: In 1927, Fritz Jahr, a Protestant pastor, philosopher, and educator in Halle an der Saale, published an article entitled "Bio-Ethics: A Review of the Ethical Relationships of Humans to Animals and Plants" and proposed a "Bioethical Imperative," extending Kant's moral imperative to all forms of life. Reviewing new physiological knowledge of his times and moral challenges associated with the development of secular and pluralistic societies, Jahr redefines moral obligations towards human and nonhuman forms of life, outlining the concept of (...) bioethics as an academic discipline, principle, and virtue. Although he had no immediate long-lasting influence during politically and morally turbulent times, his argument that new science and technology requires new ethical and philosophical reflection and resolve may contribute toward clarification of terminology and of normative and practical visions of bioethics, including understanding of the geoethical dimensions of bioethics. (shrink)

In his “The Star of Redemption”, Rosenzweig engages not only in an argument with philosophy, but also with theology. Next to Augustine and Friedrich Schleiermacher Martin Luther was a counterpart in whose face he developed his dialogical “new thinking”. The essay takes up the traces of this dispute in the letters to focus here on Rosenzweig's reading of Ricarda Huch's “Luther’s Faith”. This literary picture is then related in a sketch to Luther's Reformation theology as it emerges from contemporary (...) research. In a next step, the “Star” is interpreted as a book that, on the one hand, owes much to a previous reception of Luther, but on the other hand, also shows the Reformator's thinking in a new light. Finally, the late writings on the problem of translation come into view in order to justify Rosenzweig’s “Verdeutschung” of the Hebrew Bible, undertaken together with Buber, to Luther’s “German Bible”. (shrink)

Summary Language games can be opening and narrowing. On the base of this double sense my paper compares the language game of divine love according to Franz Rosenzweig and Karl Barth. They were contemporaries not only regarding their early publications. Both discovered revelation in the face of liberal theology which regarded it as a problematic, mythological concept. However, this similarity is contradicted by difference, based in the Christological dogma which can have a tendency to narrow the common basis of the (...) two authors’ theological language game. There is also an anachronism, brought about by Rosenzweig’s anticipation of the concept of analogy which Barth came to years later. The emphasis of my paper lies on the question how the opening function of theological language games can be promoted. In Rosenzweig’s “speaking thinking” there can be found a trace to an answer. (shrink)

Hans-Martin Sass, Honorary Professor of Philosophy. Founder and board member of the Centre for Medical Ethics, Bochum, Germany. Honorary Senior Research Fellow at Kennedy Institute of Ethics at Georgetown University, Washington, DC. Honorary Professor of the Bioethics Research Centre, Beijing. He has written more than 60 books and pamphlets, more than 250 articles in professional journals. Editor of the Ethik in der Praxis/ Practical ethics, Muenster: Lit. Founder and co-editor of the brochures “Medizinethische Materialien”, Bochum: ZME. He has (...) lectured in Argentina, Austria, Belgium, Bulgaria, Brazil, Canada, Croatia, the Chech Republic, India, Iran, Israel, Italy, Japan, France, the Netherlands, the Philippines, Poland, Portugal, Russia, Spain, Switzerland and Taiwan. The interview devoted to exposition of the concept of bioethics in America and Germany, as well as the professor`s attitude to the idea of the integrative concept of bioethics. The concept of integrative bioethics has been developed in different countries, a component of this concept is the idea of the need for discussion on bioethics in various sectors of society. Equally important in this concept are the definitions of bioethics and the bioethical imperative proposed by Fritz Jahr in 1926. The scientist`s article, which was discovered in 1997, contains a new format of bioethical ideas, as well as a valuable opportunity to enhance understanding the term of bioethics as an integrative science. Interview has been conducted by Hanna Hubenko as a part of the joint international course «Integrative Bioethics». At the meeting it was discussed the experience of cooperation and plans for the future. Cooperation and feedback between scientists remains an unconditional prerogative, also in a pandemic situation. (shrink)

