It is of fundamental importance to understand how the individual processes of gene expression, transcription, and translation, as well as mRNA and protein stability, act in concert to produce dynamic cellular proteomes. We use the concept of response times to illustrate the relation between degradation processes and responsiveness of the proteome to system changes and to provide supporting experimental evidence: proteins with short response times tend to be more strongly up‐regulated after 1 hour of TNFα stimulation than proteins with longer (...) response times. Furthermore, based on process‐dependent response times, we demonstrate that synthesis and degradation act in concert to enable rapid responses. Finally, by building on a previously published data set quantifying the mammalian gene expression cascade, we speculate on how combinations of stable and unstable mRNAs and proteins may be wired to transcriptional or translational regulation to support gene function. (shrink)

Whether the prefrontal cortex is part of the neural substrates of consciousness is currently debated. Against prefrontal theories of consciousness, many have argued that neural activity in the prefrontal cortex does not correlate with consciousness but with subjective reports. We defend prefrontal theories of consciousness against this argument. We surmise that the requirement for reports is not a satisfying explanation of the difference in neural activity between conscious and unconscious trials, and that prefrontal theories of consciousness come out of this (...) debate unscathed. (shrink)

Resultant moral luck occurs whenever aspects of an agent’s moral responsibility are affected by luck pertaining to the outcomes of their actions. Many authors reject the existence of moral luck in this sense, but they do so in different ways. Michael Zimmerman argues that resultant luck affects the scope of moral responsibility, but not its degree. That is, it affects what agents are responsible for, but not how responsible they are. Andrew Khoury takes a more resolute approach, arguing that both (...) the scope and the degree of moral responsibility are free from resultant luck. -/- In this paper, I criticize both accounts and develop an alternative. I argue, first, that Khoury’s approach leads to an implausibly far-reaching error-theory about moral responsibility. Second, Zimmerman’s account cannot account for all the ways in which moral responsibility comes in degrees. Third, these problems can be overcome by introducing a distinction between two concepts of responsibility that both come with scope and degree. The first concept I call internal responsibility, as it applies exclusively to agent-internal factors. The second concept I call external responsibility, as it applies to (partly) agent-external factors such as actions and their outcomes. Given this distinction, we can avoid the problems of Khoury’s as well as Zimmerman’s accounts while preserving the central intuition behind the rejection of resultant moral luck. (shrink)

I develop a theory of counterfactuals about relative computability, i.e. counterfactuals such as 'If the validity problem were algorithmically decidable, then the halting problem would also be algorithmically decidable,' which is true, and 'If the validity problem were algorithmically decidable, then arithmetical truth would also be algorithmically decidable,' which is false. These counterfactuals are counterpossibles, i.e. they have metaphysically impossible antecedents. They thus pose a challenge to the orthodoxy about counterfactuals, which would treat them as uniformly true. What’s more, I (...) argue that these counterpossibles don’t just appear in the periphery of relative computability theory but instead they play an ineliminable role in the development of the theory. Finally, I present and discuss a model theory for these counterfactuals that is a straightforward extension of the familiar comparative similarity models. (shrink)

Local theories of consciousness state that one is conscious of a feature if it is adequately represented and processed in sensory brain areas, given some background conditions. We challenge the core prediction of local theories based on long-lasting postdictive effects demonstrating that features can be represented for hundreds of milliseconds in perceptual areas without being consciously perceived. Unlike previous empirical data aimed against local theories, localists cannot explain these effects away by conjecturing that subjects are phenomenally conscious of features that (...) they cannot report. We also discuss alternative explanations that localists could offer. (shrink)

Traditionally, the manufacturer/operator of a machine is held (morally and legally) responsible for the consequences of its operation. Autonomous, learning machines, based on neural networks, genetic algorithms and agent architectures, create a new situation, where the manufacturer/operator of the machine is in principle not capable of predicting the future machine behaviour any more, and thus cannot be held morally responsible or liable for it. The society must decide between not using this kind of machine any more (which is not a (...) realistic option), or facing a responsibility gap, which cannot be bridged by traditional concepts of responsibility ascription. (shrink)

