Background Biomedical and ethnographic studies among indigenous people are common practice in health and geographical research. Prior health research misconduct has been documented, particularly when obtaining genetic material. The objective of this study was to crossmatch previously published data with the perceptions of the Waorani peoples about the trading of their genetic material and other biological samples. Methods We conducted a mixed methods study design using a tailored 15-item questionnaire in 72 participants and in-depth interviews in 55 participants belonging to (...) 20 Waorani communities about their experiences and perceptions of participating in biomedical research projects. Additionally, we conducted a systematic review of the literature in order to crossmatch the published results of studies stating the approval of an ethics committee and individual consent within their work. Results A total of 40 men and 32 women, with a mean age of 57 ± 15 years agreed to be interviewed for inclusion. Five main categories around the violation of good clinical practices were identified, concerning the obtention of blood samples from a recently contacted Waorani native community within the Amazonian region of Ecuador. These themes are related to the lack of adequate communication between community members and researchers as well as the voluntariness to participate in health research. Additionally, over 40 years, a total of 38 manuscripts related to the use of biological samples in Waorani indigenous people were published. The majority of the studies did not state within their article obtaining research ethics board approval, and 71% did not report obtaining the informed consent of the participants prior to the execution of the project. Conclusion Clinical Research on the Waorani community in the Ecuadorian Amazon basin has been performed on several occasions. Unfortunately, the majority of these projects did not follow the appropriate ethical and professional standards in either reporting the results or fulfilling them. The results of our investigation suggest that biological material, including genetic material, has been used by researchers globally, with some omitting the minimum information required to guarantee transparency and good clinical practices. We highlight the importance of stating ethics within research to avoid breaches in research transparency. (shrink)

Ritual consciousness is an altered state of consciousness that transpires beyond the boundaries of the known and gives rise to a duration referred to as time out of time. This extraordinary duration encompasses three interrelated factors: digital as opposed to analogue conduct of time, tempo and communitas. Under specific formal conditions, these factors may emerge in the context of networked rituals and outside their traditional and earthbound religious or spiritual settings. In this article, the three factors are analysed in relation (...) to the author’s networked rites on the Waterwheel platform. The rites are designed to explore ritual consciousness and produce prototype morphic fields of compassion, which are aimed at counteracting the prevalent narrative of violence. There is an emphasis on communitas, a liminal and nonhierarchical communal state of oneness that could generate compassion. Based on researches in anthropology, biogenetic structuralism, cognitive neuroscience and morphic resonance, communitas is metaphorically envisioned as the communion of non-local brains within a networked mind and morphic field. The article postulates that the virtual and organic hybridity of the rites involve the participants’ body, brain and fields of the mind in the explorations of ritual consciousness. (shrink)

What is the significance of the Father in psychoanalysis today? This book constructs a much needed framework to allow psychoanalysts to consider the difficulties of a generation without a solid anchor in the Father. _The Dead Father: A Psychoanalytic Inquiry_ provides a necessary addition to decades of work on the role of the mother in development. The editors bring together world renowned scholars to discuss current observations in their fields, in terms of the Father’s changing but essential functions, both in (...) the lives of the individual and collective. Divided into four parts, chapters focus on: The Lost Father The Father Embodied The Father in Theory Father Culture. Exploring the role of the father in individual psychology, everyday interpersonal and social experience and cultural phenomena writ large, this book will be essential reading for psychoanalysts, as well as psychologists, social workers and scholars in the humanities. (shrink)

How do children acquire the meaning of words? And why are words such as know harder for learners to acquire than words such as dog or jump? We suggest that the chief limiting factor in acquiring the vocabulary of natural languages consists not in overcoming conceptual difficulties with abstract word meanings but rather in mapping these meanings onto their corresponding lexical forms. This opening premise of our position, while controversial, is shared with some prior approaches. The present discussion moves forward (...) from there to a detailed proposal for how the mapping problem for the lexicon is solved, as well as a presentation of experimental findings that support this account. We describe an overlapping series of steps through which novices move in representing the lexical forms and phrase structures of the exposure language, a probabilistic multiple-cue learning process known as syntactic bootstrapping. The machinery is set in motion by word-to-world pairing, a procedure available to novices from the.. (shrink)

