BackgroundAs a consequence of precision medicine initiatives, genomic technologies have rapidly spread around the world, raising questions about genetic privacy and the ethics of data sharing. Previous scholarship in bioethics and science and technology studies has made clear that different nations have varying expectations about trust, transparency, and public reason in relation to emerging technologies and their governance. The key aims of this article are to assess genetic literacy, perceptions of genetic testing, privacy concerns, and governing norms amongst the Singapore (...) population by collecting surveys.MethodsThis study investigated genetic literacy and broad public attitudes toward genetic tests in Singapore with an online public survey (n = 560). To assess potential changes in attitudes following receipt of results from a genetic test, we also surveyed undergraduate students who underwent a genetic screen as part of a university class before and after they received their test results (n = 25).ResultsPublic participants showed broad support for the use of genetic tests; scored an average of 48.9% in genetic literacy; and expressed privacy concerns over data sharing and a desire for control over their genetic data. After taking a genetic test and receiving genetic test results, students reported less fear of genetic tests while other attitudes did not change significantly.ConclusionThese findings highlight the potential of genetic education and active engagement with genetic testing to increase support and participation in genomic projects, PM, and biobanking initiatives; and they suggest that data privacy protections could potentially reduce discrimination by giving participants control over who can access their data. More specifically, these findings and the dataset we provide may be helpful in formulating culturally sensitive education programs and regulations concerning genomic technologies and data privacy. (shrink)

In contemporary philosophy, various attempts have been made in relation to placing our minds or mental states in the natural world or nature. In this context, there is a clear divide between naturalism and anti-naturalism, materialism and immaterialism, etc. Driven by the influence of naturalistic turn in philosophy and scientism, many philosophers have tried to put forth various naturalistic accounts of the relationship between mind and natural world. However, many of these accounts are naturalistic based on the modern scientific conception (...) of nature which has been hailed as the dominating conception of nature. John McDowell in his magnum opus Mind and World, while criticizing modern scientific account of the relationship between mind and world, has not resorted back to anti-naturalism. Instead, he has tried to give us certain clues to develop an account of an alternative form of naturalism which is at the same time radically different from both scientific naturalism and mysterious anti-naturalism. In this paper, I will try to search for an alternative naturalism following McDowell and examine to what extent this account is tenable. In this context, we shall discuss various approaches to understand the relation between reason/normativity (which is one of the significant constituting elements of our mind) and natural world. (shrink)

Bangladesh continues to experience stubbornly high levels of rural malnutrition amid steady economic growth and poverty reduction. The policy response to tackling malnutrition shows an overwhelmingly technocratic bias, which depoliticizes the broader question of how the agro-food regime is structured. Taking an agrarian and human rights-based approach, this paper argues that rural malnutrition must be analyzed as symptomatic of a deepening agrarian crisis in which the obsession with productivity increases and commercialization overrides people’s democratic right to culturally appropriate, good, nutritious (...) food. Using qualitative insights from a case study of three villages, this research illustrates how agricultural modernization and commercialization reproduce rural malnutrition by degrading local biodiversity and the rural poor’s access to nutrient-rich diets. In so doing, it undermines the official discourse’s simplistic and literal reading of malnutrition as a pathological health condition resulting from the mere absence of certain micronutrients in the human body, and thus questions the adequacy of the proposed solutions. Instead, this research suggests that solving malnutrition in large part involves facilitating the rural poor’s access to nutritious diets through democratizing and reorganizing the agriculture sector in a manner that is eco-friendly and unconstrained by market imperatives. It cautiously advances agroecology and food sovereignty as possible alternatives, while recognizing that overcoming the challenges agrarian class conflict, gender disparity and urban–rural divide pose would not be easy. (shrink)

I here describe meanings attributed to the term consciousness, extracted from the literature and from recent online discussions. Forty such meanings were identified and categorized according to whether they were principally about function or about experience; some overlapped but others were apparently mutually exclusive - and this list is by no means exhaustive. Most can be regarded as expressions of authors' views about the basis of con-sciousness, or opinions about the significance of aspects of its con-tents. The prospects for reaching (...) any single, agreed, theory independent definition of consciousness thus appear remote. How-ever, much confusion could be avoided if authors were always to spec-ify which aspects of consciousness they refer to when using the term. An example is outlined of how this can be done. (shrink)

Here presented are three singular, philosophical perspectives on the Delhi student protests which took place in 2019 and 2020, before the coronavirus pandemic. The writers hail from India, England...

