The global market for biologics and biosimilar pharmaceutical products is experiencing rapid expansion, primarily driven by the continuous discovery of new molecules. However, information regarding Latin America’s biological market remains limited.

This paper explores the similarities between the conceptual structure of quantum theory and relational biology as developed within the Rashevsky-Rosen-Louie school of theoretical biology. With this aim, generalized quantum theory and the abstract formalism of (M,R)-systems are briefly presented. In particular, the notion of organizational invariance and relational identity are formalized mathematically and a particular example is given. Several quantum-like attributes of Rosen’s complex systems such as complementarity and nonseparability are discussed. Taken together, this work emphasizes the possible role of (...) self-referentiality and impredicativity in quantum theory. (shrink)

The gene regulation function (GRF) provides an operational description of a promoter behavior as a function of the concentration of one of its transcriptional regulators. Behind this apparently trivial definition lies a central concept in biological control: the GRF provides the input/output relationship of each edge in a transcriptional network, independently from the molecular interactions involved. Here we discuss how existing methods allow direct measurement of the GRF, and how several trade‐offs between scalability and accuracy have hindered its application to (...) relatively large networks. We discuss the theoretical and technical requirements for obtaining the GRF. Based on these requirements, we introduce a simplified and easily scalable method that is able to capture the significant parameters of the GRF. The GRF is able to predict the behavior of a simple genetic circuit, illustrating how addressing the quantitative nature of gene regulation substantially increases our comprehension on the mechanisms of gene control. (shrink)

The concept of the universe is used in physical cosmology differently from the usual meaning of the term, naively considered as the entire reality. Traditionally, thinking about the whole led to logical contradictions. Taking as reference the Kantian antecedent, different contemporary philosophical notions of the universe are analysed in the first part of this paper, including realist and constructivist approaches, as well as a notion of the universe as a physical object. In the second part, the specific notion from the (...) standard physical cosmology is discussed. Although modelling the universe as a physical system provides a specific way to define some global properties, the universe as a whole remains empirically inaccessible. Hence, the discussion about the under-determined global properties depends ultimately on philosophical preferences. Under these circumstances, it is argued that the realist interpretation of such properties becomes problematic because it leads to unstable conclusions. Finally, it is argued that the notion of the universe as conceived in standard cosmology is not necessarily consistent with an approach that considers it to be a physical object. (shrink)

La crítica de Feuerbach concibe el fenómeno religioso como una manifestación efectiva de la autoconciencia humana. Partiendo de este supuesto, el presente artículo tiene como objeto contextualizar, a la luz de un desarrollo histórico, el humanismo propuesto por el autor como siguiente estadio del proceso de autoconocimiento humano. Dicha propuesta implicaría necesariamente el reconocimiento de los mecanismos de enajenación implícitos en la religión y, en definitiva, su superación. Al desembarazarse de las especulaciones propias de la fe, la reducción de la (...) teología a la antropología despojaría a la realidad de todo elemento sobrenatural y supondría un avance significativo en pos de la plenitud humana. (shrink)

The aim of this paper is to present a philosophically inspired list of minimal requirements for social agency that may serve as a guideline for social robotics. Such a list does not aim at detailing the cognitive processes behind sociality but at providing an implementation-free characterization of the capacities and skills associated with sociality. We employ the notion of intentional stance as a methodological ground to study intentional agency and extend it into a social stance that takes into account social (...) features of behavior. We discuss the basic requirements of sociality and different ways to understand them, and suggest some potential benefits of understanding them in an instrumentalist way in the context of social robotics. (shrink)

