© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

I examine three accounts of divine freedom. I argue that two recent accounts which attempt to explain God’s freedom without appealing to alternative possibilities fail. I then show how a view of divine freedom based on Robert Adams’s idea that God’s grace means he has no obligation to create the best world is able to explain how God can be free while also being perfectly good and perfectly rational.

Nothing is more obvious than the fact that we are able to experience events in the world such a ball deflecting from the cross-bar of a goal. But what is the temporal relation between these two things, the event, and our experience of the event? One possibility is that the world progresses temporally through a sequence of instantaneous states – the striker’s foot in contact with the ball, then the ball between the striker and the goal, then the ball in (...) contact with the cross-bar, and so forth –, while the perceiver’s experience is likewise a sequence of experience states, each one of which corresponds to, or is experience of, a corresponding state of the world – for example, a perception of the foot in contact with the ball, followed by a perception of the ball in the air, following by a perception of the ball in contact with the cross-bar. This way of understanding the relationship between experience and the world is very natural, and nearly universal. However, it rests on two assumptions that can be brought into question. (shrink)

The purpose of this volume is to remedy this neglect, to explain Thoreau's philosophical significance, and to argue that we can still learn from his polemical conception of philosophy.

This brief commentary has three goals. The first is to argue that ‘‘framework debate’’ in cognitive science is unresolvable. The idea that one theory or framework can singly account for the vast complexity and variety of cognitive processes seems unlikely if not impossible. The second goal is a consequence of this: We should consider how the various theories on offer work together in diverse contexts of investigation. A final goal is to supply a brief review for readers who are compelled (...) by these points to explore existing literature on the topic. Despite this literature, pluralism has garnered very little attention from broader cognitive science. We end by briefly considering what it might mean for theoretical cognitive science. (shrink)

This Element considers the relationship between the traditional view of God as all-powerful, all-knowing and wholly good on the one hand, and the idea of human free will on the other. It focuses on the potential threats to human free will arising from two divine attributes: God's exhaustive foreknowledge and God's providential control of creation.

We explored the influence of negation on cognitive dynamics, measured using mouse‐movement trajectories, to test the classic notion that negation acts as an operator on linguistic processing. In three experiments, participants verified the truth or falsity of simple statements, and we tracked the computer‐mouse trajectories of their responses. Sentences expressing these facts sometimes contained a negation. Such negated statements could be true (e.g., “elephants are not small”) or false (e.g., “elephants are not large”). In the first experiment, as predicted by (...) the classic notion of negation, we found that negation caused more discreteness in the mouse trajectory of a response. The second experiment induced a simple context for these statements, yet negation still increased discreteness in trajectories. A third experiment enhanced the pragmatic context of sentences, and the discreteness was substantially diminished, with one primary measure no longer significantly showing increased discreteness at all. Traditional linguistic theories predict rapid shifts in cognitive dynamics occur due to the nature of negation: It is an operator that reverses the truth or falsity of an interpretation. We argue that these results support both propositional and contextual accounts of negation present in the literature, suggesting that contextual factors are crucial for determining the kind of cognitive dynamics displayed. We conclude by drawing broader lessons about theories of cognition from the case of negation. (shrink)

The Laws is the longest and, according to tra-dition, the last of Plato’s dialogues. It was left ‘in the wax’ at the time of Plato’s death and brought into publication by Philip of Opus (D. L. 3.37). Whether Philip had a hand in editing the work or whether he merely tran-scribed it is uncertain (for one recent account, see Nails and Thesleff 2003). The most recent analyses of its style indicate significant affini-ties with the Sophist, Politicus and Philebus, though there (...) are stark differences in places. These, however, might be explained in vari-ous ways, and there has never been any ques-tion that the Lg. substantially contains the thought of Plato. If we set special problems of composition aside, including admittedly serious questions about the overall coher-ence of the dialogue, then the chief difficul-ties remaining for an interpreter of the Lg. include (a) its dramatic date and structure, (b) its relation to other political dialogues of Plato, especially the Republic and the Plt. and (c) the extensive discussion of cosmology and theology in L. bk 10. (shrink)

The classical tradition of testimony in topics -- Three medieval traditions : Augustine, Boethius, and Cassiodoras -- Two renaissance traditions : Ciceronian and Augustinian -- The long influence of the port-royal logic -- Appreciating Aristotle : Thomists, Scots, and Oxford noetics -- Testimony becomes experience : the rise of critical thinking.

