Graphical AbstractGene editing with engineered nucleases introduce double-strand breaks that are repaired by error-prone nonhomologous end-joining (NHEJ). In article number 1900126, Sara G. Trimidal et al. propose that the length and type or resulting indels can now be controlled by editing with different engineered nucleases or by manipulating the expression of NHEJ genes.

Genome editing with engineered nucleases (GEENs) introduce site‐specific DNA double‐strand breaks (DSBs) and repairs DSBs via nonhomologous end‐joining (NHEJ) pathways that eventually create indels (insertions/deletions) in a genome. Whether the features of indels resulting from gene editing could be customized is asked. A review of the literature reveals how gene editing technologies via NHEJ pathways impact gene editing. The survey consolidates a body of literature that suggests that the type (insertion, deletion, and complex) and the approximate length of indel edits (...) can be somewhat customized with different GEENs and by manipulating the expression of key NHEJ genes. Structural data suggest that binding of GEENs to DNA may interfere with binding of key components of DNA repair complexes, favoring either classical‐ or alternative‐NHEJ. The hypotheses have some limitations, but if validated, will enable scientists to better control indel makeup, holding promise for basic science and clinical applications of gene editing. Also see the video abstract here https://youtu.be/vTkJtUsLi3w. (shrink)

Reading in Chinese is complex because readers should not only recognize characters by basic units but also integrate characters into words when reading text. While many efforts have been devoted to investigating the effect of sub-lexical orthographic knowledge in Chinese character reading, less is known about the role played by lexical orthographic knowledge at word level. A total of 424 secondary learners with Chinese as a second language in Hong Kong were assessed with character reading, reading comprehension, and two (...) lexical orthographic knowledge tasks: lexical orthographic choice and lexical orthographic choice in context. Path analysis results demonstrated that these lexical orthographic skills significantly mediated the effect of character reading on comprehension, in which OKCC was a more critical mediator as its mediating effect was bigger than that of OKC. Further analyses showed that these mediating effects were significant only among students with richer learning experience. Our results illustrate the possible trajectory of CSL learners’ literacy development from character reading to reading comprehension and provide pedagogical implications for teaching and learning. (shrink)

In this paper, we explore how the prospect of artificial placenta technology (nearing clinical trials in human subjects) should encourage further consideration of the loss experienced by individuals when their pregnancy ends unexpectedly. Discussions of pregnancy loss are intertwined with procreative loss, whereby the gestated entity has died when the pregnancy ends. However, we demonstrate how pregnancy loss can and does exist separate to procreative loss in circumstances where the gestated entity survives the premature ending of the pregnancy. In outlining (...) the value that can be attached to pregnancy beyond fetal-centric narratives, we illustrate how pregnancy loss, separate to procreative loss, can be experienced. This loss has already been recognised among parents who have experienced an unexpected early ending of their pregnancy, resulting in their child being cared for in neonatal intensive care unit. Artificial placentas, however, may exacerbate these feelings and make pregnancy loss (without procreative loss) more visible. We argue that pregnancy is an embodied state in which gestation is facilitated by the body but gestation itself should be recognised as a process—and one that could be separable from pregnancy. In demarcating the two, we explore the different ways in which pregnancy loss can be understood. Our objective in this paper goes beyond contributing to our philosophical understanding of pregnancy towards practical-orientated conclusions regarding the care pathways surrounding the artificial placenta. We make recommendations including the need for counselling and careful consideration of the language used when an artificial placenta is used. (shrink)

If the world itself is metaphysically indeterminate in a specified respect, what follows? In this paper, we develop a theory of metaphysical indeterminacy answering this question.

What do we mean when we call a work of art "beautiful"? How have artists responded to changing notions of the beautiful? Which works of art have been called beautiful, and why? Fundamental and intriguing questions to artists and art lovers, but ones that are all too often ignored in discussions of art today. Elizabeth Prettejohn argues that we simply cannot afford to ignore these questions. Charting over two hundred years of western art, she illuminates the vital relationship between (...) our changing notions of beauty and specific works of art, from the works of Kauffman to Whistler, Ingres to Rosetti, Cezanne to Pollack. Beautifully illustrated with 100 photographs--60 in full color--Beauty and Art concludes with a challenging question for the future: Why should we care about beauty in the twenty-first century? (shrink)

