Cancer screening programmes cause harm to individuals via overdiagnosis and overtreatment, even where they confer population-level benefit. Screening thus appears to violate the principle of non-maleficence, since it entails medically unnecessary harm to individuals. Can consent to screening programmes negate the moral significance of this harm? In therapeutic medical contexts, consent is used as a means of rendering medical harm morally permissible. However, in this paper, I argue that it is unclear that the model of consent used within therapeutic medicine (...) can be applied unproblematically to preventive medicine. Invitation to screening changes the pragmatic norms and expectations of the patient–doctor encounter such that two key principles of consent may be violated. First, the pragmatics of a medical invitation are such that patients may fail to be adequately informed, since patients appear to assume medical invitations are made with their best interests in mind, even where information to the contrary is outlined. Second, screening invitations may place pressure on patients; in the context of a medical encounter, to make an invitation to screening may constitute an inducement to accept. In order to be sure that a patient’s consent to a screening invitation is valid, we must make clear to patients that their decision to accept screening may be shaped not only by how information about screening is presented, but by the pragmatic form of the invitation itself. (shrink)

I claim that consciousness, just as thought or action, is only to be found at the personal level of explanation. Dennett's account is often taken to be at odds with this view, as it is seen as explicating consciousness in terms of sub-personal processes. Against this reading, and especially as it is developed by John McDowell, I argue that Dennett's work is best understood as maintaining a sharp personal/sub-personal distinction. To see this, however, we need to understand better what content (...) ascription at the sub-personal level actually means. When we do we can see how Dennett presents both a philosophical account of consciousness and informed empirical speculation on the nature of its sub-personal underpinnings. Consciousness is a product of certain capacities that are intelligible only at the personal level, capacities that are neither present at the sub-personal level of brain mechanism nor present in 'sub-persons', e.g. some, if not all, non-human animals. (shrink)

The point of departure in this article is the Danish debate about democracyin schools. This article presents a first step in a study of how the relationshipbetween democracy and education can be understood. A juxtaposition of thetwo concepts requires, first of all, an analysis of how the concept of democracyis used in the educational debate. In this article three models of democracy areapplied as an analytical framework: a liberal model (Hobbes, Locke, Kant, Rawls,Dworkin), a communitarian model (MacIntyre, Sandel, Nussbaum) and (...) a communicative/deliberativemodel (Walzer, Benhabib, Taylor, Habermas). Numerous contradictions and tensionsbetween concepts of democracy and education can be found in such a juxtaposition,depending on which conception of democracy one chooses to apply. In this articleI discuss which conception affords us the most meaningful concept of democraticteaching. As an introduction, a brief historical overview of the interplay betweendemocracy and education in Danish school is provided. (shrink)

AbstractBackgroundEthical challenges constitute an inseparable part of daily decision-making processes in all areas of healthcare. In prehospital emergency medicine, decision-making commonly takes place in everyday life, under time pressure, with limited information about a patient and with few possibilities of consultation with colleagues. This paper explores the ethical challenges experienced by prehospital emergency personnel. MethodsThe study was grounded in the tradition of action research related to interventions in health care. Ethical challenges were explored in three focus groups, each attended by (...) emergency medical technicians, paramedics, and prehospital anaesthesiologists. The participants, 15 in total, were recruited through an internal information network of the emergency services. Focus groups were audio-recorded and transcribed verbatim.ResultsThe participants described ethical challenges arising when clinical guidelines, legal requirements, and clinicians’ professional and personal value systems conflicted and complicated decision-making processes. The challenges centred around treatment at the end of life, intoxicated and non-compliant patients, children as patients—and their guardians, and the collaboration with relatives in various capacities. Other challenges concerned guarding the safety of oneself, colleagues and bystanders, prioritising scarce resources, and staying loyal to colleagues with different value systems. Finally, challenges arose when summoned to situations where other professionals had failed to make a decision or take action when attending to patients whose legitimate needs were not met by the appropriate medical or social services, and when working alongside representatives of authorities with different roles, responsibilities and tasks.ConclusionFrom the perspective of the prehospital emergency personnel, ethical challenges arise in three interrelated contexts: when caring for patients, in the prehospital emergency unit, and during external collaboration. Value conflicts may be identified within these contexts as well as across them. A proposed model of analysis integrating the above contexts can assist in shedding light on ethical challenges and value conflicts in other health care settings. The model emphasises that ethical challenges are experienced from a particular professional perspective, in the context of the task at hand, and in a particular, the organisational setting that includes work schedules, medical guidelines, legal requirements, as well as professional and personal value systems. (shrink)

Este artigo busca desenvolver a ideia de pop’filosofia, noção presente em Deleuze, como base para uma pop’educação. Buscaremos ferramentas de leitura presentes em Deleuze, Espinosa, Nietzsche, Paulo Freire e Manoel de Barros para com elas tematizarmos as relações de ensino e aprendizado a partir do cinema.

