Adverbial modification is probably one of the least understood areas of linguistics. The essays in this volume all address the problem of how to give an analysis of adverbial modifiers within truth-conditional semantics. Chapters I-VI provide analyses of particular modifiers within a possible worlds framework, and were written between 1974 and 1981. Original publication details of these chapters may be found on p. vi. Of these, all but Chapter I make essential use of the idea that the time reference (...) involved in tensed sentences should be a time interval rather than a single instant. The final chapter (Chapter VII) was written especially for this volume and investigates the question of how the 'situation semantics' recently devised by Jon Barwise and John Perry, as a rival to possible-worlds semantics, might deal with adverbs. In addition I have included an appendix to Chapter III and an introduction which links all the chapters together. (shrink)

Much recent discussion has focused on the nature of artifacts, particularly on whether they have essences. While it is often held that artifacts are intention-dependent and necessarily have functions, it is equally commonly held, though far less discussed, that artifacts are the result of physical modification of some material objects. This paper argues that the physical modification condition on artifacts is false. First, it formulates the physical modification condition perspicuously for the first time. Second, it offers counterexamples (...) to this condition, both concrete and abstract. Third, it considers, and rejects, two responses to these counterexamples, one which appeals to the distinction between being a K and being used as a K and another which argues that the counterexamples are merely of functional, not artifactual, kinds. Finally, it considers, and rejects, a more general objection that appropriation makes artifact creation too easy. As a consequence, artifacts can be created by appropriating pre-existing objects and it sketches some success conditions for such appropriation. (shrink)

Bellʼs 1964 theorem causes a severe problem for the notion that correlations require explanation, encapsulated in Reichenbachʼs principle of common cause. Despite being a hallmark of scientific thought, dropping the principle has been widely regarded as much less bitter medicine than the perceived alternative—dropping relativistic causality. Recently, however, some authors have proposed that modified forms of Reichenbachʼs principle could be maintained even with relativistic causality. Here we break down Reichenbachʼs principle into two independent assumptions—the principle of common cause proper and (...) factorization of probabilities. We show how Bellʼs theorem can be derived from these two assumptions plus relativistic causality and the law of total probability for actual events, and we review proposals to drop each of these assumptions in light of the theorem. In particular, we show that the non-commutative common causes of Hofer-Szabó and Vecsernyés fail to have an analogue of the notion that the common causes can explain the observed correlations. Moreover, we show that their definition can be satisfied trivially by any quantum product state for any quantum correlations. We also discuss how the conditional states approach of Leifer and Spekkens fares in this regard. (shrink)

You are what you eat – this well‐known phrase properly describes the phenomenon of the effects of diet on acute and chronic inflammation. Several lipids and lipophilic compounds that are delivered with food or are produced in situ in pathological conditions exert immunomodulatory activity due to their interactions with the plasma membrane. This group of compounds includes cholesterol and its oxidized derivatives, fatty acids, α‐tocopherol, and polyphenols. Despite their structural heterogeneity, all these compounds ultimately induce changes in plasma membrane (...) architecture and fluidity. By doing this, they modulate the dynamics of plasma membrane receptors, such as TLR4. This receptor is activated by lipopolysaccharide, triggering acute inflammation during bacterial infection, which often leads to sepsis and is linked with diverse chronic inflammatory diseases. In this review, we discuss how the impact on plasma membrane properties contributes to the immunomodulatory activity of dietary compounds, pointing to the therapeutic potential of some of them.Also watch the Video Abstract. (shrink)

Knowing, either by the light of natural reason or by the light of Christian revelation, that homosexuality is a disordered condition is not sufficient for its being ethically permissible to direct self-identified homosexual persons toward just any treatment that aims to modify sexual orientation. For example, such an undertaking would be morally impermissible in cases where the available “treatments” are known to be both futile and potentially damaging to persons undertaking them. I, therefore, introduce this edition of Christian Bioethics by (...) reflecting on (a) the position of homosexuality in our current psychiatric nosology, (b) problems with drawing causal inferences from the outcomes of psychotherapy studies, and (c) the advantages and disadvantages of appealing to traditional categories of sexual orientation in this discussion, all with an eye toward more deeply elucidating core ethical concerns involving the intentional psychotherapeutic modification of sexual orientation. (shrink)

In the last two decades, Davidson’s event-argument hypothesis has become very popular in natural language semantics. This article questions that event-based analyses actually add something to our understanding of the respective phenomena: I argue that they already find their explanation in independently motivated grammatical assumptions and principles which apply to all kinds of modification. Apart from a short discussion of Davidson’s original arguments in favour of his hypothesis, I address Larson’s event-based account of the distinctions between stage-level vs. individual-level (...) modification and adverbial vs. adjectival modification in the nominal domain. I argue that his analysis of the former reduces straightforwardly to the grammatical structure of the nominal phase. As for the latter, I provide reasons which motivate a re-description of the phenomenon in terms of sensitivity to descriptive content rather than events. I argue that, so described, the phenomenon can be explained in terms of interface conditions, given a phasal architecture of grammar. (shrink)

