Abstractp53 has a determinant role in cancer prevention and is among the most studied proteins in the world. The majority of studies devoted to this protein are carried out in cell lines because they are easy to use and have naturally emerged as the main research tool in laboratories. However, the p53 pathway is commonly deregulated in cancer cells, from which the experimental cell lines are generally derived. The fact that the pathway is deregulated challenges the relevance of using cancer‐derived (...) cell lines to study wild‐type p53 activities, or, in a broader sense, to study any normal cellular process. In the present article, we identify and discuss a number of limitations of cell lines using examples related to p53. Finally, we point out the general limitations of cell lines and propose solutions as alternatives to these cells. (shrink)

La notion de dénomination d’un rapport domine la théorie de la proportionnalité au Moyen Âge et à la Renaissance. Elle apparaît dans des contextes différents, traités d’arithmétique, éditions des Éléments, traités sur la théorie des proportions, etc. L’exposé le plus complet sur cette notion se trouve dans le commentaire de Clavius à la définition 4 du livre V des Éléments d’Euclide. Clavius se fait ici l’écho des travaux de ses prédécesseurs en particulier de Jordanus et de Campanus, mais ne rapporte (...) pas la théorie des rapports irrationnels initiée par Bradwardine et développée par Oresme. (shrink)

Summary The practice of the disputatio in the medieval universities gave rise to a particular literary genre, the questio. This genre is caracterised by the production of arguments in favour of or against the thesis submitted for questio, before the author develops his own answer. This genre is common to philosophy and theology. But to present a mathematical problem in the form of the questio may seem paradoxical since it leads to the production of false proofs. We shall examine three (...) texts of the 14th and 15th centuries in which is raised the question of the incommensurability of the diagonal and the side of a square: Nicole Oresme's Questions on the geometry of Euclid, an anonymous question from a 15th century manuscript and Blasius of Parma's Questions on Thomas Bradwardine's treatise on ratios. We shall establish a relationship between these three texts. We will show how the mathematical content is combined with the literary genre of the questio. We shall particularly concentrate on the false proofs and consider their status. Finally, we shall ask ourselves how these texts are linked with a possible didactic purpose. Résumé La pratique de la «dispute» dans les universités médiévales a donné lieu à un genre littéraire particulier, la Question. Ce genre est caractérisé par la production d'arguments pour ou contre la thèse soumise à questionnement, avant que l'auteur ne développe sa propre réponse. Ce genre est courant en philosophie et en théologie. Mais présenter un problème mathématique sous la forme d'une Question peut sembler paradoxal: cela conduit en effet à la production de démonstrations fausses. Nous examinerons trois textes des xiv e et xv e siècles dans lesquels est posée la question de l'incommensurabilité de la diagonale et du côté d'un même carré: Les questions sur la géométrie d'Euclide de Nicole Oresme, une question anonyme dont le manuscrit est daté du xv e siècle et les Questions sur le traité des rapports de Thomas Bradwardine rédigées par Blaise de Parme. Nous établirons une filiation entre ces trois textes. Nous montrerons comment s'articule le contenu mathématique avec le genre littéraire de la Question. Nous porterons une attention particulière aux démonstrations fausses sur le statut desquelles nous nous interrogerons. Et nous nous demanderons quel lien entretiennent ces textes avec un éventuel enseignement. (shrink)