This study aims to identify the ethical challenges in the process of product marketing. It conducted a bibliometric study to evaluate the major ethical concerns in the area of product marketing. The data for the current study was extracted using the Scopus database. The study uses VOSviewer and Biblioshiny-bibliometrix to analyze the data. The results revealed that in the twenty-first century, ethical concerns and research related to pharmaceutical marketing, consumption behavior, and sustainability have significantly grown and are emerging as important (...) issues. The study is novel in its approach and develops a theoretical model to know ethical issues related to product marketing with multidimensional process (i.e., identification, search strategy, and analysis) for a long-term sustainable business success. By this study, the academicians and researchers will focus greater attention on the rapidly developing human-techno-centric world to fulfill the organizations’ service promises. The study contributes to the marketing ethics literature, particularly to the literature related to ethical issues in product marketing. (shrink)

Post-modernism and its influence in Sri Lanka.

During meditation, consciousness/awareness is usually enhanced because of higher attention and concentration, which inter-dependently co-arise thru appropriate interactions between neural signals. Nāgārjuna rejects ‘inherent existence’ or ‘essence’ in favor of co-dependent origination (Pratītyasamutpāda), and that is also why he rejects causality; the entities that lack inherent existence dependently co-arise. Causality is a major issue in metaphysical views. The goals of this article are as follows: (I)Which entities lack ‘inherent existence’ or ‘essence’ and which ones inherently exist? (II) Do the entities (...) that lack inherent existence dependently co-arise and hence can we reject causality as in Nāgārjuna’s philosophy? (III) Do the entities that exist inherently cause entities that lack inherent existence? (IV) Do structure, function, experience, and environment cause each other? And (V)We critically analyze, extend, and examine Nāgārjuna’s philosophy of dependent co- origination in the extended Dual-Aspect Monism (eDAM) framework. Our analysis suggests that: (i) All conventional entities lack inherent existence. However, the dual-aspect unmanifested state of the primal entity (unified information field (UIF), emptiness, Śūnyatā, a neutral entity of Neutral Monism, or Brahman) inherently exists. The dual-aspect unmanifested state of UIF has (a) physical unified information field (PUIF, quantum vacuum, ‘zero- point field’/ZPF)as physical aspect and (b) unified potential consciousness information field (UPCIF) as the non-physical aspect. The subjective experiences (SEs) of objects and of the subject (self) are the excitations or modes of the UPCIF, so they are derived entities and hence they lack inherent existence. The dual-aspect unmanifested state of UIF/emptiness/Śūnyatā is fundamental and irreducible, and hence it inherently exists. (ii) The entities that lack inherent existence dependently co-arise, and hence causality for them can be rejected but instead conditions (such as efficient, percept-object, immediate, and dominant conditions) are necessary, as in Nāgārjuna’s philosophy. (iii) It is unclear that the dual-aspect primal entity UIF (Brahman/emptiness/Śūnyatā) that exists inherently cause entities that lack inherent existence. Most likely, all manifested entities inter-dependently co-arise thru natural laws built-in the UIF when necessary conditions for a manifested entity are satisfied thru interaction among relevant entities. (iv) It is unclear that structure, function, experience, and environment cause each other. A cause must, at the same time, be an effect of another cause. This implies that there is no first cause. Therefore, the structure, function, and experience inter-dependently co-arise thru co-evolution, co-development, sensorimotor co-tuning, and the interaction among relevant entities after the necessary conditions of manifestation of a specific entity are satisfied; and they are linked via conditions. (v) In the extended Dual-Aspect Monism (eDAM) framework, the physical aspect of a state of a manifested entity and that of the non-physical aspect (with functional, qualitative, cognitive, and experiential sub-aspects) of the same state of the same entity inseparably co-exist in each state of each entity at all levels. However, the degrees of manifestations of inseparable physical and non-physical aspects vary with the states, levels of entities, and contexts. Moreover, manifested entities lack inherent existence. In other words, the physical aspect and that of the non-physical aspect of manifested entities dependently co- arise, co-evolve, co-develop, and co-tuned for sensorimotor system appropriately depending on the levels of entities and contexts, which along with common “effective”information entail the inseparability of both aspects. In this sense, the symmetry between physical and non-physical aspects of a state of an entity (such as brain-mind system) is maintained, where the physical aspect (from third person perspective) does not cause the inseparable non-physical aspect (from first-person perspective) in living systems or vice- versa. (shrink)