Engaging civil society actors as knowledgeable dialogue partners in the development and governance of emerging technologies is a new challenge. The starting point of this paper is the observation that the design and orchestration of current organized interaction events shows limitations, particularly in the articulation of issues and in learning how to address the indeterminacies that go with emerging technologies. This paper uses Dewey’s notion of ‘publics’ and ‘reflective inquiry’ to outline ways of doing better and to develop requirements for (...) a more productive involvement of civil society actors. By studying four novel spaces for interaction in the domain of nanotechnology, this paper examines whether and how elements of Dewey’s thought are visible and under what conditions. One of the main findings is that, in our society, special efforts are needed in order for technology developers and civil society actors to engage in a joint inquiry on emerging nanotechnology. Third persons, like social scientists and philosophers, play a role in this respect in addition to external input such as empirically informed scenarios and somewhat protected spaces. (shrink)

O trabalho apresenta os resultados de um estudo realizado em torno do tema da qualidade nas políticas educacionais para a educação básica. Destaca o significado do termo em documentos exarados pelo MEC nesta primeira década de século e o compara com os resultados educacionais alcançados por um conjunto de municípios catarinenses no tocante às suas metas de qualidade. Realça que o cenário desafiador que se impõe aos municípios pesquisados traduz-se tanto no encargo pelo alcance das metas nacionais do IDEB, diretamente (...) implicado na melhoria do desempenho dos estudantes na Prova Brasil, quanto na devida atenção a outros referenciais orientadores das ações voltadas à construção da qualidade social da educação, dentre eles projeto político-pedagógico e as diferenças sociais. Conclui apontando a necessidade de acompanhamento atendo das condições que consubstanciariam a qualidade social almejada, em um contexto de crescente tendência ao uso de informações majoritariamente quantitativas na formulação de políticas educacionais. (shrink)

Joshua Greene argues that cognitive (neuro)science matters for ethics in two ways, the “direct route” and the “indirect route.” Greene illustrates the direct route with a debunking explanation of the inclination to condemn all incest. The indirect route is an updated version of Greene’s argument that dual-process moral psychology gives support for consequentialism over deontology. I consider each of Greene’s arguments, and I argue that neither succeeds. If there is a route from cognitive (neuro)science to ethics, Greene has not found (...) it. (shrink)

I claim that consciousness, just as thought or action, is only to be found at the personal level of explanation. Dennett's account is often taken to be at odds with this view, as it is seen as explicating consciousness in terms of sub‐personal processes. Against this reading, and especially as it is developed by John McDowell, I argue that Dennett's work is best understood as maintaining a sharp personal/sub‐personal distinction. To see this, however, we need to understand better what content (...) ascription at the sub‐personal level actually means. When we do we can see how Dennett presents both a philosophical account of consciousness and informed empirical speculation on the nature of its sub‐personal underpinnings. Consciousness is a product of certain capacities that are intelligible only at the personal level, capacities that are neither present at the sub‐personal level of brain mechanism nor present in ‘sub‐persons’, e.g. some, if not all, non‐human animals. (shrink)

Genetic engineering techniques (e.g., CRISPR-Cas) have led to an increase in biotechnological developments, possibly leading to uncertain risks. The European Union aims to anticipate these by embedding the Precautionary Principle in its regulation for risk management. This principle revolves around taking preventive action in the face of uncertainty and provides guidelines to take precautionary measures when dealing with important values such as health or environmental safety. However, when dealing with ‘new’ technologies, it can be hard for risk managers to estimate (...) the societal or environmental consequences of a biotechnology that might arise once introduced or embedded in society due to that these sometimes do not comply with the established norms within risk assessment. When there is insufficient knowledge, stakeholders active in early developmental stages (e.g., researchers) could provide necessary knowledge by conducting research specifically devoted to what these unknown risks could entail. In theory, the Safe-by-Design (SbD) approach could enable such a controlled learning environment to gradually identify what these uncertain risks are, to which we refer as responsible learning. In this paper, we argue that three conditions need to be present to enable such an environment: (1) regulatory flexibility, (2) co-responsibility between researchers and regulators, and (3) openness towards all stakeholders. If one of these conditions would not be present, the SbD approach cannot be implemented to its fullest potential, thereby limiting an environment for responsible learning and possibly leaving current policy behind to anticipate uncertain risks. (shrink)