Comment expliquer que les savoirs de sciences humaines et sociales soient à ce point contestés voire ignorés dans les lieux où ils pourraient pourtant éclairer la réflexion et l'action? Comment expliquer la défiance et l'incompréhension qu'ils suscitent parfois? Les savoirs de sciences humaines et sociales ont la particularité de circuler dans des espaces variés et de devoir composer avec une critique prompte à remettre en cause leur validité et leur légitimité. Leur acceptabilité sociale ne se joue pas dans la seule (...) communauté savante mais bien dans les multiples réinterprétations et traductions auxquelles ils donnent lieu. Les études réunies dans ce volume analysent sept controverses ayant pour enjeu le sort réservé à des savoirs issus de la réflexion philosophique, sociologique, psychologique ou se revendiquant d'une économie hétérodoxe. Elles montrent que les résistances qu'ils rencontrent sont la marque paradoxale de leur vigueur et de leur capacité à bousculer les évidences partagées. Contributeurs : Elisabeth Chatel, Sandra Laugier, Frédéric Lebaron, Alexandra Oeser, Etienne Penissat, Sophie Richardot, Sabine Rozier. (shrink)

Pour chaque volume de la collection Lectures de..., l'éditeur a fait appel aux universitaires les plus éminents dans le souci d'offrir au public francophone un ensemble d'études, hors de tout parti pris, sur les principaux philosophes de l'Antiquité à nos jours. Longtemps tenu pour un auteur ésotérique, Wittgenstein est aujourd'hui une référence centrale dans la vie intellectuelle, et il ne s'agit plus d'un simple effet de mode. Son oeuvre est présente dans le paysage international, non seulement en philosophie, mais aussi (...) en sciences humaines et sociales : la sociologie, l'anthropologie, la philosophie du droit et de l'économie s'en inspirent. Elle a largement débordé le monde anglophone, où elle façonne une partie de la réflexion depuis plus d'un demi-siècle. Pourtant, l'appréhension philosophique de cette oeuvre est loin d'être univoque, puisque l'on a assisté, depuis la mort de Wittgenstein en 1951, à une série de lectures divergentes de ses textes, dont les plus prégnantes méritent d'être ici expliquées. Les points de vue sur Wittgenstein se sont par ailleurs multipliés : d'abord lu dans les années 1950-1960 comme philosophe avant tout logicien, en fonction du Tractatus et dans le sillage de ses maîtres Frege et Russell, comme mystique ou comme philosophe du langage, au vu de sa "seconde" philosophie, il apparaît ensuite comme l'auteur d'une oeuvre complexe et multidimensionnelle touchant à des questions de philosophie générale (expérience, signification, réalité, etc.). Le présent ouvrage se donne pour tâche de cartographier ce réseau complexe qu'est la philosophie de Wittgenstein, d'abord en présentant les grands textes et les thèmes majeurs qui ont jalonné son parcours philosophique, puis en introduisant aux différentes lectures qui en ont été proposées dans la tradition interprétative. (shrink)

Summary The practice of the disputatio in the medieval universities gave rise to a particular literary genre, the questio. This genre is caracterised by the production of arguments in favour of or against the thesis submitted for questio, before the author develops his own answer. This genre is common to philosophy and theology. But to present a mathematical problem in the form of the questio may seem paradoxical since it leads to the production of false proofs. We shall examine three (...) texts of the 14th and 15th centuries in which is raised the question of the incommensurability of the diagonal and the side of a square: Nicole Oresme's Questions on the geometry of Euclid, an anonymous question from a 15th century manuscript and Blasius of Parma's Questions on Thomas Bradwardine's treatise on ratios. We shall establish a relationship between these three texts. We will show how the mathematical content is combined with the literary genre of the questio. We shall particularly concentrate on the false proofs and consider their status. Finally, we shall ask ourselves how these texts are linked with a possible didactic purpose. Résumé La pratique de la «dispute» dans les universités médiévales a donné lieu à un genre littéraire particulier, la Question. Ce genre est caractérisé par la production d'arguments pour ou contre la thèse soumise à questionnement, avant que l'auteur ne développe sa propre réponse. Ce genre est courant en philosophie et en théologie. Mais présenter un problème mathématique sous la forme d'une Question peut sembler paradoxal: cela conduit en effet à la production de démonstrations fausses. Nous examinerons trois textes des xiv e et xv e siècles dans lesquels est posée la question de l'incommensurabilité de la diagonale et du côté d'un même carré: Les questions sur la géométrie d'Euclide de Nicole Oresme, une question anonyme dont le manuscrit est daté du xv e siècle et les Questions sur le traité des rapports de Thomas Bradwardine rédigées par Blaise de Parme. Nous établirons une filiation entre ces trois textes. Nous montrerons comment s'articule le contenu mathématique avec le genre littéraire de la Question. Nous porterons une attention particulière aux démonstrations fausses sur le statut desquelles nous nous interrogerons. Et nous nous demanderons quel lien entretiennent ces textes avec un éventuel enseignement. (shrink)