This is the first re-publication and first English translation of regulations concerning Human Experimentation which were binding law prior to and during the Third Reich, 1931 to 1945. The introduction briefly describes the duties of the Reichsgesundheitsamt, which formulated these regulations. It then outlines the basic concept of the Richtlinien for protecting subjects and patients on the one hand and for encouraging New Therapy and Human Experimentation on the other hand. Major issues, like personal responsibility of the physician or researcher, (...) teaching of ethics of research and therapy, and research and therapy on vulnerable populations, are compared with the regulations in the Nuremberg Code and subsequent regulations influenced by the Nuremberg Code. CiteULike Connotea Del.icio.us What's this? (shrink)

Inhalt: Vorwort von H.-M. Pawlowski / S. Smid / R. Specht - H.-M. Pawlowski: Probleme der Rechtsbegrundung im Staat der Glaubensfreiheit - V. Gerhardt: Selbstandigkeit und Selbstbestimmung. Freiheit bei Kant und Schelling - H. Folkers: Die durch Freiheit gebaute Stadt Gottes - W. E. Ehrhardt: Mythologie und Offenbarung der Freiheit - W. Bartuschat: Uber Spinozismus und menschliche Freiheit beim fruhen Schelling - C. Cesa: Schellings Kritik des Naturrechts - H. J. Sandkuhler: F. W. J. Schelling - Philosophie als Seinsgeschichte und (...) Anti-Politik - D. Losurdo: Von Louis Philippe bis Louis Bonaparte - R. Pettoello: Die Dialektik der menschlichen Freiheit als Emanzipation und als Abfall von Gott - H. Klenner: Schelling und die Rechtsphilosophie - S. Smid: Freiheit als Keim des Rechts - W. Schmied-Kowarzik: Freiheit - Recht - Geschichte - J. Simon: Die Wirklichkeit der Freiheit (Kant, Schelling, Hegel) - W. Schild: Die verstandlichen Schwierigkeiten des Rechtsdenkens mit dem Freiheitsbegriff - Personenregister. (shrink)

This paper reviews moral and cultural assessments which led to the definition of brain death and calls for a similar normative consensus regarding the moral recognition and legal protection of embryonal life related to criteria of brain life. This paper differentiates between cortical brain life I, i.e., the first existence of post-mitotic stationary neurons forming the early cortical plate (54th day post conception), and cortical brain life II, i.e., the beginning of cortical neuro-neuronal synapses (after the 70th day p.c.). The (...) latter are preconditional for establishing the communicative network within the cortex and with subcortical structures. The paper conservatively calls for a tentative moral consensus that could recognize brain life I, i.e., the 54th day p.c., as a stage prior to which embryo research generally would be acceptable in accordance with principles similar to those which led to the acceptance of brain death. Other developmental stages such as fertilization, nidation, viability, as well as the ‘potentiality’ principle are less significant for the moral recognition of early human life. Keywords: brain death, brain life, embryo research, embryonal tissue CiteULike Connotea Del.icio.us What's this? (shrink)

in Western cultures in regard to post-mortem organ donation and the termination of care for patients meeting these strict criteria. But they are of minimal use in Asian cultures and in the ethics of caring for the persistent vegetative patient. This paper introduces a formula for a global Uniform Determination of Death statute, based on the ‘entire brain including brain stem’ criteria as a default position, but allowing competent adults by means of advance directives to choose other criteria for determining (...) death during the process of dying. Keywords: euthanasia, brain death criteria, higher brain death criteria, individual choice, multicultural society, self-determination CiteULike Connotea Del.icio.us What's this? (shrink)

First publication of a letter of Albert Einstein to Hans Vaihinger, dated May, 1919, concerning Vaihinger's concept of "Fiktionen", the role of Geometry in Poincaré's system, and the importance of "real culture" in the intellectual's style of life. The letter is introduced and annotated.