The notion that body modification occurs when one undertakes practices like tattooing, piercing or scarification, engenders discourses in which: (i) body modifiers endorse such practices as self-constructive, distancing their practitioners from social regulation and a deterministic biology, whereas; (ii) critics condemn their seemingly violent, corporeal interference. However, in suspecting that such analysis should be attentive to the concurrent individual and social co-constitution of behaviours, a sociological and post-structural interrogation of this characterization of body modification as a “sovereign, denaturalizing” (...) endeavour is demanded. An engagement with the originary violence of Derridian deconstruction will duly re-conceive body modification practice as not something which introduces violence to corporeality. Rather, violence will present as a primordial differentiating process which bodies always already condition, and by which they are conditioned/produced/modified. The second issue at stake in this article will thus develop as a contestation to the characterization of “body modification” as an exclusive category of practice. Such practices do not arrive, pre-existing, but rather manifest as the originary violence/differentiation of bodies-as-modifications-which-modify. This re-defines modification from something that agentive subjects introduce to bodies, to something that subjects-as-bodies cannot help but be. Consequently, individual agency is not divorced from behaviour, but emerges as a corporeal, social production. (shrink)

Appellate Court Modifications Extraction consists of, given an Appellate Court decision, identifying the proposed modifications by the upper Court of the lower Court judge’s decision. In this work, we propose a system to extract Appellate Court Modifications for Portuguese. Information extraction for legal texts has been previously addressed using different techniques and for several languages. Our proposal differs from previous work in two ways: our corpus is composed of Brazilian Appellate Court decisions, in which we look for a set of (...) modifications provided by the Court; and to automatically extract the modifications, we use a traditional Machine Learning approach and a Deep Learning approach, both as alternative solutions and as a combined solution. We tackle the Appellate Court Modifications Extraction task, experimenting with a wide variety of methods. In order to train and evaluate the system, we have built the KauaneJunior corpus, using public data disclosed by the Appellate State Court of Rio de Janeiro jurisprudence database. Our best method, which is a Bidirectional Long Short-Term Memory network combined with Conditional Random Fields, obtained an \ score of 94.79%. (shrink)

This paper problematizes the analogy that Hubert Dreyfus has presented between phenomenology and cognitive science. It argues that Dreyfus presents Merleau-Ponty''s modification of Husserl''s phenomenology in a misleading way. He ignores the idea of philosophy as a radical interrogation and self-responsibility that stems from Husserl''s work and recurs in Merleau-Ponty''s Phenomenology of Perception. The paper focuses on Merleau-Ponty''s understanding of the phenomenological reduction. It shows that his critical idea was not to restrict the scope of Husserl''s reductions but to (...) study the conditions of possibility for the thetic acts. Merleau-Ponty argued, following Husserl''s texts, that the thetic acts rest on the basis of primordial pre-thetic experience. This layer of experience cannot, by its nature, be explicated or clarified, but it can be questioned and unveiled. This is the recurrent task of phenomenological philosophy, as Merleau-Ponty understands it. (shrink)

Many loci in Drosophila exhibit dosage effects on single phenotypes. In the case of modifiers of position‐effect variegation, increases and decreases in dosage can have opposite effects on variegating phenotypes. This is seemingly paradoxical: if each locus encodes a limiting gene product sensitive to dosage decreases, then increasing the dosage of any one should have no effect, because the others should remain limiting. An earlier model put forward to resolve this paradox suggested that dosage‐dependent modifiers encode protein subunits of a (...) macromolecular complex that is sensitive to mass action equilibrium conditions. Because chemical equilibria are dynamic, however, such hypothetical complexes will be unstable to an extent that is inconsistent with the known properties of molecules that make up chromatin. An alternative model accounts for the dosage effects in terms of interactions between structural proteins that bind at multiple linked sites. These might include indirect interactions occurring between regulatory proteins and genes for structural proteins or their protein products. The large number of direct and inverse regulatory genes which are known to exist in Drosophila could account for the apparent genetic complexity that is seen for modifiers of position‐effect variegation and for other systems of phenotypic modification. (shrink)

It is argued that contraposition is valid for a class of natural language conditionals, if some modifications are allowed to preserve the meaning of the original conditional. In many cases, implicit temporal indices must be considered, making a change in verb tense necessary. A suitable contrapositive for implicative counterfactual conditionals can also usually be found. In some cases, the addition of certain words is necessary to preserve meaning that is present in the original sentence and would be lost or changed (...) in the contrapositive without them. A distinction is made between adding new meaning and adding new words to preserve existing meaning. For concessive conditionals and relevance conditionals, however, no valid contrapositive can be found. They do not belong to the class of contraposable conditionals, which can be independently defined. Difficult cases are also discussed in which the contradictory of the consequent semantically entails the truth of the antecedent. In such cases the content of the antecedent is implicit in the meaning of the consequent. Contraposition becomes possible if what is implicit in the original consequent is made explicit in the contrapositive antecedent. (shrink)