Confucianism has been historically intertwined with authoritarianism in general and monarchy in specific. Various contemporary attempts to reconcile Confucianism with democracy have yielded controversial results mostly due to the theoretical tension between the authoritarian character of the former and the liberal one of the latter. This article seeks to develop an alternative route to Confucian democracy by drawing from Huang Zongxi’s 黃宗羲 Waiting for the Dawn: A Plan for the Prince. In this well-known work, Huang argues for a form of (...) limited government that is built upon laws, political protection of academic freedom, good institutional designs, and separation of governmental powers. While these features seem to qualify Huang only as a defective liberal, this article argues that they are in much coherence with the insights of republicanism concerning good governance. This article will argue that the republican themes embodied in Waiting for the Dawn can justify and support a particular form of Confucian republican democracy. (shrink)

The approach of responsible research and innovation has been proposed to support the introduction of technologies that touch upon socially sensitive issues. RRI is intended to help designers and manufacturers of new technologies identify and accommodate public concerns when developing a new technology by engaging with a wide range of relevant actors in an interactive, transparent process. However what this approach amounts to exactly remains elusive as of yet, i.e. it is unclear what its contribution to the societal embedding of (...) new technologies should consists of exactly. The transition to a sustainable bio-economy that uses biomass as its main resource is a complicated trajectory involving many actors and touching upon societally sensitive issues such as the use of genetic modification. In this paper we pose the question in what way RRI can stimulate the development and diffusion of a sustainable bio-economy in The Netherlands and Europe. We claim that for the further development and diffusion of the bio-economy, trust among actors in the relevant value-chain is a prerequisite. RRI can play a pivotal part in the bio-economy by providing conditions for trustworthiness of actors and by enhancing trusting relationships. This can be achieved through instruments such as personal relationships, third person guarantors, institutions and the communication of values. From the application of RRI to the context of the bio-economy, lessons can be drawn for other socially intricate technological trajectories. (shrink)

The following article evaluates two common arguments for preterist interpretations of Mark 13:24-27, collectively dubbed the ‘time-text’ argument. These two arguments support symbolic and/or historicised interpretations. Our thesis is that the first argument is unsound and the second commits the informal fallacy of false dilemma. Owing to these problems, the arguments and preterist interpretations should be rejected in favour of more plausible futurist interpretations.