On peut considérer que ce qui se produit dans le travail familial thérapeutique avec une famille dans une institution donnée est révélateur du fonctionnement de la famille tel que cette dernière le projette sur l’institution. Mais ce qui se passe dans cette thérapie peut aussi refléter le fonctionnement de l’institution à ce moment précis : ce qui se vit dans l’institution a souvent des répercussions sur les prises en charge thérapeutiques.

On peut considérer que ce qui se produit dans le travail familial thérapeutique avec une famille dans une institution donnée est révélateur du fonctionnement de la famille tel que cette dernière le projette sur l’institution. Mais ce qui se passe dans cette thérapie peut aussi refléter le fonctionnement de l’institution à ce moment précis : ce qui se vit dans l’institution a souvent des répercussions sur les prises en charge thérapeutiques.

« Dans la première préface à la Critique de la raison pure Kant se réfère aux Métamorphoses d’Ovide pour comparer une métaphysique hors bornes à la reine Hécube. Or, ce qui semble être tu dans cette métaphore, c’est qu’Ovide fait culminer la douleur d’Hécube dans sa métamorphose en chienne enragée. Le cliché de la reine des sciences est ainsi poussée à son paroxysme : la métaphysique sauvage serait une chienne enragée! Cet article revient, par le biais de l’œuvre sonore de (...) l’artiste power noise Rosaceae (Leyla Yenirce), à une Hécube qui hante la philosophie. Hécube pose, selon l’argument exposé ici, le problème d’une aísthēsis (αἴσθησις) pure, qui hanterait la notion de raison pure comme son complément logique mais refoulé. Refoulé car, si l’idée d’une raison pure semble parfaitement innocente, celle d’une aísthēsis (αἴσθησις) pure évoque à l’inverse un scandale pour la pensée philosophique, puisque l’idée d’un objet à penser en est exclue, et puisque son spectre renvoie à tout ce qui terrorise les philosophes : la fantaisie et la folie, le désir et la culpabilité, l’enthousiasme et l’irrationalité. ». (shrink)

On croit souvent que les Big data et l’univers d’internet et des réseaux sociaux constituent une forme nouvelle de pouvoir dictatorial des contrôleurs d’internet. Mais, en fait, ce à quoi nous assistons est à une nouvelle dictature du prolétariat, celle des multitudes et du populisme.

On croit souvent que les Big data et l’univers d’internet et des réseaux sociaux constituent une forme nouvelle de pouvoir dictatorial des contrôleurs d’internet. Mais, en fait, ce à quoi nous assistons est à une nouvelle dictature du prolétariat, celle des multitudes et du populisme.

Ce volume envisage l'amour en tant qu'objet polymorphe : Eros, Philia, Agapé, mais aussi Storgé. Les mots grecs rendent compte, du large spectre amoureux : amour romantique, amour sexuel, amour de soi, de l'autre, pour l'autre... des catégories qui placent les manifestations du sentiment amoureux dans un espace de contraintes et de possibilités qui relève du social et du discursif. Les travaux qui sont ici réunis s'attachent ainsi à interroger des genres artistiques et discursifs dans lesquels s'ancre l'amour, ils abordent (...) la littérature et le cinéma, mais aussi l'histoire, l'histoire des idées, la sociologie l'ethnologie ou la psychologie. Ces recherches mettent en avant que l'amour constitue une manière d'appréhender et d'expliquer le monde puisqu'on peut lire à travers lui les rapports qui définissent nos sociétés et qui le définissent à leur tour. (shrink)