ZUSAMMENFASSUNGRudolf Otto hat sich – was weithin unbekannt geblieben ist – mehrfach mit »Darwinismus« auseinandergesetzt. Er sah in ihm eine Gefahr für Geist und Frömmigkeit, lehnte ihn aber keineswegs in Bausch und Bogen ab. Er hielt ihn für begrenzt und wenig plausibel; ihm gegenüber sei auf der Eigenständigkeit des Geistigen zu bestehen. Otto wendet sich gegen Naturalismus und Supranaturalismus. Der Religion gehe es um »Teleologie«; ohne »Teleologie« hänge die Deszendenztheorie sozusagen in der Luft. Er wirbt für eine Doppelperspektive, ohne zu (...) berücksichtigen, dass Teleologie als solche kein theologisches Argument sein kann. Angesichts der heute verschärften Fragestellung eines »neuronalen Darwinismus« muss die Verhältnisbestimmung zur Religion innerhalb des Evolutionsdenkens gesucht werden: Religion als Schutz der biologischen und kulturellen Evolution vor sich selbst.SUMMARYAlthough it has generally gone unremarked, Rudolf Otto several times took up the discussion about “Darwinism”. He saw in it a danger for spiritual life and piety while at the same time he by no means rejected it altogether. Regarding it as plausible to a certain, limited extent, he considered it necessary at the same time to insist on the autonomy of the spiritual. Otto takes a position against naturalism and supernaturalism. In religion, he argues, it is a question of “teleology”, and without teleology the theory of descent hangs, so to speak, in the air. He calls for a double perspective, while overlooking that teleology as such cannot be a theological argument. In view of today's increasingly sharply focused “neuronal Darwinism” we need to seek to position religion within evolutionary thought: i.e. religion as the protection of biological and cultural evolution from itself. (shrink)

There are contemporary tendencies to regard the human consciousness as an algorithm, or to reduce the human subjective to organic-natural processes or to see it as a social construction depending on cultural conditions. Such approaches pose a challenge to ethical humanism, as it seems, as if it requires new justification and groundings. How can we grasp and defend the concept of embodied subjectivity of man and its freedom to act? How can we think of its unity including thought, will and (...) feeling, preventing it from getting lost in specialized potentials, and maintaining the person as an alert, responsible and self-founded unit? Furthermore, how is it possible to preserve the meaning of the name of the soul, since the notion of this traditional limit concept of the human subjective has fallen into disuse and likely vanished from the horizon? The essay asks for answer with the help of Hermann Cohen, the great Jewish philosopher of Neo-Kantianism, following the traces of his repeatedly stated, however never written systematic psychology. This first part of investigation confines itself to understand Cohen's early interpretation of Plato as the "primordial cell" of his psychology in order to show how the first three parts of his system of philosophy answer to some of the questions and problems the early work had raised, with special attention to Cohens philosophy of religion. Self-movement of soul and its deep connection with the human body could be viewed and grasped from the unity of human culture as well as of the allness of man. (shrink)

The President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research published in March of 1983 its Report, Securing Access to Health Care: The Ethical Implications of Differences in the Availability of Health Services . Concluding that there are "ethical obligations" on behalf of society which are balanced by individual obligations, the Report provides an ethical framework for ensuring "ultimate responsibility" of the Federal government to arrange for equitable access to health and to a fair (...) share of cost. In doing so the Report neither makes justice nor beneficence the prime moral principle in public health care, it rather calls for a common sense approach in "approximating adequacy". But how to define equality without creating uniformity in a society rich in its diversity, including attitudes towards health? Keywords: justice, beneficence, right to health care, equality, distribution CiteULike Connotea Del.icio.us What's this? (shrink)

