Cancer chemotherapy has been the most common cancer treatment. However, it has side effects that kill both tumor cells and immune cells, which can ravage the patient’s immune system. Chemotherapy should be administered depending on the patient’s immunity as well as the level of cancer cells. Thus, we need to design an efficient treatment protocol. In this work, we study a feedback control problem of tumor-immune system to design an optimal chemotherapy strategy. For this, we first propose a mathematical model (...) of tumor-immune interactions and conduct stability analysis of two equilibria. Next, the feedback control is found by solving the Hamilton–Jacobi–Bellman equation. Here, we use an upwind finite-difference method for a numerical approximate solution of the HJB equation. Numerical simulations show that the feedback control can help determine the treatment protocol of chemotherapy for tumor and immune cells depending on the side effects. (shrink)

Lun heng / Wang Chong zhuan -- Feng su tong yi / Ying Shao zhuan -- Feng shi wen jian ji / Feng Yan zhuan -- Shang shu gu shi / Li Chuo zhuan -- Guan qi xia yu / bu zhao zhuan ren -- Chun ming tui chao lu / Song Minqiu zhuan -- Song Jingwen bi ji / Song Qi zhuan -- Dong yuan lu / Gong Dingchen zhuan -- Wang shi tan lu / Wang Qinchen zhuan -- (...) Zhu shi / Wang Dechen zhuan -- Wen chang za lu : bu yi / Pang Yuanying zhuan -- Mengxi bi tan : bu bi tan / Shen Kuo zhuan. (shrink)

1. Tan'gun sinhwa ŭi wŏnhyŏngjŏk segyegwan kwa p'ungnyu chŏngsin -- 2. Wŏnhyo ŭi hwajaeng sasang kwa muaehaeng ŭi silch'ŏn -- 3. Ŭisang ŭi 'Hwaŏm ilsŭng pŏpkyedo' e nat'anan Hwaŏm sasang -- 4. Chinul ŭi Tono chŏmsu wa Chŏnghye ssangsu sasang -- 5. Sambong Chŏng To-jŏn ŭi Pulgyo paech'ŏk ŭi naeyong kwa sŏngkyŏk -- 6. T'oegye Yi Hwang ŭi ch'ŏrhakchŏk ipchang kwa 'Kyŏng' sasang -- 7. Kobong Ki Tae-sŭng ŭi hangmun chŏngsin kwa ch'ŏrhak sasang -- 8. Ugye Sŏng Hon ŭi (...) Tohakchŏk sam kwa hangmun yŏnwŏn -- 9. Yulgok Yi I ŭi Taedong sahoeron kwa ch'ŏrhakchŏk chihyang -- 10. Sŏgye Pak Se-dang ŭi Sirhakchŏk sayu ŭi kich'o -- 11. Namdang Han Wŏn-jin ŭi yŏksa insik kwa Chosŏn chunghwajuŭi -- 12. Sŏngdam Song Hwan-gi ŭi 'T'aegŭk tosŏl' haesŏk ŭi kibon ipchang -- 13. Kanjŏng Yi Nŭng-hwa 'Chosŏn Togyosa' ŭi haksulsachŏk ŭiŭi wa han'gye -- 14. Manhae Han Yong-un i pon chuch'e ŭi munje wa minjok chagyŏl ŭi wŏnch'ik -- purok. T'algyŏnggye sidae ŭi Han'guk ch'ŏrhak ŭi inmunhakchŏk ŭiŭi wa chŏnmang: Yulgok ŭi ch'ŏrhak. (shrink)