: In prior work, we reported the followings: There are about forty meanings attributed to the term consciousness. They were identified and categorized according to whether they were principally about function or about experience. The frameworks for consciousness that are based on materialism, idealism, and dualism have serious problems. Therefore, an extended dual-aspect monism framework was proposed for consciousness, where the problematic materialism/panpsychism based integrated information theory was interpreted and the inseparability between physical and non-physical aspect holds because none of (...) the empirical fMRI/EEG data shows separability between aspects. This has the least number of problems compared to all other frameworks. It required a novel feature that the potentiality of primary irreducible subjective experiences co-exists with its physical aspect in nature. This missing information in science is provided by the eDAM, which addresses the hard problem of consciousness successfully, which is elaborated in detail in this article. Resumo: Em trabalho anterior, relatamos o seguinte: existem cerca de quarenta significados atribuídos ao termo consciência; eles foram identificados e categorizados conforme se referiam à função ou à experiência; as abordagens da consciência baseadas no materialismo, idealismo e dualismo têm sérios problemas. Por conseguinte, a abordagem do monismo de duplo aspecto estendido foi proposta para a consciência, em que: a problemática teoria da informação integrada, baseada no materialismo/pampsiquismo, foi interpretada; e se afirma a inseparabilidade entre aspectos físicos e não físicos, pois os dados empíricos das imagens por ressonância magnética funcional e eletroencefalografia não mostram dissociação entre os aspectos. O eDAM tem o menor número de problemas, em comparação com todas as outras abordagens, implicando que a potencialidade das experiências subjetivas, irredutíveis e primárias, coexiste com o seu aspecto físico na natureza. Esta informação, ausente na ciência, é fornecida pelo eDAM, que aborda com êxito o problema difícil da consciência, o que é elaborado em detalhe neste artigo. (shrink)

In the third Whitehead Psychology Nexus Studies, we have discussed (i) the dual-aspect-dual-mode proto-experience (PE)-subjective experience (SE)framework of consciousness based on neuroscience, (ii) its implication in war, suffering, peace, and happiness, (iii) the process of sublimation for optimizingthem and converting the negative aspects of seven groups of self-protective energy system (desire, anger, ego, greed, attachment, jealousy, and selfishlove)into their positive aspects from both western and eastern perspectives (Vimal, 2009b). In this article, we summarize the recent development since then as (...) follows. (1) In (Vimal, 2010), we rigorously investigated the classical and quantum matching and selection processes for precisely experiencing a specific SE in a specific neural-network. (2) In (Vimal, 2009i), we unpacked the quantum view of superposition related to the superposition-based hypothesis H1 of our framework in terms of subquantum dual-aspect primal entities (bhutatmas) and addressed the related explanatory gaps. (3) We developed alternative hypotheses of our framework, namely, the superposition-then-integration-emergence based H2, the integration-emergence based H3, the intelligent mechanism based H4, and the vacuum/Aether based H5. We concluded that our framework with H1 is the most optimal one because it has the least number of problems (Vimal, 2009j). (4) We found over 40 different but overlapping meanings attributed to the term ‘consciousness’ and suggested that authors must specify which aspect ofconsciousness they refer to when using this term to minimize confusion (Vimal, 2009f). (5) We proposed definitions of consciousness, qualia, mind, and awareness (Vimal, 2009h). (6) We investigated the necessary ingredients for access (reportable) consciousness: wakefulness, re-entry, attention, working memory and so on (Vimal, 2009g). (7) We discussed Nâgârjuna’s philosophy of dependent co-origination with respect to our PE-SE framework (Vimal, 2009a). (8) We linked dynamic systems theory and fractal catalytic theory with standard representation theory using our framework (Vimal, 2009d). (9) We introduce the PE-SE aspects of consciousness in theoretical classical and quantum physics including loop quantum gravity and string theory (Vimal, 2009k). (10) In (Vimal, 2009c), we proposed that the SE of subject or ‘self’ in self-related neural-network is tuned to the self-related SEs/PEs superposed in other innumerable entities during samadhi state via matching and selection processes. This leads to bliss, ecstasy, or exceptionally high degree of climax at samadhi state. We conclude that, so far, the dualaspect-dual-mode PE-SE framework with hypothesis H1 is the most optimal framework for explaining our conventional reality because it has the least number of problems. Keywords: Evolution of consciousness; Internal representation; Sensorimotor interaction; Dual-aspect model; Subjective experience; Protoexperiences, Explanatory gap; Mind-brain problem; Purusha; Prakriti; Eastern and Western perspectives; Yoga; Sublimation process; Whitehead; Process and Reality; Occasions of experience; Superposition; Subquantum dual-aspect primal entities (bhutatmas); Superposition-then-integration-emergence; Integration-emergence; Intelligent mechanism; Vacuum/Aether; qualia; Mind; Awareness; Nâgârjuna; Classical and quantum physics; Loop quantum gravity; String theory. (shrink)

