Human monoclonal antibodies are extremely difficult to obtain by hybridoma technology. As an alternative, ‘human‐like’ antibodies have been produced by recombinant DNA technology. The first such engineered antibodies consisted of chimaeric proteins, in which murine variable regions were linked to human constant regions. More recently ‘human’ antibodies have been ‘reshaped’ by transplanting the binding site of a murine antibody into a human antibody. Further‐more antibodies have been dissected into groups of domains (Fab's, Fc's) and for example, Fab's have been joined (...) to enzymes resulting in antibody‐enzyme chimaeras. In addition to their potential clinical applications, engineered antibodies will prove invaluable in studies of structure/function relationships of variable and constant regions. (shrink)

Vivimos dentro de sistemas socioeconámicos humanos demasiado grandes en relación con la biosfera que los contiene, por una parte; y sistemas mal adaptados, sistemas humanos que encajan mal en los ecosistemas naturales. El problema de escala reclama un movimiento de autolimitación por parte de las sociedades humanas, que podríamos concebir bajo la idea de gestión global de la demanda; el problema de estructura exige una reconstrucción de la tecnosfera de acuerdo con principios de biomímesis.

In recent years, the full text of papers are increasingly available electronically which opens up the possibility of quantitatively investigating citation contexts in more detail. In this study, we introduce a new form of citation analysis, which we call citation concept analysis (CCA). CCA is intended to reveal the cognitive impact certain concepts—published in a highly-cited landmark publication—have on the citing authors. It counts the number of times the concepts are mentioned (cited) in the citation context of citing publications. We (...) demonstrate the method using three classical highly cited books: (1) The structure of scientific revolutions by Thomas S. Kuhn, (2) The logic of scientific discovery—Logik der Forschung: Zur Erkenntnistheorie der modernen Naturwissenschaft in German—, and (3) Conjectures and refutations: the growth of scientific knowledge by Karl R. Popper. It is not surprising—as our results show—that Kuhn’s “paradigm” concept seems to have had a significant impact. What is surprising is that our results indicate a much larger impact of the concept “paradigm” than Kuhn’s other concepts, e.g., “scientific revolution”. The paradigm concept accounts for about 40% of the concept-related citations to Kuhn’s work, and its impact is resilient across all disciplines and over time. With respect to Popper, “falsification” is the most used concept derived from his books. Falsification is the cornerstone of Popper’s critical rationalism. (shrink)

Seen from a national business system perspective, the notion of corporate social responsibility (CSR) emerges as a specifically US‐American response to challenges regarding the corporate place in society. With the spread of American capitalism, however, CSR is bound to come into contact – and conflict – with other approaches to the role of business in society that have been shaped by different national cultures. Within Europe, one such area of potential conflict concerns the role of organised labour in representing employee (...) interests. Studying the perceptions held by European trade unions on stakeholding, as one of the important concepts in the CSR discourse, does indeed reveal a considerable degree of union scepticism of CSR and its terminology. There is, however, also embryonic evidence of at least some unions attempting to link the CSR discourse to traditional union goals. Furthermore, national differences in union responses to CSR are beginning to emerge, which may, in turn, further shape the evolution of national business systems in Europe. (shrink)

Der emanzipatorische Ansatz des Denkens von Mably und Rousseau und ihre Zuneigung zum «Volk» können sich nicht konsequent zu einem geschlossenen politischen System entfalten, weil die vorindustrielle Sozialperspektive der Autoren und ihre ambivalente Haltung zu den noch traditionellen Unterschichten dem entgegenstehen. Folgerichtig gewinnen ihre politischen Theorien eine verwirrende Vielgestaltigkeit, die immer wieder zu einseitigen Interpretationen geführt hat.

PLoS ONE 3(3): e1897. doi:10.1371/journal.pone.

La tentación con que seduce el utopismo tecnológico, desde los mismos orígenes de la Modernidad occidental –recordemos la isla de Bensalem de Francis Bacon en su New Atlantis–, es el completo dominio sobre la naturaleza. Hoy, la mentalidad dominante en occidente –que tiende a convertirse en una cosmovisión universal– tiene mucho en común con las creencias de los antiguos gnósticos. Se piensa que la ciencia y la técnica pueden permitir a la mente humana escapar de las limitaciones que caracterizan su (...) estado natural, liberándose del anclaje a la materia biológica y escapando de la condición humana. En definitiva, ser dioses –dioses pensados como Superingenieros Inmortales. hemos de resistir frente a esas ilusiones destructivas, lo cual significa: la racionalidad técnica tiene que realizar su propia crítica de la razón utópica. Sin esta autocrítica será inviable un uso sensato de las técnicas y tecnologías, con su enorme potencial para la mejora de la condición humana, al tiempo que evitamos –si aún fuese posible– la deriva exterminista, nihilista y suicida de la civilización industrial. (shrink)

"A commentary containing glosses on The Last Third of Book II, Book IV (De arte dialectica) entire, and approximately a third of Book V (De rhetorica) of Martianus Capella"--Introduction.