In concert with the selective pressures affecting protein folding and function in the extreme environments in which they can exist, proteins in Archaea have evolved to present permanent molecular adaptations at the amino acid sequence level. Such adaptations may not, however, suffice when Archaea encounter transient changes in their surroundings. Post‐translational modifications offer a rapid and reversible layer of adaptation for proteins to cope with such situations. Here, it is proposed that Archaea further augment their ability to survive changing growth (...) conditions by modifying the extent, position, and, where relevant, the composition of different post‐translational modifications, as a function of the environment. Support for this hypothesis comes from recent reports describing how patterns of protein glycosylation, methylation, and other post‐translational modifications of archaeal proteins are altered in response to environmental change. Indeed, adjusting post‐translational modifications as a means to cope with environmental variability may also hold true beyond the Archaea. (shrink)

This essay argues that what makes Michel Foucault’s oeuvre not only stand apart but also cohere is an assiduous philosophical practice taking the form of an ongoing yet concrete self-modification in the medium of thought. Part I gives an account of three essential aspects of Foucault’s conception of philosophical activity. Beginning with his famous characterization of philosophy in terms of ascēsis, it moves on to articulate his characterization of philosophical practice as a distinct form of meditation, differing from both (...) Cartesian meditation and Hegelian meditation, as it aims to stand vigil for the day to come and operates as a preface to transgression. Part II begins the articulation of crucial traits left implicit in this understanding of philosophy by turning to Foucault’s in-depth investigation of philosophy in Antiquity during his lectures at the Collège de France in the 1980s. First, it develops how philosophy here begins to constitute and distinguish itself by establishing itself as an activity that has a privileged relationship to truth and truth-telling as an unremitting, existentially determining challenge for the philosopher. Further, it instantiates how Platonism elaborates the need for a sustained ‘auto-ascetic’ ethical non-compliant differentiation as the condition of possibility for accessing and stating truth, and then describes how the assertion of an ethical differentiation and attitude in Cynicism takes the form of an insistent combat for another world in this world. Finally, it underlines how the ethical-practical philosophical work upon oneself in Antiquity is developed in an ongoing critical and political exchange with others. Part III indicates how ethical differentiation according to Foucault remains an essential precondition for the practice of philosophy and is further developed in the modern age. This is particularly perspicuous in Kant’s determination of the Enlightenment, in the attitude of modernity exemplified by Baudelaire, and in the history of revolt since the beginning of early Modernity. On this background, Part IV develops how philosophy as an ongoing meditative practice of self-modification leads to an affirmative critique, confirming the virtuality of this world in order to investigate the potentiality in the examined. In this manner, the essay presents Foucault’s philosophical practice as well as an outline of the history of ideas of a seemingly alternate, yet still agenda-setting conception of philosophical practice today. (shrink)

This essay argues that what makes Michel Foucault’s oeuvre not only stand apart but also cohere is an assiduous philosophical practice taking the form of an ongoing yet concrete self-modification in the medium of thought. Part I gives an account of three essential aspects of Foucault’s conception of philosophical activity. Beginning with his famous characterization of philosophy in terms of ascēsis, it moves on to articulate his characterization of philosophical practice as a distinct form of meditation, differing from both (...) Cartesian meditation and Hegelian meditation, as it aims to stand vigil for the day to come and operates as a preface to transgression. Part II begins the articulation of crucial traits left implicit in this understanding of philosophy by turning to Foucault’s in-depth investigation of philosophy in Antiquity during his lectures at the Collège de France in the 1980s. First, it develops how philosophy here begins to constitute and distinguish itself by establishing itself as an activity that has a privileged relationship to truth and truth-telling as an unremitting, existentially determining challenge for the philosopher. Further, it instantiates how Platonism elaborates the need for a sustained ‘auto-ascetic’ ethical non-compliant differentiation as the condition of possibility for accessing and stating truth, and then describes how the assertion of an ethical differentiation and attitude in Cynicism takes the form of an insistent combat for another world in this world. Finally, it underlines how the ethical-practical philosophical work upon oneself in Antiquity is developed in an ongoing critical and political exchange with others. Part III indicates how ethical differentiation according to Foucault remains an essential precondition for the practice of philosophy and is further developed in the modern age. This is particularly perspicuous in Kant’s determination of the Enlightenment, in the attitude of modernity exemplified by Baudelaire, and in the history of revolt since the beginning of early Modernity. On this background, Part IV develops how philosophy as an ongoing meditative practice of self-modification leads to an affirmative critique, confirming the virtuality of this world in order to investigate the potentiality in the examined. In this manner, the essay presents Foucault’s philosophical practice as well as an outline of the history of ideas of a seemingly alternate, yet still agenda-setting conception of philosophical practice today. (shrink)

Response to commentary. We are grateful to Crockett and Craigie for their interesting remarks on our paper. We accept Crockett’s claim that there is a need for caution in drawing inferences about patient groups from work on healthy volunteers in the laboratory. However, we believe that the evidence we cited established a strong presumption that many of the patients who are routinely taking a medication, including many people properly prescribed the medication for a medical condition, have morally significant aspects of (...) their cognition and behavior modified in a way that is unintended and may sometimes be unwelcome. Crockett notes that in some cases the effects of long-term drug use may differ, sometimes markedly, from the effects of short-term use. However, if acute use of a drug affects a neural system involved in mediating moral cognition or behavior, this nevertheless provides some evidence that chronic use of the drug may affect that same system and thus have morally significant effects. It is also plausible, in some cases, that an acute moral effect would give rise to a chronic moral effect via cognitive mechanisms. ... (shrink)