Body feedback is the proprioceptive feedback that denominates the afferent information from position and movement of the body to the central nervous system. It is crucial in experiencing emotions, in forming attitudes and in regulating emotions and behavior. This paper investigates effects of dynamic body feedback on affect and attitudes, focusing on the impact of movement rhythms with smooth vs. sharp reversals as one basic category of movement qualities. It relates those qualities to already explored effects of approach vs. avoidance (...) motor behavior as one basic category of movement shape. Studies 1 and 2 tested the effects of one of two basic movement qualities (smooth vs. sharp rhythms) on affect and cognition. The third study tested those movement qualities in combination with movement shape (approach vs. avoidance motor behavior) and the effects of those combinations on affect and attitudes toward initially valence-free stimuli. Results suggest that movement rhythms influence affect (studies 1 and 2), and attitudes (study 3), and moderate the impact of approach and avoidance motor behavior on attitudes (study 3). Extending static body feedback research with a dynamic account, findings indicate that movement qualities – next to movement shape – play an important role, when movement of the lived body is an independent variable. (shrink)

This work tells the story of the rise of the modern German environmental imagination, with particular emphasis on its narrative and visual components.

In their practice, nurses make daily decisions that are ethically informed. An ethical decision is the result of a complex reasoning process based on knowledge and experience and driven by ethical values. Especially in acute elderly care and more specifically decisions concerning the use of physical restraint require a thoughtful deliberation of the different values at stake. Qualitative evidence concerning nurses’ decision-making in cases of physical restraint provided important insights in the complexity of decision-making as a trajectory. However a nuanced (...) and refined understanding of the reasoning process in terms of ethical values is still lacking. A qualitative interview design, inspired by the Grounded Theory approach, was carried out to explore nurses’ reasoning process in terms of ethical values. We interviewed 21 acute geriatric nurses from 12 hospitals in different regions in Flanders, Belgium in the period October 2009–April 2011. The Qualitative Analysis Guide of Leuven was used to analyse interview data. Nurses’ decision-making is characterized as an ethical deliberation process where different values are identified and where the process of balancing these values forms the essence of ethical deliberation. Ethical decision-making in cases of physical restraint implies that nurses have to choose which values receive priority in the process, which entails that not all values can be respected to the same degree. As a result, decision making can be experienced as difficult, even as a dilemma. Driven by the overwhelming goal of protecting physical integrity, nurses took into account the values of dignity and justice more implicitly and less dominantly. (shrink)

Theories of practical reason must meet a psychological requirement: they must explain how normative practical reasons can be motivationally efficacious. It would be pointless to claim that we are subject to normative demands of reason, if we were in fact unable to meet those demands. Concerning this requirement to account for the possibility of rational motivation, internalist approaches are distinguished from externalist ones. I defend internalism, whilst rejecting both ways in which the belief‐desire model can be instantiated. Both the Humean (...) and the Kantian instantiation of that model fail to account for the internal connection between normative and motivating reasons required by internalism. The two classes of reasons rather come to be seen as mutually exclusive. Opposing the belief‐desire model, I argue that rational motivation can only be established by reference to emotion. Emotions are affective perceptions. They have motivational force so that they can contribute to the explanation of action. At the same time they can rationalise actions because they have an intentional content which resembles the content of sensory perception in being representational. Because of this, the emotions can noninferentially justify judgements, which in turn can justify actions. I conclude by outlining the Aristotelian account of practical reason and ethics that emerges from integrating the emotions into practical reasoning. Doing the right thing is much more a matter of seeing things right than of drawing the right inferences. Seeing things right, in its turn, is not only to justify an action: it necessarily implies to be motivated to act accordingly. (shrink)

In a unique cooperation between philosophy, linguistics, art history, and ancient studies, this volume focuses on ways in which the entangled and embodied nature of image and language enables us to symbolically articulate the world and our experience in a great variety of forms. It lays the foundation for a new cultural anthropology of symbolic processes.