Responding to calls for more substantive studies into ethical and responsible lobbying, we analyze data collected over a 5-year period in Brussels to explore how individual lobbyists understand the ethical dimensions of their work. Mobilizing insights from the sociology of the professions, we expose an emerging lobbying professionalism and unpack practitioners’ understandings of what being a professional lobbyist entails, focusing in particular on their espoused values of transparency and honesty. While expectations to lobby more transparently and honestly stem from political (...) institutions, we find individual lobbyists—acting as conduits—attempt to disseminate these expectations by setting limits that incite their clients to embrace what policymakers consider professional lobbying practice. Our study contributes to corporate political activity (CPA) scholarship by providing a professions-based understanding of ethical and responsible approaches to lobbying. We provide new insights into contextual and individual-level factors behind the emergence of such approaches, and elucidate implications of lobbying professionalism for business and European Union (EU) governance. (shrink)

How do we talk about events we perceive? And how tight is the connection between linguistic and non-linguistic representations of events? To address these questions, we experimentally compared motion descriptions produced by children and adults in two typologically distinct languages, Greek and English. Our findings confirm a well-known asymmetry between the two languages, such that English speakers are overall more likely to include manner of motion information than Greek speakers. However, mention of manner of motion in Greek speakers' descriptions increases (...) significantly when manner is not inferable; by contrast, inferability of manner has no measurable effect on motion descriptions in English, where manner is already preferentially encoded. These results show that speakers actively monitor aspects of event structure, which do not find their way into linguistic descriptions. We conclude that, in regard to the differential encoding of path and manner, which has sometimes been offered as a prime example of the effects of language encoding on non-linguistic thought, surface linguistic encoding neither faithfully represents nor strongly constrains our mental representation of events. (shrink)

This article offers an underexplored resistance strategy to gender norms, based on a feminist and queer reading of the work of French thinker Roland Barthes. Building on Barthes’s peculiar conception of what he calls “the Neutral” and revisiting his work in light of feminist and queer scholarship on sexual (in)difference, my main goal is to reshape our understanding of what it means to be gender neutral. In opposition to classical conceptions of neutrality associated with passivity, indifference, and blandness, I show (...) that Barthes’s Neutral can be conceived as an active gesture, which alters common systems of meanings and power, including the gender binary. But this conception of the Neutral, I argue, neither refers to a call for an androgynous, queer, or nonbinary gender experience. It does not target gender embodiments but gender regulations—that is, the social enforcement of gender categories (by way, for instance, of administrative forms, single-sex bathrooms, or normalizing attitudes toward others). A gender-neutral arrangement, therefore, refers to an ethical, administrative, social, or spatial relation in which subjects are not assigned based on gender categories. This practice of gender suspension, I show, has two main transformative effects. First, it opens a space of freedom and livability for gender-nonconforming subjects. Second, it contributes to lessening the significance of sexual difference in social life and therefore alleviating its symbolic and normative weight for everyone. (shrink)

Deletions, duplications, insertions, inversions, and translocations, collectively called structural variations (SVs), affect more base pairs of the genome than any other sequence variant. The recent technological advancements in genome sequencing have enabled the discovery of tens of thousands of SVs per human genome. These SVs primarily affect non‐coding DNA sequences, but the difficulties in interpreting their impact limit our understanding of human disease etiology. The functional annotation of non‐coding DNA sequences and methodologies to characterize their three‐dimensional (3D) organization in the (...) nucleus have greatly expanded our understanding of the basic mechanisms underlying gene regulation, thereby improving the interpretation of SVs for their pathogenic impact. Here, we discuss the various mechanisms by which SVs can result in altered gene regulation and how these mechanisms can result in rare genetic disorders. Beyond changing gene expression, SVs can produce novel gene‐intergenic fusion transcripts at the SV breakpoints. (shrink)

The article proposes that the modern notion of the spiritual in art, which was theorized at the beginning of the twentieth century, although remains pivotal to the discourse of art and the spiritual, has radically shifted as a result of changing attitudes to the body–mind relations instigated by popular trends of contemporary spiritualities. This cultural tendency is demonstrated by the analysis of the networked art form of Moon Ribas, e.g., dance with earthquakes. Ribas performs a cyborg body and consciousness that, (...) as contended, could be holistically enhanced and develop a unique compassionate awareness. In addition, I reflect on two examples from my performative practice of Networked Rites that interplay with speculative metaphors, spiritual and shamanic techniques, networked aesthetic forms and technologies. The first invokes communitas as a collective, non-local, networked noetic field. The second utilizes a decision-making app as a mediating device between the body and mind for the making of a prototype cyborg noetic field instilled with auspicious resonance. The article mainly implies that spiritual art continues to evolve through technoetic aesthetics fusing emerging technologies, science and shamanic, spiritual insight. Current trends may develop into benevolent and experiential applications based on the interrelations of human and cyborg body and consciousness. (shrink)

Gleitman and Trueswell’s “The easy words” forms a pair with their earlier paper, “Hard words,” completing a circle in which the authors ask how “easy” words (e.g., concrete nouns) are learned. They take up the hypothesis of “cross‐situational learning,” and argue that accumulating observations actually hinders learning if the mechanism requires holding all exemplars in memory over time. They present an alternative hypothesis, “Propose but Verify,” wherein people use one‐trial learning to confirm or disconfirm their current hypothesis—a mechanism distinctly different (...) from cross‐situational learning. (shrink)

Este artigo tem como objetivo principal investigar as ideias do senso comum de jovens brasileiros e franceses acerca das relações entre justiça e injustiça. Para tanto, utilizou-se o conceito de tematas. As tematas são concebidas como fatores organizadores de conjuntos temáticos de diferentes repres..