In the third Whitehead Psychology Nexus Studies, we have discussed (i) the dual-aspect-dual-mode proto-experience (PE)-subjective experience (SE)framework of consciousness based on neuroscience, (ii) its implication in war, suffering, peace, and happiness, (iii) the process of sublimation for optimizingthem and converting the negative aspects of seven groups of self-protective energy system (desire, anger, ego, greed, attachment, jealousy, and selfishlove)into their positive aspects from both western and eastern perspectives (Vimal, 2009b). In this article, we summarize the recent development since then as (...) follows. (1) In (Vimal, 2010), we rigorously investigated the classical and quantum matching and selection processes for precisely experiencing a specific SE in a specific neural-network. (2) In (Vimal, 2009i), we unpacked the quantum view of superposition related to the superposition-based hypothesis H1 of our framework in terms of subquantum dual-aspect primal entities (bhutatmas) and addressed the related explanatory gaps. (3) We developed alternative hypotheses of our framework, namely, the superposition-then-integration-emergence based H2, the integration-emergence based H3, the intelligent mechanism based H4, and the vacuum/Aether based H5. We concluded that our framework with H1 is the most optimal one because it has the least number of problems (Vimal, 2009j). (4) We found over 40 different but overlapping meanings attributed to the term ‘consciousness’ and suggested that authors must specify which aspect ofconsciousness they refer to when using this term to minimize confusion (Vimal, 2009f). (5) We proposed definitions of consciousness, qualia, mind, and awareness (Vimal, 2009h). (6) We investigated the necessary ingredients for access (reportable) consciousness: wakefulness, re-entry, attention, working memory and so on (Vimal, 2009g). (7) We discussed Nâgârjuna’s philosophy of dependent co-origination with respect to our PE-SE framework (Vimal, 2009a). (8) We linked dynamic systems theory and fractal catalytic theory with standard representation theory using our framework (Vimal, 2009d). (9) We introduce the PE-SE aspects of consciousness in theoretical classical and quantum physics including loop quantum gravity and string theory (Vimal, 2009k). (10) In (Vimal, 2009c), we proposed that the SE of subject or ‘self’ in self-related neural-network is tuned to the self-related SEs/PEs superposed in other innumerable entities during samadhi state via matching and selection processes. This leads to bliss, ecstasy, or exceptionally high degree of climax at samadhi state. We conclude that, so far, the dualaspect-dual-mode PE-SE framework with hypothesis H1 is the most optimal framework for explaining our conventional reality because it has the least number of problems. Keywords: Evolution of consciousness; Internal representation; Sensorimotor interaction; Dual-aspect model; Subjective experience; Protoexperiences, Explanatory gap; Mind-brain problem; Purusha; Prakriti; Eastern and Western perspectives; Yoga; Sublimation process; Whitehead; Process and Reality; Occasions of experience; Superposition; Subquantum dual-aspect primal entities (bhutatmas); Superposition-then-integration-emergence; Integration-emergence; Intelligent mechanism; Vacuum/Aether; qualia; Mind; Awareness; Nâgârjuna; Classical and quantum physics; Loop quantum gravity; String theory. (shrink)