A great variety of medical conditions are subject to the placebo effect. Although there is mounting evidence to suggest that the placebo effect is related to the expectation of clinical benefit, little is still known about the biochemical bases underlying placebo responses. Positron emission tomography studies have recently shown that the placebo effect in Parkinson’s disease, pain, and depression is related to the activation of the limbic circuitry. The observation that placebo administration induces the release of dopamine in the ventral (...) striatum of patients with Parkinson’s disease suggests a link between the placebo effect and reward mechanisms. In addition to Parkinson’s disease, the placebo-reward model may also apply to other disorders. However, the relative contribution of the different neurotransmitters and neuropeptides that are known to be involved in modulating the activity of the limbic system may be disease-specific. Thus, while the placebo-induced clinical benefit observed in Parkinson’s disease would mostly reflect the release of dopamine in the dorsal striatum, the activation of opioid and serotonin pathways could be particularly implicated in mediating placebo responses encountered in pain and depression, respectively. (shrink)

A great variety of medical conditions are subject to the placebo effect. Although there is mounting evidence to suggest that the placebo effect is related to the expectation of clinical benefit, little is still known about the biochemical bases underlying placebo responses. Positron emission tomography studies have recently shown that the placebo effect in Parkinson’s disease, pain, and depression is related to the activation of the limbic circuitry. The observation that placebo administration induces the release of dopamine in the ventral (...) striatum of patients with Parkinson’s disease suggests a link between the placebo effect and reward mechanisms. In addition to Parkinson’s disease, the placebo-reward model may also apply to other disorders. However, the relative contribution of the different neurotransmitters and neuropeptides that are known to be involved in modulating the activity of the limbic system may be disease-specific. Thus, while the placebo-induced clinical benefit observed in Parkinson’s disease would mostly reflect the release of dopamine in the dorsal striatum, the activation of opioid and serotonin pathways could be particularly implicated in mediating placebo responses encountered in pain and depression, respectively. (shrink)

El presente trabajo es un estudio descriptivo y con un enfoque sincrónico que da muestra de las deficiencias de los profesores universitarios al redactar textos científicos. Este estudio tiene como objetivo proponer varias acciones de superación para perfeccionar el manejo del lenguaje y el arte de redactar de los docentes de la Universidad de Ciencias Médicas "Dr. Faustino Pérez Hernández" de la provincia Sancti Spíritus que cursan la octava edición de la Maestría en Ciencias de la Educación de la Universidad (...) de Sancti Spíritus "José Martí Pérez". Para darle cumplimiento a este propósito, se aplicaron varios métodos y técnicas de recolección de datos a una muestra seleccionada al azar de informantes y de sus publicaciones, lo que permitió fundamentar la existencia de varias problemáticas en la redacción científica de dichos profesores y la necesidad de implementar formas organizativas básicas del proceso de educación de posgrado para su inmediata y eficaz aplicación. The present work is a descriptive study grounded in a synchronic approach that identifies the deficiencies of university professors when writing scientific texts. This study aims to propose several measures to improve the use of language and the art of writing of teachers of the " Dr. Faustino Pérez Hernández" University of Medical Sciences in Sancti Spíritus, Cuba who are participating in the eighth edition of the Master's Degree in Educational Sciences program at the "José Martí Pérez" University, also located in Sancti Spiritus. Several methods and techniques of data collection were applied to a random sample of informants and their scientific articles. This allowed for the detection of several problems in scientific writing and the need to implement basic organizational forms of postgraduate education for immediate and effective application. (shrink)

A la memoria del maestro/filósofo Álvaro B. Márquez-Fernández La necesidad de seguir promoviendo temas “no” vistos de forma positiva por los grupos cerrados del poder, y aquellos que han hecho de la academia grupúsculos tradicionales, sistémicos y funcionales a los intereses de los de arriba, se constituye en una apuesta de ir a contracorriente de esos tipos de historias y asumir un compromiso ético-político en función de las luchas, los sentimientos y las emociones de los grupos de abajo.