'A comprehensive and important collection that includes essays by some of the leading figures in the field....Essential reading for anyone interested in risk assessment.' Professor Kristin Shrader-Frechette, University of Notre Dame 'The editors are to be congratulated for bringing together a distinguished international group of theorists to reflect on the issues. This volume will be sure to raise the level of debate while at the same time showing the importance of philosophical reflection in approaches to the problems of the age.' (...) Professor Jonathan Wolff, University College London This volume brings together top authors from the fields of risk, philosophy, social sciences and psychology to address the issue of how we should decide how far technological risks are morally acceptable or not. The underlying principles are examined, along with methodological challenges, public involvement and instruments for democratization. A strong theoretical basis is complemented by a range of case studies from some of the most contentious areas, including medical ethics and GM crops. This book is a vital new resource for researchers, students and anyone concerned that traditional approaches to risk management don't adequately address ethical considerations. (shrink)

I discuss two ways in which emotions explain actions: in the first, the explanation is expressive; in the second, the action is not only explained but also rationalized by the emotion's intentional content. The belief-desire model cannot satisfactorily account for either of these cases. My main purpose is to show that the emotions constitute an irreducible category in the explanation of action, to be understood by analogy with perception. Emotions are affective perceptions. Their affect gives them motivational force, and they (...) can rationalize actions because, like perception, they have a representational intentional content. Because of this, an emotion can non-inferentially justify a belief which in its turn justifies or rationalizes an action; so emotions may constitute a source of moral knowledge. (shrink)

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: “Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets.” The answer, they suggested, would be a “continuously learning” health system. Ethicists and researchers urged the creation of “learning health organizations” that would integrate knowledge from patient‐care data to continuously improve the quality of care. Our experience with an ongoing research study on atrial fibrillation—a trial known (...) as IMPACT‐AFib—gave us some insight into one of the challenges that will have to be dealt with in creating these organizations. Although the proposed educational intervention study placed no restrictions on what providers and health plans could do, the oversight team argued that the ethical principle of beneficence did not allow the researchers to be “bystanders” in relation to a control group receiving suboptimal care. In response, the researchers designed a “workaround” that allowed the project to go forward. We believe the experience suggests that what we call “bystander ethics” will create challenges for the kinds of quality improvement research that LHOs are designed to do. (shrink)

Umberto Eco's Baudolino (2000) never achieved the success of his first novel, The Name of the Rose (1980), although both are historical fictions that provide literary clothing for philosophical ideas. In Baudolino, Eco again dramatizes the disagreement between rationalists and empiricists regarding the sources of our concepts and knowledge, ideas that came to the fore during the medieval period and which continue to be pertinent questions in epistemology. Propositions of either sense experience or logic and reasoning being the basis for (...) knowledge, offer Eco an opportunity for playing what he calls "a game of ambiguity about truth and lies."1 Historical uncertainties, the holes in the fabric of our knowledge about .. (shrink)

This paper discusses the issue of legitimacy and, in particular the processes of building, losing, and repairing environmental legitimacy in the context of the Deepwater Horizon case. Following the Deepwater Horizon catastrophe in 2010, BP plc. was accused of having set new records in the degree of divergence between its actual operations and what it had been communicating with regard to corporate responsibility. Its legitimacy crisis is here to be appraised as a case study in the discrepancy between symbolic and (...) substantive strategies in corporate greening and its communication. A narrative analysis of BP’s “beyond petroleum”-rebranding and the “making this right”-campaign issued in response to the Gulf of Mexico disaster discusses their respective implications for corporate change. Further, the question is addressed why BP’s green image endeavors were so widely accepted at first, only to find themselves dismissed as corporate greenwashing now. The study concludes that where a corporation’s “green narrative” consistently evokes established narratives, its legitimacy will be judged against narrative, rather than empirical truth. Thus, the narrative will be more willingly accepted as speaking for the issuing company’s legitimacy, irrespective of whether it reflects substantive greening or not. (shrink)