Through theoretical discussion, literature review, and a computational model, this paper poses a challenge to the notion that perspective-taking involves a fixed architecture in which particular processes have priority. For example, considerable work has shown that egocentric perspectives can arise more quickly, with other perspectives (such as of task partners) emerging only secondarily. This theoretical dichotomy is challenged here, and we propose a general view of perspective-taking as an emergent phenomenon governed by the interplay among several cognitive mechanisms. We first (...) describe the pervasive relevance of perspective-taking to cognitive science. A dynamical systems model is then introduced which explicitly formulates the timescale interaction proposed. Implications are discussed, with ideas for future empirical research. (shrink)

Using the Godel incompleteness result for leverage, Roger Penrose has argued that the mechanism for consciousness involves quantum gravitational phenomena, acting through microtubules in neurons. We show that this hypothesis is implausible. First the Godel result does not imply that human thought is in fact non-algorithmic. Second, whether or not non-algorithmic quantum gravitational phenomena actually exist, and if they did how that could conceivably implicate microtubules, and if microtubules were involved, how that could conceivably implicate consciousness, is entirely speculative. Third, (...) cytoplasmic ions such as calcium and sodium are almost certainly present in the microtubule pore, barring the quantum-mechanical effects Penrose envisages. Finally, physiological evidence indicates that consciousness does not directly depend on microtubule properties in any case, rendering doubtful any theory according to which consciousness is generated in the microtubules. (shrink)

Groundhog Day (Harold Ramis, 1993) and Only Lovers Left Alive (Jim Jarmusch, 2013) are fantasy films that use the device of practical immortality in order to raise important philosophical questions about what constitutes a good life and to explore the nature of romantic love. Groundhog Day provides fairly conventional answers about how to live a good life by focusing on issues of spiritual redemption, selflessness, and developing one’s human potential. In contrast, Lovers provides a dark portrayal of a civilization on (...) the brink of extinction but offers a glimmer of hope for the future. The lifestyle and values of married vampires Adam and Eve represent an alternative vision of the core values needed to sustain a better world: greater reliance on human imagination, maintaining a sense of wonder and curiosity about the world, creating and appreciating works of art and living in harmony with the natural world. Both films also offer a perspective on the importance of romantic love in living a good life. Although these perspectives often diverge from one another, they do overlap in some interesting ways. The style of film criticism used in this paper is inspired by the film philosophy of Stanley Cavell. (shrink)

Learn the tips and tricks used by a top photographer in the digital photography industry in Rick Sammon's Top Digital Photography Secrets. Filled with beautiful photographs and the techniques Rick Sammon used to capture them, this book offers you motivation to capture stunning photographs and the tools and tricks you need to capture them. With more than 100 techniques for use behind the camera, this book will improve the camera skills of both amateur and experienced photographers. Additionally, this (...) book includes a chapter on post-production secrets, and a Rick Sammon DVD Guide lighting, camera, and digital photography basics. In this 1-hour DVD, Rick shows you how to get great photos using a variety of lighting sources, camera-specific techniques, and basic rules of photography. (shrink)

... there are cases in which on the basis of a temporally extended content of consciousness a unitary apprehension takes place which is spread out over a temporal interval (the so-called specious present). ... That several successive tones yield a melody is possible only in this way, that the succession of psychical processes are united "forthwith" in a common structure.

In turn, the volume explains how an understanding of these contract law doctrines can be enhanced by a proper conception of exploitation.

Historians of economic thought have long recognized the possibility that the "science" of economics owes more to cultural influences than we are usually prepare to admit. Econ Art offers the first detailed study of this contradiction, highlighting the cultural and aesthetic influences of surrealism, cubism and abstract art on both economic theory and method in the twentieth century.Arguing that economics has developed more as an art form than as a science, the author looks not only at what economists have produced (...) but how they have produced it, uncovering the cultural preconceptions which have shaped economic theory and method in the last one hundred years. At a time of increasing dissatisfaction with the discipline and the practice of economics, Szostak argues that the time is now ripe —- and right —- to embarrass the profession into a whole-sale reconsideration of what economics is for, how it should be done and what might make it better and more useful to the academy and to the world at large. (shrink)

This essay is an investigation into the sense of ‘able’ relevant to free will, where free will is understood as requiring the ability to do otherwise. I argue that van Inwagen's recent functional specification of the relevant sense of ‘able’ is flawed, and that explicating the powers involved in free will shall likely require paying detailed attention to the semantics and pragmatics of ‘can’ and ‘able’. Further, I argue that van Inwagen's promise-level ability requirement on free will is too strong. (...) I also argue that Mele's conjecture that the strength of the ability to perform the ‘alternative’ action be no higher than the strength of the ability exercised in performing an action is mistaken. I suggest there is an asymmetry in the strengths of the abilities which make up the n-way power that comprises free will, and that this looks to have some interesting consequences for the connection between the abilities required for free will and, e.g. the ‘up to us’ locution. (shrink)