This new and important study of semantic change examines how new meanings arise through language use, especially the various ways in which speakers and writers experiment with uses of words and constructions in the flow of strategic interaction with addressees. In the last few decades there has been growing interest in exploring systemicities in semantic change from a number of perspectives including theories of metaphor, pragmatic inferencing, and grammaticalization. Like earlier studies, these have for the most part been based on (...) data taken out of context. This book is the first detailed examination of semantic change from the perspective of historical pragmatics and discourse analysis. Drawing on extensive corpus data from over a thousand years of English and Japanese textual history, Traugott and Dasher show that most changes in meaning originate in and are motivated by the associative flow of speech and conceptual metonymy. (shrink)

In this chapter I address the concern that UNESCO World Heritage designation leads to unregulated tourism. I argue that heritage tourism not only has a negative impact on the site but may adversely impact local populations and descendant communities. I detail two related worries, UNESCO-cide and the Disneyfication of cultural heritage. The term ‘UNESCO-cide’ was coined by Marco d’Eramo to describe the role overtourism has played in the death of cities listed on UNESCO’s World Heritage list. Disneyfication is the process (...) of sanitizing potentially controversial or seemingly negative narratives from the tourist site to make the experience more palatable. I focus my analysis on two UNESCO World Heritage sites: Angkor Archaeological Complex in Cambodia and George Town in Malaysia. After a discussion about the negative impacts World Heritage designation has had on these sites, I suggest some mitigating strategies for tourism. (shrink)

In a recent paper, Barry Loewer attempts to defend Humeanism about laws of nature from a charge that Humean laws are not adequately explanatory. Central to his defense is a distinction between metaphysical and scientific explanations: even if Humeans cannot offer further metaphysical explanations of particular features of their “mosaic,” that does not preclude them from offering scientific explanations of these features. According to Marc Lange, however, Loewer’s distinction is of no avail. Defending a transitivity principle linking scientific explanantia to (...) their metaphysical grounds, Lange argues that a charge of explanatory inadequacy resurfaces once this intuitive principle is in place. This paper surveys, on behalf of the Humean, three strategies for responding to Lange’s criticism. The ready availability of these strategies suggests that Lange’s argument may not bolster anti-Humean convictions, since the argument rests on premises that those not antecedently sharing these convictions may well reject. The three strategies also correspond to three interesting ways of thinking about relations of grounding linking Humean laws and their instances, all of which are consistent with theses of Humean supervenience, and some of which have been heretofore overlooked. (shrink)

One of the alleged advantages of a constructivist theory in metaethics is that the theory avoids the epistemological problems with moral realism while reaping many of realism's benefits. According to evolutionary debunking arguments, the epistemological problem with moral realism is that the evolutionary history of our moral beliefs makes it hard to see how our moral beliefs count as knowledge of moral facts, realistically construed. Certain forms of constructivism are supposed to be immune to this argument, giving the view a (...) key advantage. This paper considers the challenge that evolutionary debunking arguments pose for the possibility of moral knowledge and concludes that such arguments do not reveal any advantages for constructivism. Furthermore, once we consider how defenders of moral knowledge should best respond to this epistemological objection, constructivists may face more difficulties, not less, explaining how our moral beliefs represent moral knowledge. (shrink)

This comprehensive and up-to-date textbook gives a clear account of the different philosophical and theoretical approaches to psychology and discusses major philosophical questions such as free will and the relation between mind and body.

Our language system is ambiguous in that the same utterance can be interpreted in different ways depending on the intention of the speaker. For example, the phrase, “Nice job!” can be interpreted a...

Part of the Blackwell Readings in the History of Philosophy series, this survey of late modern philosophy focuses on the key texts and philosophers of the period whose beliefs changed the course of western thought.

Introduction: human rights in healthcare -- A right to treatment? the allocation of resouces in the National Health Service -- Ensuring quality healthcare: an issue of rights or duties? -- Autonomy and consent in medical treatment -- Treating incompetent patients: beneficence, welfare and rights -- Medical confidentiality and the right to privacy -- Property right in the body -- Medically assisted conception and a right to reproduce? -- Termination of pregnancy: a conflict of rights -- Pregnancy and freedom of choice (...) -- The right to life at the end of life -- The law and ethics of assisted dying: is there a right to die? (shrink)

The importance of food in our individual lives raises moral questions from the debate over eating animals to the prominence of gourmet cookery in the popular media. Through philosophy, Elizabeth Telfer discusses issues including our obligations to those who are starving; the value of the pleasure of food; food as art; our duties to animals; and the moral virtues of hospitableness and temperance. Elizabeth Telfer shows how much traditional philosophy, from Plato to John Stuart Mill, has to say (...) to illuminate this everyday yet complex subject. (shrink)

Conferralism is the view that social properties are neither intrinsic to the things that have them nor possessed simply by virtue of their causal or spatiotemporal relations to other things, but are somehow bestowed (intentionally or not, explicitly or not) upon them by persons who have both the capacity and the standing to bestow them. We argue that conferralism faces a dilemma: either it is viciously circular, or it is limited in scope in a way that undercuts its motivation.