“Acceptable Risk” – On the Rationality of Emotional Evaluations of Risk What is “acceptable risk”? That question is appropriate in a number of different contexts, political, social, ethical, and scienti c. Thus the question might be whether the voting public will support a risky proposal or project, whether people will buy or accept a risky product, whether it is morally permissible to pursue this or that potentially harmful venture, or whether it is wise or prudent to test or try out (...) some possibly dangerous hypothesis or product. But complicating all of these queries, the “sand in the machinery” of rational decision-making, are the emotions. It is often noted that voters are swayed by their passions at least as much as they are convinced by rational arguments. And it is obvious to advertisers and retailers that people are seduced by all sorts of appeals to their vanities, their fears, their extravagant hopes, their insecurities. At least one major thread of ethical discourse, the one following Kant, minimizes the importance of the emotions in favor of an emphatically rational decision-making process, and it is worth mulling over the fact that many of those who do not accept Kant’s ethical views more or less applaud his rejection of the “moral sentiment theory” of the time, promoted by such luminary philosophers as David Hume and Adam Smith. (shrink)

The term body integrity identity disorder (BIID) describes the extremely rare phenomenon of persons who desire the amputation of one or more healthy limbs or who desire a paralysis. Some of these persons mutilate themselves; others ask surgeons for an amputation or for the transection of their spinal cord. Psychologists and physicians explain this phenomenon in quite different ways; but a successful psychotherapeutic or pharmaceutical therapy is not known. Lobbies of persons suffering from BIID explain the desire for amputation in (...) analogy to the desire of transsexuals for surgical sex reassignment. Medical ethicists discuss the controversy about elective amputations of healthy limbs: on the one hand the principle of autonomy is used to deduce the right for body modifications; on the other hand the autonomy of BIID patients is doubted. Neurological results suggest that BIID is a brain disorder producing a disruption of the body image, for which parallels for stroke patients are known. If BIID were a neuropsychological disturbance, which includes missing insight into the illness and a specific lack of autonomy, then amputations would be contraindicated and must be evaluated as bodily injuries of mentally disordered patients. Instead of only curing the symptom, a causal therapy should be developed to integrate the alien limb into the body image. (shrink)

A contrarian scientist wrestles with the big questions that modern physics raises, and what physics says about the human condition Not only can we not currently explain the origin of the universe, it is questionable we will ever be able to explain it. The notion that there are universes within particles, or that particles are conscious, is ascientific, as is the hypothesis that our universe is a computer simulation. On the other hand, the idea that the universe itself is conscious (...) is difficult to rule out entirely. According to Sabine Hossenfelder, it is not a coincidence that quantum entanglement and vacuum energy have become the go-to explanations of alternative healers, or that people believe their deceased grandmother is still alive because of quantum mechanics. Science and religion have the same roots, and they still tackle some of the same questions: Where do we come from? Where do we go to? How much can we know? The area of science that is closest to answering these questions is physics. Over the last century, physicists have learned a lot about which spiritual ideas are still compatible with the laws of nature. Not always, though, have they stayed on the scientific side of the debate. In this lively, thought-provoking book, Hossenfelder takes on the biggest questions in physics: Does the past still exist? Do particles think? Was the universe made for us? Has physics ruled out free will? Will we ever have a theory of everything? She lays out how far physicists are on the way to answering these questions, where the current limits are, and what questions might well remain unanswerable forever. Her book offers a no-nonsense yet entertaining take on some of the toughest riddles in existence, and will give the reader a solid grasp on what we know-and what we don't know. (shrink)