We discuss various ways, which have been plainly justified in the secondhalf of the twentieth century, to introduce infinitesimals, and we considerthe new style of reasoning in mathematical analysis that they allow.

This was the address given on the occasion of the award of the Goethe Institute’s Goethe Medal to the Hungarian philosopher Ágnes Heller in 2010. Other recipients of the Medal have included Bruno Bettelheim, György Ligeti, Ernst Gombrich, Karl Popper, and Lars Gustafsson.

_sciousness called ‘neurophenomenology’ (Varela 1996) and illustrates it with a_ _recent pilot study (Lutz et al., 2002). At a theoretical level, neurophenomenology_ _pursues an embodied and large-scale dynamical approach to the_ _neurophysiology of consciousness (Varela 1995; Thompson and Varela 2001;_ _Varela and Thompson 2003). At a methodological level, the neurophenomeno-_ _logical strategy is to make rigorous and extensive use of first-person data about_ _subjective experience as a heuristic to describe and quantify the large-scale_ _neurodynamics of consciousness (Lutz 2002). (...) The paper foocuses on_ _neurophenomenology in relation to three challenging methodological issues_ _about incorporating first-person data into cognitive neuroscience: (i) first-person_ _reports can be biased or inaccurate; (ii) the process of generating first-person_ _reports about an experience can modify that experience; and (iii) there is an ‘ex-_ _planatory gap’ in our understanding of how to relate first-person, phenomeno-_ _logical data to third-person, biobehavioural data._. (shrink)

Studies into corporate social responsibility (CSR) in small and medium-sized enterprises (SMEs) have suggested that small businesses are different to the large companies on which CSR research usually focusses. Extending this argument, this article raises the question what differences in approaches to CSR there are within the SME category. Analysing the CSR strategy and performance of a medium-sized fashion retailer in the United Kingdom through manager interviews as well as customer and employee surveys, the article develops an analytical framework of (...) CSR in small, medium and large firms. The argument is developed that medium-sized firms occupy a transition stage, where some CSR features that are reminiscent of small enterprises are still important but get overlaid with aspects that are more typical of large companies. (shrink)

This paper analyzes an explicit instantiation of the program of “neurophenomenology” in a neuroscientific protocol. Neurophenomenology takes seriously the importance of linking the scientific study of consciousness to the careful examination of experience with a specific first-person methodology. My first claim is that such strategy is a fruitful heuristic because it produces new data and illuminates their relation to subjective experience. My second claim is that the approach could open the door to a natural account of the structure of human (...) experience as it is mobilized in itself in such methodology. In this view, generative passages define the type of circulation which explicitly roots the active and disciplined insight the subject has about his/her experience in a biological emergent process. (shrink)

Son vastas y múltiples las dimensiones éticas del uso de la energía (dimensiones ético-políticas, poliéticas, para quienes pensamos que hay continuidad entre ética y política). Tras esbozar un mapa de este campo de problemas, nos centramos en las dificultades que afrontan las transiciones energéticas y argumentamos que solo encarando una profunda transformación de las formas de producción y los modos de vida se podrían evitar, quizá, los escenarios peores. Las técnicas humildes deberían desplegarse en marcos de ecofeminismo de subsistencia o (...) ecosocialismo descalzo. (shrink)

Aristotle earns the distinction of having put forward the first comprehensive philosophical theory of justice. After the end of the antique world, St. Thomas Aquinas was the first philosopher and theologian to return to Aristotles theory of justice. This will be followed by a summary of the core aspects of Aquinass treatise on law and political theory, and explicated accordingly.

Versión previa de un capítulo del libro inédito Interdependientes y ecodependientes. Iniciación a la ética ecológica , que publicará Ed. Proteus (Barcelona) en 2012.