ABSTRACTIn this study, we developed a cognitive bias modification procedure that targets inferential style, and tested its effect on hope, mood, and self-esteem. Participants were randomly assigned to training conditions intended to encourage either a negative or a positive inferential style. Participants’ inferences for their failure on a cognitive challenge were congruent with their training condition. Moreover, compared to participants in the positive training condition, those in the negative condition reported less hope and exhibited lower mood and self-esteem (...) following the failure. Finally, the training affected mood and self-esteem indirectly via its effect on participants’ inferences for their failure. These findings provide support for the causal role of inferential style in depressed affect. (shrink)

The variably strict analysis of conditionals does not only largely dominate the philosophical literature, since its invention by Stalnaker and Lewis, it also found its way into linguistics and psychology. Yet, the shortcomings of Lewis–Stalnaker’s account initiated a plethora of modifications, such as non-vacuist conditionals, presuppositional indicatives, perfect conditionals, or other conditional constructions, for example: reason relations, difference-making conditionals, counterfactual dependency, or probabilistic relevance. Many of these new connectives can be treated as strengthened or weakened conditionals. They are definable conditionals. (...) This article develops a technique to infer the logic for such definable conditionals from the known logic of the underlying defining conditional. The technique is applied to central examples. The results show that a large part of the zoo of conditionals arises from a basic conditional—a constant nucleus of the different contextual and conceptual variations of variably strict conditionals. (shrink)

In this paper, I argue against recent modifications of the Knowledge Condition on intentional action that weaken the condition. My contention is that the condition is best understood in the context of Anscombe’s Intention and, when so understood, can be maintained in its strongest form.

Discussion of the ethics of memory modification technologies has often focused on questions about the limits of their permissibility. In the current paper, I focus primarily on a different issue: when is it rational to prefer MMTs to alternative interventions? My conclusion is that these conditions are rare. The reason stems from considerations of autonomy. When compared with other interventions, MMTs do a particularly poor job at promoting the autonomy of their users. If this conclusion is true, moreover, (...) it provides a fresh perspective on debates about the permissibility of MMTs. On the one hand, for those who would limit the use of MMTs to a narrow range of circumstances, the conclusion that MMTs are rarely preferable gives them further reason to eye MMTs with suspicion. On the other hand, for those who view MMTs as permissible in a wide range of circumstances, the conclusion may deflate their endorsement. (shrink)

Standard conditionals $\varphi > \psi$, by which I roughly mean variably strict conditionals à la Stalnaker and Lewis, are trivially true for impossible antecedents. This article investigates three modifications in a doxastic setting. For the neutral conditional, all impossible-antecedent conditionals are false, for the doxastic conditional they are only true if the consequent is absolutely necessary, and for the metaphysical conditional only if the consequent is ‘model-implied’ by the antecedent. I motivate these conditionals logically, and also doxastically by properties of (...) conditional belief and belief revision. For this I show that the Lewisian hierarchy of conditional logics can be reproduced within ranking semantics, provided we slightly stretch the notion of a ranking function. Given this, acceptance of a conditional can be interpreted as a conditional belief. The epistemic and the neutral conditional deviate from Lewis’ weakest system $V$, in that ID or even CN are dropped, and new axioms appear. The logic of the metaphysical conditional is completely axiomatised by $V$ to which we add the known Kripke axioms T5 for the outer modality. Related completeness results for variations of the ranking semantics are obtained as corollaries. (shrink)

We highlight a recent study exploring the hand‐off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV‐DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand‐off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post‐translational modifications (PTM). This new study examines the role that ubiquitylation and subsequent DDB2 degradation has during (...) this process. In total, this study suggests an intricate cellular timer mechanism that under normal conditions DDB2 helps recruit and ubiquitylate XPC, stabilizing XPC at damaged sites. If DDB2 persists at damaged sites too long, it is turned over by auto‐ubiquitylation and removed from DNA by the action of VCP/p97 for degradation in the 26S proteosome. (shrink)

This paper is concerned with constraints on the interpretation of pronominal anaphora, in particular Condition B effects. It aims to contribute to a particular approach, initiated by Reinhart (Anaphora and semantic interpretation, 1983) and further developed elsewhere. It proposes a modification of Reinhart’s Interface Rule, and argues that the resulting theory compares favorably with others, while being compatible with independently motivated general hypotheses about the interaction between different interpretive mechanisms.