In this article, I try to shed new light on Frege’s envisaged definitional introduction of real and complex numbers in _Die Grundlagen der Arithmetik_ (1884) and the status of cross-sortal identity claims with side glances at _Grundgesetze der Arithmetik_ (vol. I 1893, vol. II 1903). As far as I can see, this topic has not yet been discussed in the context of _Grundlagen_. I show why Frege’s strategy in the case of the projected definitions of real and complex numbers in (...) _Grundlagen_ is modelled on his definitional introduction of cardinal numbers in two steps, tentatively via a contextual definition and finally and definitively via an explicit definition. I argue that the strategy leaves a few important questions open, in particular one relating to the status of the envisioned abstraction principles for the real and complex numbers and another concerning the proper handling of cross-sortal identity claims. (shrink)

To study consciousness, scientists need to determine when participants are conscious and when they are not. They do so with consciousness detection procedures. A recurring skeptical argument against those procedures is that they cannot be calibrated: there is no way to make sure that detection outcomes are accurate. In this article, I address two main skeptical arguments purporting to show that consciousness scientists cannot calibrate detection procedures. I conclude that there is nothing wrong with calibration in consciousness science.

Logical empiricism is commonly seen as a counter-position to scientific realism. In the present paper it is shown that there indeed existed a realist faction within the logical empiricist movement. In particular, I shall point out that at least four types of realistic arguments can be distinguished within this faction: Reichenbach’s ‘probabilistic argument,’ Feigl’s ‘pragmatic argument,’ Hempel’s ‘indispensability argument,’ and Kaila’s ‘invariantist argument.’ All these variations of arguments are intended to prevent the logical empiricist agenda from the shortcomings of radical (...) positivism, instrumentalism, and other forms of scientific antirealism. On the whole, it will be seen that logical empiricism and scientific realism are essentially compatible with each other. Especially Kaila’s invariantist approach to science (and nature) comes quite close to what nowadays is discussed under the label ‘structural realism.’ This, in turn, necessitates a fundamental reevaluation of Kaila’s role in the logical empiricist movement in particular and in twentieth-century philosophy of science in general. (shrink)

American critical realism was defended in two versions, an “essentialist” and an “empirical.” The main proponent of the essentialist version was George Santayana, who in his Scepticism and Animal Faith (1923) outlined a critical realist account of epistemology based substantially on an articulate doctrine of essences. In the present paper, an attempt is made to critically examine the resulting approach, particularly in relation to perception. It will be argued that Santayana failed to develop a sufficiently convincing essentialist view of perception, (...) and that his actual significance in terms of the impact of the critical realist movement was, contrary to what is often claimed, quite limited. (shrink)

"Rechtsphilosophie zwischen Ost und West" ist das erste Buch, das systematisch das frA1/4he Werk des bedeutenden chinesischen Rechtsgelehrten, Richters, Diplomaten und Schriftstellers John C.H. Wu (1899-1986) behandelt. Die Arbeit setzt sich in chronologischer Reihenfolge kritisch mit den VerAffentlichungen Wus im Zeitraum von 1921 bis 1936 auseinander. Wu, spAter Verfechter einer dynamischen Naturrechtslehre, versucht, die mehr pragmatisch-funktionale Rechtsauffassung der fA1/4hrenden amerikanischen Rechtsgelehrten mit dem von Kant geprAgten Denken R. Stammlers zu einer inneren Begegnung zu bringen. Gleichzeitig ist die Thematik chinesischen Rechtsdenkens (...) und Philosophierens immer gegenwArtig. Die Arbeit legt ein besonderes Augenmerk auf den EinfluA von Wus kulturellem Hintergrund auf die Auseinandersetzung mit westlichem Denken und umgekehrt auf den EinfluA seiner westlichen Ausbildung auf seine Analyse der chinesischen Gedankenwelt. Das Buch will verstArkt auf diesen wichtigen Denker aufmerksam machen und den Grundstein fA1/4r eine wissenschafliche Auseinandersetzung mit ihm legen. Der Leser bekommt nicht nur einen interessanten Einblick in die zeitgeschichtlichen, rechtsphilosophischen Auseinandersetzungen, er bekommt auf einem wenig begangenen Weg Zugang zur chinesischen Kultur. (shrink)