Recruitment and Reproduction: The Careers and Carriers of Digital Photography and Floorball The claim that social practices have a relatively durable existence in space and time, and that their persistence depends upon their recurrent reproduction through necessarily localised performances is theoretically plausible, but what of the detail? How do the careers of practices and those who "carry" them actually intersect? In this paper we have two related ambitions. One is to show how selected practices are concurrently shaped by the ebb (...) and flow of recruits and defectors and by what it is that cohorts of practitioners actually do. The second is to learn more about the relation between recruitment and reproduction by comparing the ways in which these processes play out in different situations. In taking these two ambitions forward through a discussion of digital and film photography and of floorball (a team game in which players use plastic sticks to hit a small ball into a goal) we explore ways of concretely examining processes that are implied in Giddens' theory of structuration (1984) and in Bourdieu's concept of habitus (1984). This exercise generates insights into the internal dynamics of practice and the methodological challenges of pinning them down. (shrink)

This class-tested text provides a comprehensive overview of the classical and current theories of moral development and applications of these theories in various counseling and educational settings.

This paper defends the avowal view of self-deception, according to which the self-deceived agent has been led by the evidence to believe that ¬p and yet is sincere in asserting that p. I argue that the agent qualifies as sincere in asserting the contrary of what they in the most basic sense believe in virtue of asserting what they are committed to believing. It is only by recognizing such commitments and distinguishing them from the more basic beliefs whose rational regulation (...) is automatic that the tension between the self-deceived agent’s actions and assertions can be explained in a core subset of cases of self-deception. (shrink)

This book looks at business ethics from the perspective of the business practitioner, but with the rigour of the moral philosopher. Intended for introductory students of business, commerce and management studies, Business Ethics at Work begins by setting business clearly in the context of creating value for its owners, and develops a practical ethical decision model which can be simply and relevantly applied to the hard moral choices with which business people are faced day to day. Against this background, some (...) of the major ethical issues which arise in business are explored, for example, in human resource management, finance, marketing and advertising, the management of the environment and corporate governance. In conclusion the book looks at the nature of ethical audit and argues that for the business of the future, the identification of its ethical values and their integration into its policies and practices will be a crucial ingredient of success. (shrink)

A simple argument proposes a direct link between realism about quantum mechanics and one kind of metaphysical holism: if elementary quantum theory is at least approximately true, then there are entangled systems with intrinsic whole states for which the intrinsic properties and spatiotemporal arrangements of salient subsystem parts do not suffice. Initially, the proposal is compelling: we can find variations on such reasoning throughout influential discussions of entanglement. Upon further consideration, though, this simple argument proves a bit too simple. To (...) get such metaphysically robust consequences out, we need to put more than minimal realism in. This paper offers a diagnosis: our simple argument seems so compelling thanks to an equivocation. The predictions of textbook quantum theory already resonate with familiar holistic slogans; for realists, then, any underlying reality, conforming to such predictions, also counts as holistic in some sense or other, if only by association. Such associated holism, though, does not establish the sort of specific, robust supervenience failure claimed by our simple argument. While it may be natural to slide to this stronger conclusion, facilitating the slide is not minimal realism per se but an additional explanatory assumption about how and why reality behaves in accordance with our theory: roughly, quantum theory accurately captures patterns in the features and behaviors of physical reality because some underlying metaphysical structure constrains reality to exhibit these patterns. Along with the diagnosis comes a recommendation: we can and should understand one traditional disagreement about the metaphysics of entanglement as another manifestation of a familiar and more general conflict between reductive and non-reductive conceptions of metaphysical theorizing. Such reframing makes clearer what resources reductionists have for resisting the simple argument’s challenge from quantum holism. It also has an important moral for their opponents. Traditional focus on whole-part supervenience failure distracts from a root disagreement about metaphysical structure and its role in our theorizing. Non-reductionists fond of our simple argument would be better off tackling this root directly. (shrink)

