Mechanical pain sensing, adipogenesis, and STING‐dependent innate immunity seem three distinct biological processes without substantial relationships. Intriguingly, TMEM120A, a transmembrane protein, has been shown to detect mechanical pain stimuli as a mechanosensitive channel, contribute to adipocyte differentiation/function by regulating genome organization and promote STING trafficking to active cellular innate immune response. However, the role of TMEM120A as a mechanosensitive channel was challenged by recent studies which cannot reproduce data supporting its role in mechanosensing. Furthermore, the molecular mechanism by which TMEM120A (...) contributes to adipocyte differentiation/function and promotes STING trafficking remains elusive. In this review, we discuss these multiple proposed functions of TMEM120A and hypothesize the molecular mechanism underlying TMEM120A's role in fatty acid metabolism and STING signaling. (shrink)

本书为法制研究文集,致力于探讨中国社会与人生所表达的生活方式,探索其中所蕴藏的活的规则,即自然之法,从追索中国自家的“立法”,讨一个“说法”,进而得出一个“活法”。.

BackgroundThe cognitive level of post-stroke aphasia patients is generally lower than non-aphasia patients, and cognitive impairment affects the outcome of stroke. However, for different types of PSA, what kind of cognitive assessment methods to choose is not completely clear. We investigated the Montreal Cognitive Assessment, the Mini-Mental State Examination, and the Non-language-based Cognitive Assessment to observe the evaluation effect of CI in patients with fluent aphasia and non-fluent aphasia.Methods92 stroke patients were included in this study. Demographic and clinical data of (...) the stroke group were documented. The language and cognition were evaluated by Western Aphasia Battery, MoCA, MMSE, and NLCA. PSA were divided into FA and NFA according to the Chinese aphasia fluency characteristic scale. Pearson’s product–moment correlation coefficient test and multiple linear regression analysis were performed to explore the relationship between the sub-items of WAB and cognitive scores. The classification rate of CI was tested by Pearson’s Chi-square test or Fisher’s exact test.ResultsThe scores of aphasia quotient, MoCA, MMSE, and NLCA in NFA were lower than FA. AQ was positively correlated with MoCA, MMSE, and NLCA scores. Stepwise multiple linear regression analysis suggested that naming explained 70.7% of variance of MoCA and 79.9% of variance of MMSE; comprehension explained 46.7% of variance of NLCA. In the same type of PSA, there was no significant difference in the classification rate. The classification rate of CI in NFA by MoCA and MMSE was higher than that in FA. There was no significant difference in the classification rate of CI between FA and NFA by NLCA.ConclusionMoCA, MMSE, and NLCA can be applied in FA. NLCA is recommended for NFA. (shrink)

本书分四个部分:第一部分以梁漱溟先生的思虑为个案样本,探讨法的一般理念问题;第二部分论及宪政、普通法和近代西方法律教育与法学研究;第三部分意在研索“罪孽理念与罪刑关系”;第四部分为通讯体论文。.

本书内容包括:马克思以人为本的共产主义理想与中国共产党“以人为本”的执政新理念、马克思以人为本的社会发展思想与中国共产党科学发展观等。.

现代西方逻辑哲学把传统哲学从理性平面转移到了语言平面,哲学问题相应地被逻辑语义学和语法学所代替了,逻辑哲学成了一种独特的哲学语法学。哲学语法学关注语言的存在方式和特性、关注事实的合理表达或言说的逻辑语 言学条件。.

中华文明能于艰难困苦之中存亡继绝，延绵至今，与中国哲学的精神特质密切相关，而中国伦理思想不单是中国哲学的核心内容，也是体现其精神特质的典型样式。所谓“伦理中国”，便是关于中国的合理想象和美好期许。 《中华六家道德学说精要：伦理中国》将儒、道、墨、法四家及佛、道两教中的相关伦理学说专门提取出来，对其演进流变历程作细致辨析，对其价值意义积淀作深入探讨，旨在沟通传统与现代，接续理论架构和生活实践，于深 沉历史之上，开拓晴朗壮丽的未来。.

本书分为三个部分。第一部分是自序,包括前言、序、代序、序言等;第二部分是他序,即为他人所撰之序;第三部分是自跋。.