In lieu of an abstract, here is a brief excerpt of the content:Aristotle’s Nicomachean Ethics and Shakespeare’s Troilus and CressidaW. R. EltonIn Shakespeare’s Troilus and Cressida there occurs a particular pattern of parallels with Aristotle’s Nicomachean Ethics regarding ethical-legal questions surrounding an action: issues of the role of the voluntary or the involuntary, of volition and choice, of choice and virtue, and of virtue and habitual action. 1Aristotle’s EN was familiar to Elizabethan higher education and was reprinted in translation in (...) numerous editions, with commentaries, in the sixteenth century. 2 Twice Shakespeare alludes to Aristotle by name: first, recalling his ethics, in Taming of the Shrew (I.i.32)—cf. I.i.18–20 on [End Page 331]Virtue and that part of philosophy... that treats of happiness By virtue specially to be achiev’d,and second, in Troilus (II.ii.166–67) on Aristotle and “moral philosophy.” 3Opening EN, III, Aristotle distinguishes those actions that are “voluntary” from those that are “involuntary,” remarking the necessity to determine their limits. Such a course, he adds, is “useful also for legislators with a view to the assigning both of honours and of punishments” (1109 b 32–34). What Aristotle examines, in effect, is the procedure of determining culpability for an act. 4Under what circumstances and to what extent is one responsible for his action? In addition to the voluntary and the involuntary, there are such act-related dualisms as volition and choice, choice and virtue, and virtue and habitual practice. Such ethical-legal issues are appropriate to a play whose war-plot turns on an abductor’s culpability for an action and the subsequent issue of prescriptive possession—the Grecian claim to Helen against her Trojan possessors. 5The VoluntaryIn Troilus Aristotle’s voluntary-involuntary distinctions seem exemplified. 6 A passage (I.iii.354–56), previously glossed by the present writer, suggests a [End Page 332] parallel EN instance of the voluntary. 7 Aristotle defines the voluntary as “that of which the moving principle is in the agent himself “ (1111 a 23–24). In Troilus Nestor, recalling the agent’s responsibility for acts, explains:Limbes are in his instruments, In no lesse working, then are Swords and Bowes Directiue by the Limbes(I.iii.368–70).These lines occur in Troilus, Folio (1623), and are omitted, along with other relatively specialized lines, from Quarto (1609): 8 according to Aristotle, “the movement of the limbs instrumental to the action originates in the agent himself, and when this is so it is in a man’s own power to act or not to act.” 9 Where EN has “limbs... are the instruments,” F Troilus has “Limbes are in his instruments” (cf. Walker ed., I.iii.354).Limbs are instruments of the agent’s responsibility, as are the swords and bows employed by those limbs. Such a passage in Troilus on the responsibility and voluntariness of acts could have been recognizable to an academic (especially legal) audience and, as rehearsed by the ancient Nestor, might have drawn reminiscent response.The InvoluntaryIf Nestor (I.iii.354–56) had been voice of the voluntary, the combat-withdrawn Achilles is arbitrator of the involuntary. Responding to Thersites’ “I serve here voluntary,” Achilles adjudicates, “Your last service was sufferance, ‘twas not voluntary. No man is beaten voluntary. Ajax was here the voluntary, and you as under an impress” (II.i.94–97). Mocking Thersites’s “service,” including being beaten, Achilles argues this could not be “voluntary.” His “no man is beaten voluntary” echoes Aristotle’s own familiar terms, denying that a man can be wronged or injured voluntarily. In his commentary on EN John Case [End Page 333] gives the assurance that “No one voluntarily suffers injury..., no one voluntarily and maliciously harms himself: therefore no one willingly suffers injury.” 10In such instances as those above, Troilus (II.i.94–97) recalls basic legal procedure, including determination of the degree of responsibility for an action. What is the minimum requirement of the law before a man can be held accountable? “Those things... are thought involuntary,” says Aristotle, “which take place under compulsion... and that is compulsory of which the moving principle is outside, being a principle... (shrink)

In her Natural Goodness, Philippa Foot argues both that a distinctive grammar of goodness applies to living things generally, and that moral goodness in human beings is a special instance of natural goodness. My goal in this chapter is to provide a sympathetic interpretation of Foots’ grammar of goodness, clarifying and expanding it in a few places, and defending it against some objections. I begin by sketching Foot’s grammar. As I understand it, that grammar includes four main notions: 1) THE (...) GOOD OF, 2) GOOD AS / GOOD IN, 3) GOOD FOR, and 4) GOODS / GOOD THINGS. I then consider the relation between GOOD FOR, on the one hand, and THE GOOD OF and GOOD AS, on the other. Is it always GOOD FOR a living thing to be GOOD AS the kind of thing it is? Could something be GOOD FOR an organism without being part of THE GOOD OF that kind of thing? I argue that GOOD FOR, GOOD AS, and THE GOOD OF are inseparable: what is GOOD FOR a living thing just is that which furthers or constitutes THE GOOD OF such a creature, and THE GOOD OF any creature is the actualization of those well-formed capacities that make it GOOD AS the kind of creature that it is. In the final part of this chapter, I consider how happiness fits into Foot’s grammar of goodness as applied to human beings, paying special attention to the idea that THE GOOD OF any living thing consists in a certain form of activity. (shrink)

Acoustic speech output results from coordinated articulation of dozens of muscles, bones and cartilages of the vocal mechanism. While we commonly take the fluency and speed of our speech productions for granted, the neural mechanisms facilitating the requisite muscular control are not completely understood. Previous neuroimaging and electrophysiology studies of speech sensorimotor control has typically concentrated on speech sounds (i.e., phonemes, syllables and words) in isolation; sentence-length investigations have largely been used to inform coincident linguistic processing. In this study, we (...) examined the neural representations of segmental features (place and manner of articulation, and voicing status) in the context of fluent, continuous speech production. We used recordings from the cortical surface (electrocorticography (ECoG)) to simultaneously evaluate the spatial topography and temporal dynamics of the neural correlates of speech articulation that may mediate the generation of hypothesized gestural or articulatory scores. We found that the representation of place of articulation involved broad networks of brain regions during all phases of speech production: preparation, execution and monitoring. In contrast, manner of articulation and voicing status were dominated by auditory cortical responses after speech had been initiated. These results provide a new insight into the articulatory and auditory processes underlying speech production in terms of their motor requirements and acoustic correlates. (shrink)