La narrativa de José Saramago es centro de análisis reciente para todos aquel que incursionen en la literatura contemporánea. A través de La caverna, el escritor expone un sinnúmero de situaciones que deben ser reflexionadas y que en el presente artículo se abordan desde la perspectiva de los estudios culturales. Entre otros, se resalta el uso del lenguaje popular, la dialéctica entre lo rural y lo urbano, y finalmente la exclusión social y el consumismo. Este es, por lo tanto, un (...) estudio de análisis crítico de la obra La caverna de José Saramago, apoyado además en los trabajos interdisciplinarios que otros pensadores han ofrecido al respecto. El aporte desde los estudios culturales y la crítica realizada por Saramago no son ajenos a la preocupación por el ser, pues este se ve acorralado por las dinámicas que la sociedad impone. (shrink)

This chapter argues that from a particularly weak recombination principle and plausible assumptions about the nature of parthood and location, it follows that it is possible that the mereological structure of the material world and that of space-time fail to correspond to one another in very radical ways. The chapter suggests, moreover, that rejecting the possibility of such failures of correspondence leaves us with a choice of no less unappealing alternatives. It also discusses a few ways in which their possibility (...) is relevant to various important debates in metaphysics. (shrink)

I argue that from a very weak recombination principle and plausible assumptions about the nature of parthood and location it follows that it's possible that the mereological structure of the material world and that of spacetime fail to correspond to one another in very radical ways. I defend, moreover, that rejecting the possibility of such failures of correspondence leaves us with a choice of equally radical alternatives. I also discuss a few ways in which their possibility is relevant to various (...) debates in metaphysics. (shrink)

El presente artículo se centra en una investigación sobre los vínculos entre la teoría crítica de la educación inclusiva, la justicia social y la literatura de tradición oral, puesto que a través de los referentes hallados se interpela a la literatura desde el mismo contexto del Sur Global, visto como un punto de partida para comprender los problemas culturales, sociales e interculturales. Desde estas consideraciones, se hizo una revisión sistemática de la producción y publicación de trabajos investigativos referentes al estudio (...) de las variables Literatura de tradición oral, Justicia social y Educación inclusiva, bajo el enfoque PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses). El objetivo del análisis propuesto fue conocer las características principales de las publicaciones registradas en base de datos Scopus y Web of Science y su alcance en el estudio de las variables propuestas, logrando la identificación de 106 publicaciones en total. Gracias a esta primera identificación, se refinaron los resultados a través de dos palabras clave, “Social justice (and) Inclusive education”, llegando a un total de 23 documentos, después de excluir los duplicados y aquellos que no cumplían con los criterios de análisis. Luego fueron analizados esperando conocer la relación entre las variables, y cómo en América se ha avanzado en materia de lucha contra la corrupción. Los hallazgos apuntan a: 1) que la educación inclusiva establece vínculos con la literatura de tradición oral desde el reconocimiento de la pluralidad y las diferencias culturales; 2) que los autores resaltan expresiones culturales transmitidas de generación en generación para fecundar nuevos conocimientos desde la comunidad; 3) y que la justicia social se traduce en una educación que reconoce diferencias y genera espacios para otros saberes, como es el caso de la literatura de tradición. (shrink)

I give shape to a neglected debate in metaphysics, the debate over the ontological priority between individuality and collectivity. I distinguish the debate from more familiar ones in the recent literature and articulate what I call ontological collectivism, the view that collectivity is prior to individuality. I defend the in-principle intelligibility of the view from forceful general objections and argue that not only is it coherent but also of significant interest to the literature: it allows for overlooked alternatives on a (...) variety of central discussions. (shrink)

We study whether robots can satisfy the conditions of an agent fit to be held morally responsible, with a focus on autonomy and self-control. An analogy between robots and human groups enables us to modify arguments concerning collective responsibility for studying questions of robot responsibility. We employ Mele’s history-sensitive account of autonomy and responsibility to argue that even if robots were to have all the capacities required of moral agency, their history would deprive them from autonomy in a responsibility-undermining way. (...) We will also study whether humans and technological artifacts like robots can form hybrid collective agents that could be morally responsible for their actions and give an argument against such a possibility. (shrink)

Page 1. Economics and Philosophy, 26 291--320 Copyright C Cambridge University Press doi: 10.1017 / S0266267110000386 TWO KINDS OF WE-REASONING RAUL HAKLI, KAARLO MILLER AND RAIMO TUOMELA University of Helsinki.