Event segmentation theory posits that people segment continuous experience into discrete events and that event boundaries occur when there are large transient increases in prediction error. Here, we set out to test this theory in the context of story listening, by using a deep learning language model (GPT‐2) to compute the predicted probability distribution of the next word, at each point in the story. For three stories, we used the probability distributions generated by GPT‐2 to compute the time series of (...) prediction error. We also asked participants to listen to these stories while marking event boundaries. We used regression models to relate the GPT‐2 measures to the human segmentation data. We found that event boundaries are associated with transient increases in Bayesian surprise but not with a simpler measure of prediction error (surprisal) that tracks, for each word in the story, how strongly that word was predicted at the previous time point. These results support the hypothesis that prediction error serves as a control mechanism governing event segmentation and point to important differences between operational definitions of prediction error. (shrink)

Journal of Human Values, Volume 28, Issue 1, Page 7-10, January 2022.

The study is an attempt to understand the prevailing discourse in India on education as a right by closely reading the parliamentary debates on The Right of Children to Free and Compulsory Educatio...

The extended dual-aspect monism framework of consciousness, based on neuroscience, consists of five components: (1) dual-aspect primal entities; (2) neural-Darwinism: co-evolution and co-development of subjective experiences (SEs) and associated neural-nets from the mental aspect (that carries the SEs/proto-experiences (PEs) in superposed and unexpressed form) and the material aspect (mass, charge, spin and space-time) of fundamental entities (elementary particles), respectively and co-tuning via sensorimotor interaction; (3) matching and selection processes: interaction of two modes, namely, (a) the non-tilde mode that is the (...) material and mental aspect of cognition (memory and attention) related feedback signals in a neural-network, which is the cognitive nearest past approaching towards present; and (b) the tilde mode that is the material and mental aspect of the feed forward signals due to external environmental input and internal endogenous input, which is the nearest future approaching towards present and is a entropy-reversed representation of non-tilde mode; (4) the segregation and integration of information, and (5) the necessary ingredients of SEs (such as wakefulness, attention, re-entry, working memory, stimulus at or above threshold level, and neural-net PEs). This framework leads to structural and functional coherence between the mind and the brain, bridges the explanatory gap (the gap between SEs and their neural-correlates), and leads to our mundane subjective experiences. This extended dual-aspect monism (eDAM) framework (Vimal, 2008, 2010, 2013, 2015a, 2015b) could be the fundamental basis of various religions and philosophies. This is a Western perspective. On the other hand, Eastern perspectives emphasize the practical methods for achieving altered experience at samadhi state. An important corollary of these methods (such as yogic method) is the sublimation of negative aspects of seven groups of self-protective energy system (desire, anger, ego, greed, attachment, jealousy, and selfish-love) into their positive aspects. Their negative aspects create war and suffering, whereas their positive aspects advance science and technology, family values, peace, and happiness. Here, the Western perspective framework is extended to include the concepts of the sublimation process to encompass Eastern perspectives. The four elements (war, suffering, peace, and happiness) are ubiquitous in both space and time because they are essential contributors to the variations for natural selection in our evolutionary system. The sublimation process optimizes the system: minimizes war and suffering, maximizes peace and happiness, and enhances family values and individual progress. This is consistent with both Eastern and Western perspectives. (shrink)