Depression is a highly recurrent disorder with limited treatment alternatives for reducing risk of subsequent episodes. Acceptance and commitment therapy (ACT) and attention bias modification (ABM) separately have shown some promise in reducing depressive symptoms. This study investigates (a) if group-based ACT had a greater impact in reducing residual symptoms of depression over a 12-month follow-up than a control condition, and (b) if preceding ACT with ABM produced added benefits. This multisite study consisted of two phases. In phase 1, (...) participants with a history of depression, currently in remission (N= 244), were randomized to either receive 14 days of ABM or a control condition. In phase 2, a quasi- experimental design was adopted, and only phase-1 participants from the Sørlandet site (N= 124) next received an 8-week group-based ACT intervention. Self-reported and clinician-rated depression symptoms were assessed at baseline, immediately after phase 1 and at 1, 2, 6, and 12 months after the conclusion of phase 1. At 12-month follow-up, participants who received ACT exhibited fewer self-reported and clinician-rated depressive symptoms. There were no significant differences between ACT groups preceded by ABM or a control condition. There were no significant differences between ACT groups preceded by ABM or a control condition. Group-based ACT successfully decreased residual symptoms in depression over 12 months, suggesting some promise in preventing relapse. (shrink)

Responding to the co-production of screen seriality and human subjectivity within contemporary machine cultures and economies of excess, this article examines televisual affect and proposes concepts that address the languages, components and processes of particular televisual subjectivities. Discussions focus on science fiction fantasy series Farscape – a space odyssey fascinated with biotechnological evolution and mutative consciousness. This article aims to invigorate and extend the critical analysis of contemporary televisual affect, taking up questions and methodologies from Félix Guattari’s machinic ontology and (...) Georges Bataille’s formulation of a sacrificial economy to address the conditions of consumption–production relevant to television today. (shrink)

It has been shown that the orbits of motion for a wide class of non-relativistic Hamiltonian systems can be described as geodesic flows on a manifold and an associated dual by means of a conformal map. This method can be applied to a four dimensional manifold of orbits in spacetime associated with a relativistic system. We show that a relativistic Hamiltonian which generates Einstein geodesics, with the addition of a world scalar field, can be put into correspondence in this way (...) with another Hamiltonian with conformally modified metric. Such a construction could account for part of the requirements of Bekenstein for achieving the MOND theory of Milgrom in the post-Newtonian limit. The constraints on the MOND theory imposed by the galactic rotation curves, through this correspondence, would then imply constraints on the structure of the world scalar field. We then use the fact that a Hamiltonian with vector gauge fields results, through such a conformal map, in a Kaluza-Klein type theory, and indicate how the TeVeS structure of Bekenstein and Saunders can be put into this framework. We exhibit a class of infinitesimal gauge transformations on the gauge fields ${\mathcal{U}}_{\mu}(x)$ which preserve the Bekenstein-Sanders condition ${\mathcal{U}}_{\mu}{\mathcal{U}}^{\mu}=-1$ . The underlying quantum structure giving rise to these gauge fields is a Hilbert bundle, and the gauge transformations induce a non-commutative behavior to the fields, i.e. they become of Yang-Mills type. Working in the infinitesimal gauge neighborhood of the initial Abelian theory we show that in the Abelian limit the Yang-Mills field equations provide residual nonlinear terms which may avoid the caustic singularity found by Contaldi et al. (shrink)

Dysfunctional body- and shape-related attentional biases are involved in the aetiology and maintenance of eating disorders (ED). Various studies suggest that women, particularly those with ED diagnoses, focus on negatively evaluated parts of their own body, which leads to an increase in body dissatisfaction. The present study aims to empirically test the hypothesis that non-ED women show an attentional bias towards negative body parts, and that the focus on positive and negative parts of one’s own body can be modified by (...) attentional bias modification training based on a dot-probe task. Although several studies have measured body-related attentional biases by using pictures of participants’ own bodies, the approach of investigating attentional bias via a dot-probe task while presenting pictures of the participants’ own body parts and modifying the biased attention using such pictures is novel. Women (n = 60) rank-ordered ten parts of their own body regarding their attractiveness. To examine and modify the attentional focus, pictures of the self-defined positive and negative parts of one’s own body were presented by means of a dot-probe task. A paired-sample t-test revealed no difference between reaction times to negative compared to positive body parts, indicating no attentional bias towards negative parts of one’s own body. A two-way ANOVA revealed a main effect of time for pictures of positive and negative parts of one’s own body, with a decrease in reaction times from pre- to post-training. However, there was no significant interaction between time and training condition concerning reaction times to positive and negative body parts. Our findings replicate previous evidence of a balanced attentional pattern regarding one’s own body in women without ED diagnoses. However, the dot-probe task failed to modify the attentional focus. As the modifiability of state body image increases with more pronounced body dissatisfaction, the next step would be to test this approach in clinical samples of women with ED diagnoses. (shrink)

This article focuses on the philosophy underpinning the non-mainstream body modification practices of `Modern Primitives'. This subculture seeks inspiration in the body modification techniques and bodily rituals of so-called `primitive societies'. Establishing their prioritization of body, sexuality, community and spirituality as analytical links, the author shows that these self-perceived radical opponents of Western modernity nonetheless remain captured in its foundational discursive assumptions. The author argues that the movement's enthusiastic turn towards `primitivism' represents a particular identity strategy within the (...) late modern condition. Drawing on colonial discourse analysis, the author argues that the primitivist discourse originated as an ideology within colonialism and has informed the construction of the Western self-image. Modern Primitives' notion of `primitivism' is seen as a postcolonial legacy of this tradition of `othering', which inevitably reproduces stereotypes of racialized people. (shrink)