The policies of the European Union concerning the development of biofuels can be termed a lock-in. Biofuels were initially hailed as a green, sustainability technology. However evidence to the contrary quickly emerged. The European Commission proposed to alter its policies to accommodate for these effects but met with fierce resistance from a considerable number of member states who have an economic interest in these first generation biofuels. In this paper I argue that such a lock-in might have been avoided if (...) an experimental approach to governance had been adopted. Existing approaches such as anticipation and niche management either do not reduce uncertainty sufficiently or fail to explicitly address conflicts between values motivating political and economic support for new technologies. In this paper, I suggest to apply an experimental framework to the development of sustainable biobased technologies. Such an approach builds on insights from adaptive management and transition management in that it has the stimulation of learning effects at its core. I argue that these learning effects should occur on the actual impacts of new technologies, on the institutionalisation of new technologies and most specifically on the norms and values that underly policies supporting new technologies. This approach can be relevant for other emerging technologies. (shrink)

A major obstacle to the political revival of Confucianism has been its tension with the rule of law. Systemic features of Confucianism such as social hierarchy (and the corresponding social inequal...

Respect for autonomy is problematic in relation to public health programmes such as vaccination, as the success of such programmes depends on widespread compliance. European countries have different policies for dealing with objectors to vaccination programmes. In some countries compliance is compulsory, while in others objectors are exempted or allowed to enter the programme under specific conditions. In this paper I argue that the objectors should not be treated as a homogenous group as is done in the above-mentioned policies. Objectors (...) have different arguments for not participating in vaccination programmes. Considering the value of respect for autonomy, some but not all of these arguments need to be accommodated by authorities. The concept of 'narrative autonomy' provides criteria to distinguish between tenable and untenable claims to the right to refuse vaccination. Narrative autonomy understands autonomy as essentially linked to identity, as this provides the moral framework with which we assess our first-order preferences. The above-mentioned concept of autonomy is derived from the concept of narrative identity as described by Marya Schechtman. She suggests that the application of the Articulation Constraint and the Reality Constraint enables us to establish the validity of personal narratives. Additionally, form and content features of identity, as proposed by Anthony Laden, will be used as criteria to establish the compatibility of the defectors' arguments with shared scientific and political values. Such compatibility is essential to accommodate respect for autonomy in the context of public health. (shrink)