This book by an internationally reputed Indian scientist traces the developments of Science, Religion and Philosophy in human civilization through the ages. The common underlying bond-more specifically, a linkage of philosophy with both science and religion-has been examined incisively. All the three sub-areas of human culture have been presented from a holistic point of view, and at the same time, stressing some of their irreconcilable basic differences in scope and outlook. Meant primarily for general readers, the book achieves a fine (...) balance between basic comcepts, historical evolution and a critical unbiased analysis of rituals, dogmas, unresolved queries and it leads to an enlightened view of 'humanism', 'Nature', 'Unity of man', need for a new paradigm of social and political order transcending globalization and control of resources of weaker nations by supremacy in global power equation. The book reviews the wisdom of the ancient Hindus, Buddhism, Jainism and of the three semitic religions-Judaism, Christianity and Islam. It presents a concise account of the Indian Vedas, Vedangan, Saddarsana, the two epics and the Bhagavadgita, of the philosophy and science of the Greeks, science and technology of ancient Egypt, Babylonia and China. A valuable special feature is a summary of the status of present-day science, starting with the classical phase, and ending with the developments in the last century comprising the Theory of Relativity, quantum physics, genetics, various aspects of human consciousness, modern astronomy, astrophysics and cosmology. Last but not least, the author critically reviews some of the presentday fashionable discourses on 'science as the best way to reach God' and leads the readers to an appraisal of the on-going researches on the unification of the four fundamental interactions of physical sciences. He ends with the inexorable conclusion that this unification, when fully achieved, would still not strictly identify the unique force as 'God as concieved in different religions. (shrink)

We present an inventory of business ethics-related content to supplement and reinforce classroom education. The 23 films and documentaries introduced here allow the instructor to illustrate ethical issues in a manner which resonates with students. While sixteen of these selections involve fictitious plots, three selections (The Corporation, Enron: The Smartest Guys in the Room, and Inside Job) are documentaries, and four selections (Barbarians at the Gate, Rogue Trader, The Pursuit of Happyness, and Too Big to Fail) are based on a (...) dramatization of actual events. For each selection, we present a contextual synopsis and leading questions to help instructors demonstrate the existence of ethical issues so that students may gain a better understanding of the need for ethical behavior and practices in business. We also categorize various ethical breaches by functional business areas. (shrink)

About forty meanings attributed to the term consciousness can be identified and categorized based on functions and experiences. The prospects for reaching any single, agreed-upon, theory-independent definition of consciousness appear remote. Here, the goal is to search for a theory-dependent optimal and general definition accommodating most views. This quest is mostly based on the premise that evolution must have optimized our mental system in terms of experience and function. Based on a dual-aspect dual-mode proto-experience/subjective experience optimal framework, an optimal definition (...) of consciousness describes it as a mental aspect of a system or a process with two sub-aspects: conscious experience and conscious function. A more general definition describes consciousness as a mental aspect of a system or a process, which is a conscious experience, a conscious function, or both, depending on contexts and particular biases . Both experiences and functions can be conscious and/or non-conscious. Our definitions are a posteriori insofar as they are based on observation and categorization. (shrink)

Topics in Cognitive Science, Volume 14, Issue 2, Page 414-425, April 2022.

Incomplete penetrance and variable expressivity are non‐Mendelian phenomena resulting in the lack of correlation between genotype and phenotype. Not withstanding the diversity in mechanisms, differential expression of homologous alleles within cells manifests as variations in penetrance and expressivity of mutations between individuals of the same genotype. These phenomena are seen most often in dominantly inherited diseases, implying that they are sensitive to concentration of the gene product. In this framework and the advances in understanding the role of microRNA (miRNA) in (...) fine‐tuning gene expression at translational level, we propose miRNA‐mediated regulation as a mechanism for incomplete penetrance and variable expressivity. The presence of miRNA binding sites at 3′ UTR, co‐expression of target gene–miRNA pairs for genes showing incomplete penetrance and variable expressivity derived from available data lend support to our hypothesis. Single nucleotide polymorphisms in the miRNA target site facilitate the implied differential targeting of the transcripts from homologous alleles. (shrink)

We propose a novel edge detector in the presence of Gaussian noise with the use of proximal support vector machine (PSVM). The edges of a noisy image are detected using a two-stage architecture: smoothing of image is first performed using regularized anisotropic diffusion, followed by the classification using PSVM, termed as regularized anisotropic diffusion-based PSVM (RAD-PSVM) method. In this process, a feature vector is formed for a pixel using the denoised coefficient’s class and the local orientations to detect edges in (...) all possible directions in images. From the experiments, conducted on both synthetic and benchmark images, it is observed that our RAD-PSVM approach outperforms the other state-of-the-art edge detection approaches, both qualitatively and quantitatively. (shrink)

Examples are worked out using a new equation proposed in the previous paper to show that it has new physical predictions for mesoscopic systems.