The emulation theory of representation is developed and explored as a framework that can revealingly synthesize a wide variety of representational functions of the brain. The framework is based on constructs from control theory (forward models) and signal processing (Kalman filters). The idea is that in addition to simply engaging with the body and environment, the brain constructs neural circuits that act as models of the body and environment. During overt sensorimotor engagement, these models are driven by efference copies in (...) parallel with the body and environment, in order to provide expectations of the sensory feedback, and to enhance and process sensory information. These models can also be run off-line in order to produce imagery, estimate outcomes of different actions, and evaluate and develop motor plans. The framework is initially developed within the context of motor control, where it has been shown that inner models running in parallel with the body can reduce the effects of feedback delay problems. The same mechanisms can account for motor imagery as the off-line driving of the emulator via efference copies. The framework is extended to account for visual imagery as the off-line driving of an emulator of the motor-visual loop. I also show how such systems can provide for amodal spatial imagery. Perception, including visual perception, results from such models being used to form expectations of, and to interpret, sensory input. I close by briefly outlining other cognitive functions that might also be synthesized within this framework, including reasoning, theory of mind phenomena, and language. Key Words: efference copies; emulation theory of representation; forward models; Kalman filters; motor control; motor imagery; perception; visual imagery. (shrink)

In this paper I argue that there are different ways that an agent may be able to do otherwise and that therefore, when free will is understood as requiring that an agent be able to do otherwise, we face the following question: which way of being able to do otherwise is most relevant to free will? I answer this question by first discussing the nature of intrinsic dispositions and abilities, arguing that for each action type there is a spectrum of (...) intrinsic abilities. I suggest that recognising this allows us to articulate two ways in which an intrinsic ability is general (such that there are two kinds of non-general ability). And I argue that the abilities most relevant to free will need to be non-general in both of the ways identified. Along the way I show why these points threaten to undermine Vihvelin’s dispositionalist account of free will. (shrink)

Philosophers disagree over whether dispositions can be intrinsically finked or masked. Choi suggests that there are no clear, relevant differences between cases where intrinsic finks would be absurd and those where they seem plausible, and as a result rejects them wholesale. Here, I highlight two features of dispositional properties which, when considered together, provide a plausible explanation for when dispositions can be subject to intrinsic finks and when not.

According to some, free will requires alternative possibilities. But not any old alternative possibility will do. Sometimes, being able to bring about an alternative does not bestow any control on an agent. In order to bestow control, and so be directly relevant qua alternative to grounding the agent's moral responsibility, alternatives need to be robust. Here, I investigate the nature of robust alternatives. I argue that Derk Pereboom's latest robustness criterion is too strong, and I suggest a different criterion based (...) on the idea that what agents need to be able to do is keep open the possibility of securing their blamelessness, rather than needing to directly ensure their own blamelessness at the time of decision. (shrink)

We discuss two problems for a general scientific understanding of language, sequences and synergies: how language is an intricately sequenced behavior and how language is manifested as a multidimensionally structured behavior. Though both are central in our understanding, we observe that the former tends to be studied more than the latter. We consider very general conditions that hold in human brain evolution and its computational implications, and identify multimodal and multiscale organization as two key characteristics of emerging cognitive function in (...) our species. This suggests that human brains, and cognitive function specifically, became more adept at integrating diverse information sources and operating at multiple levels for linguistic performance. We argue that framing language evolution, learning, and use in terms of synergies suggests new research questions, and it may be a fruitful direction for new developments in theory and modeling of language as an integrated system. (shrink)

Work injury compensation and pensions are often determined according to medical disability rating scales attributing a percentage to each impaired body part or function. Incorporated into central medical–administrative networks of committees and examinations, these produce disability as a calculable space. This article examines the specific case of the Israeli National Insurance regulations regarding work injuries of 1956 and analyzes the shifted order they set. Looking at this system in the specific historical context of transition from the British Mandate workmen’s compensation (...) system to the “disability percentages” system, provides insight into the process of structuring and stabilizing durable numerical forms and the production of centralized government. Drawing on conceptualizations regarding the sociotechnical role of classification systems, I contend that through encoding and calculating classifications of disability, heterogeneity is eliminated and an ordering based on physiology is “black boxed,” illustrating the importance of technoscientific formations in structuring the “medical model of disability.”. (shrink)

This article outlines the main tenets of affect theory and links these to Sloterdijk’s spherology. Where affect foregrounds prepersonal energies and posthuman impulses, spherology provides a lens for considering how humans congregate in constantly reconfiguring socialities in their pursuit of legitimacy and immunity. The article then explores the relevance of “affective spheres” for contemporary social science research. The article’s main argument here is that research of contemporary organisational and professional practices must increasingly be spherogenic, or seeking to build “affective spheres.” (...) The basis of this argument are the in situ complexity and fast-changing nature of practices, and the increasing challenges involved in objectifying or ‘freezing’, and analysing or dissecting such practices. The article draws for its case study on a video-reflexive project conducted in a U.S. health service. The article concludes that the notion of research as spherogenics counterbalances the conventional methodological emphasis on a predetermined stance —whether neutral or political—in our construction and enactment of social science research. (shrink)

