparental investment as follows: maternal grandmothers (MGMs) > maternal grandfathers (MGFs) > paternal grandmothers (PGMs) > paternal grandfathers (PGFs). This pattern is in line with the expectation from evolutionary reasoning. Yet whether or not this pattern applies in China is in question. The present study was based on a questionnaire survey at a university in Central China (N = 1,195). Results show that (1) when grandparent–grandchild residential distance during grandchildren’s childhood (...) is controlled, in the case of grandsons and granddaughters as a whole and granddaughters only, both grandparental caregiving and grandchildren’s emotional closeness to grandparents display a rank order of MGM > MGF > PGM > PGF, but in the case of grandsons only, this order is not statistically significant. (2) There are stable relationships between grandparental caregiving/grandchildren’s emotional closeness and residential distance/similarity in appearance. (3) The effects of residential distance on either PGFs’ or PGMs’ caregiving exceed those on either MGFs’ or MGMs’. (4) The PGF and PGM prefer grandsons to granddaughters in their caregiving, whereas the MGF and MGM do not have a sex preference, and (5) the fact that the PGF and PGM invest more in grandsons than in granddaughters does not depend on grandsons’ duration of living in a rural area. Our results suggest that (1) in general, the Chinese display a pattern of differential grandparental investment predicted by an evolutionary perspective, (2) the evolutionary perspective that combines the two factors of paternal uncertainty and sex-specific reproductive strategies is applicable to grandparental investment in China, and (3) the traditional son-preference culture also plays some role in affecting grandparental investment in China, though the roles of culture and urban–rural cultural difference should not be exaggerated. (shrink)

Believing rationally is epistemically valuable, or so we tend to think. It’s something we strive for in our own beliefs, and we criticize others for falling short of it. We theorize about rationality, in part, because we want to be rational. But why? I argue that how we answer this question depends on how permissive our theory of rationality is. Impermissive and extremely permissive views can give good answers; moderately permissive views cannot.

Keine ausführliche Beschreibung für "Die Überwindung des mathematischen Erkenntnisideals" verfügbar.

A multilingual thesaurus’ development needs the appropriate methodological considerations not only for linguistics, but also cultural heterogeneity, as demonstrated in this report on the multilingual project of the Art & Architecture Thesaurus (AAT) in the Chinese language, which has been a collaboration between the Academia Sinica Center for Digital Culture and the Getty Research Institute for more than a decade. After a brief overview of the project, the paper will introduce a holistic methodology for considering how to enable Western art (...) to be accessible to Chinese users and Chinese art accessible to Western users. The conceptual and structural issues will be discussed, especially the challenges of developing terminology in two different cultures. For instance, some terms shared by Western and Chinese cultures could be understood differently in each culture, which raises questions regarding their locations within the hierarchical structure of the AAT. Finally, the report will provide cases to demonstrate how the Chinese-Language AAT language supports online exhibitions, digital humanities and linking of digital art history content to the web of data. (shrink)

本卷包括三部分:“学术规范”(包括思想史与学术史、民间思想的坚守等12篇),“后学”(包括没有时尚的时代、后现代主义与中国现代性等8篇),“人文精神”(知识分子在现代社会转型时期的三种价值取向等14篇 )。.

On appelle « Affaire Sokal » l’ensemble de controverses que suscitèrent la publication en 1996 d’une parodie écrite par un physicien américain, Alan Sokal, puis, en 1997, de l’ouvrage Impostures intellectuelles, qu’il co-signa avec un physicien belge, Jean Bricmont. Dans Retours sur l’Affaire Sokal¸ des historiens des sciences reviennent sur cette affaire. Ils montrent qu’elle recouvre différentes controverses et qu’il faut distinguer ces dernières non seulement selon la nature des écrits qui les ont occasionnées, mais aussi en fonction des questions (...) abordées, et peut-être surtout des manières de concevoir et pratiquer les échanges intellectuels. Les auteurs analysent en particulier ces controverses en France, aux États-Unis et au Royaume-Uni ; ils examinent aussi la façon dont ont été traités la relation entre le domaine scientifique et le domaine littéraire ou l’usage des métaphores en sciences. (shrink)