Akshaya Mukul, Gita Press and the Making of Hindu India. Noida: HarperCollins Publishers India, The New India Foundation, 2015. 540 pp., ₹799. ISBN: 139789351772309; 109351772306.

Euthanasia has been a subject of debate worldwide. It has brought up multiple controversies in different countries and among different societies. Over the years, euthanasia has been an active topic of research in the field of bioethics, owing to its numerous ethical and legal implications. In this article, we take a brief look into the laws and legislation surrounding euthanasia in different parts of the world.

This brief paper argue about a possible philosophical description of the implicate order starting from a simple theoretical experiment. Utilizing an EPR source and the human eyes of a "single" person, we try to investigate the philosophical and physical implications of quantum entanglement in terms of implicate order. We know, that most specialists still disagree on the exact number of photons required to trigger a neural response, although there will be many technical challenges, we assume that neural response will be (...) achieved in some way. The objective of paper is to investigate possible links between: quantum mechanics, quantum cognitive science, brain and mind. At the moment, the questions are more than the answers. We argue that we are perennially immersed in the implicate order and that the "real path" of quantum entanglement process is from the implicate order towards explicate order, not vice versa. Finally, we speculate about the common ground between the implicate order and chitta. (shrink)

A great deal has been made of the question of whether nano-materials provide a unique set of ethical challenges. Equally important is the question of whether they provide a unique set of regulatory challenges. In the last 18 months, the US Environmental Protection Agency has begun the process of trying to meet the regulatory challenge of nano using the Toxic Substances Control Act (1976)(TSCA). In this central piece of legislation, ‘newness’ is a critical concept. Current EPA policy, we argue, does (...) not adequately (or ethically) deal with the novelty of nano. This paper is an exploration of how to do a better job of accounting for nanomaterials as ‘new.’ We explore three alternative ways that nanomaterials might be made to fall under the TSCA regulatory umbrella. Since nanomaterials are of interest precisely because of the exciting new properties that emerge at the nano-scale, each of these three alternatives must meet what we call the ‘novelty condition’ and avoid what we call the ‘central paradox’ of existing regulatory policy. Failure to meet either of these conditions is a moral failure. We examine both the strengths and weaknesses of each alternative in order to illuminate the conceptual, practical, and moral challenges of novelty. (shrink)

A great deal has been made of the question of whether nano-materials provide a unique set of ethical challenges. Equally important is the question of whether they provide a unique set of regulatory challenges. In the last 18 months, the US Environmental Protection Agency has begun the process of trying to meet the regulatory challenge of nano using the Toxic Substances Control Act (1976)(TSCA). In this central piece of legislation, ‘newness’ is a critical concept. Current EPA policy, we argue, does (...) not adequately (or ethically) deal with the novelty of nano. This paper is an exploration of how to do a better job of accounting for nanomaterials as ‘new.’ We explore three alternative ways that nanomaterials might be made to fall under the TSCA regulatory umbrella. Since nanomaterials are of interest precisely because of the exciting new properties that emerge at the nano-scale, each of these three alternatives must meet what we call the ‘novelty condition’ and avoid what we call the ‘central paradox’ of existing regulatory policy. Failure to meet either of these conditions is a moral failure. We examine both the strengths and weaknesses of each alternative in order to illuminate the conceptual, practical, and moral challenges of novelty. (shrink)

Professor Brian V. Johnstone, CSsR, has been quietly and unobtrusively contributing to the intellectual life of Catholicism, especially in the field of moral theology, for nearly four decades. Having published numerous theological articles on many topics, including biomedical ethics, peace and war, and fundamental moral theology, and directed many doctoral dissertations, it is no exaggeration to say that he has dedicated his entire life to teaching and writing theology. In honor of Johnstone's work, this felicitation volume covers a wide range (...) of themes in the Christian moral life with original articles written by internationally recognized theologians. In the spirit of Johnstone's thought and work, each article challenges the reader to reflect upon the present while contemplating the future of moral theology. (shrink)