A widespread need to explain the behavior and outcomes of AI-based systems has emerged, due to their ubiquitous presence. Thus, providing renewed momentum to the relatively new research area of eXplainable AI (XAI). Nowadays, the importance of XAI lies in the fact that the increasing control transference to this kind of system for decision making -or, at least, its use for assisting executive stakeholders- already affects many sensitive realms (as in Politics, Social Sciences, or Law). The decision-making power handover to (...) opaque AI systems makes mandatory explaining those, primarily in application scenarios where the stakeholders are unaware of both the high technology applied and the basic principles governing the technological solutions. The issue should not be reduced to a merely technical problem; the explainer would be compelled to transmit richer knowledge about the system (including its role within the informational ecosystem where he/she works). To achieve such an aim, the explainer could exploit, if necessary, practices from other scientific and humanistic areas. The first aim of the paper is to emphasize and justify the need for a multidisciplinary approach that is beneficiated from part of the scientific and philosophical corpus on Explaining, underscoring the particular nuances of the issue within the field of Data Science. The second objective is to develop some arguments justifying the authors’ bet by a more relevant role of ideas inspired by, on the one hand, formal techniques from Knowledge Representation and Reasoning, and on the other hand, the modeling of human reasoning when facing the explanation. This way, explaining modeling practices would seek a sound balance between the pure technical justification and the explainer-explainee agreement. (shrink)

This paper focuses on the consolidation of Molecular Evolution, a field originating in the 1960s at the interface of molecular biology, biochemistry, evolutionary biology, biophysics and studies on the origin of life and exobiology. The claim is made that Molecular Evolution became a discipline by integrating different sorts of scientific traditions: experimental, theoretical and comparative. The author critically incorporates Timothy Lenoir’s treatment of disciplines , as well as ideas developed by Stephen Toulmin on the same subject. On their account disciplines (...) are spaces where the social and epistemic dimensions of science are deeply and complexly interwoven. However, a more detailed account of discipline formation and the dynamics of an emerging disciplinary field is lacking in their analysis. The present essay suggests focusing on the role of scientific concepts in the double configuration of disciplines: the social/political and the epistemic order. In the case of Molecular Evolution the concepts of molecular clock and informational molecules played a central role, both in differentiating molecular from classical evolutionists, and in promoting communication between the different sorts of traditions integrated in Molecular Evolution. The paper finishes with a reflection on the historicity of disciplines, and the historicity of our concepts of disciplines. (shrink)

Theorems of arithmetic are used, perhaps essentially, to reach conclusions about the natural world. This applicability can be explained in a natural way by analogy with the applicability of statements of law to the world. ;In order to carry out an ontological argument for my thesis, I assume the existence of universals as a working hypothesis. I motivate a theory of laws according to which statements of law are singular statements about scientific properties. Such statements entail generalizations about instances of (...) those properties. My task, then, is to show that theorems of arithmetic, in application, are similar to statements of law in this respect. On the basis of my working hypothesis, I argue that there are inclining reasons to think that cardinal numbers are scientific properties whose instances occur in the natural world. The works of Mill, Frege and Benacerraf play central roles in these arguments. ;In general, I urge that there are no conclusive epistemological or ontological factors which preclude arithmetical truths from being laws of nature. Consequently, I think we can extend any semantic theory which is adequate for statements of law to theorems of arithmetic. This would apply even to a theory of predication which does not involve commitment to universals. So, to the degree that my argument succeeds with the working hypothesis, it also supports the unconditioned thesis that arithmetical truths are laws of nature. (shrink)

To what extent does perceptual language reflect universals of experience and cognition, and to what extent is it shaped by particular cultural preoccupations? This paper investigates the universality~relativity of perceptual language by examining the use of basic perception terms in spontaneous conversation across 13 diverse languages and cultures. We analyze the frequency of perception words to test two universalist hypotheses: that sight is always a dominant sense, and that the relative ranking of the senses will be the same across different (...) cultures. We find that references to sight outstrip references to the other senses, suggesting a pan-human preoccupation with visual phenomena. However, the relative frequency of the other senses was found to vary cross-linguistically. Cultural relativity was conspicuous as exemplified by the high ranking of smell in Semai, an Aslian language. Together these results suggest a place for both universal constraints and cultural shaping of the language of perception. (shrink)