The aim of the current investigation is to analyze the writings On Kingship in the context of sole rulership in Antiquity. Writings On Kingship first appeared in the time of Alexander the Great and flourished during the Hellenistic period, but there are although some treatises written under Roman rule during the Imperial period and in Late Antiquity. Starting point of the analysis is to understand the treatises On Kingship as a literary genre. By taking into account the authors, the addressees, (...) the implicit readers, and the content as well as the literary form it can be shown that the writings On Kingship played an important role in the always difficult communication between kings and Greek cities during the Hellenistic period. As the communicative contexts changed during the Roman Imperial period and in Late Antiquity, the treatises On Kingship lost their original social function. Therefore, the sporadic writings originating from post-Hellenistic times can be understood as a case of failed literary reception. (shrink)

Die Beiträge zur Altertumskunde enthalten Monographien, Sammelbände, Editionen, Übersetzungen und Kommentare zu Themen aus den Bereichen Klassische, Mittel- und Neulateinische Philologie, Alte Geschichte, Archäologie, Antike Philosophie sowie Nachwirken der Antike bis in die Neuzeit. Dadurch leistet die Reihe einen umfassenden Beitrag zur Erschließung klassischer Literatur und zur Forschung im gesamten Gebiet der Altertumswissenschaften.

This paper deals with the question whether some morally normative content is grounded in the dialogical practice that both Apel and Habermas call argumentative discourse, and if so how to demonstrate that it is so grounded. Apel (unlike Habermas) claims that discourse has rationally necessary conceptual presuppositions; that morally normative content is part of such presuppositions; and that this can be ascertained in transcendendal reflection, i.e. by a kind of transcendental argument. I argue that these claims can be charitably interpreted (...) but require clarifications of their key concepts, i.e. “discourse”, “validity claims”, “performative self-contradiction”, and “community of communication”. I argue that discourse as a practice of reason-sensitive agents who are communicatively connected via argumentation can be explained by its normatively constitutive aim, namely fixing the true values of our reasons; that the primary level of validity claims are claims concerning good reasons; that performative self-contradictions are pragmatic-cum-logical inconsistencies that we can know apriori to be incompatible with discourse’s constitutive aim; and finally, that competent discourse participants can know apriori that they would be performatively inconsistent if they flouted a moral kernel that is intrinsic in discourse. (shrink)

This volume explores the relation between legal reasoning and logic from both a historical and a systematic perspective. The topics addressed include, among others, conditional legal acts, disjunctions in legal acts, presumptions and conjectures, conflicts of values, Jørgensen´s Dilemma, the Rhetor´s Dilemma, the theory of legal fictions and the categorization of contracts. The unifying problematic of these contributions concerns the conditional structures and, more particularly, the relationship between legal theory and legal reasoning in the context of conditions.

Introspection is the capacity by which we know our own conscious mental states. Several theories aim to explain it. According to acquaintance theory, we know our experiences by being acquainted with them. Acquaintance is non-causal, non-inferential, and non-observational. I present a dilemma for the acquaintance theory of introspection. Either subjects are always acquainted with all their experiences; or some attentional mechanism selects the relevant experiences (or aspects of experiences) for introspection. The first option is implausible: it implies that subjects are (...) omniscient about their own experiences. The second option is also implausible: if acquaintance is a non-causal relation, introspection cannot target specific (aspects of) experiences without violating the principle of causal closure of the physical. (shrink)

For several decades, Monographien und Texte zur Nietzsche-Forschung (MTNF) has set the agenda in a rapidly growing and changing field of Nietzsche scholarship. The book series is international in orientation and reflects the entire spectrum of research on Nietzsche. The series publishes monographs and edited volumes that undergo a strict peer-review process. The series is led by an international team of editors.