BackgroundNeuropsychological profile of Indian Duchenne muscular dystrophy subjects remains unidentified and needs to be evaluated.MethodsA total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsychological assessment. The factor indexes were derived from various components of Malin’s Intelligence Scale for Indian Children and Rey Auditory Verbal Learning Test.ResultsPoor verbal and visual memory profiles were demonstrated by DMDs, which include RAVLT-immediate recall, RAVLT-delayed recall, Rey–Osterrieth complex figure test -IR, and RCFT-DR. RAVLT-memory efficiency index demonstrated poor verbal memory efficiency. (...) Significant differences in the functioning of working memory axis [RAVLT T1, recency T1, Digit Span Backward ] were observed along with reduced performance in visuomotor coordination, visuospatial, and visual recognition abilities. Block designing efficiency index and attention fraction showed a normal performance in DMD kids.ConclusionWorking memory deficits were found to be the crucial element of cognitive functioning in DMD cases. Working memory interventions may be beneficial to improve the neuropsychological profile in DMD. (shrink)

Interleukin‐1 receptor‐associated kinase‐1 (IRAK1) is linked to the pathogenesis of atherosclerosis; however, its role in macrophage foam cell formation is not known. Therefore, the present study investigated the role of IRAK1 in lipid uptake, biosynthesis, and efflux in THP‐1 derived macrophages and human monocyte‐derived macrophages (HMDMs). Ox‐LDL (40 μg/mL, 15 minutes–48 hours) treatment induced time‐dependent increase in IRAK1, IRAK4, and Stat1 activation in THP‐1 derived macrophages. IRAK1/4 inhibitor (INH) or IRAK1 siRNA significantly attenuated cholesterol accumulation, DiI‐Ox‐LDL binding, and uptake while (...) cholesterol efflux to apoAI and HDL was enhanced in THP‐1 derived macrophages and HMDMs. Ox‐LDL treatment significantly increased the mRNA expression of CD36, LOX‐1, SR‐A, ABCA1, ABCG1, Caveolin‐1, CYP27A1 while that of SR‐BI was decreased. IRAK1/4 inhibition or IRAK1 knockdown, however, attenuated Ox‐LDL‐induced CD36 expression; augmented ABCA1 and ABCG1 expression while expression of others was unaffected in THP‐1 derived macrophages and HMDMs. Moreover, IRAK1/4 inhibition had no significant effect on genes involved in lipid biosynthesis. In IRAK1/4 INH pre‐treated THP‐1 derived macrophages Ox‐LDL‐induced Stat1 phosphorylation and its binding to CD36 promoter was significantly attenuated while LXRα expression and its binding to the ABCA1/ABCG1 locus, NFATc2 activation and its binding to ABCA1 locus was enhanced. The present study thus demonstrates that IRAK regulates lipid accumulation by modulating CD36‐mediated uptake and ABCA1‐, ABCG1‐dependent cholesterol efflux. Therefore, IRAK1 can be a potential target for preventing macrophage foam cell formation. (shrink)

In multiple robot systems, the problem of allocation of complex tasks to heterogeneous teams of robots, also known as the multiple robot coalition formation problem, has begun to receive considerable attention. Efforts to address the problem range from heuristics based approaches that search the subspaces of the coalition structure to evolutionary learning approaches. Conventional approaches typically strive to optimize a single objective function such as the number of tasks executed or the time required to execute all tasks, or a weighted (...) function of such objectives. In real world applications, objectives such as minimizing distance traveled and maximizing the number of tasks completed are often conflicting in nature. The coalition formation problem thus naturally lends itself to a multi-objective optimization approach based on evolutionary learning. In this paper, we formulate the problem of mapping coalitions of robots to a set of tasks as a multi-objective optimization problem and propose a variant of non-dominated sorting genetic algorithm to arrive at trade-off solutions. Additionally, we extend the solution to domains where robot resources are non-additive. Simulations demonstrate the efficacy of the proposed approach in generating the set of Pareto-optimal solutions. (shrink)