The use of molecules and reactions as evidence, markers and/or traits for evolutionary processes has a history more than a century long. Molecules have been used in studies of intra-specific variation and studies of similarity among species that do not necessarily result in the analysis of phylogenetic relations. Promoters of the use of molecular data have sustained the need for quantification as the main argument to make use of them. Moreover, quantification has allowed intensive statistical analysis, as a condition and (...) a product of increasing automation. All of these analyses are subject to the methodological anxiety characteristic of a community in search of objectivity. It is in this context that scientists compared and evaluated protein and nucleic acid sequence data with other types of molecular data – including immunological, electrophoretic and hybridization data. This paper argues that by looking at long-term historical processes, such as the use of molecular evidence in evolutionary biology, we gain valuable insights into the history of science. In that sense, it accompanies a growing concern among historians for big-pictures of science that incorporate the fruitful historical research on local cases of the last decades. (shrink)

THERE IS GREAT MOTIVATION WITHIN FREGE'S THEORY TO\nCONSTRUE THE CARDINAL NUMBERS AS QUANTIFIERS, WHICH ARE\nHIGHER LEVEL CONCEPTS. BUT FREGE ARGUED THAT THE CARDINAL\nNUMBERS ARE OBJECTS, NOT CONCEPTS, AND DEFINED THEM\nACCORDINGLY. MOREOVER, FREGE'S HIERARCHY OF CONCEPTS\nPREVENTED HIM FROM CONSTRUING THE NUMBERS AS CONCEPTS. MY\nPURPOSE IS TO BRING OUT THE QUANTIFICATIONAL NATURE OF THE\nNUMBERS IN THE FACE OF THESE OBSTACLES. THE PAPER PRESSES\nTHE QUANTIFICATIONAL VIEW ONTO FREGE'S CONCEPT OF NUMBER AS\nIT TRACES ITS DEVELOPMENT FROM THE "BEGRIFFSSCHRIFT",\nTHROUGH THE 1880S, INTO ITS FORMALIZATION IN (...) THE\n"GRUNDGESETZE". THE THEORY YIELDS SURPRISINGLY EASILY UNDER\nPRESSURE FROM THE QUANTIFICATIONAL VIEW, AND ONE\nSYMPATHETIC WITH THAT VIEW MAY TAKE ENCOURAGEMENT FROM THE\nFACT THAT IT WAS FREGE'S HIERARCHY OF CONCEPTS, NOT HIS\nACTUAL ARGUMENTS, THAT PREVENTED HIS CONSTRUING NUMBERS AS\nQUANTIFIERS. (shrink)

This paper extends previous arguments against the assumption that the study of variation at the molecular level was instigated with a view to solving an internal conflict between the balance and classical schools of population genetics. It does so by focusing on the intersection of basic research in protein chemistry and the molecular approach to disease with the enactment of global health campaigns during the Cold War period. The paper connects advances in research on protein structure and function as reflected (...) in Christian Anfinsen’s The molecular basis of evolution, with a political reading of Emilé Zuckerkandl and Linus Pauling’s identification of molecular disease and evolution. Beyond atomic fallout, these advances constituted a rationale for the promotion of genetic surveys of human populations in the Third World, in connection with international health programs. Light is shed not only on the experimental roots of the molecular challenge but on the broader geopolitical context where the rising role of biomedicine and public health had an impact on evolutionary biology. (shrink)

ArgumentThis paper explores the connection between the epistemic and the “political” dimensions of the metaphor of information during the early days of the study of Molecular Evolution. While preserving some of the meanings already documented in the history of molecular biology, the metaphor acquired a new, powerful use as a substitute for “history.” A rhetorical analysis of Emilé Zuckerkandl's paper, “Molecules as Documents of Evolutionary History,” highlights the ways in which epistemic claims on the validity and superiority of molecular evidence (...) for evolution were intimately connected with authority issues in evolutionary biology. The debate is situated within the framework of the battle for resources between traditional evolutionists and molecular biologists at the beginning of the 1960s. The architects of evolutionary synthesis questioned the idea that molecular characters constitute “cleaner” and “more direct” evidence of evolution. Nevertheless, the information discourse constituted a productive space for the development of a new research program that, paradoxically, has made explicit the limitations of the information metaphor in reconstructing life's history. (shrink)