The particular situation of the French administrative detention center medical units appears to be an exemplary case to study the difficulties facing medical practice. Indeed, the starting point of our inquiry was an amazing observation that needed to be addressed and understood: why are professional interpreters so seldom requested in ADC medical units, where one would expect that they would be “naturally” present? Aiming to fully explore the meanings of the “absent interpreter”, this article takes into account the possible meanings (...) of this situation: the recourse to professional interpreters in France is far from expected given cumulative evidence of its benefits; perceptions of illegal immigrants and medical habitus itself may both hamper the use of a third party; the ADCs are a very stressful place for healthcare professionals, with conflicting missions, political issues enmeshed with medical goals, and heavy affective burden that may lead to self-protection. Silencing voices of suffering others might be seen as the hidden indecent truth of the “absent interpreter”. These reflections open a window to a larger issue with regard to the full range of medicine: what are the place, the role and the function of patient’s words and narratives in contemporary medicine? The highly invested somatic perspective and its political corollary giving primacy to bare life harbor potential risks of obscuring speeches and undervaluing narratives. (shrink)

Seen from a national business system perspective, the notion of corporate social responsibility emerges as a specifically US‐American response to challenges regarding the corporate place in society. With the spread of American capitalism, however, CSR is bound to come into contact – and conflict – with other approaches to the role of business in society that have been shaped by different national cultures. Within Europe, one such area of potential conflict concerns the role of organised labour in representing employee interests. (...) Studying the perceptions held by European trade unions on stakeholding, as one of the important concepts in the CSR discourse, does indeed reveal a considerable degree of union scepticism of CSR and its terminology. There is, however, also embryonic evidence of at least some unions attempting to link the CSR discourse to traditional union goals. Furthermore, national differences in union responses to CSR are beginning to emerge, which may, in turn, further shape the evolution of national business systems in Europe. (shrink)

Codes of conduct have become the perhaps most often used tool to manage corporate social responsibility (CSR). Researchers have primarily analysed such documents at company-wide or trans-company levels, whereas there is a dearth of studies into the use of codes for particular corporate functions. Hence, this article will examine one particular group of sub-company level codes, namely codes of conduct that stipulate CSR criteria for suppliers. Examining such ethical sourcing policies adopted by the FTSE100 corporations, the article draws out what (...) environmental, social and economic issues large corporations perceive to be important in the management of their supply chains. At an aggregate level, the coverage of CSR issues is rather extensive, yet at the level of the individual corporation a degree of selectivity in the issues that are addressed becomes noticeable. The code content analysis furthermore confirms the business case and public pressure to be the most important drivers of CSR. Finally, the study highlights the role of isomorphic processes in the adoption of CSR tools. (shrink)

In 1638, the Jesuit, poet, preacher, and historianJohannes Bisselius published the first volume of his seasonal poem Deliciae Veris, Pleasures of Spring. The subtly composed, stylistically unique cycle is presented here for the first time in a modern edition with a German translation and insightful commentary, including an introduction to each poem.".

In contrast to the recent rise to economic importance of offshore finance centres (OFCs), the topic of taxation has so far created little interest among scholars of corporate social responsibility (CSR). This paper makes two contributions to addressing this lacuna. Applying a range of influential normative theories of ethics, it first offers an ethical evaluation of tax havens. Second, the paper examines what use large firms that are headquartered in two OFCs—Bermuda and the Cayman Islands—make of formal CSR tools. The (...) emerging duplicity in tax havenbased companies professing social responsibility highlights once more the political nature of CSR, where at least some firms and/or industries can successfully limit government power to enact regulation as well as shape the discourse around CSR. The study of CSR in OFC-based firms thus calls into question the usefulness of the often quoted definition of CSR as going beyond the law. (shrink)

Der Autor analysiert die Bedeutung und die methodische wie systematische Funktion des Begriffs der Negation in der Philosophie Sartres und unternimmt eine Nachkonstruktion ihres Ansatzes als eine Theorie der Negation. Das leitende Erkenntnisinteresse ist die Begrundung der Einheit von Bewusstsein und Freiheit durch den Aufweis ihrer jeweiligen negativen Strukturen.".