Term and concept of bioethics originally were developed by Fritz Jahr, a Protestant Pastor in Halle an der Saale in 1927, long before the period, when bioethics in the modern sense was recreated in the US in 1970s and since that time has spread globally. Jahr’s bioethical imperative, influenced by Christian and humanist traditions from Assisi to Schopenhauer and by Buddhist philosophy holds its own position against Kant’s anthropological imperative and against dogmatic Buddhist reasoning: ‘Respect each living being as an (...) end in itself and treat it, if possible, as such’. Jahr interprets the 5th Commandment ‘Thou shall not kill’ offensively and liberally as ‘common morality’ which includes the obligation of caring for one’s own health, public health and health education within the wider framework of a universal bioethical Sittengesetz. In the article-translation the actual contemporary thoughts about the bioethical imperative, which serves not only the object of interdisciplinary study, but also the practical approach to acquiring responsibility and environmental image of thinking, are found. Didactic considerations of Yahr go beyond the paternalistic upbringing, they point to the content and methodological purpose of teaching ethics to ethical discourse. According to Yahr, ethics does not regulate philosophical, theological or political knowledge, does not act as a dictatorship of a way of behavior. Ethics is the conduct of discussions, the culture of discussion and communication. Following the philosophy of Yahr, Professor Hans-Martin Zass formulated the geo-ethical imperative: "Respect the Mother Earth and all natural life as it is, for which the responsible person is an end in itself, and get around as much as possible in this way!". In respect for all living things, there is a relationship between man and animals, plants, nature, including the health systems, educational-informational and research organizations. Pastor Fritz Jahr, who had no immediate influence during his times, built a strong first Protestant foundation for contemporary theological and ethical concepts in medical ethics, bioethics, and environmental ethics. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Clinic as Testing Ground for Moral Theory: A European ViewHans-Martin Sass (bio)A Philosopher’s View of Theory in the Clinical SettingThe clinic is a testing ground for theories. I am not clinician; I am a philosopher who has been in the clinic only as a patient or as an ethicist who never has had the final word nor was ever intended to have the final word. I have (...) learned that in the clinical setting general norms and conceptualizations in the Kantian sense must be tailored to real-life situations. From the philosophical schools of analytical reasoning, I learned the skills needed to analyze words and meanings and to dissect problems and so-called “solutions.” But even more impressive are the methodological skills of differential diagnosis, looking at medical problems from different angles and using different methods and instruments. The detail- and patient-oriented work of the clinician provides an excellent model of methodological clarity and professional devotion for a philosopher who assists those working for the “good of the patient.” That model has led to the development of what I call a theory and methodology of differential ethics. [End Page 351]Differential ethics is normative ethics, as it does not give up norms in favor of situational utility. Differential ethics does not venture out empty-handed in order to explore and find principles pre-existing in a given situation; rather it brings basic values and principles along with it and tries to discover the shape they must take and the priority they must be given in the situation at hand. Differential ethics differentiates between general norms and mid-level principles, virtues, and visions that must be introduced and protected effectively and specifically according to different scenarios (Sass 1993). From this European point of view, I shall briefly explain my position and comment on (1) the controversy between principlism and virtue theory, (2) differentiating and balancing, and (3) the importance of trust, both as a principle and as a virtue in the clinical setting.Principlism Versus Virtue Theory: A Mistaken ControversyFrom a European perspective, I find that the debate between the schools of virtue-theory and principlism in the United States is a mistaken controversy. The real conflict between the schools of thought is not methodology, but content. Tom Beauchamp (1995) gives examples of how one language or method can be translated into the other, and Edmund Pellegrino and David Thomasma (1988, p. 206) have formulated a rule for the virtuous physician that, in the language of principlism, reads “respect for autonomy,” but in the language of virtue theory reads “To assist my patients to make choices that coincide with their own values or beliefs, without coercion, deception, or duplicity.”In different situations, however, some systems of reference are more authoritative and effective than others. Appealing to professional virtues would be the most efficacious way to address an audience coherent in attitudes and concerned about personal character. Reaffirmation of personal and professional obligations in secular fraternities or religious communities works best when it includes an appeal to virtues in the language of the humanist tradition, moral theology, or professional ethics.But there are other situations in which authoritative attitudes and expectations are absent and society in general is searching for common, often dormant, principles that will hold it together whatever specific disagreements arise. Such a situation was present in 1978 when the Belmont Report (National Commission 1978) presented principles—respect for autonomy, nonmaleficence, beneficence, justice—and not virtues to guide moral and political reflections on and reactions to the ethical, legal, and social implications of modern biomedicine in a multi-faceted and multi-cultural society.The formal difference between the systems of principlism, virtue theory, and value theory becomes even less important when clinical-ethical questionnaires are used to understand specific scenarios or cases and to assess different options for proceeding. Thus, my first thesis is: Case discussion, scenario assessment, [End Page 352] and open questionnaires, rather than definite guidelines, bridge the difference between virtue theory and principlism, since such processes can employ any one language or a combination of all three.Differentiating and BalancingMy second thesis is: Whatever system of reference is used... (shrink)

First publication of a letter of Albert Einstein to Hans Vaihinger, dated May, 1919, concerning Vaihinger's concept of "Fiktionen", the role of Geometry in Poincaré's system, and the importance of "real culture" in the intellectual's style of life. The letter is introduced and annotated.

