Fifty-seven years ago. Hiroshima and Nagasaki were annihilated by unprecedented state terrorism. But survivors of both cities never said "Remember Hiroshima and Nagasaki!" No survivors harbored the feeling "once recovered from devastation of the holy land, Japan will not fail to revenge". Instead, they realized in the atomic inferno that violence begets violence and pledged: "Rest in peace. We will never repeat the mistakes. No more Hiroshima, No more Nagasaki".

Pyridoxal 5′‐phosphate, the vitamin B6 derivative, acts as the coenzyme of many enzymes involved in amino acid metabolism. Exceptionally, this compound was found covalently bound to glycogen phosphorylase, the key enzyme in the regulation of glycogen metabolism. Although it is essential for the function of phosphorylase, its direct role has remained an enigma. We have recently found that the glucose moiety of pyridoxal (5′)diphospho (1)‐α‐D‐glucose, a conjugate of pyridoxal 5′‐phosphate and glucose 1‐phosphate through a pyrophosphate linkage, is transferred to the (...) nonreducing end of glycogen, forming a new α‐1,4‐glucosidic linkage. This finding emphasizes the importance of the direct phosphate‐phosphate interaction between the coenzyme and the substrate in the phosphorylase catalytic reaction. We have proposed a catalytic mechanism for phosphorylase in which the phosphate group of pyridoxal 5′‐phosphate acts as an electrophile to the phosphate group of glucose 1‐phosphate. This appears to represent the first instance of the direct involvement of a phosphate group in catalysis by enzymes. (shrink)

Progress in artificial intelligence technological innovation raises questions about the role of medical staff and the meaning of medical specialization. This study involved a qualitative survey of medical professionals and ordinary citizens to expand knowledge of this topic. A combination of Neo-Socratic Dialogue and Transfer Dialogue techniques, was used to acquire knowledge related to emerging forms of medical care and changing work demands after the implementation of AI, qualitatively analyzing the TD transcript only. Eleven subjects participated in two surveys. The (...) main points raised during TD were classified into five categories: i) Functions which AI could perform/would find difficult to perform, ii) Changes in medicine caused by AI, iii) Necessary preparations for the application of AI to medicine, iv) Concerns about AI, and v) Others. The survey findings suggest that initiatives to promote the acceptance of each individual in society and appropriate technological development are essential to the process of preparing for the changes in medicine following the implementation of AI. These preparatory conditions cannot be limited to medical professionals, and must extend to workers across all disciplines and to society as a whole. (shrink)

In recent years, ethical questions related to the development of artificial intelligence are being increasingly discussed. However, there has not been enough corresponding increase in the research and development associated with AI technology that incorporates with ethical discussion. We therefore implemented an organic and dynamic tool for use with knowledge base of AI ethics for engineers to promote engineers’ practice of ethical AI design to realize further social values. Here, “organic” means that the tool deals with complex relationships among different (...) AI ethics. “Dynamic” means that the tool dynamically adopts new issues and helps engineers think in their own contexts. Data in the knowledge base of the tool is standardized based on the ethical design theory that consists of an extension of the hierarchical representation of artifacts to understand ethical considerations from the perspective of engineering, and a description method to express the design ideas. In addition, we apply the dynamic knowledge management model called knowledge liquidization and crystallization. To discuss the effects, we introduce three cases: a case for the clarification of differences in the structures among AI ethics and design ideas, a case for the presentation of semantic distance among them, and a case for the recommendation of the scenario paths that allow engineers to seamlessly use AI ethics in their own contexts. We discuss the effectiveness of the tool. We also show the probability that engineers can reconstruct AI ethics as a more practical one with professional ethicists. (shrink)

When we examine the quality of life for each individual, several specific dimensions need to be considered. Health conditions and quality of family relationships are critical. When the individual in question is married, his/her marital quality is important. When he/she has a job, subjective assessment of that job is important. Social relationships regarding friends, neighbors, colleagues, relatives, etc. may be critical also. Although the quality of life is more than the sum of qualities of these specific areas of one's life, (...) it is still determined to a great extent by the qualities of these sub-areas, including marital and family relationships. (shrink)

When Sasaki Sokei-an founded his First Zen Institute of North America in 1930 he suggested that bringing Zen Buddhism to America was like "holding a lotus against a rock and waiting for it to set down roots." Today, Buddhism is part of the cultural and religious mainstream. Flowers on the Rock examines the dramatic growth of Buddhism in Canada and questions some of the underlying assumptions about how this tradition has changed in the West. Using historical, ethnographic, and biographical approaches, (...) contributors illuminate local expressions of Buddhism found throughout Canada and relate the growth of Buddhism in Canada to global networks. A global perspective allows the volume to overcome the stereotype that Asia and the West are in opposition to each other and recognizes the continuities between Buddhist movements in Asia and the West that are shaped by the same influences of modernity and globalization. Flowers on the Rock studies the fascinating and ingenious changes, inflections, and adaptations that Buddhists make when they set down roots in a local culture. It is essential reading for anyone interested in Buddhism, religious life in Canada, and the broader issues of multiculturalism and immigration. Contributors include Michihiro Ama, D. Mitra Barua, Paul Crowe, Melissa Anne-Marie Curley, Mavis Fenn, Kory Goldberg, Sarah F. Haynes, Jackie Larm, Paul McIvor, James Placzek, and Angela Sumegi. (shrink)

In this paper it is argued that a proper understanding of the justification of perceptual beliefs leaves open the possibility that normal humans, unaided by microscopes, could genuinely know, by direct observation, of the existence of a theoretical entity like an electron. A particular theory of justification called perceptual responsibilism is presented. If successful, this kind of view would undercut one line of argument that has been given (for example, by Bas van Fraassen) in support of scientific anti-realism. Various objections (...) to the idea that electrons can be directly observed are also considered. (shrink)

The growing scholarship on the Kyoto School of Japanese Buddhist philosophy has brought it to the attention of more and more people in the West, but in the process, the Kyoto School has acquired a fixed identity. It is usually depicted as centered around three main figures—Nishida Kitarō, Tanabe Hajime and Nishitani Keiji—and concerned with the philosophy of nothingness. In fact, however, as the thirteen scholars in this volume show, the Kyoto School included several other members beside the inner circle (...) of three, and these members were concerned with a wide range of philosophical issues beyond the philosophy of nothingness. The range and variety of these essays give a much more realistic picture of the many fronts on which the Japanese encountered Western philosophy. (shrink)