The paper introduces a proof-theoretic semantics for adjectival modification as an alternative to the traditional model-theoretic semantics basing meaning on truth-conditions. The paper considers the proof-theoretic meaning of modification by means of the three traditional adjective classes: intersective, subsective and privative. It does so by introducing a meaning-conferring natural-deduction proof system for such modification. The PTS theory of meaning is not polluted by ontological commitments, for example, a scale for beauty and a yardstick for being beautiful. (...) It only uses syntactic artefacts of the proof language. The paper also defines, by suitable rules, iterated modification, shedding light on the relationship between iteration and adjectival classes. Modification via coordinated adjectives is covered too. An appendix delineates briefly the main ingredients of PTS. (shrink)

The moral justification of Will Kymlicka's theory of minority rights is unconvincing. According to Kymlicka, cultural embeddedness is a necessary condition for personal autonomy (which is, in turn, the precondition for the good life) and for that reason liberals should be concerned about culture. I will criticize this instrumentalism of social attachments and the moral monism behind it. On the basis of a modification of Axel Honneth's theory of recognition, I will reject the false opposition between the instrumental value (...) and the intrinsic value of culture. Honneth makes a distinction between three types of recognition: (1) love; (2) respect; and (3) social esteem. Recognition of cultural difference is situated in the third sphere. But the logic of a recognition of cultural difference also demands a non-evaluative recognition, a respect for difference. Difference-respect cannot be reduced to the recognition of personal autonomy or to the recognition of a culture ‘as such’. Difference-respect is concerned with a formal recognition of difference, namely the recognition of a culture's intrinsic value for the other. By recognizing the moral importance both of personal autonomy and of social attachments, we do not have to surrender to the reductive bent in modern moral philosophy. 1 Key Words: Axel Honneth • identity • instrumentalism • intrinsic value of culture • moral justification • multiculturalism • recognition • value pluralism • Will Kymlicka. (shrink)

The genetic modification of children is becoming a more likely possibility given our rapid progress in medical technologies. I argue, from a broadly Kantian point of view, that at least one kind of such modification—modification by a parent for the sake of a child's comparative advantage—is not rationally justified. To argue this, I first characterize a necessary condition on reasons and rational justification: what is a reason for an agent to do an action in one set of (...) circumstances must be a reason for any in those circumstances to do the action. I then show that comparatively advantageous genetic modification violates this principle since a child's “getting ahead” through genetic modification cannot be rationally justified unless other children also could receive the modification, thus rendering the advantage useless. Finally, I consider the major objection to this conclusion: it seems to disallow all cases of a parent's helping a child get ahead, something that parents normally engage in with their children. I argue that typical practices of developing a comparative advantage in a child, as well as practices of societal competition in general, do not conflict because they involve circumstances that mitigate the universal character of reasons. Many ordinary cases of competitive advantage that we think of as unjust, in fact, can be explained by my argument. (shrink)

This paper explores whether terrorist violence could be morally justified or excused. It defends the absolute immunity of innocent people against those who might want to sacrifice them for other goals. The defense is based on recognizing people’s stringent natural duty of nonmaleficence, which entails an obligation on moral agents to refrain from intentionally bringing about harm or significant risk of it to the innocent. The paper is divided into two parts. The first part distinguishes between unconditional and conditional critics’ (...) arguments regarding the use of terrorist violence, and between a narrow and a broad definition of terrorism. While unconditional critics accept the narrow definition or one akin to it because they equate terrorism with murder, conditional critics accept the broad definition or one akin to it because they attempt to justify or excuse the use of terrorism based, e.g., on an analogy with a just war approach, consequentialism, moral relativism, supreme emergency or last resort. Exception is taken with the latter arguments since they attempt to justify or excuse morally unjustifiable and inexcusable actions such as the deliberate use of violence against the innocent. The second part explores plausible conditional critics’ reasons for justifying or excusing the 9/11/01 attacks and find them wanting. If the argument works, then, with minor modifications, it could also apply to the 3/11/04 attacks in Madrid, the 7/7/05 attacks in London, and similar attacks elsewhere. (shrink)

As research involving gene editing continues to advance, we are headed in the direction of being able to modify the human germline. Should we reach a point where an argument can be made that the benefits of preventing unborn children and future generations from inheriting genetic conditions that cause tremendous suffering outweigh the risks associated with altering the human germline, the next step will be to design clinical trials using this technology in humans. These clinical trials will likely require (...) careful follow-up and monitoring of future generations born with altered genes. This paper addresses some of the ethical issues raised by intergenerational monitoring and sets out to show that these issues can be avoided with careful consideration and clinical trial design. (shrink)