It is generally understood that Hegel’s influence in the United States was more or less restricted to the field of speculative philosophy. The philosophical importance of the St. Louis movement and The Journal of Speculative Philosophy is well known, just as Hegelian relationships to the New England Transcendentalists. Loyd D. Easton’s pioneering book Hegel’s First American Followers, described the independent Hegelian discussion in mid-nineteenth century Ohio. John B. Stallo and August Willich demonstrated clearly that under totally different cultural, social and (...) political preconditions than in Europe, controversial Hegelian concepts of state and society could yet be developed. Until now, however, it has not been noted that in the 1850’s there was, for a short time, a small, but significant expression of Hegelianism in the Texas Hill Country southwest of Austin, at Sisterdale, Comal County. Only some historians in the field of early Texas history have noticed that among the “lateinische Bauern” who emigrated in 1849/50 to Texas there was the Hegelian Ernst Kapp, a well-known author in the field of environmentology [Erdkunde], who settled in Sisterdale in 1849. (shrink)

The paper presents an overview of political and professional committees in the Federal Republic of Germany dealing with issues of biomedical ethics. The prevailing tendencies of paternalistic atittudes, the worst-casescenario argumentation method, and the unfortunate practice of applying general principles rather than mid-level principles in the assessment of concrete challenges in treatment and regulation are analyzed. Keywords: conflict, control, consent, commission design, paternalism, political ethics, regulation, self-regulation CiteULike Connotea Del.icio.us What's this?

This paper discusses ethical and theological issues of Sterbehilfe, assistance in the process of dying versus assistance to die, in particular the challenges of comfort care and palliative for the dying. Advance Directives are evaluated as instruments to establish patients preferences, to guide caregivers and physicians, and to honor patient~s values, visions and beliefs. It is recommended that churches and pastors take a lead in addressing these issues and help patients and their families in preparing for and executing Advance Directives, (...) churches also should take a Iead in developing model forms. The appendix contains a sample of an integrated Patientenverfügrung, Advance Medical Directive including a durable power of attomey and a value-based wish-and-directive list, taking the German legal framework into account and based on monotheistic systems of regious orientation. (shrink)

This paper reports on recent regulations and guidelines in the Federal Republic of Germany bearing on perinatal medical ethics, embryo research and trophoblast biopsy. Some of the regulations are defensive responses to new moral opportunities. In contrast, this paper calls for a more aggressive moral cost-benefit assessment of high technology medicine, which would include large-scale research on embryos prior to the fiftieth day post-menstruation. Keywords: abortion, embryo research, moral triage, prenatal diagnosis, withholding treatment CiteULike Connotea Del.icio.us What's this?

The term and concept of bioethics (Bio-Ethik) originally were developed by Fritz Jahr, a Protestant Pastor in Halle an der Saale in 1927, long before in the 1970ties bioethics in the modern sense was recreated in the US and since has spread globally. Jahr’s bioethical imperative, influenced by Christian and humanist traditions from Assisi to Schopenhauer and by Buddhist philosophy holds its own position against Kant’s anthropological imperative and against dogmatic Buddhist reasoning: ‘Respect each living being as an end in (...) itself and treat it, if possible, as such’. Jahr interprets the 5th Commandment ‘Thou shalt not kill’ offensively and liberally as ‘common morality’ which includes the obligation of caring for one’s own health, public health and health education within the wider framework of a universal bioethical Sittengesetz. Pastor Fritz Jahr, who had no immediate influence during his times, built a strong first Protestant foundation for contemporary theological and ethical concepts in medical ethics, bioethics, and environmental ethics. (shrink)