English law gives the competent patient the right to refuse life-saving medical treatment, either contemporaneously or in an advance directive, and a physician commits a battery when treating a patient who validly refused treatment. However, with regard to the details of a physician's liability, many questions remain unanswered, and it is not at all clear under what circumstances a patient's tort action for unwanted life-saving treatment will succeed, and what remedies would be available to the patient. The article suggests that (...) a physician should be liable in battery for administering life-saving treatment, even if he/she had doubts about the validity of the patient's treatment refusal, unless a defence of reasonable mistake can be established. Furthermore, in case of a battery which resulted in keeping the patient alive, the patient should not only be able to claim nominal damages, but general and special damages, including mental and physical pain and suffering caused by the prolongation of the patient's life, should equally be available. (shrink)

Using the example of architecture, this article defends the thesis that designing should not be regarded as a kind of experimenting. This is in contrast to a widespread methodological claim that design processes are equivalent to experimentation processes. The contrary thesis can be proven by focusing on actual practices, techniques and design strategies. Closely connected with the thesis is an even more important epistemological claim, which contends that designing serves not only to develop artefacts but is also a means of (...) acquiring genuine knowledge. When the epistemic relevance of said practices, techniques and strategies is reassessed, designing emerges clearly as an independent epistemic praxis. To defend the thesis, the present article draws on and analyses empirical material from an ethnographic field study in order to back up the conceptual analysis. (shrink)

Wenn es in der ersten Hälfte des 20. Jahrhunderts so etwas wie die "arme Verwandtschaft" unter den philosophischen Themen gab, so waren das die Gefühle. Zwar hatten sich Klassiker wie Platon, Aristoteles, Spinoza, Descartes und Hume eingehend mit ihnen befaßt, aber seit Kant, der sie als "Gegner der Vernunft" abtat, wurde den Gefühlen in der Philosophie nur noch wenig Beachtung geschenkt. Erst seit den 1960er Jahren rückten sie wieder in den Fokus des Interesses, und zwar aufgrund der Einsicht, daß Gefühle (...) kognitive mentale Zustände sind, die dazu dienen können, andere Zustände und Handlungen rational zu machen. Strittig ist indes, von welcher Art emotionale Kognitionen sind. Der Band versammelt in historisch-systematischen Einzelstudien die wichtigsten Positionen in der Philosophie der Gefühle und eignet sich gleichermaßen als umfassende Einführung in die Thematik wie auch als Seminarvorlage. (shrink)

For valid informed consent, it is crucial that patients or research participants fully understand all that their consent entails. Testing and revising informed consent documents with the assistance of their addressees can improve their understandability. In this study we aimed at further developing a method for testing and improving informed consent documents with regard to readability and test-readers’ understanding and reactions. We tested, revised, and retested template informed consent documents for biobank research by means of 11 focus group interviews with (...) members from the documents’ target population. For the analysis of focus group excerpts we used qualitative content analysis. Revisions were made based on focus group feedback in an iterative process. Focus group participants gave substantial feedback on the original and on the revised version of the tested documents. Revisions included adding and clarifying explanations, including an info-box summarizing the main points of the text and an illustrative graphic. Our results indicate positive effects on the tested and revised informed consent documents in regard to general readability and test-readers’ understanding and reactions. Participatory methods for improving informed consent should be more often applied and further evaluated for both, medical interventions and clinical research. Particular conceptual and methodological challenges need to be addressed in the future. (shrink)