ABSTRACTPrevious work has shown that a stooped posture may activate negative mood. Extending this work, the present experiments examine how stooped body posture influences recovery from pre-existing negative mood. In Experiment 1, participants were randomly assigned to receive either a negative or neutral mood induction, after which participants were instructed to take either a stooped, straight, or control posture while writing down their thoughts. Stooped posture led to less mood recovery in the negative mood condition, and more negative mood in (...) the neutral mood condition. Furthermore, stooped posture led to more negative thoughts overall compared to straight or control postures. In Experiment 2, all participants underwent a negative mood induction, after which half received cognitive reappraisal instructions and half received no instructions. Mood-congruent cognitions were assessed through autobiographical memory recall. Again, stooped position led to less mood recovery. Notably, this was independent of regulation instruction. These findings demonstrate for the first time that posture plays an important role in recovering from negative mood. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY PEIRGE'S MARGINALIA IN W. T. HARRIS' Hegel's Logic Among the most eminent philosophers of nineteenth-century America were William Torrey Harris (1835-1909) and Charles Sanders Peirce (18391914 ). The former, by his establishment in 1867 of The Journal of Speculative Philosophy, furnished a starting point for American philosophical maturity. The latter, who contributed to that iournal, has been considered America's greatest logician. It may therefore be (...) of interest to examine Peirce's marginalia in the first edition of Harris' chief work, Hegel's Logic: A Book on the Genesis of the Categories of the Mind (Chicago: S. C. Griggs, 1890). Discovered by the present writer on a New York book-stall, in a cheaply priced, coverless, and water-stained copy, and now in his possession, it bears imprinted on the reverse of the title page: "Harvard University: Philos. Dept. Library. Gift of Mrs. Charles S. Peirce. June 28, 1915." Shortly after Peirce, in depressed circumstances, died on April 19, 1914, the Harvard Philosophy Department acquired from his wife the manuscripts that were published in the Collected Papers.1 Harris' Hegel's Logic, which presumably accompanied that transaction, contains several marginal annotations, mostly in faded ink, in a neat, small hand, similar to that reproduced in the frontispiece to Volume IV of Peirce's Collected Papers. Recalling a notable philosophical conjunction, the markings also reveal aspects of Peirce's character and confirm his complex attitude toward Hegel, crucial to the development of his philosophy. Peirce's shifting view and persistent concern regarding Hegel may be traced in some other remarks. For example, in a letter to Harris dated January 1, 1868, he says, "I admit there is music in the logic of Hegel, but that is all I discover there. ''2 In another letter to Harris, dated May 13, 1868, he indicates his ambivalence: "But as I should draw the line... I should come on the same side as Hegel, because I am idealistic. I do not 1eel very much opposed to Hegel, though I think his main point.s tin his own estimate of importance) are wrong. ''s About 1890, Peirce declared, "I reiect his philosophy in toto, ''~ and about 1896, he accused Hegel of reaching "each category from the last preceding by virtually calling 'next!'-5 Yet, in 1903, he acclaimed Hegel "in some respects the greatest philosopher that ever lived. ''6 And, in the very same year, reviewing another treatment of Hegel's logic, and including a reference to Harris' t Eds. Charles Hartshorne, Paul Weiss,and Arthur Burks (Vols.I-VIII; Cambridge: Harvard University Press, 1958). 2,.C.S. Peirce to W. T. Harris." ed. WallaceNethery, The Personalist,XLIII (19fi2),37. I am indebted to Dr. Nethery for his kindness in letting me see these letters in advanceof publication. sIbid.,40. 4Collected Papers,I, 193. 5 Ibid., I, 246. eIbid., I, 277. NOTES AND DISCUSSIONS 83 treatise, Peirce flatly remarks: "But all these Hegelians--Harris, XVallace, Hibben, Everett, etc.--who dog the steps of their master in almost textual comments, are profoundly unfaithful to the spirit of his philosophy... the Logik now condemns itself. ''7 A constant feature in Peirce's negative attitude toward Hegel concerns the latter's failure to equip himself scientifically to deal with a subject the American considered basically scientific. For instance, about 1899, Peirce writes: Hegel, while regarding scientific men with disdain, has for his chief topic the importance of continuity, which was the very idea the mathematicians and physicists had been chiefly engaged in following out for three centuries. This made Hegel's work less correct and excellent in itself than it might have been; and at the same time hid its true mode of affinity with the scientific thought into which the life of the race had been chiefly laid up. It was a misfortune for Hegelism~ a misfortune for "philosophy," and a misfortune (in lesser degree) for science: Although Peirce adds, "My philosophy resuscitates Hegel, though in a strange costume, ''9 and his dialectic parallels Hegel's, he attempts to escape the Hegelian subjectivism by an "objective logic" and by avoiding Hegel's supposed mathematical ignorance. "Most of what is true in... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY PEIRGE'S MARGINALIA IN W. T. HARRIS' Hegel's Logic Among the most eminent philosophers of nineteenth-century America were William Torrey Harris (1835-1909) and Charles Sanders Peirce (18391914 ). The former, by his establishment in 1867 of The Journal of Speculative Philosophy, furnished a starting point for American philosophical maturity. The latter, who contributed to that iournal, has been considered America's greatest logician. It may therefore be (...) of interest to examine Peirce's marginalia in the first edition of Harris' chief work, Hegel's Logic: A Book on the Genesis of the Categories of the Mind (Chicago: S. C. Griggs, 1890). Discovered by the present writer on a New York book-stall, in a cheaply priced, coverless, and water-stained copy, and now in his possession, it bears imprinted on the reverse of the title page: "Harvard University: Philos. Dept. Library. Gift of Mrs. Charles S. Peirce. June 28, 1915." Shortly after Peirce, in depressed circumstances, died on April 19, 1914, the Harvard Philosophy Department acquired from his wife the manuscripts that were published in the Collected Papers.1 Harris' Hegel's Logic, which presumably accompanied that transaction, contains several marginal annotations, mostly in faded ink, in a neat, small hand, similar to that reproduced in the frontispiece to Volume IV of Peirce's Collected Papers. Recalling a notable philosophical conjunction, the markings also reveal aspects of Peirce's character and confirm his complex attitude toward Hegel, crucial to the development of his philosophy. Peirce's shifting view and persistent concern regarding Hegel may be traced in some other remarks. For example, in a letter to Harris dated January 1, 1868, he says, "I admit there is music in the logic of Hegel, but that is all I discover there. ''2 In another letter to Harris, dated May 13, 1868, he indicates his ambivalence: "But as I should draw the line... I should come on the same side as Hegel, because I am idealistic. I do not 1eel very much opposed to Hegel, though I think his main point.s tin his own estimate of importance) are wrong. ''s About 1890, Peirce declared, "I reiect his philosophy in toto, ''~ and about 1896, he accused Hegel of reaching "each category from the last preceding by virtually calling 'next!'-5 Yet, in 1903, he acclaimed Hegel "in some respects the greatest philosopher that ever lived. ''6 And, in the very same year, reviewing another treatment of Hegel's logic, and including a reference to Harris' t Eds. Charles Hartshorne, Paul Weiss,and Arthur Burks (Vols.I-VIII; Cambridge: Harvard University Press, 1958). 2,.C.S. Peirce to W. T. Harris." ed. WallaceNethery, The Personalist,XLIII (19fi2),37. I am indebted to Dr. Nethery for his kindness in letting me see these letters in advanceof publication. sIbid.,40. 4Collected Papers,I, 193. 5 Ibid., I, 246. eIbid., I, 277. NOTES AND DISCUSSIONS 83 treatise, Peirce flatly remarks: "But all these Hegelians--Harris, XVallace, Hibben, Everett, etc.--who dog the steps of their master in almost textual comments, are profoundly unfaithful to the spirit of his philosophy... the Logik now condemns itself. ''7 A constant feature in Peirce's negative attitude toward Hegel concerns the latter's failure to equip himself scientifically to deal with a subject the American considered basically scientific. For instance, about 1899, Peirce writes: Hegel, while regarding scientific men with disdain, has for his chief topic the importance of continuity, which was the very idea the mathematicians and physicists had been chiefly engaged in following out for three centuries. This made Hegel's work less correct and excellent in itself than it might have been; and at the same time hid its true mode of affinity with the scientific thought into which the life of the race had been chiefly laid up. It was a misfortune for Hegelism~ a misfortune for "philosophy," and a misfortune (in lesser degree) for science: Although Peirce adds, "My philosophy resuscitates Hegel, though in a strange costume, ''9 and his dialectic parallels Hegel's, he attempts to escape the Hegelian subjectivism by an "objective logic" and by avoiding Hegel's supposed mathematical ignorance. "Most of what is true in... (shrink)