Time and Poverty in Western Welfare States is the English-language adaptation of one of the most important contributions to welfare economics published in recent years. Professors Leibfried and Leisering offer a time-based analysis of the study of poverty, and suggest the need for a radical re-think of conventional theoretical and policy approaches. The core of this study is the empirical analysis of the life course of recipients of 'Social Assistance' in Germany, although the conclusions are put into a wider context (...) of socio-economic and socio-political analysis and comparative observations are made with other countries, notably the USA. Time, Life and Poverty will be of interest to upper-level students, researchers and policy-makers in a wide range of social science disciplines, including: economics, social policy, sociology, psychology and European studies. (shrink)

Zusammenfassung Anhand empirischer Daten zum organisationalem Verhalten von Ganztagsschulen und Sportvereinen wird der Frage nachgegangen, welche allgemeine Organisationstheorie Ansätze zur Erklärung von Kooperationen zwischen Ganztagsschulen und Sportvereinen bereitstellen kann. Nach der kriteriengestützten Identifikation erkenntnisträchtiger Organisationstheorien erfolgt eine explorative hypothesengeleitete empirische Prüfung der Transaktionskostentheorie, der Evolutionstheorie sowie der Theorie der Strukturation mit Längsschnittdaten aus Rheinland-Pfalz. Es zeigt sich, dass der Transaktionskostenansatz das Kooperationsverhalten von Sportvereinen, jedoch nicht von Ganztagsschulen, erklären kann. Die Evolutionstheorie leistet Beiträge zur Erklärung von Stabilität in der Population (...) der Ganztagsschulen sowie zum Wandel bei einem Teil der Kooperationspartner. Das Kooperationsverhalten von Ganztagsschulen kann damit ebenso wie mit der Theorie der Strukturation nicht theoriekonform interpretiert werden. (shrink)

Narrative is increasingly being recognised as an important tool both to manage and understand organisations. In particular, narrative is recognised to have an important influence on the perception of environmental issues in business, a particularly contested area of modern management. Management literature is, however, only beginning to develop a framework for evaluating the quality and legitimacy of narratives. Due to the highly fluid nature of narratives, the traditional notion of truth as reflecting ' objective reality' is not useful here. In (...) this article, an alternative approach that evaluates a narrative in two stages is developed. First, a horizontal reading investigates the surface of the narrative, its textual features, instrumental devices and its integrity as a text, to assess the quality of a narrative. Second, a more philosophical or vertical reading makes explicit the underlying value assumptions that author and reader bring to the writing and reading of the narrative to assess the narrative's claim to legitimacy. The framework is then tested against a narrative on the relationship between business and environment as espoused by a supply chain manager of a UK-based manufacturing company. (shrink)

Rationality has been a principle widely assumed in economics from early on. In contrast, rationality in the formation of economic expectations is rather new. Since the term “rational expectations” has meanwhile become a kind of slogan for diverse issues in economics as in related fields, there is some danger of authors’ not always being aware of the true meaning of this technical term. Sometimes it is used, in a context where expectation formation about uncertain events is essential, as if rational (...) expectations solved this fundamental problem. (shrink)

The existing scholarly literature on the work and life of Max Weber has almost nothing to say about Max Weber's dissertation which was part of his first book, The History of Commercial Partnerships. This article reconstructs the development of this work. It explores how Weber chose and developed his dissertation, describes its major themes, and analyzes the academic contexts that framed it. Of particular interest is Max Weber's relationship to Levin Goldschmidt, a leading scholar in the history of commercial law, (...) and Weber's dissertation chair; also the assessment of each scholar's work by the other. The article also sheds light on how Weber's dissertation influenced his early career and it addresses Weber's personal life during this time, including Weber's relationship to his cousin Emmy Baumgarten, and his life as a bachelor at his parents' home, ruled by Max Weber Sr. The analysis reveals the remarkable academic challenges Weber faced and the obstacles he overcame in writing his first book, as well as his own extraordinarily difficult personal circumstances. An appendix presents a synopsis of the main arguments and themes of Weber's dissertation. (shrink)

The supply chain management function is currently undergoing a dramatic change: it is adopting an increasingly strategic role. However, this growing financial importance is matched in only a handful of exemplary companies by a greater contribution to environmental protection initiatives in the supply chain. This paper explores some of the obstacles to greater supply chain management involvement in environmental protection and offers suggestions for greener supply. At a personal level, the gap between public opinion on the environment and managerial values (...) needs to be closed, and the support offered by management education and by professional bodies needs to be improved. Within the organisation, the reward structure for supply chain managers needs to move away from narrow economic criteria. Greener supply would also benefit from a larger supply chain management role in corporate strategy making; the function could even be offered a seat on the Board of Management. Changes to the mode of supply chain management, including improvements to the information flow on environmental issues, the decision–making tools used in the face of complex environmental challenges and novel approaches to supply chain management need to receive urgent attention. (shrink)