This chapter presents some reflections by Lila Gleitman on the development of her thinking and her research – in concert with a host of esteemed collaborators over the years – on issues of language and mind, focusing on how language is acquired. Gleitman entered the field of linguistics as a student of Zellig Harris, and learned firsthand of Noam Chomsky's early work. The chapter points out that Goldin‐Meadow's first looks at isolate language, and deaf language, transmuted into her life's (...) work on gesture and sign. Linguists, including particularly Anne Senghas, had the opportunity to look at a remarkable case of a language rising in a hithertofore‐isolated deaf community. Behaviorist psychology saw language learning as an instance of more general principles of operant conditioning, a relatively straightforward distillation and organization of experience. Chomsky continues to frame and expatiate upon the central questions of language learning and knowledge. (shrink)

In this special issue we explore practices of scientific inquiry into human populations in Latin America in order to generate new insights into the complex historical and sociopolitical dynamics that have made certain human groups integral to the production of scientific knowledge in and about the region. In important contributions, other scholars have shown that the science of human difference is racist and all too often has been a mediator of development ideologies. To further unpack these arguments we focus attention (...) on the complex interaction between scientists and the populations they study. We explore cases from across the fields of evolutionary biology, demography, epidemiology... (shrink)

El presente artículo tiene como objeto llevar a cabo un estudio pragmático y analítico sobre la acción de valoración, el valor y los valores a la luz de la ciencia semiótica y de la ciencia cibernética. Por ello, se desarrollará un proceso axiológico que ilustre cómo sucede el ingreso, la transición y la salida de códigos morales en función de un esquema cognitivo. Así pues, el proceso axiológico se postula, primero, en fundamento de tres sistemas: de mentalidad, de valores y (...) de biomoralidad y, segundo, conforme a la teoría de la información y de la teoría general de sistemas. (shrink)

A recent quarrel over faultless disagreements assumes that disputes over evaluative sentences should be understood as regular, factual disagreements. Instead, I propose that evaluative disagreements should be understood in Lewisian terms. Language use works like a rule-governed game. In it, the assertion of an evaluative sentence is an attempt to establish one value as default in the conversation; its rejection, in turn, is in most cases the refusal to accept this move.

Between December 14 and 20, 1965, the World Health Organization Scientific Group on Haemoglobinopathies and Allied Disorders metatthe Geneva agency's headquarters. The group comprised eight well-known physicians including Tulio Arends, a leading Latin American human geneticist from the Venezuelan Institute for Scientific Investigations. Others came from North America, Northern and Southern Europe, the Middle East and South East Asia, an array that reflected the delicate geopolitical equilibriums of postwar international health programs, but also the development of highly specialized biomedical research (...) around the globe. They elected Herman Lehmann, from the Abnormal Haemoglobin Research Unit of the Medical Research... (shrink)

Adults (more than 18 years old) are likely to reproduce the habits that they acquired during childhood and adolescence (from 6 to 16 years old). For that reason, teachers and parents have the responsibility to promote an active and healthy lifestyle in children and adolescents. Even though every school subject should promote healthy activities, Physical Education (PE) is the most important subject to foster well-being habits associated to healthy lifestyle during sport practice and other kinds of active tasks. Indeed, there (...) are many factors that influence the acquisition of healthy habits that should be taken into account when programs and activities are implemented in both educational and extracurricular context. In this sense, psychological and social factors are of utmost importance to achieve optimal experiences for an active and healthy lifestyle. However, due to the myriad of studies analyzing different factors in different contexts, there could be confusion when programs and pedagogical strategies are applied in educational or extracurricular contexts. The objective of this investigation is to analyze the state of art of the psychosocial factors which influence the engagement in physical activities and sport practice. The keywords used in this review were mainly: ‘Self-Determination Theory’, ‘motivation’, ‘Psychological need satisfaction, ‘physical activity and sport engagement’, ‘Elementary Education’, ‘Secondary Education’, ‘Physical Education’. The articles were selected according to the following criteria: (a) peer-reviewed original research published in international journals indexed in JCR or SJR, (b) published in English or Spanish, (c) about psychosocial factors which influence the physical activity and sport engagement, (b) in educational or extracurricular context. Research articles selected were found through nine databases. It was observed that physical activities and sport practice engagement are closely related to psychological factors. In particularly, intrinsic motivation was able to determine the active participation in any activity, including physical activity and sport practice during the implementation of Small-Sided Games and other kinds of pedagogical strategies (e.g., Pedagogical Models). Motivation was also closely related to flow state. Finally, these variables should be considered in order to organize effective programs to promote an active and healthy lifestyle in Physical Education classes. (shrink)