In science policy, it is generally acknowledged that science-based problem-solving requires interdisciplinary research. For example, policy makers invest in funding programs such as Horizon 2020 that aim to stimulate interdisciplinary research. Yet the epistemological processes that lead to effective interdisciplinary research are poorly understood. This article aims at an epistemology for interdisciplinary research, in particular, IDR for solving ‘real-world’ problems. Focus is on the question why researchers experience cognitive and epistemic difficulties in conducting IDR. Based on a study of educational (...) literature it is concluded that higher-education is missing clear ideas on the epistemology of IDR, and as a consequence, on how to teach it. It is conjectured that the lack of philosophical interest in the epistemology of IDR is due to a philosophical paradigm of science, which prevents recognizing severe epistemological challenges of IDR, both in the philosophy of science as well as in science education and research. The proposed alternative philosophical paradigm entails alternative philosophical presuppositions regarding aspects such as the aim of science, the character of knowledge, the epistemic and pragmatic criteria for accepting knowledge, and the role of technological instruments. This alternative philosophical paradigm assume the production of knowledge for epistemic functions as the aim of science, and interprets ‘knowledge’ as epistemic tools that must allow for conducting epistemic tasks by epistemic agents, rather than interpreting knowledge as representations that objectively represent aspects of the world independent of the way in which it was constructed. The engineering paradigm of science involves that knowledge is indelibly shaped by how it is constructed. Additionally, the way in which scientific disciplines construct knowledge is guided by the specificities of the discipline, which can be analyzed in terms of disciplinary perspectives. This implies that knowledge and the epistemic uses of knowledge cannot be understood without at least some understanding of how the knowledge is constructed. Accordingly, scientific researchers need so-called metacognitive scaffolds to assist in analyzing and reconstructing how ‘knowledge’ is constructed and how different disciplines do this differently. In an engineering paradigm of science, these metacognitive scaffolds can also be interpreted as epistemic tools, but in this case as tools that guide, enable and constrain analyzing and articulating how knowledge is produced. In interdisciplinary research, metacognitive scaffolds assist interdisciplinary communication aiming to analyze and articulate how the discipline constructs knowledge. (shrink)

Epistemologists often assume that rationality bears an important connection to the truth. In this paper I examine the implications of this commitment for permissivism: if rationality is a guide to the truth, can it also allow some leeway in how we should respond to our evidence? I first discuss a particular strategy for connecting permissive rationality and the truth, developed in a recent paper by Miriam Schoenfield. I argue that this limited truth-connection is unsatisfying, and the version of permissivism that (...) supports it faces serious challenges; so, for mainstream permissivism, the truth problem is still unsolved. I then discuss a strategy available to impermissivists, according to which rationality bears a quite strong connection to truth. I argue that this second strategy is successful. (shrink)

On sait peu de choses d’Edme Mariotte, membre de l’Académie royale des sciences de 1668 à 1684. Une analyse de son Essai de logique montre cependant que, pour défendre ses pratiques expérimentales, il s’appropria des bribes venues de différentes traditions intellectuelles. Ainsi, ce livre examine ce qu’on entendait par « méthode » à la fin du XVIIe siècle, les épistémologies de la physique qui s’affrontaient alors, quelques débats ouverts par la gestion de l’héritage cartésien. Mais l’essentiel sera peut-être la question (...) suivante : comment reconstituer les idées d’un savant ordinaire, qui n’a ni bouleversé l’ordre des sciences, ni montré une perspicacité épistémologique exceptionnelle ? (shrink)

Sophie Grace Chappell develops a picture of what philosophical ethics can be like, once set aside from the idealising and reductive pressures of conventional moral theory. Her question is 'How are we to know what to do?', and the answer she defends is 'By developing our moral imaginations'.

Computer vision is widely used in manufacturing, sports, medical diagnosis, and other fields. In this article, a multifeature fusion error action expression method based on silhouette and optical flow information is proposed to overcome the shortcomings in the effectiveness of a single error action expression method based on the fusion of features for human body error action recognition. We analyse and discuss the human error action recognition method based on the idea of template matching to analyse the key issues that (...) affect the overall expression of the error action sequences, and then, we propose a motion energy model based on the direct motion energy decomposition of the video clips of human error actions in the 3 Deron action sequence space through the filter group. The method can avoid preprocessing operations such as target localization and segmentation; then, we use MET features and combine with SVM to test the human body error database and compare the experimental results obtained by using different feature reduction and classification methods, and the results show that the method has the obvious comparative advantage in the recognition rate and is suitable for other dynamic scenes. (shrink)

Pertinent to understand the role of fate in this world, issues of political wisdom. "Hamlet" raises a question: potential rulers encountered misfortune, should be how to deal with. Hamlet by showing an error on the fate of the two views, Shakespeare shows consistent with the classical philosopher: personal misfortune should not be attributed to fate or God, but should be attributed to their nature and choice. Hamlet and Homer's epic and drama links, to some extent, reveal the fate of his (...) misunderstanding of the reason. Although Hamlet's view is similar to the fate of Machiavelli, but he vowed to pursue justice, it shows the difference between him and Machiavelli. (shrink)

Credences, unlike full beliefs, can’t be true or false. So what makes credences more or less accurate? This chapter offers a new answer to this question: credences are accurate insofar as they license true educated guesses, and less accurate insofar as they license false educated guesses. This account is compatible with immodesty; : a rational agent will regard her own credences to be best for the purposes of making true educated guesses. The guessing account can also be used to justify (...) certain coherence constraints on rational credence, such as probabilism. The chapter concludes by discussing some advantages of the guessing account over rival accounts of accuracy. (shrink)