本书围绕全球正义的哲学论述、跨文明视野中人权与正义原则、民主与和平的政治哲学三个专题,收入论文15篇。.

Thomas Aquinas has argued that the passion of hope is the movement of the sensitive appetite and the first of the irascible passion. The first part of the article aims to explore the cause and the mechanism of the passion of hope, and tries to clarify the relationship between the passion of hope and the perception. In human beings, it is possible that the passion of hope is caused by false judgement of the perception, which will lead to the result (...) of false hope. In Aquinas’s argument, the problem of false hope could be solved through the moral virtue and the prudence. In the second part of this article, the aim is to analyse how the virtue of magnanimity, humility and the prudence work impact on the passion of hope and perfect it.Contribution: This research concentrates on the topic of the passion of hope of Thomas Aquinas, and provides a new perspective on the understanding of the relationship between the passion and the virtue. (shrink)

Ben shu dui ke xue mei xue si xiang shi de yan jiu dui xiang, ren wu he fang fa jin xing le xi tong di lun shu.

本书介绍了职业道德的特征、社会主义职业道德的基本原则和规范,职业道德的教育、修养和评价等内容。.

In this paper, I provide a framework for accounting for the self, based on a reconstruction of Galen Strawson’s “theory of SESMETs,” or the Pearl view, with Barry Dainton’s continuous consciousness thesis. I argue that the framework I provide adequately accounts for the self and is preferable to solely adopting either Strawson’s or Dainton’s theory. I call my reconstruction the “Necklace” view of the self.

本书以个案研究和横向研究的方式梳理中西法学思想,梳理法学事件,于“真理、道理、情理与法理”的交融中审视法律、法学和法学家的时代使命。.

本书对科技与政治交互作用空间的性质、结构及其张力进行了基本阐述,探讨科技政治空间价值张力的离合及有机统一的作用规律以及科技政治空间自由与干涉的权力张力及其作用规律等。.

本书是关于新意识形态批评的论文集,本书要论述的意图是:以理论与社会生活的密切关系而言,中国文论家可以创造出自己的“本位话语”,其具体问题集中为两个,即文化转型中的当代中国的精神建构和建立文学理论的本位 话语。.

本书内容包括:孔子思想的主要特征、老子思想的文化地位、墨子思想的历史影响、孟子思想的历史影响、董仲舒在学术思想史上的地位、张衡在中国思想文化上的地位等内容。.

本书简要地介绍了《周易》的一些重要概念及其在二十一世纪的可能应用,指出以《周易》为代表的东方文明对人类社会在新世纪的可持续发展所可能做出的贡献。.

The subject of this work is the worldview of subculture and its complex interaction with the elements and structure of these groups. To do this, various types of subcultures are analyzed in detail in order to identify their unique ideological features and characteristics. The main purpose of the research is to find links between the worldview of subcultures and their structural elements, as well as to understand the impact of these links on socio-cultural processes. By analyzing these issues, the study (...) seeks to expand our understanding of subcultural dynamics and their place in the modern sociocultural context. The results of this work can be useful for further research in the field of anthropology, sociology, cultural studies, as well as for the development of practical strategies for managing and supporting subcultural communities. To achieve the goals of the study, an anthropological analysis of subcultures is used, which includes an analysis of synchronous and diachronic aspects of the subcultural worldview, as well as comparative analysis. The scientific novelty of this work is manifested in a deep and comprehensive analysis of the diversity of types of worldview representation in various subcultures and their impact on a wide range of socio-cultural processes. The analysis presented in the study reveals unique aspects of the subcultural worldview and its diverse manifestations, which not only contributes to a deeper understanding of the socio-cultural dynamics of modern society, but also expands our knowledge of the mechanisms of formation and functioning of subcultural communities. The conclusions of this work are important both for academic research in the field of anthropology and sociology, and for practical applications, for example, those aimed at effective management and support of subcultural groups in modern society, including the development of policies and programs that promote inclusivity, cultural diversity and socio-cultural harmony. (shrink)

许地山(1894~1941),名赞〓,字地山,笔名落华生,乳名叔丑,著名文学家.