Over the last decades, it has become evident that highly complex networks of regulators govern post‐transcriptional regulation of gene expression. A novel class of Argonaute (Ago)‐associated RNA molecules, the agotrons, was recently shown to function in a Drosha‐ and Dicer‐independent manner, hence bypassing the maturation steps required for canonical microRNA (miRNA) biogenesis. Agotrons are found in most mammals and associate with Ago as ∼100 nucleotide (nt) long RNA species. Here, we speculate on the functional and biological relevance of agotrons: (i) (...) agotrons could serve as non‐promiscuous miRNA‐like regulators with reduced off‐targeting or (ii) agotrons could encompass other putative functions, such as protecting Ago proteins from taking up aberrant short RNAs or by rescuing and stabilizing otherwise unloaded Ago‐proteins from degradation. Collectively, agotrons have emerged as a novel class of interesting non‐coding RNA molecules, but their full functional potential and biological impact still remain to be disclosed. (shrink)

Technological developments often bring about new risks. Informed consent has been proposed as a means to legitimize the imposition of technological risks. This principle was first introduced in medical practice to assure the autonomy of the patient.The introduction of IC in the field of technological practice raises questions about the comparability of the type of informed consent. To what extent are thepossibilities to include laypeople in making decisions regarding risks similar in the technological field to giving informed consent in the (...) medical field and whatdoes this imply for the design and implementation of IC in the technological field? Medical and the technological practice are clearly alike in that both fieldsare characterized by highly specialized, technical knowledge which can be quite inaccessible to the average layperson. However, a fundamental difference ariseswith regard to the aim, knowledge of risks and exclusiveness of the practices in each field. The differences in aim imply that the necessity for each practice isperceived differently by laypeople, thus leading them to assess the respective risks differently. The differences in knowledge of risks arise from the variabilityin the ways that can be used to describe a given risk. Definition of risk in medical practice is more homogenous in this respect than the risk definition intechnological fields. Futhermore, medical practice tends to be more exclusive, leading laypeople immersed in that practice to necessarily embrace most of thefundamental underlying that practice. These differences result in divergent recommendations for the implementation of informed consent in the technological field, basically: there is a need for more extensive procedure and for less decisive authority for the individual. (shrink)

Alasdair MacIntyre's account of tradition-based rationality has been the subject of much discussion, as well as the object of some recent charges of inconsistency. The author considers arguments by Jennifer Herdt, Peter Mehl, and John Haldane which attempt to show that MacIntyre's account of rationality is, in some way, inconsistent. It is argued that the various charges of inconsistency brought against MacIntyre by these critics can be understood as variations on two general types of criticism: (1) that MacIntyre's account of (...) tradition-based rationality presents a picture of rationality with inconsistent internal elements, and (2) that MacIntyre, in the act of presenting his picture of rationality, makes the sort of claims to which his own account of rationality denies legitimacy, and thus MacIntyre's account is self-referentially incoherent. In response to criticisms of the first sort, it is argued that MacIntyre can further clarify or develop his position to take the current criticisms into account without altering the fundamental aspects of his picture of rationality. In response to the charge of self-referential incoherence, it is argued that the charge rests on a mistaken understanding of MacIntyre's position and of the nature of justification. In dealing with these arguments, the author hopes to not only vindicate MacIntyre's account of rationality against the charges of some of its recent critics, but also to shed some light on the nature of arguments both for and against relativism and historicism. (shrink)

The central claim of Aristotelian naturalism is that moral goodness is a kind of species-specific natural goodness. Aristotelian naturalism has recently enjoyed a resurgence in the work of philosophers such as Philippa Foot, Rosalind Hursthouse, and Michael Thompson. However, any view that takes moral goodness to be a type of natural goodness faces a challenge: Granting that moral goodness is natural goodness for human beings, why should we care about being good human beings? Given that we are rational creatures who (...) can ‘step back’ from our nature, why should we see human nature as authoritative for us? This is the authority-of-nature challenge. In this essay, I state this challenge clearly, identify its deep motivation, and distinguish it from other criticisms of Aristotelian naturalism. I also articulate what I consider the best response, which I term the practical reason response. This response, however, exposes Aristotelian naturalism to a new criticism – that it has abandoned the naturalist claim that moral goodness is species-specific natural goodness. Thus, I argue, Aristotelian naturalists appear to face a dilemma: Either they cannot answer the authority-of-nature challenge, or in meeting the challenge they must abandon naturalism. Aristotelian naturalists might overcome this dilemma, but doing so is harder than some Aristotelians have supposed. In the final sections of the paper, I examine the difficulties in overcoming the dilemma, and I suggest ways that Aristotelians might answer the authority-of-nature challenge while preserving naturalism. (shrink)

In recent discussions about whether the use of a love pill to enhance love in our romantic relationships is desirable, one argument centres on the question whether this love pill would secure the final value we attribute to love. Sven Nyholm argues that it would not, because one thing we desire for its own sake is to be at the origin of the love others feel for us. In a reply, Hichem Naar argues against Nyholm that a love pill does (...) not need to be incompatible with the final value we attribute to love and that a love pill can have a facilitating role in the creation and sustainment of loving attachment. I think Naar is right but does not address Nyholm's worry completely. I will argue that Naar and Nyholm are speaking of different ends for which the love pill is used as a means, and that whether the love pill would fail or not fail to secure the final value we attribute to love, depends on this particular end. (shrink)

The United Network for Organ Sharing , the national organisation responsible for transplantable organ distribution in the United States, recently condemned the direct solicitation of organs in situations “where no personal bond exists between the patient and the donor or donor family”.1 UNOS worries that “such appeals, although well-intentioned, compromise the principle of fairness” or worse, “may divert organs from patients with critical need to those who are less ill.”.