BackgroundHealthcare providers have to make ethically complex clinical decisions which may be a source of stress. Researchers have recently introduced Artificial Intelligence (AI)-based applications to assist in clinical ethical decision-making. However, the use of such tools is controversial. This review aims to provide a comprehensive overview of the reasons given in the academic literature for and against their use.MethodsPubMed, Web of Science, Philpapers.org and Google Scholar were searched for all relevant publications. The resulting set of publications was title and abstract (...) screened according to defined inclusion and exclusion criteria, resulting in 44 papers whose full texts were analysed using the Kuckartz method of qualitative text analysis.ResultsArtificial Intelligence might increase patient autonomy by improving the accuracy of predictions and allowing patients to receive their preferred treatment. It is thought to increase beneficence by providing reliable information, thereby, supporting surrogate decision-making. Some authors fear that reducing ethical decision-making to statistical correlations may limit autonomy. Others argue that AI may not be able to replicate the process of ethical deliberation because it lacks human characteristics. Concerns have been raised about issues of justice, as AI may replicate existing biases in the decision-making process.ConclusionsThe prospective benefits of using AI in clinical ethical decision-making are manifold, but its development and use should be undertaken carefully to avoid ethical pitfalls. Several issues that are central to the discussion of Clinical Decision Support Systems, such as justice, explicability or human–machine interaction, have been neglected in the debate on AI for clinical ethics so far.Trial registrationThis review is registered at Open Science Framework (https://osf.io/wvcs9). (shrink)

This paper addresses the question of whether the appearance ofthen in a conditional construction has any effect on the meaning of the sentence as a whole. It will be suggested thatthen does make a contribution by way of a particular presupposition associated with it. This also results inthen sometimes conflicting with the intended meaning of the sentence; in such cases its appearance is precluded. Certain aspects of the syntax ofthen will be discussed in parallel.

I argue that, in experiencing a recalcitrant emotion, one does not violate a rational requirement of any sort. Rational requirements, as the expression has come to be used, are requirements of coherence. Accordingly, my argument is that there is nothing incoherent in any way about experiencing a recalcitrant emotion. One becomes incoherent only if one allows the emotion to influence one's reasoning and/or action, in which case one violates the ‘consistency principle’ and/or the ‘enkratic principle’. From the standpoint of rationality, (...) it would even be counterproductive to put subjects under the obligation that their emotional experiences and their evaluative judgements must always fit together. When we nevertheless intuitively sense that the subject is irrational in experiencing a recalcitrant emotion this is in cases in which the emotion challenges the subject's agential identity. However, emotions can, but need not, challenge one's agential identity, and, furthermore, perceptions can do so as well. In any case, challenges of this kind do not involve the violation of a rational requirement. (shrink)

Almost all contemporary philosophers on the subject agree that emotions play an indispensable role in the justification (as opposed to the mere causation) of other mental states and actions. However, how this role is to be understood is still an open question. At the core of the debate is the phenomenon of conflict without contradiction: why is it that an emotion need not be revised in the light of better judgment and knowledge? Conflict without contradiction has been explained either by (...) difference in content between emotion and judgment, or by a difference in the respective attitude towards content. I argue that conflict without contradiction is due to both differences, where difference in content is prior to difference in attitude. (shrink)

Evaluativism about desire, the view that desires just are, or necessarily involve, positive evaluations of their objects, currently enjoys widespread popularity in many philosophical circles. This chapter argues that evaluativism, in both of its doxastic and perceptual versions, overstates and mischaracterises the connection between desires and evaluations. Whereas doxastic evaluativism implausibly rules out cases where someone has a desire, despite evaluating its object negatively, being uncertain about its value, or having no doxastic attitude whatsoever towards its evaluative status at all, (...) perceptual evaluativism cannot even properly apply to the large class of standing desires. It is also argued that evaluativism about desire is not even well-motivated in the first place: the theory is supposed to solve a particular puzzle about the role desires play in the explanation of action, yet, in fact, it does not offer any help whatsoever in dealing with the relevant puzzle. (shrink)

This book opens up a new route to the study of knowledge dynamics and the sociology of knowledge. The focus is on the role of metaphors as powerful catalysts and the book dissects their role in the construction of theories of knowledge and will therefore be of vital interest to social and cognitive scientists alike.