Art plays a significant role in Iris Murdoch’s moral philosophy, a major part of which may be interpreted as a proposal for the revision of religious belief. In this paper, I identify within Murdoch’s philosophical writings five distinct but related ways in which great art can assist moral/religious belief and practice: art can reveal to us “the world as we were never able so clearly to see it before”; this revelatory capacity provides us with evidence for the existence of the (...) Good, a metaphor for a transcendent reality of which God was also a symbol; art is a “hall of reflection” in which “everything under the sun can be examined and considered”; art provides us with an analogue for the way in which we should try to perceive our world; and art enables us to transcend our selfish concerns. I consider three possible objections: that Murdoch’s theory is not applicable to all forms of art; that the meaning of works of art is often ambiguous; and that there is disagreement about what constitutes a great work of art. I argue that none of these objections are decisive, and that all forms of art have at least the potential to furnish us with important tools for developing the insight required to live a moral/religious life. (shrink)

In Tague's book, An Ape Ethic and the Question of Personhood, he presents his call for what he refers to as “Ape Forest Sovereignty” in three parts. In the first part of the book, he explores “The Case for an Ape Ethic.” Here he lays the groundwork for his call for Ape Forest Sovereignty, arguing that apes are ethical players in both their ecosystems and within their society's social structures. He explores this argument through the lens of “personhood,” a concept (...) that he recognizes as having multiple facets: legal, ethical, and metaphysical. He is clear that, in his exploration of the concept of personhood, “An Ape Ethic is not a legal argument but, nonetheless, a call for recognition of great apes as persons of tropical forests” (p. 4). This point is where I find the book somewhat lacking in ways that I will explore later in this review.Tague goes on in Part 2, which deals with cognition and environmental adaptation, and Part 3, which deals with the complex social interactions in ape societies, to build a convincing and extremely well-referenced argument, leaving the reader in little doubt as to his call that, if humans can be considered “persons,” there is very good reason to also consider apes as “persons,” too. These parts of the book will be useful for those interested in ape cognition and social structure as they bring together both historical and current work on this issue from a truly global perspective. It is perhaps the most current and comprehensive analysis of these points in print today and will serve students and those with an interest in those subjects extremely well.In addition to possessing the relevant cognitive and social attributes that would see them considered “persons,” Tague further argues that great apes—and he makes particular mention of orangutans throughout the book—operate in such a way that is intrinsically morally good in their interactions with their environment. Indeed, the existence of great apes in forest environments, says Tague, actively benefits those environments, particularly in their role as important seed dispersers. Tague argues that this establishes great apes as “moral eco-engineers” who, in stark contrast to the damaging capitalist social and political structures maintained by humans that have had such devastating impact on global forest environments, actively benefit their environment.Drawing together the various threads of his analysis, Tague argues that apes should be considered “forest persons” and be granted sovereignty over their forest land.Frustratingly, having laid an intricate groundwork as the basis of his call for ape personhood that, he says, is the rationale for the call for ape land sovereignty, Tague devotes very little of the book to his radical and compelling call. I had hoped that the final chapter of the book would explore exactly what ape sovereignty might look like in practice. The book left me with more questions than answers in this regard, and I would have liked Tague to explore the practical potential of his call in his concluding chapter.An exploration of the practical outcomes would be complex and could not help but become not just ethical, but also political and legal in nature. Land sovereignty cannot just be considered through an ethical lens, but must be addressed though the political and legal constructs upon which the principle of land sovereignty is based. For example, I would have liked to have seen Tague's work explore the following questions: How would nation states within whose jurisdiction these forests are located cede sovereignty to apes and how might it be maintained or managed?How would humans living or working in these forests, particularly those with long-standing ancestral land rights over the same land in question, interact with apes within these spaces?How would other nonhuman species who also share the environment engage and exist within these spaces? Would or could there be any feasible ceding of land sovereignty to nonhuman species when the principle of land sovereignty is based on human-made political and legal principles and, indeed, while indigenous human populations continue to struggle for their sovereignty to be recognized and respected?I was also left wondering how Tague's call might apply to captive apes. The theory espoused in the book relies heavily on land sovereignty being granted to apes on the basis of them being “moral eco-engineers” of their forest homes. I would be interested to understand where this might leave apes born or maintained in captivity who cannot, and will not, ever form part of free-living societies in those forest environments. If ape personhood and, by extension, the right to land sovereignty, is contingent on those apes playing a positive conservation role in their natural environment, one can perhaps conclude that captive apes are excluded from personhood recognition due to their inability to play this role. I would be interested to understand where Tague positions captive apes within his theory.Important work has been done in this academic area, most notably by Donaldson and Kymlicka (2013) in their book Zoopolis and, specifically, in the chapter “Wild Animal Sovereignty.” Tague does reference this work in parts of his text and it may be that An Ape Ethic and Zoopolis could be read together, with the arguments of one informing, and providing context, to the other. That said, I would have been interested to understand Tague's specific view on the practical implementation of his call for ape land sovereignty, perhaps in a volume of work to accompany the text currently under consideration.Tague's book presents an urgent and compelling argument that, under human management, forest habitats are under immediate threat of irreparable harm. His call to cede land to nonhuman “forest persons” who will better care for and maintain this land—which is vital for the health and welfare of all living beings on Earth—is a radical and important one. I hope Tague continues to develop and expand on this work in the near future to explore the way in which his call might be realized in practice. (shrink)