This comprehensive volume gives a panorama of the best current work in this lively field, through twenty specially written essays by the leading figures in the field. All essays deal with foundational issues, from the nature of mathematical knowledge and mathematical existence to logical consequence, abstraction, and the notions of set and natural number. The contributors also represent and criticize a variety of prominent approaches to the philosophy of mathematics, including platonism, realism, nomalism, constructivism, and formalism.

In diesem Open-Access-Buch wird eine Verteidigung des nicht-reduktiven Physikalismus gegen den Vorwurf des Epiphänomenalismus entwickelt. Der nicht-reduktive Physikalismus besagt im Kern, dass mentale Eigenschaften zwar nicht mit physischen Eigenschaften identisch sind, sie aber dennoch so eng an physische Eigenschaften gebunden sind, dass man sinnvollerweise von einer auf grundlegender Ebene rein physischen Welt sprechen kann. Der Vorwurf des Epiphänomenalismus wendet gegen den nicht-reduktiven Physikalismus ein, dass aus seiner Grundidee folgt, dass es keine mentale Verursachung gibt: Wenn mentale Eigenschaften tatsächlich nicht mit (...) physischen Eigenschaften identisch sind, sondern lediglich eng an sie gebunden sind, dann können mentale Eigenschaften niemals kausal wirksam werden. Die in diesem Buch entwickelte Verteidigung beruht auf einer Unterscheidung zwischen zwei Begriffen der Kausalität: Kausaler Produktion und kausaler Abhängigkeit. Es wird dafür argumentiert, dass der nicht-reduktive Physikalismus zwar darauf festgelegt ist, dass es keine mentale Verursachung im Sinne von kausaler Produktion gibt. Diese Konsequenz kann jedoch akzeptiert werden. Denn aus dem nicht-reduktiven Physikalismus folgt keineswegs, dass es keine mentale Verursachung im Sinne von kausaler Abhängigkeit gibt. (shrink)

In his paper `Finitism', W.W.~Tait maintained that the chief difficulty for everyone who wishes to understand Hilbert's conception of finitist mathematics is this: to specify the sense of the provability of general statements about the natural numbers without presupposing infinite totalities. Tait further argued that all finitist reasoning is essentially primitive recursive. In our paper, we attempt to show that his thesis ``The finitist functions are precisely the primitive recursive functions'' is disputable and that another, likewise defended by him, is (...) untenable. The second thesis is that the finitist theorems are precisely those $\Pi^0_1$-sentences that can be proved in. (shrink)

This book considers Robert Brandom's philosophy and presents an original and exciting analysis of the semantic argument in legal argumentation.

Theories of graded causation attract growing attention in the philosophical debate on causation. An important field of application is the controversial relationship between causation and moral responsibility. However, it is still unclear how exactly the notion of graded causation should be understood in the context of moral responsibility. One question is whether we should endorse a proportionality principle, according to which the degree of an agent’s moral responsibility is proportionate to their degree of causal contribution. A second question is whether (...) a theory of graded causation should measure closeness to necessity or closeness to sufficiency. In this paper, we argue that we should indeed endorse a proportionality principle and that this principle supports a notion of graded causation relying on closeness to sufficiency rather than closeness to necessity. Furthermore, we argue that this insight helps to provide a plausible analysis of the so-called ‘Moral Difference Puzzle’ recently described by Bernstein. (shrink)