In her recent paper ‘The Epistemology of Propaganda’ Rachel McKinnon discusses what she refers to as ‘TERF propaganda’. We take issue with three points in her paper. The first is her rejection of the claim that ‘TERF’ is a misogynistic slur. The second is the examples she presents as commitments of so-called ‘TERFs’, in order to establish that radical (and gender critical) feminists rely on a flawed ideology. The third is her claim that standpoint epistemology can be used to establish (...) that such feminists are wrong to worry about a threat of male violence in relation to trans women. In Section 1 we argue that ‘TERF’ is not a merely descriptive term; that to the extent that McKinnon offers considerations in support of the claim that ‘TERF’ is not a slur, these considerations fail; and that ‘TERF’ is a slur according to several prominent accounts in the contemporary literature. In Section 2, we argue that McKinnon misrepresents the position of gender critical feminists, and in doing so fails to establish the claim that the ideology behind these positions is flawed. In Section 3 we argue that McKinnon’s criticism of Stanley fails, and one implication of this is that those she characterizes as ‘positively privileged’ cannot rely on the standpoint-relative knowledge of those she characterizes as ‘negatively privileged’. We also emphasize in this section McKinnon’s failure to understand and account for multiple axes of oppression, of which the cis/trans axis is only one. (shrink)

Bernard Williams' Ethics and the Limits of Philosophy is widely regarded as one of the most important works of moral philosophy in the last fifty years. In this outstanding collection of new essays, fourteen internationally-recognised philosophers examine the enduring contribution that Williams's book continues to make to ethics. Required.

Epiphanies is a philosophical exploration of epiphanies, peak experiences, 'wow moments', or ecstasies as they are sometimes called. What are epiphanies, and why do so many people so frequently experience them? Are they just transient phenomena in our brains, or are they the revelations of objective value that they very often seem to be? What do they tell us about the world, and about ourselves? How, if at all, do epiphanies fit in with our moral systems and our theories of (...) how to live? And how do epiphanic experiences fit in with the rest of our lives? These are Sophie Grace Chappell's questions in this ground-breaking new study of an area of inquiry that has always been right under our noses, but remains surprisingly under-explored in contemporary philosophy. (shrink)

Recueil d'actes du SIRL (Bruxelles, septembre 1999-juin 2001) et d'autres contributions. Réflexions sur la dimension épistémique de l'oeuvre littéraire, l'oeuvre littéraire comme réorganisation du réel, les relations entre savoir littéraire et autres sciences humaines et l'originalité du savoir littéraire.

This paper explores Zha Changping’s humanistic criticism of pioneering Chinese art as a new paradigm in art criticism after the postmodern disintegration of traditional art history with its linear art history writing. It introduces the “seven forming factors” at the heart of Zha’s “world relational aesthetics,” which, on one hand, gauges the pulse of the time, while on the other hand seeking to uncover the underlying relational logic informing this generation of pioneering artists’ intellectual outlook and artistic output.

本书包括:天人论;人性论;处世论;道德论;纲常论;忠教论;存理、养性、致良知等内容。.

Le projet ANR Profiterole avait pour objectifs la constitution de ressources pour le français médiéval (9e-15e s.) : un corpus annoté en (morpho-)syntaxe et des lexiques, la conception d'analyseurs syntaxiques pour le français médiéval, le développement d’outils de diffusion et d’analyse textométrique de l’annotation syntaxique dans le contexte de la plateforme TXM, et, enfin, la modélisation de certains aspects syntaxiques de l’évolution du français. Nous commençons par décrire la constitution du corpus Profiterole en termes de choix de textes, genres et (...) périodes et de types d’annotation. Puis nous présentons les modèles d’analyse syntaxique développés conjointement à la constitution du corpus, ainsi que la manière dont leurs prédictions ont été combinées pour assister la correction manuelle de l’annotation du corpus. Enfin, nous abordons les modalités de diffusion des données et modèles produits dans le cadre du projet avec un accent particulier sur l’intégration du corpus annoté à TXM, tant dans sa version en ligne accessible depuis le portail de la Base de français médiéval (BFM) que dans sa version pour ordinateur personnel, avec des exemples de requêtes CQP et TIGER facilitant l’exploration et l’analyse du corpus. (shrink)

The conventional view of Hobbes’s commonwealth is that it was inspired by contemporary theories of tyranny. This article explores the idea that a paradigm for Hobbes’s state could in fact be found in early modern readings of Aristotle on democracy, as found in Book Three of the Politics. It argues that by the late sixteenth century, these meditations on the democratic body politic had developed claims about unity, mythology, and personation that would become central to Hobbes’s own theory of the (...) commonwealth. Tracing the history of commentary on the relevant passages in Aristotle reveals new perspectives not only on the political theories of both Aristotle and Hobbes but also introduces modern readers to the richness of early modern commentaries on classical political texts. The article ends with some thoughts on why attention to traditions of commentary might be valuable for political theorists today. (shrink)