The earth is not just a piece of rock, water and soil; she is a living being. This fact is demonstrated by millennia of her life‘s history, growing in ages, having tempers, moods and seasons, and allowing all forms of life living on her and interacting with them and their interactions. Recent natural disasters and accidents, caused by humans in their drive to cultivate and to control, have again brought the powers of the earth and the land to our attention. (...) A new dimension in the visions and virtues of cultivation needs to extend on a global scale the Hippocratic ‗do no harm‘ virtue and principle from the singular doctor-patient interaction towards all forms of life, including the life of the earth.This paper interprets the Bioethical Imperative, developed by Fritz Jahr in 1927, into land ethics and earth ethics; it also discusses the concept of cultural geography of Ernst Kapp, 1845 in Germany, and the land ethics of Aldo Leopold, 1949 in the USA. Of particular new moral and cultural concern is the risk of radiation to the genetic heritage of all forms of life, to livable biotopes and interactive environments. The Bioethical Imperative includes Land Ethics and the Earth: ―Respect mother earth with all her forms of life, whether natural or man-made, basically as goals in themselves and treat them, if possible, as such.‖“The guiding rule for our actions may be the Bioethical Demand: Respect every living being on principle as an end in itself and treat it, if possible, as such!”- Fritz Jahr. (shrink)

I will present evidence that nature does not optimize in the sense of Fermat's principle of least time, contrary to what Schoemaker's unintentionally ambiguous exposition might suggest. First, Huygens' principle, an alternative nonteleological account of Snell's law, is outlined. Second, I confront Fermat's principle with a substantive conceptual problem.

What is health? This question figures prominently in several ethical, medicinal and psychological issues. Against this background the paper investigates the definition and the understanding of health in Karl Barth‘s dogmatics in its theological framework. The reconstruction provides a model of health, which allows treating contemporary issues, because it presents a dynamic and relational model with several dimensions, including the dimension of will. The will to health, though depending on somatic, psychic and social conditions, plays an important role in handling (...) with diseases, in living with imperfections and in supporting healthy lifestyle and preventive measures. This will must be interpreted as the will and the power to be a human being with its gifts and limits. (shrink)

Book reviewed in this article: Medicine and Culture: Varieties of Treatment in the United States, England, West Germany, and France. By Lynn Payer. Health Care Systems: Moral Conflicts in European and American Public Policy. Edited by Hans‐Martin Sass and Robert U. Massey.

If not for the interest in the more professional aspects of Nietzsche’s rooting in the history of academic philosophy in Germany, this book would not have been written. Following Vaihinger’s remark that Nietzsche had studied Lange’s History of Materialism, and that he might have been influenced by chapter four of the second volume entitled “The Standpoint of the Ideal,” Salaquarda studied the relationship between Lange and Nietzsche more in detail. Stack follows Salaquarda, but credits Lange with an even greater influence (...) on Nietzsche’s post-Kantian concept of Ideal. Stack’s scholarly book gives us good insights into the lesser known topography of German philosophical history, which, due to an unfortunate fashionable concentration on recognizing only selected mountains from Kant to Hegel to Nietzsche, disregards the lower hills and the valleys. The rich yield of Stack’s book, therefore, lies in his exploration of a certain part of the terra incognita of nineteenth-century academic philosophy. (shrink)

Marquard wrote this book in 1963 as a Habilitation Thesis with Hegel scholar Joachim Ritter under the title “On depotentiation [Depotentialisierung] of transcendental philosophy—some philosophical motives of a recent pyschologism in philosophy.” He elaborates the thesis that one aspect of the attractiveness of Freud’s psychoanalysis is its relationship with the transcendental natural philosophy of German Idealism: both classical philosophy of nature in German Idealism and Freud’s psychoanalysis, de-potentiate transcendental philosophy. As the philosophy of nature in Kant, Fichte, Schelling, and Hegel (...) is not widely known, Freud’s psychoanalysis makes the transcendental arguments against transcendentalism indirectly present, according to Marquard. In publishing the Habilitation project of 1963 in 1987, 24 years after its original concept was drafted, the thesis does not address the fashion fads of Freudianism in the Federal Republic of Germany during the last 20 years in the form of Freudian Marxism directly, rather it allows a critical and fresh look at the left-Hegelian Freud reception during those years indirectly, presenting the old thesis of 1963 in a 1987 perspective. (shrink)