Reseña del libro En el principio existía el axioma de no contradicción (Hacia Guillermo de Ockham por la Literatura y la Filosofía) Andrés Felipe López (2019). Madrid: Editorial Verbum, S.L. 140 pp.

Este artículo presenta la traducción al español de la parte sexta del De multiplicatione specierum de Roger Bacon, originalmente escrito en latín, y que posee como tema transversal la filosofía natural. Esta traducción tiene el carácter de ser comprensiva, esto es, fue escrita de tal forma que pueda ser entendida por el lector. También, para efectos de un mejor ejercicio pedagógico, se propone un comentario filosófico– crítico, es decir, una breve paráfrasis explicativa, que otorgue luces a la comunidad de habla (...) hispana en función de potenciar el acercamiento a este texto traducido. Nos encontramos ad portas de la primera traducción comentada en español de una parte de la obra de Roger Bacon3, quien es real e indudablemente el padre del método científico y el verdadero reformador de la ciencia moderna. (shrink)

The article begins with an integrative theory of neurosis and with the notion of the “patriarchal mind,” which I conceive as the psycho-social foundation of what we call “civilisation” and proceed to characterize as a despotic and repressive activity of the father on the mother and on the child in the family, and also of an analogous relation between the intellect on the emotional and on the instinctual sub-selves in the individual mind. Next, I propose that patriarchy entails four interrelated (...) problems: violent authority; the eclipse of caring; the repression of instinct; and the invalidation of intuition; and point out that since these are evident in our well-recognized social problems, these may be traced down to the “patriarchal complex” that in turn defines patriarchal society. Finally, I develop the idea that not only is the patriarchal mind is embodied in each of the known interpersonal or character pathologies, but that each of these pathologies contributes to the systemic and cultural presence of the patriarchal mind. The corollary of this analysis is that the healing of both our interpersonal and social pathologies will depend on the healing of the patriarchal mind, which is conceivably possible to bring about through a specially designed education oriented to the balanced development of “three-brained beings,” in whom a balance has been achieved between the intellectual, emotional, and instinctive sub-selves that constitute our mind. (shrink)

Various sources in the literature claim that the deduction theorem does not hold for normal modal or epistemic logic, whereas others present versions of the deduction theorem for several normal modal systems. It is shown here that the apparent problem arises from an objectionable notion of derivability from assumptions in an axiomatic system. When a traditional Hilbert-type system of axiomatic logic is generalized into a system for derivations from assumptions, the necessitation rule has to be modified in a way that (...) restricts its use to cases in which the premiss does not depend on assumptions. This restriction is entirely analogous to the restriction of the rule of universal generalization of first-order logic. A necessitation rule with this restriction permits a proof of the deduction theorem in its usual formulation. Other suggestions presented in the literature to deal with the problem are reviewed, and the present solution is argued to be preferable to the other alternatives. A contraction-and cut-free sequent calculus equivalent to the Hubert system for basic modal logic shows the standard failure argument untenable by proving the underivability of DA from A. (shrink)

Animals have always been important for human life due to the ecological, cultural and economic functions that they represent. This has allowed building several kinds of relationships that have promoted different emotions in human societies. The objective of this review was to identify the main emotions that humans show towards wildlife species and the impact of such emotions on animal populations’ management. We reviewed academic databases to identify previous studies on this topic worldwide. An analysis of the emotions on wildlife (...) and factors causing them is described here. We identified a controversy about these emotions. Large predators such as wolves, coyotes, bears, big felids, as well as reptiles such as snakes and geckos promote mainly anger, fear, and disgust. This is likely due to the perceptions, beliefs and experiences that societies have historically built around them. However, in some social groups these animals have promoted emotions such as happiness due to their values for people. Likewise, sadness is an emotion expressed for the threatening situations that animals are facing nowadays. Furthermore, we associated the conservation status of wildlife species identified in the study with human emotions to discuss their relevance for emerging conservation strategies, particularly focused on endangered species promoting ambiguous emotions in different social groups. (shrink)