Phänomenologie der Normativität ist der Versuch zu zeigen, wie Normativität in der menschlichen Natur gründet. Im Anschluss an die phänomenologische Anthropologie Max Schelers und Helmuth Plessners stellt der Autor die Strukturen menschlichen Lebens heraus, die alle menschlichen Lebensformen fundieren. Menschen sind Lebewesen, die einen Leib haben, und dieses Phänomen ist ursprünglicher als die Unterscheidung von Körper und Geist. Hält man sich dies vor Augen, werden bestimmte Formen menschlicher Normativität verständlich: Die menschliche Lebensweise ist auf ein Gleichgewicht verschiedener Formen des Miteinanders (...) angelegt, das nur möglich ist, weil es leiblich vermitteltes Ausdrucksverstehen gibt. Mitfühlen mit dem anderen und Liebe zu ihm fundiert das Erkennen, und was menschliche Würde ist, verstehen wir, weil wir wissen, wie die Integrität des Leibes geschützt, aber auch verletzt werden kann. (shrink)

Die vorliegende erste deutschsprachige Monographie über den russischen Literaturwissenschaftler und Kulturphilosophen Michail Bachtin (1895-1975) geht der unter der schillernd-mehrdeutigen Oberfläche von Bachtins Arbeiten verborgenen Tiefenstruktur seines Denkens nach. In der Tiefe zeigt sich als die entscheidende Eigenart literarischer Texte ihr Wertcharakter. Die Konsequenzen, die sich daraus für die Produktion und Rezeption von literarischer Kunst ergeben, werden in der vorliegenden Arbeit kritisch erörtert.

Conditional structures lie at the heart of the sciences, humanities, and everyday reasoning. It is hence not surprising that conditional logics – logics specifically designed to account for natural language conditionals – are an active and interdisciplinary area. The present book gives a formal and a philosophical account of indicative and counterfactual conditionals in terms of Chellas-Segerberg semantics. For that purpose a range of topics are discussed such as Bennett’s arguments against truth value based semantics for indicative conditionals.

The core feature that distinguishes moods from emotions is that moods, in contrast to emotions, are diffuse and global. This article outlines a dispositional theory of moods (DTM) that accounts for this and other features of mood experience. DTM holds that moods are temporary dispositions to have or to generate particular kinds of emotion-relevant appraisals. Furthermore, DTM assumes that the cognitions and appraisals one is disposed to have in a given mood partly constitute the experience of mood. This article outlines (...) a number of implications of DTM (e.g., regarding the noncognitive causation and rationality of moods) and summarizes empirical results supporting the theory. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 1, Page 80-99, January 2022.

Opponents to consciousness in fish argue that fish do not feel pain because they do not have a neocortex, which is a necessary condition for feeling pain. A common counter-argument appeals to the multiple realizability of pain: while a neocortex might be necessary for feeling pain in humans, pain might be realized differently in fish. This paper argues, first, that it is impossible to find a criterion allowing us to demarcate between plausible and implausible cases of multiple realization of pain (...) without running into a circular argument. Second, opponents to consciousness in fish cannot be provided with reasons to believe in the multiple realizability of pain. I conclude that the debate on the existence of pain in fish is impossible to settle by relying on the multiple realization argument. (shrink)

The current global COVID-19 pandemic has led to a deep and multidimensional crisis across all sectors of society. As countries contemplate their mobility and social-distancing policy restrictions, we have a unique opportunity to re-imagine the deliberative frameworks and value priorities in our food systems. Pre-pandemic food systems at global, national, regional and local scales already needed revision to chart a common vision for sustainable and ethical food futures. Re-orientation is also needed by the relevant sciences, traditionally siloed in their disciplines (...) and without adequate attention paid to how the food system problem is variously framed by diverse stakeholders according to their values. From the transdisciplinary perspective of food ethics, we argue that a post-pandemic scheme focused on bottom-up, regional, cross-sectoral and non-partisan deliberation may provide the re-orientation and benchmarks needed for not only more sustainable, but also more ethical food futures. (shrink)