In this paper, I present a close study of Hume’s treatment of contrary passions, asking questions about his description of the psychology of emotional difference and opposition. In treating this topic, I examine two opposed, but noteworthy, psychological functions that Hume imputes to human beings: sympathy and comparison. In brief, sympathy is the mechanism by which we share others’ feelings, and comparison is the function of our minds by which we find ourselves feeling passions opposed to others’ experiences. Sympathy can (...) lead me to feel pleased at your good fortune, while comparison can lead me to feel resentment or envy at the same. I also examine another form of opposition in Hume’s theory: the distinction between calm and violent passions, a distinction which plays an important part in Hume’s account of motivation. Among the questions I ask here are: what counts as contrary passions; how conflicts are psychologically possible within the context of Hume’s theory, which declares that dominant passions “swallow” inferior ones; and what the effects of contrariety are on our psychology and motivation to action. (shrink)

Focuses on the encounters of feminist and queer theories, on the ways in which basic terms such as - sex, gender, and sexuality change meaning as they move from one body of theory to another. This book includes essays by Judith Butler, Evelynn Hammonds, Biddy Martin, Kim Michasiw, Carole-Anne Tyler, and Elizabeth Weed.

This paper aims to better understand and account for potential difficulties in empathising with each other in online spaces. I argue that two important differences between online and in-person communication are both to do with what information comes across in equivalent interactions. Firstly, there are ways in which less information comes across in online interactions (both consciously and unconsciously). Secondly, agents have greater control over what information comes across in online interactions. I argue that these differences can cause problems in (...) terms of whether online spaces are as fruitful ground for empathising with each other. This is because the information that gets left out is often what’s important for building up a fuller and more vivid picture of what the other person’s experiences are like, such as identity-markers or vulnerabilities. But despite this, I end on an optimistic note, because we will become more practiced at reading between the lines, as well as adapting and using media more creatively. (shrink)

Despite a growing literature on identity theory in the last two decades, much of its current use in archaeology is still driven toward locating and dating static categories such as 'Phoenician,' 'Christian' or 'native.' Previous studies have highlighted the various problems and challenges presented by identity, with the overall effect of deconstructing it to insignificance. As the humanities and social sciences turn to material culture, archaeology provides a unique perspective on the interaction between people and things over the long term. (...) This volume argues that identity is worth studying not despite its slippery nature, but because of it. Identity can be seen as an emergent property of living in a material world, an ongoing process of becoming which archaeologists are particularly well suited to study. The geographic and temporal scale of the papers included is purposefully broad to demonstrate the variety of ways in which archaeology is redefining identity. Research areas span from the Great Lakes to the Mediterranean, with case studies from the Mesolithic to the contemporary world by emerging voices in the field. The volume contains a critical review of theories of identity by the editors, as well as a response and afterword by A. Bernard Knapp"--From publisher's website. (shrink)

In this chapter, the author explains Rorty's neopragmatist feminism and some feminist criticism of his work, limiting her to questions not yet settled in the literature. She argues that Rorty can defeat the criticisms that his reformism is too conservative and that his feminism flounders without representationalist truth. "Feminism and Pragmatism" discusses the apparent paradox that injustices, on a Rortyan view, are not injustices until they are so perceived. Thus, if our society begins to accept gay marriage, passes legislation supporting (...) gay marriage, and begins criticizing those who oppose gay marriage, we have made a significant change in our practices, norms, and language. Our society still, at least at this time, thinks of "gay marriage" as a somewhat different category than "marriage," despite the fact that we treat both as marriages. We still rely on legislatures and courts to determine the legality of our marriage practices. (shrink)