Profinite groups are Galois groups. The effective study of infinite Galois groups was initiated by Metakides and Nerode [8] and further developed by LaRoche [5]. In this paper we study profinite groups without considering Galois extensions of fields. The Artin method of representing a finite group as a Galois group has been generalized by Waterhouse [14] to profinite groups. Thus, there is no loss of relevance in our approach.The fundamental notions of a co-r.e. profinite group, recursively profinite group, and the (...) degree of a co-r.e. profinite group are defined in §1. In this section we prove that every co-r.e. profinite group can be effectively represented as an inverse limit of finite groups. The degree invariant is shown to behave very well with respect to open subgroups and quotients. The work done in this section is basic to the rest of the paper.The commutator subgroup, the Frattini subgroup, thep-Sylow subgroups, and the center of a profinite group are essential in the study of profinite groups. It is only natural to ask if these subgroups are effective. The following question exemplifies our approach to this problem: Is the center a co-r.e. profinite group? Theorem 2 provides a general method for answering this type of question negatively. Examples 3,4 and 5 are all applications of this theorem. (shrink)

The concept of the postsecular is a challenge to systematic theological thought, as it points to some context where the opposition between the religious and the secular, or between theism and atheism, is weakened or even surpassed. In this perspective, the postsecular is not about the visibility of religion in the public sphere, but about the way in which we interpret ourselves in the world in order to find orientation and fulfillment. In a postsecular context, religious perspectives and secularist outlooks (...) are no longer opposed of necessity, but draw on a common religious and secular heritage. In this article, Richard Kearney’s Anatheism and Jean-Luc Nancy’s The Deconstruction of Christianity are presented as exemplifications of postsecular thought that may open up new perspectives to systematic theology. In different ways, Kearney and Nancy reflect on a transcendent dimension in our experience or in the world, which is beyond the secular. Yet they distinguish themselves due to a religious transcendence-oriented approach and a secularist world-oriented approach, which shows that the opposition between the religious and the secular may be weakened, but the demarcations between the two still have their impact. (shrink)

Christopher Franklin argues that, despite appearances, everyone thinks that the ability to do otherwise is required for free will and moral responsibility. Moreover, he says that the way to decide which ability to do otherwise is required will involve settling the nature of moral responsibility. In this paper I highlight one point on which those usually called leeway theorists - i.e. those who accept the need for alternatives - agree, in contradistinction to those who deny that the ability to do (...) otherwise is needed for free will. And I explain why it falsifies both of Franklin’s claims. (shrink)

This study investigates the relations between narrative experiences and film enjoyment, and explores the possibility that transportability and perceived realism facilitate narrative experience and indirectly influence enjoyment. The study measured narrative experience and realism in three films from different genres. Results demonstrate that transportability, and both external realism and narrative realism positively influence at least one aspect of narrative experience, and that narrative experience in turn is a significant predictor for enjoyment.

Stump and Timpe have recently proposed Thomistic based solutions to the traditional problem in Christian theology of how to relate grace and free will. By taking a closer look at the notion of control, I subject Timpe’s account – itself an extension of Stump’s account – to extended critique. I argue that the centrepiece of Timpe’s solution, his reliance on Dowe’s notion of quasi-causation, is misguided and irrelevant to the problem. As a result, Timpe’s account fails to avoid Semi-Pelagianism. I (...) canvass two alternatives, each of which adheres to the broad theological assumptions made by Stump and Timpe, including the positing of only one “unique” grace. I conclude that each of these proposals fails, although I argue that one comes as close as it is possible to get to a solution given the assumptions made. -/- . (shrink)

The Philosophy of Matter is a journey in thinking through the material fate of the earth itself; its surfaces and undercurrrents, ecologies, environments and irreparable cracks. With figures such as Spinoza, Gilles Deleuze and Michel Serres as philosophical guides and writings on New Materialism, Posthumanism and Affect Theory as intellectual context, Rick Dolphijn proposes a radical rethinking of some of the basic themes of philosophy: subjectivity, materiality, body (both human and otherwise) and the act of living. This rethink is (...) a work of imagination and meditation in order to conceive of "another earth for another people". It is a homage to courageous thinking that dares to question the religious, capitalist and humanist realities of the day. A poetic philosophy of how to live in troubling times when even the earth beneath us feels unstable, Dolphijn offers a way to think about the world with depth, honesty and glimpses of hope. (shrink)