Autophagy functions in both selective and non‐selective ways to maintain cellular homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy responsible for the degradation of the endoplasmic reticulum through selective encapsulation into autophagosomes. ER‐phagy occurs both under physiological conditions and in response to stress cues, and plays a crucial role in maintaining the homeostatic control of the organelle. Although specific receptors that target parts of the ER membrane, as well as, internal proteins for lysosomal degradation have been identified, (...) the molecular regulation of ER‐phagy has been elusive. Recent work has uncovered novel regulators of ER‐phagy that involve post‐translational modifications of ER‐resident proteins and functional cross‐talk with other cellular processes. Herein, we discuss how morphology affects the function of the peripheral ER, and how ER‐phagy modulates the turnover of this organelle. We also address how ER‐phagy is regulated at the molecular level, considering implications relevant to human diseases. (shrink)

ABSTRACT A trivalent theory of indicative conditionals automatically enforces Stalnaker's thesis – the equation between probabilities of conditionals and conditional probabilities. This result holds because the trivalent semantics requires, for principled reasons, a modification of the ratio definition of conditional probability in order to accommodate the possibility of undefinedness. I explain how this modification is motivated and how it allows the trivalent semantics to avoid a number of well-known triviality results, in the process clarifying why these results hold (...) for many bivalent theories. In short, the slew of triviality results published in the last 40-odd years need not be viewed as an argument against Stalnaker's thesis: it can be construed instead as an argument for abandoning the bivalent requirement that indicative conditionals somehow be assigned a truth-value in worlds in which their antecedents are false. (shrink)

ABSTRACT This article focuses on issues of gender identity and bodily integrity in the context of profound desires to modify the body. It contends that, while hormonal and surgical interventions in treating gender dysphoria must continue to be considered medically necessary for many people, we do not yet fully understand why it is justified as medically necessary for this condition and not for others with similar features. The article discusses the difference between the medical classification of “gender dysphoria” and “body (...) dysmorphic disorder” and the notion of mental distress in embodiment. It discusses the role that gender essentialism may have played in the medical sanction of hormonal interventions and gender reassignment surgeries. Finally, it proffers the alternative justificatory criterion, following Eve Kosofsky Sedgwick, of “propriodescriptive authority” and explains why this justification, though highly subjective, provides better rational grounds for adjudicating which types of body modification can be considered medically necessary, grounds that can include, but also go well beyond, cases of gender dysphoria. (shrink)

Controversy swept the U.K. in January of 2000 over public disclosure of the fact that a Scottish surgeon named Robert Smith had amputated the limbs of two able-bodied individuals who reportedly suffered from a condition known as apotemnophilia. The patients, both of whom had sought and consented to the surgery, claimed they had desperately desired for years to live as amputees and had been unable, despite considerable efforts, to reconcile themselves psychologically to living with the bodies with which they were (...) born. Both surgeries were successful, and both patients, who had undergone psychiatric evaluation prior to the amputations, subsequently reported having no regrets. In the wake of a wave of sensationalistic stories in the media, the hospital at which the surgeries had been performed, the Falkirk and District Royal Infirmary, banned any future surgeries of the kind. Outraged local politicians promptly announced their intention to pass laws banning the procedure outright. One member of Scottish Parliament declared the surgery obscene and asserted that the whole thing is repugnant and legislation needs to be brought in now to outlaw this. (shrink)

Controversy swept the U.K. in January of 2000 over public disclosure of the fact that a Scottish surgeon named Robert Smith had amputated the limbs of two able-bodied individuals who reportedly suffered from a condition known as apotemnophilia. The patients, both of whom had sought and consented to the surgery, claimed they had desperately desired for years to live as amputees and had been unable, despite considerable efforts, to reconcile themselves psychologically to living with the bodies with which they were (...) born. Both surgeries were successful, and both patients, who had undergone psychiatric evaluation prior to the amputations, subsequently reported having no regrets. In the wake of a wave of sensationalistic stories in the media, the hospital at which the surgeries had been performed, the Falkirk and District Royal Infirmary, banned any future surgeries of the kind. Outraged local politicians promptly announced their intention to pass laws banning the procedure outright. One member of Scottish Parliament declared the surgery obscene and asserted that the whole thing is repugnant and legislation needs to be brought in now to outlaw this. (shrink)

When the use of CRIsPR-Cas9 to edit DNA was first reported in 2012, it was quickly heralded by scientists, policymakers, and journalists as a transformative technology. CRISPR-Cas9 provides the means to change DNA in ways that either were not generally possible using previous genetic technologies or that were orders of magnitude more laborious or inefficient to undertake. CRISPR's possible applications were readily apparent and seemingly endless, from supercharging laboratory research to modifying insects that transmit disease to eliminating genetic conditions. (...) By 2015, Wired magazine was calling the discovery "The Genesis Engine."Against a backdrop of disappointing results from gene transfer... (shrink)