Modern medicine, based on enormous progress in science and its applications, has lost dimensions of individualized treatment and compassion which traditionally were an essential part of physician’s service over the millennia in Eastern and Western cultures. Today diseases and symptoms, rather than persons, are treated, based on objective quality norms and inflexible payment schemes rather than the rather than persons. We present a checklist model for personalized health care, which has been successful in teaching and practice to reclaim lost territory (...) in treating patients as persons. (shrink)

Like biological species, languages change over time. As noted by Darwin, there are many parallels between language evolution and biological evolution. Insights into these parallels have also undergone change in the past 150 years. Just like genes, words change over time, and language evolution can be likened to genome evolution accordingly, but what kind of evolution? There are fundamental differences between eukaryotic and prokaryotic evolution. In the former, natural variation entails the gradual accumulation of minor mutations in alleles. In the (...) latter, lateral gene transfer is an integral mechanism of natural variation. The study of language evolution using biological methods has attracted much interest of late, most approaches focusing on language tree construction. These approaches may underestimate the important role that borrowing plays in language evolution. Network approaches that were originally designed to study lateral gene transfer may provide more realistic insights into the complexities of language evolution.Editor's suggested further reading in BioEssaysLinguistic evidence supports date for Homeric epics Abstract. (shrink)

The main impetus for organizing this event was the publication, in 2011, of Philip Pettit’s and Christian List’s book, *Group Agency*. List and Pettit argue that interpreting institutions like commercial corporations, governments, political parties, trade unions, churches, and universities as group agents offers a better understanding of their internal working and their effects on social life. Pettit and List base their account of group agency on a so-called “functionalist account of agency” which assumes that an agent is constituted by a (...) method of transforming representational and motivational states into actions. They reject essentialist conceptions of collective willing by claiming that group attitudes supervene on the individual attitudes of the group members.The invited speakers were asked to consider the following issues arising out of List’s and Pettit’s work: Can and should we consider groups as agents? What normative commitments come with such an assumption? What model of agen .. (shrink)

Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

A consideration of the ethical implications of an aesthetic view of life, _The Question of Value _reintroduces the Nietzschean imperative to weigh the things of the world anew. James S. Hans assumes that we must and do value the world we live in every day. Rejecting the deconstructionist view, which is always willing to defer the question of value because there are no grounds for considering it, he argues that we continue to measure the world in spite of the (...) apparent lack of reason for doing so, and that we ought therefore to give serious thought to the way we make our choices. The book begins with the premise that the major task Nietzsche set for the Western world has yet to be undertaken in its fullest sense and connects this task to Heidegger’s mode of questioning in his later work and to Freud’s reflections on the death instinct and the pleasure principle. The study’s central premise is that Nietzsche was correct in diagnosing the ills of our culture and in prescribing a cure because he came to recognize the essential connection between time and revenge. He saw that the desire for revenge stems from our disgust at being temporal creatures and that a new system of values will only be possible once we overcome that self-loathing and the endless acts of revenge that stem from it. This is the most difficult of human tasks, but it is the only one worth attempting once one is able to see the full consequences of the human desire for revenge. Instead of being a critical discussion of Nietzsche’s, Heidegger’s, or Freud’s work, then, _The Question of Value _is an attempt to think through their ideas and to implement them in our world in a new way. It establishes the necessity to affirm the value of time and seeks to provide a framework through which such an affirmation of temporality can take place on a larger ethical scale. (shrink)