덜그럭 덜그럭 소란한 우리네 마음 살림살이를 깨끗하게 청소해주는 산중 큰스님을 만나다 “쩔쩔 맬 것 없이, 집착할 것도 없이, 한세상 훨훨 살아라!” ‘집안 살림’이 아무리 풍족해도 ‘마음 살림’ 부족하면 다 헛인생이다. 진짜 잘사는 사람은 쩔쩔 맬 일도 없이, 집착할 것도 없이 트인 마음으로 훨훨 살아가는 사람이 아닐까? 그런 길로 안내하는 스물일곱 산중 선승들을 만났다.“우리는 누구인가”, “어떻게 살아야 하는가”, “마음과 몸이 힘들고 어려울 때는 어떻게 해야 할까”. 저자는 오래전부터 팍팍한 세상에 필요한 ‘마음 살림살이’를 탁발하러 선승들을 찾아다녔다. 때로는 시대와 역사와 사회에 대한 촌철의 (...) 말씀을 청했고, 때로는 노스님의 살아온 이야기를 듣고 일상을 엿보기도 했다. 모든 스님들이 무더운 여름날 한줄기 시원한 소나기였다. 이 책에는 ‘염화실의 향기’라는 이름으로 경향신문에 연재한 글을 보완해 다시 쓴 것과 이후 만난 큰스님까지 모두 스물일곱 분의 이야기를 담았다. 그사이 이 세상을 떠나가신 큰스님들은 2부에 따로 모셨다. 스님들 몸은 산중에 있어서도 그 말씀은 속세를 떠나지 않았다. 어지럽고 어려운 이 세상을 향한 한 말씀 한 말씀은 송곳처럼 정곡을 찌르며 우리네 눈과 귀, 마음을 환하게 밝혀준다. 깨끗하게 비질 된 큰스님들의 ‘마음 마당’을 거닐다보면, 누구나 잃었던 마음의 본래 밝음을 되찾고, 저마다 ‘마음을 살리는 화두’ 하나씩 가슴에 품게 된다. (shrink)

本书包括:人生境界;利己与利地;公德和私德;道德现象评析;关于高考改革问题;美国素质教育述评;科学发现与创新思维等内容。.

本书内容包括:儒家与人际关系的改善;谈儒家与心灵生活;谈孟子与成功之道;感悟老子的人生大智慧等。.

세계경제의 시대별 변천과정, 우리나라의 경제성장 및 발전과정을 살피고 한국 기업의 역할 및 기여를 규범적으로 평가하여 경제 후유증 및 부작용의 원인 을 살폈다.

Ng :255–285, 1995. https://doi.org/10.1007/bf00852469) models the evolutionary dynamics underlying the existence of suffering and enjoyment and concludes that there is likely to be more suffering than enjoyment in nature. In this paper, we find an error in Ng’s model that, when fixed, negates the original conclusion. Instead, the model offers only ambiguity as to whether suffering or enjoyment predominates in nature. We illustrate the dynamics around suffering and enjoyment with the most plausible parameters. In our illustration, we find surprising results: (...) the rate of failure to reproduce can improve or worsen average welfare depending on other characteristics of a species. Our illustration suggests that for organisms with more intense conscious experiences, the balance of enjoyment and suffering may lean more toward suffering. We offer some suggestions for empirical study of wild animal welfare. We conclude by noting that recent writings on wild animal welfare should be revised based on this correction to have a somewhat less pessimistic view of nature. (shrink)

Intergenerational impartiality requires putting the welfare of future generations at par with that of our own. However, rational choice requires weighting all welfare values by the respective probabilities of realization. As the risk of non-survival of mankind is strictly positive for all time periods and as the probability of non-survival is cumulative, the probability weights operate like discount factors, though justified on a morally justifiable and completely different ground. Impartial intertemporal welfare maximization is acceptable, though the welfare of people in (...) the very far future has lower effects as the probabilities of their existence are also lower. However, the effective discount rate on future welfare values justified on this ground is likely to be less than 0.1 per annum. Such discounting does not compromise environmental protection and sustainability unduly. The finiteness of our universe implies that the sum of our expected welfare to infinity remains finite, solving the paradox of having to compare different infinite values in optimal growth/conservation theories. (shrink)