Adams’s Thesis, the claim that the probabilities of indicative conditionals equal the conditional probabilities of their consequents given their antecedents, has proven impossible to accommodate within orthodox possible-world semantics. This essay proposes a modification to the orthodoxy that removes this impossibility. The starting point is a proposal by Jeffrey and Stalnaker that conditionals take semantic values in the unit interval, interpreting these (à la McGee) as their expected truth-values at a world. Their theories imply a false principle, namely, that (...) the probability of a conditional is independent of any proposition inconsistent with its antecedent. But they also point to something important, namely, that our uncertainty about conditionals is not confined to uncertainty about the facts (what the actual world is like) but also expresses uncertainty about the counterfacts (what the world would be like if one or another supposition were true). To capture this observation, this essay proposes that the semantic contents of conditionals be treated as sets of vectors of possible worlds, not singleton worlds, with the coordinates of each specifying the world that is or would be true under the supposition that it represents. The probabilities of truth for conditionals will then depend on the joint probabilities of the facts and counterfacts, the latter in turn depending on the mode of supposition. The implication of this treatment is that the probabilities of conditionals are conditional probabilities whenever the mode of supposition is evidential. (shrink)

According to existing accounts of indicative conditionals, any argument of the following form is valid: ϕ → ψ, ( ϕ ∧ ψ ) → χ ∴ ϕ → χ. Here, I present a set of counterexamples to show that there exist invalid arguments of this form. I argue that this data poses serious problems to variably strict accounts of conditionals, as such accounts are structurally unable to accommodate it. Dynamic strict accounts, however, are a different story. While existing dynamic strict (...) accounts do not accommodate the data, they are in principle able to, and I propose a modified dynamic strict account, drawing from von Fintel, that does. The key modification is this: whereas existing dynamic strict accounts take into account only the effects of conditional antecedents in changing the semantic context, the data shows that we must also take into account the effects of conditional consequents in changing the semantic context. (shrink)

The author has constructed a concept of conditionals by synthetizing and developing unconnected insights scattered through the literature. The result is incorporated in a formal deductive system, based on a series of "paradox-free" systems initiated by Alonzo Church and interpreted according to principles suggested chiefly by Everett Nelson and by Anderson and Belnap. The basic concept is the sufficiency relation holding between clauses of a conditional, or rather between the relevant states of affairs asserted by the clauses. The logic of (...) sufficiency is developed by using a phenomenological method, much like that of the ordinary-language linguists, to place restrictions on truth-functional logic. For example, conjunction is replaced by adjunction [ = df. ~ ] and this concept is used to modify modus ponens and simplification. Relevance requirements avoid the paradoxes of material implication. These principles, together with a number of physical modalities and some modifications of the concept of induction, are used to attack Goodman's paradox and the paradoxes of confirmation, and to form a concept of cause. The formal system incorporates the principles judged desirable by the analysis of how conditionals are used in discourse. Mr. Barker is modest in his claims, emphasizing that his material is not original and saying only that some of the famous paradoxes "show signs of yielding." Interested students will be grateful for this monograph. It is a valuable compendium of widely scattered work of a difficult and complicated subject, and should be both helpful and stimulating. Moreover, it is particularly clear and readable.--L. G. (shrink)

Transhumanism is a scientific and philosophical movement that proposes to overcome, through new technologies, the restrictions imposed on us by our biological condition. Some transhumanists assume that the struggle against natural limits could lead to a radical change in our body or even to its replacement. Other authors, such as Nicholas Agar, propose a moderate enhancement that does not exceed the framework of what we understand to be human. In this article, I will offer a plausible interpretation of the project (...) of human enhancement from a Thomistic perspective. To carry out my analysis, I will focus on three fundamental metaphysical and anthropological questions: How do advocates of radical enhancement understand the relationship between limits, imperfections and evils in human nature? How is this relationship understood from moderate positions? And Is any of these proposals compatible with Aquinas’ anthropology? I will conclude that the identification of limits with imperfections and evils assumed by radical positions is incompatible with Aquinas’ anthropology. Nevertheless, this does not entail that any bio-modification is unacceptable. Aquinas’ peculiar metaphysics, together with its anthropology in which the natural, the supernatural and the preternatural realms intertwine, can offer an interesting framework to assess the human enhancement project. (shrink)

In a previous paper I described a range of nonmonotonic conditionals that behave like conditional probability functions at various levels of probabilistic support. These conditionals were defined as semantic relations on an object language for sentential logic. In this paper I extend the most prominent family of these conditionals to a language for predicate logic. My approach to quantifiers is closely related to Hartry Field's probabilistic semantics. Along the way I will show how Field's semantics differs from a substitutional interpretation (...) of quantifiers in crucial ways, and show that Field's approach is closely related to the usual objectual semantics. One of Field's quantifier rules, however, must be significantly modified to be adapted to nonmonotonic conditional semantics. And this modification suggests, in turn, an alternative quantifier rule for probabilistic semantics. (shrink)

We show that a $$ -simplified morass can be added by a forcing with working parts of size smaller than $\kappa $. This answers affirmatively the question, asked independently by Shelah and Velleman in the early 1990s, of whether it is possible to do so.Our argument use a modification of a technique of Mitchell’s for adding objects of size $\omega _2$ in which collections of models – all of equal, countable size – are used as side conditions. In (...) our modification, whilst the individual models are, as in Mitchell’s technique, taken ad hoc from quite general classes, the collections of models are very highly structured, in a way that is somewhat different from, perhaps more stringent than, Mitchell’s original, arguably making the method more wieldy and giving the prospect of further uses with more delicate working parts. (shrink)