Objectives:Social isolation is increasing in aging societies and several studies have shown a relation with worse cognition in old age. However, less is known about the association in the oldest-old (85+); the group that is at highest risk for both social isolation and dementia. Methods:Analyses were based on follow-up 5 to 9 of the longitudinal German study on aging, cognition, and dementia in primary care patients (AgeCoDe) and the study on needs, health service use, costs, and health-related quality of life (...) in a large sample of oldest-old primary care patients (AgeQualiDe), a multi-center population-based prospective cohort study. Measurements included the Lubben Social Network Scale (LSNS-6), with a score below 12 indicating social isolation, as well as the Mini-Mental Status Examination (MMSE) as an indicator of cognitive function. Results:Dementia-free study participants (n = 942) were M = 86.4 (SD = 3.0) years old at observation onset, 68.2% were women. One third (32.3%) of them were socially isolated. Adjusted linear hybrid mixed effects models revealed significantly lower cognitive function in individuals with smaller social networks (β = 0.5, 95% CI = 0.3-0.7, p <.001). Moreover, changes in an individual's social network size were significantly associated with cognitive changes over time (β = 0.2, 95% CI = 0.1-0.4, p =.003), indicating worse cognitive function with shrinking social networks. Conclusion:Social isolation is highly prevalent among oldest-old individuals, being a risk factor for decreases in cognitive function. Consequently, it is important to maintain a socially active lifestyle into very old age. Likewise, this calls for effective ways to prevent social isolation. (shrink)

Undersøgelser af sammenhængen mellem tysk filosofi og nazismens teorier med særlig vægt på Martin Heidegger (1889-1976).

The preoccupation with the "historicity" of thought and existence is central to thehermeneutic-phenomenological branch of modern philosophy. Its foremostrepresentative is Martin Heidegger, who in his main work Sein und Zeit (1927)developed a theory of historicity, according to which human beings not only exist inhistory, but are themselves historical. In subsequent writings Heidegger argued thatnot only man, but also truth and being, must be understood "historically" in aparticular sense. The meaning and the impHcations of Heidegger's "historicization" ofphilosophy are here analyzed (...) along two parallel tracks: as a theory of the conditions ofphilosophical understanding; second, as an incentive to new ways of respondingphilosophically to these conditions. The study focuses on the sense of belongingwhich Heidegger assigns to historicity, as a dialogical relation to an enigmatic originthat cannot be exhaustively articulated, but to which understanding must neverthelessrespond in repetition and critique. The idea of the "hermeneutic situation," and what itmeans to occupy such a situation, is shown to be central in this regard. Heidegger's"historicization" of the philosophical territory is inte reted as an exemplary attempt topreserve philosophy as a quest for "origins" in the explicit recognition of theinterminable historical mediation of thinking. His approach leads to a criticalquestioning of fundamental philosophical distinctions, such as the temporal and theeternal, the absolute and the relative, subject and object, and of truth as correspondence.Eventually he is led to question the ability of language to express thehistoricity of thought and of being, which can only be indicated by means of conceptssuch as "moment" (Augenblick) and "event" (Ereignis). In seven chapters the themeof historicity is explored from different angles, which together provide a guide toHeidegger's path from a philosophy of life to a thinking of being in the "otherbeginning." The study covers the full range of his writings, but it emphasizes thedevelopment from the earliest lectures, over Sein und Zeit, to the second major work,Beiträge zur Philosophie (1938, published posthumously in 1989). (shrink)

Plato's Dialectical Ethics, Gadamer's earliest work, has now been translated into English for the first time. This classic book, published in 1931 and reprinted in 1967 and 1982, is still important today. It is one of the most extensive and imaginative interpretations of Plato's Philebus and an ideal introduction to Gadamer's thinking. It shows how his influential hermeneutics emerged from the application of his teacher Martin Heidegger's phenomenological method to classical texts and problems. The work consists of two chapters. (...) The first, which puts Socratic/Platonic dialectics and ethics in the context of Gadamer's thinking about how we come to shared understanding through conversation, helps to clarify the intentions and trajectory of all Gadamer's subsequent work. The second chapter, on the Philebus, will interest everyone who is concerned with the connection between Plato's discussions of ethics and those of Aristotle, and with the substantive issues of the relation between pleasure and reason that Plato explores and Gadamer interprets. This edition includes a new and useful introduction by the translator, Robert M. Wallace. (shrink)